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E+H - Global Offering for LIfe Sciences

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Innovation and Compliance - process monitoring for LIfe Sciences

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E+H - Global Offering for LIfe Sciences

  1. 1. Products Solutions Services Global offering for the Life Sciences industry Innovation and compliance
  2. 2. 2 Global offering for the Life Sciences industry Contents 3 Achieving excellence together 5 Ensure compliance and reliable process monitoring 6 Media preparation 8 Fermentation 11 Sensor management tool Memobase Plus 12 Separation and filtration 14 Chromatography 16 Water purification 18 Water for injection, sterile steam 19 Water distribution loop 20 Buffer tanks / Storage 24 Cleaning-in-place CIP / Sterilization-in-place SIP 27 Compliant services and advanced technologies For more information: www.us.endress.com/life-sciences
  3. 3. 3 Doing more with less is an opportunity Regardless of your location or the focus of your operation, you can trust a reliable biotechnology partner with the know how and skills to help you reduce risk and optimize operational performance. From pilot to automated production units, we support you daily in delivering quality on-time through stable processes. Simplify your projects, reduce operational costs  Standardize with the largest offering of measurement instruments to minimize project’s complexity, maintenance costs and plant downtime. Complexity starts when process equipment is composed of skids from various suppliers. Early phase standardization allows you to reduce engineering complexity for CAPEX projects and deliver on-time and on-budget. Spare part costs are optimized, training efforts are limited and documentation is readily available throughout the entire life cycle. As a result, operational expenditure (OPEX) is minimized, availability is increased and you get a faster return-on-investment (ROI). Profit from the largest compliance offering Benefit from the largest selection of instruments that meet life sciences industry standards. GxPs requirements and design specifications are our focus: the offering is permanently adapted to current industry regulations such as USP, ASME BPE (material of construction, internal and external surface roughness, process connection design). Open communication standards allow for seamless integration into all relevant DCS and AMS systems. Be right the first time with our embedded engineers  In order to manage the complexity of instrumentation and shorten start-up time, qualified resources and expertise are key. Experienced Endress+Hauser engineers embedded into your project engineering team take over responsibility to select the right product for each application. With plant availability and reliability in focus, a specific effort is conducted to facilitate whenever possible inline calibration and anticipate future steps such as documentation availability for audits. Ease standardization through efficient project management Once the instrumentation standard catalog is defined, it has to be rolled out and coordinated among all skid suppliers. This time consuming task is the responsibility of the Endress+Hauser project manager: One contact partner for everything, to ease standardization, to coordinate with third parties and to report any specific issues. Achieving excellence together Trust a reliable partner who considers cost, quality and compliance as binding links to market. Achieving excellence together
  4. 4. 4 Global offering for the Life Sciences industry
  5. 5. Overview of the Endress+Hauser product range of process measuring instruments Level Flow Liquid analysis Pressure Temperature Monitoring Media preparation Fermentation Yes Separation and Filtration Yes Chromatography Yes Water purification WFI, Sterile Steam Water Distribution Loop Buffer tanks / Storage Yes CIP/SIP DAS* OEM filling machines Level continuous Level switch Cell growth Bubble and product detector Conductivity * Data acquisition system 5 Qualification is your top priority We supply process measurement instruments that fully comply with the numerous requirements, codes and standards, such as FDA, ISPE GAMP, ASME BPE, EHEDG, etc. Where required, we offer: • Material certificates for the process wetted parts • Compliance certificates to USP <88> Class VI and • USP <87>, where applicable • Calibration certificates • Surface roughness finish certificates (including mechanical polishing and electropolishing) • SOPs for calibration and maintenance • Completion of IQ and OQ documentation, on request • Manufacturer’s declaration of TSE compliance (free from animal derivatives) For total peace of mind, we have designed training programs according to the GxPs, thus enabling compliant operation. Our extended range of sensors, transmitters and data acquisition systems cover all your main processes. The table below provides an overview of Endress+Hauser’s offering. Find more details on the following pages. Ensure compliance and reliable process monitoring Qualified and documented process measuring instruments for easy integration into automation systems Reliable instruments that offer easy integration Ensure compliance and reliable process monitoring
