5. INCIDENT RATE
It accounts for 2% to 3% of all malignancies.
Four times more in men than women.
Most common in age above 60.
Each year approximately 9000 new cases are
detecting.
3700 persons with cancer of larynx will dies.
90% of untreated people will die with in 3years.
Potentially curable if diagnosed and treated early.
6. ETIOLOGY AND RISK FACTORS
CARCINOGENS
Tobacco
Combined effects of tobacco and alcohol
Asbestos
Second hand smoke
Paint fumes
Cement dust
Chemicals
Tar products
Leather and metals
7. Contn..
OTHER FACTORS
Straining the voice
Chronic laryngitis
Nutritional deficiencies
Familial predisposition
Age
Gender
Race (more prevalent in African American)
Weakened immune system
9. CLINICAL MANIFESTATIONS
The manifestations dependent upon the location
of the tumor:
Glottic tumor
Voice change
Hemoptysis
Dyspnea
Respiratory obstuction
Dyspgagia
Weight loss
Pain
10. contn….
Supra glottic
Aspiration on swallowing.
Sore throat
Foreign body sensation
Dysphagia
Neck mass
Hemoptysis
Dyspnea
Pain in the throat referred to the ear
14. MEDICAL MANAGEMENT
Chemotherapy:
Drugs are used to prevent the multiplication of tumor
cells, either by killing or by preventing cell division
Systemic chemotherapy
Regional chemotherapy
Chemoprevention
Drug Isotretinoin used to prevent the recurrence.
15. Contn….
Radiosensiteizers: drugs that make tumor cells more
sensitive to radiation therapy
when used in combination with chemotherapy, it
is more effective.
16. SURGICAL MANAGEMENT
Cordectomy
Supraglottic laryngectomy
Hemilaryngectomy
Partial laryngectomy
Total laryngectomy
Thyroidectomy
Laser surgery
Adjuvent therapy