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Chenopodium Quinoa Saponins
The Next Generation Adjuvant
What are quinoa titerpene saponins?
• Natural non ionic surfactants produced by plants as a defense
mechanism
• Surfactant
• Contains both water-soluble and lipid-soluble components
• Their application is growing rapidly
• Organic origin
• No synthetic-surfactant downside
Important facts - Quinoa saponins
• Resistant to salt & heat
• Stable to acid PH
• Low to negligible toxicity profile
• Does not accumulate over time
• High compatibility with nature
• Virtually zero contamination footprint
Saponin applications - Biosurfactants
Pharmaceutical
• Vaccines
• Adjuvant
• Delivery method
• Improves Effectiveness
• Drug delivery enhancer
Technical | R&D
• To permeabilize cell membranes
Cosmetic
• Cleansing formulae
• Delaying of skin aging
• Antifungal & antibacterial
• Hypo allergic
Bio-pesticide
• FDA approved
• Nematode control
• Negligible environmental
footprint
Saponin Pharmaceutical Applications
Vaccine Adjuvant
• Adjuvant effects well known (20 + years)
• Increases antigen specific antibody and T-cel response
• Potentiates weaker antigens
• Enhances duration and onset of immune response
• Used in prophylactic and therapeutic vaccines
Saponin Pharmaceutical Applications
Formulation Flexibility
• Potent with small amounts of antigen
• Can be used with other adjuvants and in various formulations
• Provides vaccine antigen sparing effect
• Effective via parenteral or mucosal applications
• Advantageous safety profile
Saponin Pharmaceutical Applications
Pre-clinical Chenopodium Quinoa Saponins
• Available directly without licensing agreements
• GMP material planned for Q2 2019
• 5 – 500 mg are in stock and ready to ship
• Samples are provided free of charge
• Discounts offered to Academic Researchers
Saponin Pharmaceutical Applications
Clinical Experience
• Tested in over 40,000 humans
• Currently in over 16 human vaccine candidates
• Currently used in 4 Phase III clinical trials for Malaria, Melanoma & NSCLC
• Can be used with other TLR Agonists to form adjuvant systems
• Testing underway in HIV, TB, Alzheimer's disease and various oncology
tumor type vaccine programs
Saponin Pharmaceutical Applications
GlaxoSmithKlein – Shingles Vaccine - Shingrix
• FDA approved on October 20, 2017 for use in human commercial vaccines
• Uses Quijalla Bark Saponin as adjuvant
• Saponins were not used as adjuvants due to lack of supply
• There were no precedents of FDA-approved saponin-adjuvant based
vaccines
• The market is now ready to adopt high purity saponins for human vaccine
use
Saponin Veterinary Applications
Adjuvant Overview
• Supplied as a light taupe to taupe crystals with less than 1% moisture content
• Shelf life is two years at room temperature
• Standardized in non-saponin impurities (polyphenols & polysaccharides) to
establish batch consistency
Saponin Veterinary Applications
Adjuvant VET-CQS 08
• It is a highly purified form of Chenopodium Quinoa Saponins handled to
reduce low molecular weight contaminants
• Provides the opportunity to formulate with one of the purest saponin
adjuvants in the market (93 - 95%+)
• Sapogenin content : 60%+ - best in class
• Product is traceable from the crop phase to its final presentation
• Supply is assured by our raw material inventories and our cooperation
agreements with local quinoa processing companies
Quinoa Saponin Composition
Five-ringed acid backbone
4 Main Aglycones
4 Monodesmosidic Titerpene Saponins
22 Bidesmosidic Titerpene Saponins
89 Detected and profiled saponins
• 70 verified by NMR spectroscopy
Quinoa Saponin Composition
4 Main aglycones
• Oleanolic Acid (OA)
• Hederagenin (Hed)
• Phytolaccagenic Acid (PA)
• Serjanic Acid (SA)
Sugars linked to aglycone in C23 and C28
• Glucose (Glc)
• Galactose (Gal)
• Arabinose (Ara)
• Glucuronic Acid (GlcA)
• Xylose (Xyl)
Quinoa Saponin Composition
• Average molecular weight 1,800 – 2,000 Daltons
• Below 200 – 500 ppm concentration => saponins exist as a monomer
• Above 200 – 500 ppm => micelles with apparent molecular weight of approximately
100,000 Daltons
Pharma & Vet Grade Quinoa Saponins
• Quinoa extracts need careful purification
• Purification - THI Proprietary AOSS technology (Green Tech)
• Product is made out of light-taupe to taupe crystals
• Aqueous solution has a yellow-brown appearance
Concentration 93 - 96 %+
Sapogenin 60%+
Ash 1 - 2%
Other 2 - 4%
Pharma & Vet Grade Quinoa Saponins
• Production can be scaled easily
• No contaminants from purification tech (AOSS)
• Can be certified as an organic ingredient
• Product not previously available
• Supply was the main road block to market incorporation
• Saponin use will phase out other traditional vaccine adjuvants
Titerpenic Quinoa Saponins Products
Pharma
Product : CQS-07
• Saponin content: 95%+
• Sapogenin: 60%+
• Sample: 25 g
• 25, 100 g
Veterinary
• Product : VET CQS-08
• Saponin content: 93 - 95%+
• Sapogenin: 60%+
• Sample: 25 g
• 25, 100 g
PRICING AND MSDS TO BE PROVIDED ON REQUEST
Sample & enquiry instructions
Andres Zavaleta
CEO
andres@terrehauteindustries.com
+591 7679-4166
Please Include the following information:
• Name:
• Company:
• Email:
• Phone number:
• Product Required:
• Intended use:
Mariana Zavaleta
VP Marketing & Sales
andres@terrehauteindustries.com
+591 7676-8504
THANK YOU FOR YOUR TIME

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Saponin for Vaccine Adjuvants