  6. 6. T LS LS F F F F pH T T Y Media preparation process map F Flow LS Level Switch T Temperature Molasses Nutrition Sterile steam supply Condensate return Hot DI water Hot DI water supply 6 Global offering for the Life Sciences industry The different media or buffer solutions are produced and then pre-sterilized. Since sterility is a crucial aspect of the pharmaceutical and biotechnological process, the microbiological quality must be controlled and monitored in order to avoid any contamination. The operations have to be conducted under very strict environmental conditions. The validation of the process evolution is of utmost importance. Our offering All our process measuring instruments are designed for enduring the process conditions and also sterilization. They are documented according to the rules for this part of the process which is particularly critical regarding the contamination aspects. Media preparation Control critical parameters to master solution quality De-facto standard in process analytics The innovative Memosens systems provide the ideal solution for safety and operating comfort in analytical measuring technology. Teamed with all common fieldbusses, Memosens systems are open for all process control and asset management systems. Benefits: • Lifetime of Memosens sensors up to 40% longer • Fewer calibration cycles • Reduction in process downtime as non-specialized staff can replace the sensor • More precise calibration in the laboratory under reproducible conditions • Predictive maintenance as an integrated part of the sensor technology
  7. 7. 7 Flow measurement Promag H electromagnetic flowmeter • Advanced diagnostic functions e.g. variation of conductivity, abrasion, build-up, air bubbles • Sterilization in place • Wide range of hygienic process connections • EHEDG certificate for Life Sciences process applications • Roughness up to 0.38 µm electropolished • Specific versions for dosage applications pH measurement Multiparameter transmitter Liquiline CM442 • Easy to commission: Open communication standards simplify process integration • Simple to use: One device for all parameters • Flexible: Upgrade the controller anytime, up to 8 channels • Easy maintenance: Pre-calibrated sensors with Memosens technology Ensure compliance and reliable process monitoring
  8. 8. WT F F F F WT WT WT DCO2 Air / CO2 Air Foam Level F F F F LC SC SIC O2 N2 CO2 pH DO P T Fermentation process map DO Dissolved Oxygen F Flow LC Level Continuous P Pressure SC Speed Controller SIC Speed Indicator Controller T Temperature WT Weighting System Off Gas Nutrient Antifoam Base Medium Inoculum CO2 Air / CO2 Harvest Cell growth N2 O2 Air 8 Global offering for the Life Sciences industry The efficiency of the biological process highly depends on obtaining the right conditions so that the microorganisms can thrive and yields can be maximized – in a stable and predictable manner. Therefore, a sophisticated concept to collect information on what is happening in the bioreactor needs to be installed. This concept uses suitable measurement and control equipment. The most important parameters are pH, dissolved oxygen, temperature and turbidity. They have to be recorded and controlled carefully. All our process measuring instruments are designed to endure the process conditions and also sterilization. They are documented according to the rules for this part of the process which is particularly critical regarding the contamination aspects. Fermentation Get the most accurate measurement information in challenging conditions
  9. 9. 9Ensure compliance and reliable process monitoring Cell growth measurement by light absorption Cell growth sensor OUSBT66 • Measurement of biomass and cell growth by NIR absorption • Hygienic design, suitable for CIP and SIP • Easy calibration • Easy integration into fermenters • Determine starting point of propagation • Regulate feed according to consumption Transmitter and data manager Memograph CVM40 • Max. 2 photometric sensors depending on the sensor • Universal analog channels support combined multiparameter measurement or recording • Convenient: Menu-guided calibration of photometric sensors • Security package with person-specific access authorization and electronic signature (FDA 21 CFR 11) • Integrated Web server, fieldbus (PROFIBUS, Modbus) • Common standard protocols and interfaces such as USB, TCP/IP, OPC and Ethernet are supported
