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Urinary Tract Infection

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Urinary Tract Infection
B pharm Third year VI semester

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Urinary Tract Infection

  1. 1. Urinary Tract Infection Presented by: Mr. Shaikh Akhil. M. M.Pharm Asst. Prof. Dept. of Pharmacology, BCCO Pharmacy, Naigaon, S.R.T.M.University, Nanded
  2. 2. Urinary Tract Infection - Introduction  UTI is a common disorder at all age & gender  Types- A. Lower urinary tract infection B. upper UTI  Symptoms – A. Lower UTI- 1. increase frequency of urination without passing much urine 2. burning with urination 3. cloudy urine 4. urine look like- cola or tea 5. strong odour 6. pain B. Upper UTI- 1. pain tenderness in upper back side 2. chills with headache 3. fever-come-go 4. nausea – vomiting  Cause + Risk factor- 1. female anatomy 2. certain birth control 3. menopause 4. infection of bladder , urethra 5. blockage of UT 6. suppressed immune system 7. catheter use + stent use in stone  It is important to know the cause and type of microorganism  95% case of uncomplicated UTI in female – due to gram negative bacilli. E.coli is common-80%, other like- staphylococci . Aerobactex, pseudomonas aerogenosa, entercocci, streptococci,
  3. 3. UTI-Drug Therapy  Goal for treatment – 1. To eradicate the infecting organism 2. To provide symptomatic relief by altering PH of urine or giving – phenazopyridine 3. To prevent and treat recurrence of UTI 4. To identify and treat predisposing factors  General principle of therapy- 1. In acute case- appropriate drugs may be started as soon as urine sample has collected for bacteriological examination 2. In chronic case- mixed infection and renal failure may possible – no desperate hurry to start therapy before the case is throughly investigated. 3. Pregnant woman must be screen fore bactreiurea in 1st trimester 4. Alkalisation of urine – decrease irritation of urinary tract
  4. 4. Drug therapy-Classification of drug –  Bacteriostatic – sulphonamide, doxycycline, nitrofurantoin  Bacterocidal- cotrimoxazole, ampicillin, extended spectrum penicillin, aminoglycoside, fluroquinolones, azithromycin  Urinary antiseptic- orally administerd antimicrobial agent which attain antibacterial concentration only in urine with no systemic antibacterial effect  They are concentrated in kidney tubules and useful in lower urinary tract infection. Urinary antiseptic- at locally  Nitrofurantoin – low conc.- static higher conc.- cidal.  Activity is increase in acidic urine 2. many gram negative bacteria except proteus E.coli now uses E.coli  Mechanism – susceptible bacteria enzymatically reduce nitrofurantoin to generate reactive intermediate which affect DNA & affect protein synthesis  Containdication- renal failure, pregnancy & neonates  ADR- GI intolarance, nausea, vomiting, epigastric pain, diarrhoea  Use- uncomplicated lower UTI now reserved drug – 50-100 mg TDS- 5- 10days
  5. 5. Thank You
  • OmSomwanshi

    Jun. 25, 2021
  • AKHILSHAIKH2

    Jun. 7, 2021

Urinary Tract Infection B pharm Third year VI semester

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