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Knee joint Osteoarthritis
1.
2. Prepared by: Dr.Abdul Ahad Khoshal
PGR3Y, Orthopedic surgery
MRH, Kandahar, Afghanistan
Supervisor: Dr. Niamatullah shehzad
Trainer specialist, Orthopedic surgery
MRH, Kandahar, Afghanistan
Contact: daan4ig@gmail.com
3. D e f i n i t i o n
A DEGENERATIVE, NON-INFLAMMATORY
JOINT DISEASE CHARACTERIZED BY DESTRUCTION OF ARTICULAR
CARTILAGE AND FORMATION OF NEW BONE AT THE JOINT
SURFACES AND MARGINS.
THE TERM OSTEOARTHRITIS WAS COINED BY JOHN
SPENDON. HOWEVER, IT IS A MISNOMER AND THE RIGHT
TERM IS OSTEOARTHROSIS OR DEGENERATIVE JOINT DISEASE.
IT COULD BE PRIMARY OR SECONDARY AND THE FORMER IS
MORE COMMON
3
4. O s t e o a r t h r i t i s A ff e c t s T h e S y n o v i a l J o i n t s ,
T h o u g h
I t C a n A ff e c t A n y J o i n t , I t I s M o r e
C o m m o n I n T h e
We i g h t B e a r i n g J o i n t s L i k e T h e :
H i p
K n e e
S p i n e , E t c .
4
5. Primary Osteoarthritis Of The Knee
(Also Called Idiopathic)
Etiological causes for primary osteoarthritis:
Though exact cause is not known, the
following factors are
suspected to play an important role in the
causation
of primary osteoarthritis:
• Obesity
• genetics and
• Heredity
• occupation involving prolonged standing
• Sports
• multiple endocrinal disorders
• Multiple metabolic disorders.
5
6. SECONDARY OSTEOARTHRITIS OF THE KNEE
It Is Generally Observed That Secondary Osteoarthritis
Occurs In The Younger Age Groups And Is More Severe
Than The Primary.
6
7. The Causes For Secondary Osteoarthritis
The Knee Are As Follows:
•Obesity.
•Valgus And Varus Deformities Of The Knee.
•Intra-articular Fractures Of The Knee, Etc.
•Rheumatoid Arthritis, Infection, Trauma, Tb, Etc.
•Hyperparathyroidism.
•Hemophilia.
•Syringomyelia.
•Neurological Disease Like Diabetes.
•Overuse Of Intra-articular Steroid Therapy.
7
8. Features
•it commonly affects the knee joint.
•All races are susceptible.
•Common in older age group/middle-aged patients
• It causes varus deformity of the knee in the late stages
•Eighty percent of people are affected by 40 years,
but only 40 percent show symptoms.
8
9. Feature…..
. One in three people over 60 years are affected and
more than three in four persons over the age of
seventy show some radiographic evidence of the
condition
•Very rarely it can be seen in younger people.
• Women have a greater tendency than men do
• More than 50 percent have bilateral OA knee.
9
10. What are the typical symptoms of osteoarthritis?
• P A I N
• E A R L Y M O R N I N G S T I F F N E S S
• R E S T R I C T E D R A N G E O F J O I N T M O V E M E N T S
• S W E L L I N G O F T H E J O I N T S .
10
11. Remember the risk factors
o O – O B E S I T Y
o S – S E N I L I T Y O R O L D A G E
o T – T R AU M A
o E – E M O T I O N A L S T R E S S
o O – O S T E O P O R O S I S
o A – A L C O H O L
o R – R I G O R O U S L I F E S T Y L E S
o T – TA X I N G P R O F E S S I O N S
o H – H O R M O N A L I M B A L A N C E S
o R – R E P E T I T I V E I N J U R I E S
o I – I N D I A N C U LT U R A L H A B I T S
o T – A X I N G S P O R T S
o I – I M P R O P E R P O S T U R A L H A B I T S
o S – S M O K I N G
11
12. MECHANISMS FOR MAINTAINING
JOINT STABILITY
o Alignment of joint components
o Shape and fit of articular surfaces
o Adhesive property of synovial fluid
o Integrity of capsule and ligaments
o Muscle tone and power
o Neurological control of balance
12
13. Sequence of pathological events in
osteoarthritis
The disease process usually begins in the
anteromedial compartment of the knee joint.
Fibrillation due to loss of water of the weight bearing
articular cartilage is seen in early stages of the
disease followed by complete loss of
articularcartilage.
This puts enormous pressure on the underlying
bone, which causes sclerosis and later
eburnation.
