發炎反應

INFLAMMATION 人體的發炎反應

發炎是血管組織對傷害刺激所產生的複雜生物反應 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

發炎反應病源、組織損傷阻止攻擊清除致病原修補損傷組織對外來物質產生反應分泌促進發炎的物質白血球穿透血管聚集白血球釋放自由基對抗病源恢復期

功能喪失痛腫熱紅細胞分泌的化學物質刺激末梢神經組織間液大量增加血管擴張，發炎部位血流增加神經對疼痛的反應急性發炎的基本症狀

發炎的類型急性慢性

人類血液在電子顯微鏡下的樣子

White Blood Cells 巨噬細胞樹狀細胞組織細胞庫氏細胞巨大細胞

急性發炎時發生了什麼事 Vascular Stage Cellular Stage 血管收縮血管擴張白血球外滲吞噬病原滲出發炎終止血流聚集流速變慢白血球抵達病原處增加血管通透白血球吞噬病原補體系統激肽系統凝結系統纖溶系統 Plasma derived mediators 再生 Cell derived mediators TXA2 PGE2 LTB4 Histamine Serotonin NO TNF-α and IL 纖維化修復？

停止發炎的機制 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

急性發炎的結果急性發炎復原纖維化 ( 疤痕 ) 腫傷形成慢性發炎

病原全數消滅急性發炎復原跑到其他地方 System effects

Acute-phase proteins 淋巴 System Effects 發炎組織血液病原病原病原疾病淋巴管炎 / 淋巴結炎細菌型敗血症病毒型敗血症症狀敗血性休克器官功能喪失發燒血壓上升出汗減少全身無力食慾不振嗜睡 Acute-phase proteins ,[object Object],[object Object],[object Object],[object Object]

代謝症候群與發炎發炎不侷限某處、沒有典型症狀

肥胖的人 IL-6 、 IL-10 、 TNF- α 等發炎因子濃度較常人高出許多

低卡飲食四周發炎因子濃度下降抗發炎因子提昇 Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects The FASEB Journal. 2004;18:1657-1669.

發炎失調的疾病 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

炎症的分類依病理變化分類

漿液性炎症 (Serous inflammation) ,[object Object],[object Object],[object Object],[object Object]

纖維蛋白性炎症 (Fibrinous inflammation) ,[object Object],[object Object],[object Object],[object Object],[object Object]

化膿性炎症 (Purulent inflammation) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

潰瘍性炎症 (Ulcerative inflammation) ,[object Object],[object Object]

肉芽腫性炎症 (Granulomatous inflammation) ,[object Object],[object Object],[object Object]

花生四烯酸代謝為類二十碳酸的反應途徑

抑制環氧化酵素也會影響到 Omega-3 脂肪酸的代謝

發炎反應

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