It includes the UGI reaction & Brook rearrangement.
mechanism & application also included that presentation.
student will be helpful for easilly available this reaction.
2. UGI REACTION
-discovered by Ivank Ugi in 1968
-formed peptide bonding formation
-used four compound &no catalyst used
-interconversion atomic reaction
-condensation reaction
3. General Reaction
*
H
O
CH3 NH2
CH3NC CH3COOH CH3 C
O
N
NHCH3CH3
CH3 O
Aldehyde
amine isocynide acid
peptide bonding
H
O
CH3 NH2
CH3NC CH3COOH CH3 C
O
N
NHCH3CH3
CH3 O
Aldehyde
amine isocynide acid
peptide bonding
4. MECHANISM-------
-firstly aldehyde react with amine & formed intermediate-I
by removal of water molecule.
-second step react above compound isocynide and formed
intermediate-II
-these intermediate react with acid and formed peptide
bonding and also called UGI Reaction.
7. MECHANISM----
Rearrangement of α-silyl oxy-anion to car anion via
reversible process involving pentad-coordinate
silicon intermediate or [1,2]-silly migration.
8. General Reaction
Mechanism :-
CH3 C SiH3
OH
CH3
CH3 Li
CH3 Li
O
CH3
SiH3
CH3 SiH3
O
CH3
H
Base
CH3 SiH3
O
CH3
CH3 SiH
CH3
O
H
CH3 C
O
CH3
SiH3
H2O
CH3 H
O
CH3
SiH3
Silyl ether
Silane
9. Application:
-analogue of phosphate brook rearrangement of 1-hydroxy
phosphonates has also been reported.
-alkylation of brook rearrangement.
-synthesis of scalaren dye using acyl silane.
-stereospecific & regiospecific synthesis of enol silly ether.
-potential application.