  • 1. Chenopodium Quinoa Saponins The Next Generation Adjuvant
  • 2. What are quinoa titerpene saponins? • Natural non ionic surfactants produced by plants as a defense mechanism • Surfactant • Contains both water-soluble and lipid-soluble components • Their application is growing rapidly • Organic origin • No synthetic-surfactant downside
  • 3. Important facts - Quinoa saponins • Resistant to salt & heat • Stable to acid PH • Low to negligible toxicity profile • Does not accumulate over time • High compatibility with nature • Virtually zero contamination footprint
  • 4. Saponin applications - Biosurfactants Pharmaceutical • Vaccines • Adjuvant • Delivery method • Improves Effectiveness • Drug delivery enhancer Technical | R&D • To permeabilize cell membranes Cosmetic • Cleansing formulae • Delaying of skin aging • Antifungal & antibacterial • Hypo allergic Bio-pesticide • FDA approved • Nematode control • Negligible environmental footprint
  • 5. Saponin Pharmaceutical Applications Vaccine Adjuvant • Adjuvant effects well known (20 + years) • Increases antigen specific antibody and T-cel response • Potentiates weaker antigens • Enhances duration and onset of immune response • Used in prophylactic and therapeutic vaccines
  • 6. Saponin Pharmaceutical Applications Formulation Flexibility • Potent with small amounts of antigen • Can be used with other adjuvants and in various formulations • Provides vaccine antigen sparing effect • Effective via parenteral or mucosal applications • Advantageous safety profile
  • 7. Saponin Pharmaceutical Applications Pre-clinical Chenopodium Quinoa Saponins • Available directly without licensing agreements • GMP material planned for Q2 2019 • 5 – 500 mg are in stock and ready to ship • Samples are provided free of charge • Discounts offered to Academic Researchers
  • 8. Saponin Pharmaceutical Applications Clinical Experience • Tested in over 40,000 humans • Currently in over 16 human vaccine candidates • Currently used in 4 Phase III clinical trials for Malaria, Melanoma & NSCLC • Can be used with other TLR Agonists to form adjuvant systems • Testing underway in HIV, TB, Alzheimer's disease and various oncology tumor type vaccine programs
  • 9. Saponin Pharmaceutical Applications GlaxoSmithKlein – Shingles Vaccine - Shingrix • FDA approved on October 20, 2017 for use in human commercial vaccines • Uses Quijalla Bark Saponin as adjuvant • Saponins were not used as adjuvants due to lack of supply • There were no precedents of FDA-approved saponin-adjuvant based vaccines • The market is now ready to adopt high purity saponins for human vaccine use
  • 10. Saponin Veterinary Applications Adjuvant Overview • Supplied as a light taupe to taupe crystals with less than 1% moisture content • Shelf life is two years at room temperature • Standardized in non-saponin impurities (polyphenols & polysaccharides) to establish batch consistency
  • 11. Saponin Veterinary Applications Adjuvant VET-CQS 08 • It is a highly purified form of Chenopodium Quinoa Saponins handled to reduce low molecular weight contaminants • Provides the opportunity to formulate with one of the purest saponin adjuvants in the market (93 - 95%+) • Sapogenin content : 60%+ - best in class • Product is traceable from the crop phase to its final presentation • Supply is assured by our raw material inventories and our cooperation agreements with local quinoa processing companies
  • 12. Quinoa Saponin Composition Five-ringed acid backbone 4 Main Aglycones 4 Monodesmosidic Titerpene Saponins 22 Bidesmosidic Titerpene Saponins 89 Detected and profiled saponins • 70 verified by NMR spectroscopy
  • 13. Quinoa Saponin Composition 4 Main aglycones • Oleanolic Acid (OA) • Hederagenin (Hed) • Phytolaccagenic Acid (PA) • Serjanic Acid (SA) Sugars linked to aglycone in C23 and C28 • Glucose (Glc) • Galactose (Gal) • Arabinose (Ara) • Glucuronic Acid (GlcA) • Xylose (Xyl)
  • 14. Quinoa Saponin Composition • Average molecular weight 1,800 – 2,000 Daltons • Below 200 – 500 ppm concentration => saponins exist as a monomer • Above 200 – 500 ppm => micelles with apparent molecular weight of approximately 100,000 Daltons
  • 15. Pharma & Vet Grade Quinoa Saponins • Quinoa extracts need careful purification • Purification - THI Proprietary AOSS technology (Green Tech) • Product is made out of light-taupe to taupe crystals • Aqueous solution has a yellow-brown appearance Concentration 93 - 96 %+ Sapogenin 60%+ Ash 1 - 2% Other 2 - 4%
  • 16. Pharma & Vet Grade Quinoa Saponins • Production can be scaled easily • No contaminants from purification tech (AOSS) • Can be certified as an organic ingredient • Product not previously available • Supply was the main road block to market incorporation • Saponin use will phase out other traditional vaccine adjuvants
  • 17. Titerpenic Quinoa Saponins Products Pharma Product : CQS-07 • Saponin content: 95%+ • Sapogenin: 60%+ • Sample: 25 g • 25, 100 g Veterinary • Product : VET CQS-08 • Saponin content: 93 - 95%+ • Sapogenin: 60%+ • Sample: 25 g • 25, 100 g PRICING AND MSDS TO BE PROVIDED ON REQUEST
  • 18. Sample & enquiry instructions Andres Zavaleta CEO andres@terrehauteindustries.com +591 7679-4166 Please Include the following information: • Name: • Company: • Email: • Phone number: • Product Required: • Intended use: Mariana Zavaleta VP Marketing & Sales andres@terrehauteindustries.com +591 7676-8504
  • 19. THANK YOU FOR YOUR TIME