Cysts may develop in the subchondral area due to
microfractures that degenerate.
New bone formation takes place and results in
osteophyte formatio
13
15. Clinical feature
PREDOMINANT SYMPTOM IS PAIN WHICH DECREASES ON WALKING.
THE PAIN IS POORLY LOCALIZED AND
IS DULL ACHING IN NATURE.
MILD SWELLING OF THE KNEE JOINT AND EARLY MORNING STIFFNESS.
EARLY MORNING STIFFNESS, WHICH SUBSIDES OVER THE DAY AFTER SOME
ACTIVITY.
MINIMAL TENDERNESS AND COARSE CREPITUS CANBE ELICITED.
IF THERE ARE LOOSE BODIES IN A JOINT,
THE PATIENT GIVES HISTORY OF LOCKING .
TERMINAL MOVEMENTS OF THE KNEE ARE RESTRICTED
THE PATIENT COMPLAINS OF GENU VARUM DEFORMITY MAY BE SEEN IN VERY
ADVANCED CASES
IN SOME CASES, OSTEOPHYTES MAY BE PALPABLE.
WASTING OF QUADRICEPS FEMORIS MUSCLE*
15
16. How to make a diagnosis?
• Physical examination
• Symptomatology
• Radiography
• Blood tests
• CT scan and MRI.
16
18. Criteria and Classification of OA Knee
(American College of Rheumatology—ACR)
Clinical:
1. Knee Pain For Most Days Of Prior Month.
2. Crepitus On Active Joint Motion.
3. Morning Stiffness Equal And Not More Than 30
Minutes In Duration.
4. Age Equal To More Than 38 Years.
5. Bony Enlargement Of The Knee On Examination.
Oa Is Present (Clinical)
1, 2, 3, 4 Or 1, 2, 5 Or 1, 4, 5
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19. Clinical and Radiological
1. Knee pain for most days of the prior month.
2. Osteophytes at joint margins.
3. Synovial fluid typical of OA knee.
4. Age—40 years.
5. Morning stiffness equal and not more than 30
minutes.
6. Crepitus on active joint motion.
19
OA Present (Clinical And Radiological)
1, 2 Or 1, 3, 5, 6 Or 1, 4, 5, 6.
20. Investigations
LABORATORY INVESTIGATIONS ARE USUALLY WITHIN NORMAL LIMITS.
SEROLOGICAL TESTS AND ESR TO RULE OUT RHEUMATOID ARTHRITIS*
SERUM URIC ACID TO RULE OUT GOUT *
RADIOLOGICAL EXAMINATION OF THE KNEE JOINT IS THE MOST IMPORTANT
DIAGNOSTIC TOOL.
LOSS OF JOINT SPACE (DUE TO DESTRUCTION
OF ARTICULAR CARTILAGE).
20
21. 21
•S C L E R O S I S ( D U E T O I N C R E A S E C E L L U L A R I T Y
A N D B O N E
D E P O S I T I O N ) .
• S U B C H O N D R A L C Y S T S ( D U E T O S Y N O V I A L F L U I D
I N T R U S I O N
I N T O T H E B O N E ) .
• O S T E O P H Y T E S ( D U E T O R E VA S C U L A R I Z AT I O N O F
R E M A I N I N G C A R T I L A G E A N D C A P S U L A R
T R A C T I O N ) .
• B O N Y C O L L A P S E ( D U E T O C O M P R E S S I O N O F
W E A K E N E D
B O N E ) .
• L O O S E B O D I E S ( D U E T O F R A G M E N TAT I O N O F
O S T E O C H O N D R A L S U R FA C E ) .
• D E F O R M I T Y A N D M A L A L I G N M E N T ( D U E T O
D E S T R U C T I O N
O F C A P S U L E S A N D L I G A M E N T S ) .
22. Kellegren and Lawrence
Radiological Grading
Grade I: Doubtful narrowing of joint space and
possible osteophyte lipping.
Grade II: Definite osteophytes and possible narrowing
of the joint space.
Grade III: Moderate multiple osteophytes, definite
narrowing of joint space and some sclerosis and
possible deformity of the bone ends.
Grade IV: Large osteophytes, marked narrowing of
joint space, severe sclerosis and definite deformity
of the bone ends.
22
23. Radiological Classification of OA Knee
(Ahlbach)
AP weight bearing and Lateral Views
Type I : Joint space narrowing.
Type II : Total loss of joint space.
Type III : < 5 mm tibial erosion but posterior part of the
plateau intact.
Type IV : > 5 mm tibial erosion and erosion of posterior
plateau.
