This curriculum vitae outlines the qualifications and experience of Brijesh Darji. It summarizes his current role as a Senior Research Associate at Zydus Research Centre, where his responsibilities include designing synthetic strategies, synthesizing and purifying molecules, and coordinating with team members on drug discovery projects. It also lists his educational background, including an MSc in Chemistry, publications, conference presentations, skills and personal details.

1. CURRICULUM-VITAE
Name Darji Brijesh Atulbhai
Correspondence Address E-34 Hariom nagar ,Maghiya
Dholka-387810,
Dist.- Ahmedabad,
Postal Code-387810
Permanent Address E-34 Hariom nagar ,Maghiya
Dholka-387810,
Dist.- Ahmedabad
Postal Code-387810
Mobile No +91-9662034605 (9;00am to 6;00 pm not
available (Office Hour))
E-mail darji_brijesh2009@yahoo.com
OBJECTIVE:
* To explore and learn the frontiers of Organic Chemistry, new horizons in Synthetic Organic
Chemistry and Medicinal Chemistry through research.
RESEARCH EXPERIENCE:
Designation: Sr. Research Associate, New Drug Discovery, Medicinal Chemistry R&D
Division.
Company: Zydus Research Centre, Sarkhej-Bavla N. H. No. 8 A.,
Moraiya, Ahmedabad. (Gujarat), India
Duration: August 2005 – present date
Job responsibilities:
As a part of drug discovery team, my daily responsibility includes:
• Literature search and design of multi-step synthetic strategies.
• Patent search, finding novelties.
• Synthesis of biologically active molecules.
• Scale-up of selected compounds up mg to kilogram batch size.

2. • Purification of new chemical entities (NCE’s) by various techniques, such as Flash
Chromatography, Vacuum distillation and Crystallization, Thin layer Chromatography (TLC),
Preparative HPLC, Column chromatography.
• Characterization of NCE’s by various spectroscopic techniques, such as IR, NMR, and ESI-
MS, HPLC, UPLC spectroscopy.
• Co-ordination with team members, training to new staff members, monthly presentation,
writing reports, group discussion, lab book and record maintenance, chemicals ordering and
reporting to senior staff. Involving in synthesis of various multi step drugs.
• Handled air, moisture sensitive reagents & dry reactions.
• Literature survey of organic molecules.
• Perform reactions on a day to day basis.
• Preparation of intermediates / final compounds.
• Electronic lab Notebook writing. Documentation of Analytical data, literature paper,
review.
• Developed several cost effective synthetic strategies, performed wide range of chemical
reactions, including named reactions and Chiral synthesis. Design and perform the trial on
lab scale and analyse the results with proper documentation (mg to Kg product)
Improve the existing test method. According to range of that particular parameter.
Study & introduce new testing methods. To develop awareness in workers related to
chemical safety.
• Named reactions performed in various projects: Aldol condensation, Backmann rearrangement,
Suzuki coupling, Friedal-craft reaction, Hoffman reaction, Mannich reaction, Sandmayer
reaction, Sommlet reaction, Witting reaction, Grignard reaction, Fisher-indole reaction, Photo-
bromination of methyl ketone, Ulmann-coupling, Vilsmayer reaction, Pictet Spengler reaction
and Mitsunobu coupling. Prepared optically pure ( with % ee > 99 %) unnatural amino acids,
such as N-methylated amino acids, α-methylated amino acids, tetrazole containing amino acids,
Phospho-amino acids and bi-phenyl containing amino acids.
• Skill in handling specialized reagents, such as n-BuLi, LDA, LiAlH4, NaBH4, , Pd / C, KHMDS
,LHMDS, Pd(OH)2.
• Additional skill of making peptides and peptidomimetics, using solution phase (Boc chemistry)
and SPPS (Fmoc based) approach.
Salient achievements:
Acheivement at Zydus Cadila. :

3. Basic Research : Antidiabetic : Project : GLP-1
• Synthesized more than 150 bioactive molecules (both peptide & peptidomimetics) in GLP-
1 projects. Some of them were selected for advanced biological and toxicological studies
and currently two of them are in advanced pre-clinical trials. (ZY D1 & ZYOG1)
• Successfully scale-up two molecules, up to 1-kilogram batch size, for Phase I & II clinical
trials. i.e. ZYOG1 (Phase II) & ZY D1 (Phase I).I am prepared many long chain
peptides & its purification using by Preparative .HPLC. (Gherlin, Des Octanyl
Gherlin, GLP-1 analogue, PTH(Parathyroid hormone) analogue, insulin receptor
analogue, JAK-3 peptide, LHRH hormone )
• On Going Project :
Antidiabetic: Oxyntomodulin & insulinmemintic.
• Synthesized more than 100 bioactive molecules (both peptide & peptidomimetics) in
Oxyntomodulin & insulinmemintic projects.
• Purification of peptides by Semi-Prep HPLC (Schimadzu LC 8A).
Educational Qualifications:
Degree University Subject Year of
passing
% Of
Marks
Grade
M.Sc. Madurai Kamaraj
University, Madurai,
India
Chemistry 2010 57 % II div
B.Sc. Gujarat University,
India
Maths, Physics,
Chemistry
2005 61 % I div
10+2 G.S.E.Board of Gujarat ,
India
Maths, Physics,
Chemistry
2002 45% III div
PUBLICATION:
1. Discovery of orally active, potent, selective Benzotriazole-based PTP1B inhibitors.
Dipam patel, Mukul Jain, Shailesh Shah, Rajesh bahekar, Pradip Jadav, Brijesh Darji,
Yernaidu Siriki, Debdutta Bandyopadhyay, Amit Joharpurakar, Samadhan Khirsagar, Harilal
Patel, Mubeen Shaikh, Kalapatapu V.V.M.Sairam, Pankaj Patel. Chem Medchem Volume 6,
Issue 6, Page 1011–1016, 2011.

