Multiple pregnancy chandni

Powerpoint Templates
Multiple Pregnancy
Chandni Thampi
Assistant professor
Travancore college of nursing
Page 1

Multiple pregnancy
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• When more than one fetus simultaneously develops in
the uterus then it is called multiple pregnancy.
• Simultaneous development of two fetuses (twins) is the
commonest; although rare, development of three fetuses
(triplets), four fetuses (quadruplets), five fetuses
(quintuplets or six fetuses (sextuplets) may also occur.

Twins pregnancy
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(two-third) and
Varieties:
• Dizygotic twins: is the commonest
results from the fertilization of two ova.
from the• Monozygotic twins (one-third) results
fertilization of single ovum.

Genesis of twins
• Imonozygotic twins (syn. identical, uniovulvar)
• Dizygotic twins (syn: fraternal, binovular
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On rare occasion, the following
possibilities may occur
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• If the division takes place within 72 hours after
fertilization the resulting embryos will have two separate
placenta, chorions and amnions (D/D)
• If the division takes place between the 4th and 8th day
after the formation of inner cell mass when chorion has
already developed diamniotic monochorionic twins
develop (D/M)
• If the division after 8th day of fertilization, when the
amniotic cavity has already formed, a monoamniotic
monochorionic twins develop (M/M)

Page 9
Diamniotic
Dichorionic
Separate placenta
Frequency: 35%
Mortality: 13%
Diamniotic
DiChorionic
fused placenta
Frequency 27%
Mortality 11%
Diamniotic
Monochorionic single
placenta
Frequency 36%
Mortality 32%
Monoamniotic
Monochorionic
single placenta
Frequency 2%
Mortality 44%

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Multiple pregnancy contd…
• On extreme rare occasions, division occurs after 2 weeks
of the development of embryonic disc resulting in the
formation of conjoined twins called-Siamese twins.
• Four types of fusion may occur
– Thoracopagus (commonest)
– Pyopagus (Posterior fusion)
– Craniopagus (cephalic)
– Ischiopagus (caudal)

Examination of placenta and
membranes
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Dizygotic Twin Monozygotic twin
Two placenta, either completely
separated or more commonly fused at
the margin appearing to be one.
No anastomosis between the two fetal
vessels.
Placenta is single.
Varying degrees of anastomosis
between the two fetal vessels.
Each fetus is surrounded by a amnion
and chorion
Each fetus is surrounded by a separate
amniotic sac with the chorionic layer
common to both.
Intervening membranes consist of 4
layers-amnion, chorion, chorion and
amnion.
Intervening membrane consists of two
layers of amnion only.

• Sex: while twins having opposite sex are almost always
binovular and twins of the same sex are not always uniovular
but the uniovular twins are always of the same sex.
• If the fetuses are of the same sex and have the same genetic
features (dominant blood groups), monozygosity is likely.
• A test skin graft: Acceptance of reciprocal skin graft—proof of
monozygosity.
• DNA microprobe technique is more definitive.
• Follow-up study between 2-4 years—showing almost similar
physical and behavioral features suggestive of monozygosity.
Page 10

Factors that Influence Twinning
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• The causes of twin pregnancy is not known.
• Race: Highest amongst Negroes (once in every 20 births),
lowest amongst Mongols and intermediate among Caucasians
• Heredity: Family history in mother.
• Maternal Age and Parity: Twinning peaks at age 37 years
• Increasing parity: 5th gravid onwards.
• Nutritional Factors: Taller, heavier women—twinning rate 25 to
30 % greater.
• Pituitary Gonadotropin
• Infertility Therapy
• Assisted Reproductive Technology

Terms
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• Superfecundation
• Superfetation
• Fetus papyraceous or compressus
• Fetus acardius
• Hydatidiform mole
• Vanishing twin

Diagnosis
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History and Clinical Examination
• Recent administration of either clomiphene citrate or
gonadotropins or pregnancy accomplished by ART are
much stronger associates.
• Clinical examination with accurate measurement of
fundal height.

Diagnosis contd…
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• In women with a uterus that appears large for gestational
age, the following possibilities are considered:
– Multiple fetuses
– Elevation of the uterus by a distended bladder
– Inaccurate menstrual history
– Hydramnios
– Hydatidiform mole
– Uterine leiomyomas
– A closely attached adnexal mass
– Fetal macrosomia (late in pregnancy)

Diagnosis contd…
of normal
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pregnancy are often
Symptoms
• Minor symptoms
exaggerated.
• Increased nausea and vomiting in early months
• Cardio-respiratory embarrassment
• Tendency of swelling in the legs, varicose veins and
hemorrhoids is greater
• Unusual rate of uterine enlargement and excessive fetal
movements

Diagnosis contd…
Page 16
explained by
is a common
General examination
• Prevalence of anemia is more
• Unusual weight gain, not
preeclampsia or obesity
• Evidence of preeclampsia
association.

Diagnosis contd…
Page 17
Abdominal examination
Inspection: Barrel shaped and the abdomen is unduly enlarged
Palpation
– Height of uterus > period of amenorrhoea
– Girth of abdomen> normal average at term (100 cm)
– Fetal bulk disproportionately larger in relation to the size of the
fetal head.
– Palpation of too many fetal parts
– Finding of two fetal heads or three fetal poles
Auscultation
• Two distinct FHS at separate spots, difference in heart rates
is at least 10 beats/minute.