  10. 10. 10 Global offering for the Life Sciences industry pH ISFET electrode Tophit CPS471D • Glass-free ISFET sensor • Same hygienic ceramic diaphragm as CLS71D • 3-A certificate • Memosens technology • Calibration in laboratory possible; calibration data stored in the sensor head • Safe - due to unbreakable PEEK™ body Dissolved oxygen measurement with Memosens Dissolved oxygen sensor Oxymax H COS22D • Hygienic design in stainless steel sensor housing • Reproducible measurement also after sterilization cycles • Fast polarization and response time • Memosens technology • Calibration possible in laboratory or in-situ (calibration data stored in the sensor head) • Precise and reproducible oxygen measurement • Reliable measurement also in harsh process conditions pH measurement with Memosens pH electrode Ceragel CPS71D • Hygienic design thanks to fine-porous ceramic diaphragm • Upside down mounting possible • EHEDG certificate for in-place cleanability, in-place steam sterilizability and bacteria restriction • Memosens technology • Calibration in laboratory possible; calibration data stored in the sensor head • Operation with the state-of-the-art transmitter Liquiline CM42 with all advantages of the Memosens technology including logbooks • Easy to clean • Poison-resistant reference with ion trap Our offering Endress+Hauser supplies biotech manufacturers with a wide range of measuring equipment. All of our process measuring instruments are designed to support the process conditions including the sterilization process. Common benefits • Hygienic design • Reliable measurement • No risk of product contamination Additional offering suitable for fermentation processes • Level measurement (guided radar, hydrostatic pressure, tuning fork, differential pressure, capacitance level measurement) • Flow measurement (Coriolis mass meters, thermal mass meters) • Pressure measurement • Temperature measurement • Monitoring system
  11. 11. 11Ensure compliance and reliable process monitoring Memobase Plus is the all-in-one management tool for Memosens sensors. The software does not only calibrate the sensors and read out sensor data but gives you detailed reports on sensor history and status. Memobase Plus features user management and audit trail that enable you to work according to FDA 21 CFR Part 11: • Any modification of existing data sets is detected and marked. • Memobase Plus saves all measurement, calibration and sensor-related data in a local and central data base. • With the “as found – as left” option activated, Memobase Plus provides a complete performance profile for the sensors. • You are also optimally informed about test solutions. The integrated monitoring system tracks which solution you are using, when it was opened and when it expires. Out of this data, you can generate reports of measurement, calibration and sensor history fulfilling all requirements on traceability and being perfectly prepared for any audit without doing any manual paperwork. Your benefits • Time saving: Plug & Play with up to four sensors simultaneously and independent from each other • Increased product quality: Calibrate under optimum conditions in the lab or on the work bench, ensuring higher accuracy. • Improved quality management: Documented, full traceability of sensors and reference solutions ensures compliance with audit guidelines. Manual paperwork is a thing of the past. • Data consistency: Identical measurement technology in process and lab minimizes variability of measured values. Sensor management tool Memobase Plus Measure, calibrate and document with one single tool
  12. 12. SIC SIC Mixer Heat Exchanger Filter P P P T T F W F T Filtration process map F Flow P Pressure SIC Speed Indicator Controller T Temperature WT Weighting System Inlet Weighting system Coolant Outlet 12 Global offering for the Life Sciences industry Separation Industrial centrifugation leads to the separation of the product from the bulk liquid. The time spent on the separation (residence time) depends on the separator’s capacity. In bioproduction, the separation of cells can be achieved by different steps of filtration using a variety of microporous materials. Beside filters, micro and ultrafilters, reverse osmosis and nanofilters technologies are also used. Filtration The critical process parameters which are normally measured during each filtration step are the residence time, temperature, pH, cell concentration, inlet and outlet/permeate flows, and the pressures at the inlet and at the outlets (retentate and permeate). During the starting phase the pressure drop through the membrane is monitored as well as the permeate flow in order to prevent any clogging and runtime. Separation and filtration The right operating conditions