Type V : Subluxation.
Note: Grades IV and V: TKR is the line of treatment
23
24. Other Investigations
• Arthroscopic examination:
This allows direct inspection and visualization of the damaged joint
surfaces.
• But arthroscopy alone for diagnostic purposes is rarely used.
•Synovial fluid analysis shows non-inflammatory picture.
• Bone scan , MRI
and CT scan also helps to diagnose, subchondral cysts,
osteophytes, etc.
24
25. Treatment
Before beginning the treatment, the diagnosis of
OA is a must. ACR diagnostic criteria for OA
knee to be followed.
•Treatment to be individualized and tailored to
severity.
•Multiple strategies may be required in most of
the cases.
25
26. ACR Guidelines: Traditional Format
•KNEE PAIN.
•RADIOGRAPHIC OSTEOPHYTES.
•AT LEAST ONE OF THE FOLLOWING THREE:
–AGE GREATER THAN 50 YEARS.
–MORNING STIFFNESS LESS THAN OR EQUAL TO 30
MINUTES.
–CREPITUS ON MOTION.
26
27. Aims of Treatment of OA Knee
It can be best illustrated by 4 R’s:
•Relieve pain.
•Restore function.
•Reduce disability if any
•Rehabilitation.
27
28. Conservative Methods
This Forms The Mainstay Of Management In Osteoarthritis Of The Knee.
About 50 Percent Of Patients Respond To Conservative Treatment, Which
Consists Of The Following Measures.
28
29. Nonpharmacological Treatment
This is the initial and main stay of treatment in OA knees.
Self education—Educating the patient and his
relatives measures about the disease is the most
important aspect of the non-pharmacological
treatment and should be done first.
•Weight loss
•Physiotherapy
•Therapuetic exercises
•Assistive devices
•Occupational therapy
•Aerobic exercise program
•Strengthening of the quadriceps
•Supervised fitness walking program
•Swimming/hydrotherapy
•Modifications of activity of daily living
Avoidance of stress
29
30. Mechanical aids
They reduce the load on the knee joint and provides
support to the weak knees. The following are used
in OA knees:
•Cane
•Shoe inserts
•Shoe supplements: Good shock absorber, good
mediolateral support, adequate arch support>
•Lateral heel wedges: To reduce pain of medial
tibiofemoral joint OA.
•Knee brace and support in varus knees.
30
31. Components of Therapeutic Exercise
Range of motion and flexibility:
Soft tissue flexibility of both contractile (muscle, tendon) and noncontractile tissues (capsule,
ligaments) is affected by arthritis and inactivity. Joint stiffness and soft tissue shortening
can be reduced with:
appropriate range of motion (ROM) and
stretching exercises.
31
32. 32
• All aspects of muscle strength (strength, endurance, power) can be
impacted as a result of intra-articular and extra-articular inflammatory
processes, disuse, reflex
inhibition in response to pain and joint effusion,
decreased protective muscular reflexes, loss of
mechanical integrity around the joint, and even
medication side effects. Muscle strengthening
exercises helps to overcome these problems.
Quadriceps exercises strengthening of quadriceps
musculature with either isometric or isotonic,
resistive exercises was associated with significant
improvement in quadriceps strength, knee pain,
and function.
33. • Aerobic (Cardiovascular) exercise:
Persons with arthritis tend to be less fit than noninvolved peers. However, there is
strong evidence for the role of regular and vigorous exercise to improve
all components of physical fitness, including cardiovascular fitness and endurance even
in people with arthritis.
Most studies have limited their interventions to
walking,
Stationarybicycling
aerobic dancing
aquatic exercise
33
35. Avoidance of stress
Avoidance of stress and strain to the affected
joint in day-to-day activities. For example, a
patient with OA of the knee is advised to
avoid standing or running whenever possible.
Sitting cross legged and squatting is harmful
for OA of the knee.
35
37. Physiotherapy
Physical modalities that may contribute to pain relief include
the application of superficial heat (hot packs,heating pads, hot water bottles, or paraffin) and/or
cold (cold packs or ice packs).
37
38. Weight Loss
• Obesity is a risk factor for the development of OA, and is associated with radiological
progression of the disease, and disability.
• When people walk their body weight is transferred across the knee joint
• any excess weight should be multiplied by this factor to estimate the excess force across
the knee joint of overweight people.
• In managing OA, weight reduction should be a key goal. Exercise plays a role, but pain
and disability can make it difficult for patients to exercise
sufficiently to lose weight.
• Weight loss can be achieved with:
regular sessions with a dietitian who can provide instruction on reducing caloric intake
and the use of food diaries, and
cognitive-behavioral
modification to change dietary habits.
