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Topic Refinement

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Effective Health Care Program
Health & Medicine
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Topic Refinement Prepared for: The Agency for Healthcare Research and Quality (AHRQ) Training Modules for Systematic Reviews Methods Guide www.ahrq.gov
Systematic Review Process Overview
[object Object],[object Object],[object Object],[object Object],[object Object],Learning Objectives
[object Object],[object Object],[object Object],[object Object],[object Object],Effective Health Care Program Principles Whitlock EP, et al. In: Methods guide for comparative effectiveness reviews . Available at: http://www.effectivehealthcare.ahrq.gov/ index.cfm/search-for-guides-reviews-and-reports/ ?pageaction= displayproduct&productid=318.
Topic Refinement in the Comparative Effectiveness Review (CER) Process Develop Topic Identify and triage topics based on appropriateness, importance, desirability of new research/duplication, feasibility, and potential impact. Refine Topic Identify patient intervention, comparator, outcomes, timing, and setting of each topic. Review Topic Prepare topic, search for and select studies, abstract data, analyze and synthesize data, and present findings. Engage Stakeholders in Clarifying Areas for Future Research Identify future research needs and inform real world health care decisions.
[object Object],[object Object],[object Object],[object Object],[object Object],Topic Refinement Whitlock EP, et al. In: Methods guide for comparative effectiveness reviews . Available at: http://www.effectivehealthcare.ahrq.gov/ index.cfm/search-for-guides-reviews-and-reports/ ?pageaction=displayproduct&productid=318.
[object Object],[object Object],[object Object],A Question That Does Not Reflect Uncertainty
[object Object],[object Object],[object Object],[object Object],[object Object],Questions That Reflect Uncertainty (I)
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Questions That Reflect Uncertainty (II)
[object Object],[object Object],[object Object],[object Object],[object Object],Importance of Getting the Questions Right Whitlock EP, et al. In: Methods guide for comparative effectiveness reviews . Available at: http://www.effectivehealthcare.ahrq.gov/ index.cfm/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productid=318.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Key Questions Derived From Assessing PICOTS Whitlock EP, et al. In: Methods guide for comparative effectiveness reviews . Available at: http://www.effectivehealthcare.ahrq.gov/ index.cfm/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productid=318.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Defining Good Key Questions Whitlock EP, et al. In: Methods guide for comparative effectiveness reviews . Available at: http://www.effectivehealthcare.ahrq.gov/ index.cfm/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productid=318. PICOTS = population, intervention, comparators, outcomes, timing, and setting
Devise an Analytic Framework* *See Analytic Frameworks module Phung OJ, et al. Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients With Cystic Fibrosis [draft report]. Available at: http://www.effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction= displayproduct&productid=391.
[object Object],[object Object],[object Object],[object Object],[object Object],Roles of Key Informants Whitlock EP, et al. In: Methods guide for comparative effectiveness reviews . Available at: http://www.effectivehealthcare.ahrq.gov/ index.cfm/search-for-guides-reviews-and-reports/ ?pageaction=displayproduct&productid=318.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Gaining Context Through Key Informants Whitlock EP, et al. In: Methods guide for comparative effectiveness reviews . Available at: http://www.effectivehealthcare.ahrq.gov/ index.cfm/search-for-guides-reviews-and-reports/ ?pageaction=displayproduct&productid=318.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Types of Key Informants (I) Whitlock EP, et al. In: Methods guide for comparative effectiveness reviews . Available at: http://www.effectivehealthcare.ahrq.gov/ index.cfm/search-for-guides-reviews-and-reports/ ?pageaction=displayproduct&productid=318.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Types of Key Informants (II) Whitlock EP, et al. In: Methods guide for comparative effectiveness reviews . Available at: http://www.effectivehealthcare.ahrq.gov/ index.cfm/search-for-guides-reviews-and-reports/ ?pageaction=displayproduct&productid=318.
[object Object],[object Object],[object Object],Public Comment Enhances Input and Transparency Whitlock EP, et al. In: Methods guide for comparative effectiveness reviews . Available at: http://www.effectivehealthcare.ahrq.gov/ index.cfm/search-for-guides-reviews-and-reports/ ?pageaction=displayproduct&productid=318.