  13. 13. 13 Additional offering • Flow measurement: Coriolis flowmeters, thermal mass meters • Analysis: conductivity measurement, UV • Pressure measurement • Temperature measurement • Monitoring system Pressure measurement Cerabar M PMP51 / PMC51 • USP class VI gasket and ceramic membrane • Ra < 0.38 μm electropolishing for the wetted parts • Wide range of hygienic process connections • All certificates and documents available (material certificates, 3A, ASME BPE, CoC, roughness, calibration, …) Differential pressure measurement Cerabar M FMB50 • Excellent reproducibility and long-term stability • Ra < 0.38 μm electropolishing for the wetted parts • Wide range of hygienic process connections • Hermetically sealed CONTITE™ compensates temperature effects • Available with ASME BPE certificate • Optimized for hydrostatic level measurement Ensure compliance and reliable process monitoring
  14. 14. pH UV LSH LSL PT PT PT PT PT F F F T T T C A SC SC SC PT Pressure Transmitter SC Speed Controller T Temperature A Analysis F Flow C Conductivity LS Level Switch Input Input Input Bubble transmitter Output Output Chromatography process map 14 Global offering for the Life Sciences industry During the different steps, process measuring instruments are used to control the conditions of the transfer as well as the properties of the purified medium. Instruments should not increase the volume of the installation and avoid dead zones. Essential measured parameters: pH and conductivity measurements • Verify the quality of the buffers on the column • Control the quality of the gradient • Detect the separation of phases • Assure a perfect cleaning and rinsing cycle of the column Optical density measurement • To follow up the outlet of the proteins • UV: ultraviolet for optimal sensitivity • Used for the acceptance of the product Pressure measurements are installed before and after the filter. Flow measurement can be placed before the filter, before or after the column. Level measurement buffers the effect of pulses of the pump. Our offering All our process measuring instruments are delivered with material certificates for the wetted parts, calibration certificate and roughness (including electropolishing). We also provide SOPs for calibration and maintenance, and completion of IQ and OQ, on request. Chromatography High or low pressure columns, control at all steps
  15. 15. 15 pH measurement with Memosens pH electrode Ceragel CPS71D • Hygienic design thanks to fine-porous ceramic diaphragm • Upside down mounting possible • EHEDG certificate for in-place cleanability, in-place steam sterilizability and bacteria restriction • Memosens technology • Calibration in laboratory possible; calibration data stored in the sensor head • Easy to clean • Poison-resistant reference with ion trap Optical density measurement OUSAF44 optical density measurement • Specialized filters for precise wavelengths • Wide variety of flow cell configurations • Lowest hold-up volume • Multiple process connections (Tri-Clamp®, flanged, welded, etc.) • Various materials (316L, Titanium, Hastelloy®, PEEK™, Kynar®, etc.) • EasyCal™ System for NIST traceable, accurate calibration • Precision Optical Path length Adjustor • Optimized lamp coatings Ensure compliance and reliable process monitoring
  16. 16. F F C C Redox Redox LS Y Y Y Y Bisulfite Sodium hydroxide Chlorine Multimedia filter Water softener F F LS LS P P T P P P PpH P Pressure T Temperature F Flow C Conductivity LS Level Switch City water Chlorine injection Cartridge filter Bisulfite addition Sodium hydroxide Reverse osmosis stage 1 Reverse osmosis stage 2 USP water tank Water Purification process map 16 Global offering for the Life Sciences industry Treated and purified waters can be classified as: • Potable water • Purified water • Sterile purified water • Water for injection • Bacteriostatic water for injection • Sterile water for irrigation • Sterile water for inhalation The purity requirements, production, storage and use of treated and purified water is defined by international pharmacopoeias and are heavily scrutinized and regulated by governing agencies such as the FDA. Based on tap water, the purification process usually starts with a water softener, ion exchanger, various fine filters followed by reverse osmosis, ultrafiltration and membrane degasification. The measurement of the different process parameters ensures a smooth operation. Temperatures have to be adjusted and flow rates controlled; pressure differences monitor the quality of the used filters. Water purification Process parameter measurements to ensure smooth operation and conformity to regulations
