Urinary Tract Infection B pharm Third year VI semester

1. Urinary Tract Infection
Presented by:
Mr. Shaikh Akhil. M.
M.Pharm
Asst. Prof. Dept. of Pharmacology,
BCCO Pharmacy, Naigaon,
S.R.T.M.University, Nanded

5. Urinary Tract Infection - Introduction
 UTI is a common disorder at all age & gender
 Types- A. Lower urinary tract infection B. upper UTI
 Symptoms –
A. Lower UTI- 1. increase frequency of urination without passing much
urine 2. burning with urination 3. cloudy urine 4. urine look like- cola
or tea 5. strong odour 6. pain
B. Upper UTI- 1. pain tenderness in upper back side 2. chills with
headache 3. fever-come-go 4. nausea – vomiting
 Cause + Risk factor- 1. female anatomy 2. certain birth control 3.
menopause 4. infection of bladder , urethra 5. blockage of UT 6.
suppressed immune system 7. catheter use + stent use in stone
 It is important to know the cause and type of microorganism
 95% case of uncomplicated UTI in female – due to gram negative
bacilli. E.coli is common-80%, other like- staphylococci .
Aerobactex, pseudomonas aerogenosa, entercocci, streptococci,

9. UTI-Drug Therapy
 Goal for treatment –
1. To eradicate the infecting organism
2. To provide symptomatic relief by altering PH of urine or giving –
phenazopyridine
3. To prevent and treat recurrence of UTI
4. To identify and treat predisposing factors
 General principle of therapy-
1. In acute case- appropriate drugs may be started as soon as urine
sample has collected for bacteriological examination
2. In chronic case- mixed infection and renal failure may possible – no
desperate hurry to start therapy before the case is throughly
investigated.
3. Pregnant woman must be screen fore bactreiurea in 1st trimester
4. Alkalisation of urine – decrease irritation of urinary tract

11. Drug therapy-Classification of drug –
 Bacteriostatic – sulphonamide, doxycycline, nitrofurantoin
 Bacterocidal- cotrimoxazole, ampicillin, extended spectrum penicillin,
aminoglycoside, fluroquinolones, azithromycin
 Urinary antiseptic- orally administerd antimicrobial agent which attain
antibacterial concentration only in urine with no systemic antibacterial effect
 They are concentrated in kidney tubules and useful in lower urinary tract
infection. Urinary antiseptic- at locally
 Nitrofurantoin – low conc.- static higher conc.- cidal.
 Activity is increase in acidic urine 2. many gram negative bacteria except
proteus E.coli now uses E.coli
 Mechanism – susceptible bacteria enzymatically reduce nitrofurantoin to
generate reactive intermediate which affect DNA & affect protein synthesis
 Containdication- renal failure, pregnancy & neonates
 ADR- GI intolarance, nausea, vomiting, epigastric pain, diarrhoea
 Use- uncomplicated lower UTI now reserved drug – 50-100 mg TDS- 5-
10days

12. Thank You