4. POSTER PRESENTATION IN CONFERENCE:
1. Synthesis and Glucose Depedent Insulinotropic Activity of Subsitituted-Hetro-Aryl
Oxazolyl Derivatives. Dipam N.Patel,Pradip A.Jadav,Brijesh A Darji,Yernaidu.siriki,
Mukul R. Jain and Rajesh H.Bahekar. Poster presented at The Ramanbhai Foundation
4th
International Symposium on Current Trends in Pharmaceutical Sciences “Advances
in Cardiometabolic Research-Basic Science and Clinical Aspects” at Zydus Research
Centre, Ahmedabad, India,
2-5 Feb. 2009, PS-13
2. Design, synthesis and Pharmacological Evaluation of Dipeptide Based DPP-IV
Inhibitors as New Class of Antidiabetic Drugs. ,Pradip A.Jadav, Dipam N.Patel,Bony
R.Shah,D.J.Sen, Brijesh A Darji,Yernaidu.siriki, Mukul R. Jain,Debdutta
Bandyopadhyay,Amit Joharapurkar and Rajesh H.Bahekar. Poster presented at The
Ramanbhai Foundation 4th
International Symposium on Current Trends in
Pharmaceutical Sciences “Advances in Cardiometabolic Research-Basic Science and
Clinical Aspects” at Zydus Research Centre, Ahmedabad, India,
2-5 Feb. 2009, PS-50
3. Synthesis and Glucose Depedent Insulinotropic Activity of Subsitituted-Hetro-Aryl
Oxazolyl Derivatives. Rajendra Chopade,Vijay Prajapati, Dipam N.Patel,Pradip
A.Jadav,Brijesh A Darji,Yernaidu.siriki,Ganesh Rahane,Jitendra Padsumbiya,Dinesh
Reddy, Amit Joharapurkar ,Mukul R. Jain and Rajesh H.Bahekar. Poster presented at
The Ramanbhai Foundation 5th
International Symposium on Current Trends in
Pharmaceutical Sciences “Advances in Translational Research&Medicine” at Zydus
Research Centre, Ahmedabad, India,
1-4 Feb. 2011, PS-098.
4 Identification Of Novel Orally Bioavailable TGR5 Receptor Agonist. Brijesh Darji,
prashant Deshmukh, Santosh Sasane, Amit Patil, Umesh Aware, Priyanka priyadarsiny,
Harilal Patel, Suresh Giri, Mukul Jain, Sameer Agarwal.Poster presented at The
Ramanbhai Foundation 7th
International Symposium on Current Trends in
Pharmaceutical Sciences “Advances in New Drug Discovery & Development’’ at YMCA ,
Ahmedabad, India, 2-4Feb. 2015, PS-13.
PARTICIPATION IN CONFERENCE:
• 2nd
International Symposium Attended held at Zydus research center, in
January 2007.
• Participated in The Ramanbhai Foundation 4th
International Symposium on Current
Trends in Pharmaceutical Sciences “Advances in Cardiometabolic Research-Basic
Science and Clinical Aspects” at Zydus Research Centre, Ahmedabad, India, 2-5 Feb.
2009.

5. • Three days training on scale up in preparative HPLC organized by Nishotech
systems pvt Ltd. Hyderabad.
• The Ramanbhai Foundation 5th
International Symposium on Current Trends in
Pharmaceutical Sciences “Advances in Translational Research &Medicine” at Zydus
Research Centre, Ahmedabad, India,
• The Ramanbhai Foundation 7th
International Symposium on Current Trends in
Pharmaceutical Sciences “Advances in New Drug Discovery & Development’’ at
YMCA, Ahmedabad, India, 2-4Feb. 2015.
COMPUTER AWARENESS:
• Basic knowledge of computer and use of Internet, SAP.
• Knowledge of Microsoft Office,SAP.
INSTRUMENTAL EXPERTISATION:
• Preparative HPLC (Shimadzu & Knaur make)
• Analytical HPLC.(Shimadzu make,Agillent make-1100 series).
• Lyophilizer (Freeze Drier)
• YMC-Kyoto Prep Column Packing Machine.
• Buchi ROTA Evaporator
• Analytical balance(Mettler Toledo)
• pH meter (Mettler Toledo).
• Barn-stead milliQ water system, Thermo hygrometers, Auto pipettes,
Sonicator and Vortexer
PERSONAL INFORMATION:
Name: Brijesh Darji
Father name: Mr.Atulbhai
Date of birth: 22-04-1985.
Gender: Male.
Martial status: married.
Nationality: Indian.
Religion: Hindu.
Languages known: English, Hindi&Gujrati