  17. 17. 17 Additional offering suitable for water purification processes • Level measurement: guided radar, hydrostatic pressure, tuning fork, differential pressure, capacitance level measurement • Flow measurement: Coriolis flowmeters • Analysis: pH measurement • Pressure measurement • Temperature measurement Our offering The key parameter during water purification is conductivity. Pharmacopoeias give clear advice on how to conduct the measurement. Endress+Hauser supplies biotech manufacturers with a wide range of measuring equipment. All instruments are delivered with material certificates for the wetted parts, calibration certificates and roughness, including electropolishing. Conductivity measurement Liquiline M CM42 conductivity transmitter • Ultra-simple installation with large display and alarm LED • Easy, intuitive operation via navigator, plain-text menu and online help • Available with hygienic stainless steel housing • Interfaces: current output, HART®, Profibus® PA, FOUNDATION™ Fieldbus • With fault-signalling and preliminary alarm contacts for WFI and purified water (PW) as per USP (United States Pharmacopeia) Condumax CLS16D conductivity measurement • High measuring accuracy as cell constant is individually measured • Hygienic process connections for installation in pipes or flow chambers • Easy to clean due to electro-polished measuring surfaces • Quality certificate stating the individual cell constant • Available with biological reactivity test certificate according to USP (United States Pharmacopeia) Part <87> and <88> Class VI • Available with inspection certificate according to EN 10204 3.1 Ensure compliance and reliable process monitoring
  18. 18. Vapor Separator Vapor Separator LSH LSL LSH LSL LSH LSL LSH LSL Vapor Separator Vapor Separator Condenser F P P C AFP T T T T T T LS Level Switch P Pressure T Temperature A Analysis F Flow C Conductivity Water for injection process map WFI to tank Coolant inlet Coolant outlet Condensate outlet Steam inlet Water inlet 18 Global offering for the Life Sciences industry In this application, measurement instrumentation is not only important in controlling the operation of the storage and distribution loop, it provides the critical measurements required by the regulatory agencies to prove that water quality is achieved and maintained. One example is the monitoring of the conductivity. The conductivity (uncompensated for temperature) of Water for Injection must be below a certain value for different temperatures for the purified water to be classified as Water for Injection. For these critical applications, Endress+Hauser provides highly accurate hygienic conductivity cells, temperature sensors and conductivity transmitters with the US Pharmacopeia tables per Section <645> built into the transmitter software. An alarm output is provided and is usually set in terms of a percentage of the maximum allowable conductivity for a corresponding temperature. Water for injection / Sterile steam Critical measurements to ensure that water quality level is achieved and maintained iTHERM® temperature measurement iTHERM® QuickSens Shortest response times worldwide to temperature changes: • Fast, high-precision measurements • Optional display • Minimization of the needed insertion length (small piping) • Use of thermowells without affecting the measuring performance iTHERM® QuickNeck Divisible neck with quick release: • Removal with the insert without tools • Easy to calibrate, time saving for operations
  19. 19. 19 TM411 temperature sensor designed according to ASME BPE guidelines • Large offering of hygienic process connections • Mechanically polished or electropolished up to Ra < 0.38 µm • Very short response time via QuickSens • Stainless steel housing with display available • Easy calibration via QuickNeck • Available with ASME BPE certificate TMR35 temperature sensor • Small and compact design in stainless steel only • Very short response time • Highly accurate even with short insertion lengths • Available with T- and corner pieces TMR35F for small diameter pipes (electropolished up to Ra < 0.38 µm) Additional offering suitable for WFI processes • Level measurement: guided radar, tuning fork • Flow measurement: Coriolis flowmeters • Analysis: conductivity measurement • Pressure measurement • Temperature measurement Ensure compliance and reliable process monitoring
  20. 20. Y Y Y LS F F T P P P P C T F Flow C Conductivity LS Level Switch P Pressure T Temperature Water distribution loop process map Vent line Nitrogen gas WFI water Steam supply WFI user 1 WFI user 2 WFI user 5 WFI user 3 WFI user 4 Cleansteam Condensate return Condensate return 20 Global offering for the Life Sciences industry The water distribution loop includes multiple user points. When the water is not needed, it recirculates to the main loop. During the usage phase the relevant water valve is open and the water goes to the process; after use, the valve is closed again. There can be several active users at the same time on the distribution loop. Attention must be paid to the piping’s design: • All pipes must be sloped in order to provide self-draining • Dead angles must be avoided • Potential sources of contaminations must be reduced All our process measuring instruments are delivered with material certificates for the wetted parts, calibration certificate and roughness (including electropolishing). Water distribution loop Avoiding contamination is a must Heartbeat Technology™ Diagnostics with remedy measurements reduce downtime • Improved flowmeter reliability through self-diagnostics • Immediate indication of flowmeter out of specification’ and ‘maintenance required’ • Extended calibration intervals • Online monitoring and diagnostics • Improved flowmeter confidence