38
39. 39
Pharmacologic Drugs
• Nonopioid analgesics – E.g. Acetaminophen:
This is the drug of first choice. Up to 4 gm/day can be given.
• NSAIDs: If patients fail to respond to paracetamol or other
oral or topical analgesics, then the use of an NSAID is
indicated.
• Opioid analgesics: These can be tried if patients fail to
respond to paracetamol and NSAIDs
• Food supplementation: Glucosamine andChondroitin
sulfate: Can reduce 20-25 percent pain in mild to moderate
OA. Over the counter food supplements, 1500 mg/day for
at least 3months.
40. • Intra-articular steroids:
o This is indicated if there is effusion and there are signs of inflammation
o The basic intra-articular steroid injections are designed to provide 2 to 6 weeks of pain
relief for patients with knee osteoarthritis
o Such steroids are used to decrease the inflammatory reaction associated with
osteoarthritis
40
41. contraindicated in patients with:
• bacteremia,
• Sepsis
• periarticular or intra-articular infections (eg, septic arthritis, periarticular cellulitis,
osteomyelitis)
• significant skin breakdown at the target site
• known hypersensitivity to the steroid injection
• intraarticular or osteochondral fracture at the target site
• severe joint destruction
• joint prosthesis, or uncontrolled coagulopathy.
41
42. • Viscosupplementation: Injection of hyaluronic acid
into the joint.
• Once a week for 3 weeks. Adverse reactions in 2-3 percent.
• Topical analgesics: These are indicated in the following situations:
–If patients do not respond to oral analgesics.
–If patients do not wish to take systemic drugs.
–Can be used as a monotherapy or adjunct.
–Capsaicin cream – 4 times a day.
42
43. 43
Viscosuplementation in OA knee?
Viscosuplementation: (Intra-articular hyaluronan therapy)
This procedure consists of removal of pathologic
osteoarthritis synovial fluid
and replacement of hyaluronan-based products that restore
the molecular weight and concentration of hyaluronan to normal
values that is reduced in OA knee.
Hyaluronan helps in joint lubrication
buffers load transmission
imparts anti-inflammatory properties to synovial fluid.
Indications for Intra-articular Hyaluronic Acid Injection
•Failed conservative treatment
•If there are major risk factors for surgery
•Failed intra-articular steroid injections
•Advanced osteoarthritis.
45. Alternative Therapies
•Acupuncture
•Bio-feedback
• Aquatic physical therapy
•Massage
•Acupressure
•Tai Chi
•Balenotherapy
•Yoga
The proponents of alternative therapies claim
good results from their respective interventions. The
results are good in the hands of experts.
45
46. Surgery
Indications for surgery
•Pain refractory to conservative measures.
•History of frequent locking episodes.
•Hemarthrosis due to loose bodies or
osteochondral fractures.
•Deformity, usually genu varum.
•Joint instability.
•Progressive limitation of knee motion.
46
47. Surgical Methods
• Excision of osteophytes is rarely done alone.
• Excision of loose bodies, meniscectomy, synovectomy,
and reconstruction or joint debridement are best done
by arthroscopy.
47
48. • PROXIMAL TIBIAL OSTEOTOMY (SLOCUM’S):
Indicated for:
unicompartmental osteoarthritis of knee with pain
correct varus (less than 15°) or
valgus deformity (less than 12°).
Pain is decreased in 80 percent of the cases following surgery as
osteotomy changes the line of weightbearing and
brings the more normal surface
Mean
failure rate is 40 percent at 4 years.
48
49. • D i s t a l F e m o r a l O s t e o t o m y I s I n d i c a t e d W h e n Va r u s
O r Va l g u s D e f o r m i t y O f T h e K n e e I s M o r e T h a n 1 2 -
1 5 ° .
• C h o n d r a l R e s u r f a c i n g P r o c e d u r e
– A u t o l o g o u s C h o n d r o c y t e G r a f t i n g : A u t o l o g o u s
C h o n d r o c y t e s F r o m T h e P a t i e n t ’ s K n e e A r e
C u l t u r e d F o r Tw o W e e k s , R e i n s e r t e d U n d e r A
P a t c h O f P e r i o s t e u m .
M o s a i c P l a s t y : S p a r e A u t o l o g o u s H y a l i n e
C a r t i l a g e F r o m O t h e r A r e a s O f K n e e I s I n s e r t e d
I n t o T h e D e f e c t .
49
50. • Arthroscopic debridement: This is a successful
palliative, temporizing treatment of OA knee.