[object Object],[object Object],[object Object],[object Object],Revising Key Questions After Public Comment Whitlock EP, et al. In: Methods guide for comparative effectiveness reviews . Available at: http://www.effectivehealthcare.ahrq.gov/ index.cfm/search-for-guides-reviews-and-reports/ ?pageaction=displayproduct&productid=318.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Topic Refinement Process: UCONN/HH EPC Example (I) PICOTS = population, intervention, comparators, outcomes, timing, and setting; UCONN/HH EPC = University of Connecticut/Hartford Hospital Evidence-based Practice Center
[object Object],[object Object],[object Object],[object Object],[object Object],Topic Refinement Process: UCONN/HH EPC Example (II) PICOTS = population, intervention, comparators, outcomes, timing, and setting; UCONN/HH EPC = University of Connecticut/Hartford Hospital Evidence-based Practice Center
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Topic Refinement Process: UCONN/HH EPC Example (III) UCONN/HH EPC = University of Connecticut/Hartford Hospital Evidence-based Practice Center
Topic Refinement Process: UCONN/HH EPC Example (IV) Phung OJ, et al. Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients With Cystic Fibrosis [draft report]. Available at: http://www.effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction= displayproduct&productid=391. UCONN/HH EPC = University of Connecticut/Hartford Hospital Evidence-based Practice Center
[object Object],[object Object],[object Object],[object Object],Topic Refinement Process: UCONN/HH EPC Example (V) UCONN/HH EPC = University of Connecticut/Hartford Hospital Evidence-based Practice Center
[object Object],[object Object],[object Object],[object Object],[object Object],Topic Refinement Process: UCONN/HH EPC Example (VI) UCONN/HH EPC = University of Connecticut/Hartford Hospital Evidence-based Practice Center
[object Object],[object Object],[object Object],Topic Refinement Process: UCONN/HH EPC Example (VII) BIA = bioelectric impedance analysis; DEXA = dual energy x-ray absorptometry; UCONN/HH EPC = University of Connecticut/Hartford Hospital Evidence-based Practice Center
[object Object],[object Object],[object Object],[object Object],Topic Refinement Process: UCONN/HH EPC Example (VIII) FEV1 = forced expiratory volume in 1 second; UCONN/HH EPC = University of Connecticut/Hartford Hospital Evidence-based Practice Center
[object Object],[object Object],[object Object],Topic Refinement Process: UCONN/HH EPC Example (IX) UCONN/HH EPC = University of Connecticut/Hartford Hospital Evidence-based Practice Center
[object Object],[object Object],Topic Refinement Process: UCONN/HH EPC Example (X) UCONN/HH EPC = University of Connecticut/Hartford Hospital Evidence-based Practice Center
[object Object],[object Object],[object Object],[object Object],Key Questions (I)
[object Object],[object Object],[object Object],Key Questions (II)
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Key Messages
[object Object],[object Object],References
[object Object],[object Object],Author

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Topic Refinement

  • 1. Topic Refinement Prepared for: The Agency for Healthcare Research and Quality (AHRQ) Training Modules for Systematic Reviews Methods Guide www.ahrq.gov
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  • 5. Topic Refinement in the Comparative Effectiveness Review (CER) Process Develop Topic Identify and triage topics based on appropriateness, importance, desirability of new research/duplication, feasibility, and potential impact. Refine Topic Identify patient intervention, comparator, outcomes, timing, and setting of each topic. Review Topic Prepare topic, search for and select studies, abstract data, analyze and synthesize data, and present findings. Engage Stakeholders in Clarifying Areas for Future Research Identify future research needs and inform real world health care decisions.
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  • 13. Devise an Analytic Framework* *See Analytic Frameworks module Phung OJ, et al. Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients With Cystic Fibrosis [draft report]. Available at: http://www.effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction= displayproduct&productid=391.
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  • 23. Topic Refinement Process: UCONN/HH EPC Example (IV) Phung OJ, et al. Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients With Cystic Fibrosis [draft report]. Available at: http://www.effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction= displayproduct&productid=391. UCONN/HH EPC = University of Connecticut/Hartford Hospital Evidence-based Practice Center
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