  21. 21. 21Ensure compliance and reliable process monitoring Promass P Coriolis flowmeter designed according to ASME BPE guidelines • Certificates CoC, 3.1 for materials, surface finish • All wetted parts in 316L/ 1.4435 (low delta ferrite < 1%) • Multivariable instrument: flow, density, temperature • Fully drainable in horizontal position, ensuring no hold-up volume • Designed for CIP/SIP continuous measurement with fast recovery - no delay • Fully welded sensor design, no seals/gaskets • Accredited flow calibration to ISO/ IEC 17025 Promass F Coriolis flowmeter • Multivariable process parameters instrument: mass flow, density, temperature, concentration • Damping of the pumps pulses e.g. peristaltic pumps • Advanced diagnostic functions: presence of entrained air, build-up, abrasion, corrosion as examples • Wetted parts mechanically polished or electropolished up to Ra < 0.38 μm • Temperature up to +200°C / +392°F • Insensibility to vibration • Fully welded sensor design, no seals/gaskets
  22. 22. Y LC LS P P P A Analysis F Flow C Conductivity LS Level Switch P Pressure T Temperature Buffer tanks / storage process map Chilled water return Vent line Nitrogen gas USF water Clean steam 22 Global offering for the Life Sciences industry Buffers and tanks represent some of the most common equipment in the manufacturing process and utilities. We see a wide variety of sizes, volumes, shapes, materials, contents, applications in the process – starting upstream to downstream but also storage tanks before media mix as well as finished products. The tanks and buffers which are used during the evolution of the process do not only have to endure the process phases of the medium; according to the application, they also might need to be sterilizable. Our offering Endress+Hauser offers the measurement of critical parameters as well as monitoring, qualification and documentation, from the smallest buffers and tanks sizes (few liters/gallons) to the biggest ones according to Good Practice. All of our process measuring instruments are delivered with material certificates for the wetted parts, calibration certificate and roughness (including electropolishing). Buffer tanks / Storage Taking process conditions and diversity into account for optimum and reliable measurement
  23. 23. 23Ensure compliance and reliable process monitoring Deltapilot S FMB70 - hydrostatic pressure level Hydrostatic level measurement in tanks is based on the determination of the hydrostatic pressure which is generated by the height of the liquid column. The obtained pressure is thus a direct measure for the level. • Optimized temperature shock behavior • Unaffected by dielectric constant, foam, turbulence and obstacles inside the vessel • Condensate-proof, watertight and long- term stable Contite-measuring cell • Process temperature up to +100°C / +212°F (+135°C / +275°F short term) • Measuring ranges up to 10 bar / 150 psi • Accuracy: 0.1% Levelflex M FMP53 - guided radar designed according to ASME BPE guidelines • Reliable and maintenance free measurement (high frequency pulses radar) in liquids, also in turbulent media and foam • Unaffected by density, temperature, conductibility and humidity • Gas layers do not impair measurement • Process temperatures up to +150°C / +302°F • Process pressures up to 40 bar / 580 psi • Very small blocking distance and measurement almost down to the tank bottom • FDA listed and USP Class VI tested gasket • Electro polished < 0.38 µm 316L stainless steel rod probe • Compact, removable or remote housing (removable housing for in-situ recurrent test) • Spray ball operation does not affect the level measurement • Autoclavable • Available with stainless steel housing • Available with ASME BPE certificate
  24. 24. Acid Y Caustic Water LSH LSL LSL LSL C C C F F LSH LSH C C Conductivity F Flow LS Level Switch CIP / SIP process map CIP-return flow 1 CIP-return flow 2 Make-up water To heat exchanger CIP-line 2 Sanitizer solution CIP-line 1 24 Global offering for the Life Sciences industry Typical pharmaceutical processes consist of mainstream processing steps associated with different support processes like cleaning-in-place (CIP) or sterilization-in-place (SIP). As these support processes can be associated with the purest processes like water-for-injections (WFI) or other raw material preparations, CIP and SIP are considered as critical to the process. Recording - a necessity All critical parameters regarding sterilization cycles have to be recorded and stored. The process measuring instruments’ output values have to be connected to the PLC and also to the data acquisition system which will manage the above GxP data according to the 21 CFR part 11 (electronic records and electronic signatures). Cleaning-in-place CIP / Sterilization-in-place SIP Critical process measurement, data recording and storage to meet regulations and compliancy