• Total knee arthroplasty: This is indicated when both
the compartments of the knee joint are destroyed
or if valgus or varus deformity is more than 15°.
It is also indicated in failed conservative treatment
50
51. • Arthrodesis is indicated less commonly than
arthroplasty. If the patient is young and involved
in heavy occupation, arthrodesis is indicated to
give him a stable and strong knee. However,
arthrodesis results in a stiff knee, which is a
severe disability.
• Patellectomy: It is rarely done.
• Unicompartmental knee arthroplasty (UKA): This is
again regaining its popularity over tibial
osteotomy in treating unicompartmental OA, as
it helps in early postoperative rehabilitation.
51
Jionts : Structure(materials): 1fibrous 2 cartiligenus 3 synovial
Synovial Joints:
Hange
Condyloid
Povit
Saddle
Plan
Ball and socket
Difference Between Genetic and Hereditary Diseases. The main difference between these two terms lies in the fact that hereditary diseases have the potential of being carried from one generation to another whereas a genetic disease can either be
hereditary or not, but there will always be a mutational change in the genome
Endocrine Dis: DM ,Cushing syndrome, Osteoporosis
Metabolic Dis: fish eye syndrome , Gaucher’s Disease
Arthritis in people with hemophilia is caused by frequent or inadequately treated bleeding into joints. It is sometimes called degenerative joint disease. It may be the most common complication of severe hemophilia. Arthritis can be avoided by properly taking care of joint bleeds. Once it occurs, it is difficult to treat
Syringomyelia is a rare neurogenic disease which can damage the spinal cord due to formation of a fluid-filled area in the form of a cyst (Syrinx), usually found in the high cervical spine. (Also found in lumbar area but this is very rare) The name derives from the word Syrinx, greek for a tube-formed object and the Myelum, referring to the spinal cord
Hemophilia is a rare disorder in which your blood doesn't clot normally because it lacks sufficient blood-clotting proteins (clotting factors). If you have hemophilia, you may bleed for a longer time after an injury than you would if your blood clotted normally.Small cuts usually aren't much of a problem. If you have a severe deficiency of the clotting factor protein, the greater health concern is deep bleeding inside your body, especially in your knees, ankles and elbows.
PATHOLOGY
Osteoarthritis is a degenerative condition primarily
affecting the articular cartilage. The first change
observed is an increase in water content and
depletion of the proteoglycans from the cartilage
matrix. Repeated weight bearing on such a cartilage
leads to its fbrillation. The cartilage gets abraded
by the grinding mechanism at work at the points
of contact between the apposing articular surfaces,
until eventually the underlying bone is exposed.
With further ‘rubbing’, the subchondral bone
becomes hard and glossy (eburnated). Meanwhile,
the bone at the margins of the joint hypertrophies to
form a rim of projecting spurs known as osteophytes.
A similar mechanism results in the formation of
subchondral cysts and sclerosis.
The loose flakes of cartilage incite synovial
infammation and thickening of the capsule, leading
to deformity and stiffness of the joint. Often one
compartment of a joint is affected more than the
other. For example, in the knee joint, the medial
compartment is affected more than the lateral,
leading to a varus deformity (genu varum).
Essential of Orthopeadics 5th Edition
Essential of orthopaedics 5th Edition
Pitfalls of X-rays in OA Knee
•Not reliable in about 15 percent of the cases.
•Weight bearing AP and lateral views are desired.
•Only 40 percent of the people with severe X-ray changes
experience pain.
( ځواکمنتیا، زغم، او قدرت)
By combining steroid injection with joint lavage,
OA patients get more effective pain relief than with
either therapy alone and pain could reduce for as
long as 24 weeks.
Tai Chi:Tai chi is an ancient Chinese tradition that, today, is practiced as a graceful form of exercise. It involves a series of movements performed in a slow, focused manner and accompanied by deep breathing. Tai chi, also called tai chi chuan, is a noncompetitive, self-paced system of gentle physical exercise and stretching
Balneotherapy is the presumed benefit from disease by bathing, a traditional medicine technique usually practiced at spas. While it is considered distinct from hydrotherapy, there are some overlaps in practice and in underlying principles. Balneotherapy may involve hot or cold water, massage through moving water, relaxation, or stimulation. Many mineral waters at spas are rich in particular minerals such as silica, sulfur, selenium, and radium. Medicinal clays are also widely used, a practice known as 'fangotherapy‘
a system of alternative medicine based on the theory that diseases can be successfully treated or prevented without the use of drugs, by techniques such as control of diet, exercise, and massage