  25. 25. 25 Our offering Endress+Hauser offers measurement of the critical parameters, our data acquisition systems cover all your needs regarding traceability for CIP/SIP processes. All our process measuring instruments are designed for enduring the process conditions and also sterilization. Memograph M RSG40 - data acquisition systems • 21 CFR part 11 compliant data acquisition system • Functions: recording, visualization, communication, acquisition • Up to 20 analog inputs or 40 different measuring points with Profibus® • Qualification IQ & OQ, engineering and trainings on request • Screen 7” TFT – USB communication ports • Interface for configuration and data transfer Additional offering suitable for CIP / SIP processes • Level measurement: guided radar, hydrostatic pressure, tuning fork, differential pressure, capacitance level measurement • Flow measurement: Coriolis flowmeters • Analysis: conductivity measurement • Pressure measurement • Temperature measurement • Monitoring system Ensure compliance and reliable process monitoring
  26. 26. 26 Global offering for the Life Sciences industry
  27. 27. 27 Compliant services and advanced technologies Improve asset performance during operation, continuously optimize your process and results while maintaining compliance Assure operational excellence wherever you produce in the world Our global availability and local support help you increase efficiency and maintain the required GMP level. No matter where you are located in the world, or where you want to be, we are always by your side. Our global service force of over 1,000 experts is strategically located worldwide ensuring active local presence to meet all your service needs. Application expertise – we understand your business  Because instrumentation is vital for your process, we capitalize on decades of experience in a wide range of life sciences applications. Our network of experts is perfectly positioned to provide your business with the right support. Training of the process users and technical departments is performed as required according to the regulations of the life sciences industry. People qualified to work at your site Our service teams are trained and equipped to intervene at your site in accordance with Good Practice or with any of your specific health & safety requirements. Also trained on a regular basis, they work according to defined SOPs and provide on-site calibration certificates according to ISO 17025. Traceability of all the services is ensured through the entire life cycle. Looking after your business – we care! Because we care, we add value to your business at every phase of the life cycle. We are by your side not only to support and to service but also to optimize your processes. By your side at every step along the way, we are firmly committed to providing the right service to fulfill all your needs. Whatever you require, we have the adapted service answer. Make the right decision based on valuable information from the field Advanced data management solutions for calibration and instrument diagnostics help you reach your KPIs throughout the entire life cycle. Outstanding calibration management solutions combining metrology expertise, instrument technology based on innovation and software. Compliant services and advanced technologies “I need full access to the information about the services provided.”  Our response: • All actions are traceable • All documents (calibration certificates, etc.) are stored in one place • Data to prove compliance is at your fingertips Discover the benefits of using W@M Portal in combination with these services www.us.endress.com/life-cycle-management
  28. 28. SO00202L/24/EN/02.14 (07.14) USA Endress+Hauser, Inc. 2350 Endress Place Greenwood, IN 46143 Tel: 317-535-7138 Sales: 888-ENDRESS (888-363-7377) Service: 800-642-8737 Fax: 317-535-8498 info@us.endress.com www.us.endress.com Canada Endress+Hauser Canada 1075 Sutton Drive Burlington, ON L7L 5Z8 Tel: 905-681-9292 800-668-3199 Fax: 905-681-9444 info@ca.endress.com www.ca.endress.com Mexico Endress+Hauser México S.A. de C.V. Fernando Montes de Oca 21 Edificio A Piso 3 Fracc. Industrial San Nicolás 54030 Tlalnepantla de Baz Estado de México México Tel: +52 55 5321 2080 Fax: +52 55 5321 2099 eh.mexico@mx.endress.com www.mx.endress.com Other locations www.addresses.endress.com ISO 9001 Certified Additional documentation • CM01012L Life Sciences Industry Perspectives magazine • CP01062L A Partner to Help You Stay Compliant

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