Diagnosis contd…
Page 18
Investigations
Sonography
10th
• separate gestational sacs identified early
• Confirmation of diagnosis as early as week of
pregnancy
• Variability of fetuses, vanishing twin in second trimester
• Chorionicity (twin peak sign)
• Pregnancy dating, Fetal anomalies
• Fetal growth monitoring, Presentation and lie of fetuses
• Twin transfusion localization, Amniotic fluid volume

Twin peak sign
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Diagnosis contd…
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Biochemical Tests:
• Levels of hCG in plasma and in urine are higher
• Maternal serum alpha-fetoprotein level: Elevated
• Unconjugated oestriol: approximately double

Complications
Maternal During
pregnancy
Nausea and vomiting
Anemia
Pre-eclapmsia (25%)
Hydramnios (10%)
Antepartum hemorrhage
Malpresentation
Preterm labour (50%)
Mechanical distress
Page 21

Complications contd…
• During labour
Early rupture of membranes and
cord prolapse
Prolonged labour
Increased operative interference
Bleeding
Postpartum hemorrhage
Page 22

Page 27
Complications contd…
• During puerperium
Subinvolution
Infection
Lactation failure
• Fetal
Miscarriage
Prematurity (80%)
Growth problem (25%)
Intrauterine death
Asphyxia and still birth
Fetal anomalies

Complications of monochorionic twins
Page 24
Twin twin transfusion syndrome (TTS)
• one twin appears to bleed into other through placental
vascular anastomosis.
• Receptor twin becomes larger with hydramnios,
polycythemic, hypertensive and hypervolemic
• Donor twin which become smaller with oligohydramnios,
anemic, hypotensive and hypovolemic.
• Donor may appear stuck due to severe oligohydramnios.
• Difference of hemoglobin concentration between the twin
usually exceeds 5 gm% and estimated fetal weight
discrepancy is 25% or more.

contd…
Page 25
TTTS contd..
Management
• Antenatal diagnosis: ultrasound with doppler flow study
in the placental vascular bed.
• Repeated amniocentesis to control polyhydramnios in
recipient twin.
– prevent preterm labour and placental abruption.
• Selective reduction of one twin is done when survival of
both the fetuses is at risk.
• Smaller twin generally have got better outcome.
• Plethoric twin: risk of CCF and hydrops.
• Perinatal mortality: 70%.

contd…
Dead fetus syndrome
• Death of one twin (2-7%) is associated
Page 27
with poor
outcome of the Co-twin (25%) specially in monochorionic
placenta.
• The surviving twin runs the risk of cerebral palsy,
microcephaly, renal cortical necrosis and DIC.
• This is due to thromboplastin liberated from the dead
twin that crosses via placental anastomosis to the living
twin.

contd…
Page 28
Twin reversed arterial perfusion (TRAP):
• Characterized by an acardiac perfused twin having blood
supply from a normal co-twin via large arterio-arterial
anastomosis.
Conjoint twin:
high
• Rare.
• Perinatal survival depends upon the type of joint.
• Major cardiovascular anastomosis leads to
mortality.

contd…
Page 30
Monoamniocity:
• Monochorionoc twins leads to high perinatal mortality
due to cord problems.
• Prostaglandin synthase inhibitor used to reduce fetal
urine output, creating borderline oligohydramnios and to
reduce the excessive movements.

Antepartum Management of Twin
Pregnancy
Page 31
To reduce perinatal mortality and morbidity rates in
pregnancies complicated by twins, it is imperative that:
• Delivery of markedly preterm neonates be prevented
• Fetal-growth restriction be identified and afflicted fetuses
be delivered before they become moribund
• Fetal trauma during labor and delivery be avoided, and
• Expert neonatal care be available.

Management contd…
Page 32
• Diet: increased requirement of calories, protein, minerals,
vitamins, and essential fatty acids. Caloric should be
increased by another 300 kcal/day. Supplementation with 60
to 100 mg/day of iron and1 mg/day of folic acid.
• Bed Rest
• Antepartum Surveillance: sonographic examinations
• Tests of Fetal Well-Being
• Prevention of Preterm Delivery
• Hospitalization
• Use of corticosteroids to accelerate fetal lung maturation.

Management during labour
Page 39
First stage:
• A skilled obstetrician, presence of ultrasound machine and
experienced anesthetist
• Bed rest to prevent early rupture of membrane.
• Limit use of analgesic drugs
• Careful monitoring
• Internal examination soon after the rupture of membranes
• An intravenous line with ringer’s solution
• Availability of one unit of compatible and cross matched blood
• Neonatologist:Present at the time of delivery.

Management during labour contd..
Page 34
with
Delivery of the first baby:
• Delivery: Same guidelines as in normal labour
liberal episiotomy.
• Forceps delivery: if needed, should be done preferably
under pudendal block anaesthesia.
• Do not give intravenous ergometrine with delivery of the
anterior shoulder of the first baby.
• Clamp the cord at two places and cut it between.
• At least 8-10 cm of cord is left behind for administration
of any drug or transfusion, if required.
• The baby should be labeled one.

Management during labour contd..
Page 35
Conduction of labour after the delivery of the first baby:
Steps of management:
Step I:
• Ascertain lie, presentation, size and FHS of the second
baby.
• Vaginal examination: To confirm the abdominal findings
and to exclude cord prolapsed, if any to note the status
of membrane.

Management during labour contd...
Page 36
Lie longitudinal:
• Step I: Low rupture of membranes, syntocinon, internal
examination to exclude cord prolapse.
• Step II: If the uterine contraction is poor, 5 units of
oxytocin is added.
• Step III: Is there is still a delay, interference is to be
done.

Page 37
1. Vertex: Low down—forceps are applied.
• High up—CPD should be ruled out.
• The possibility of hydrocephalic head should also be
kept in mind and excluded by ultrasonography.
• If these are excluded, internal version followed by breech
extraction is performed under general anesthesia.
• Ventouse: effective alternative.
2. Breech: Breech extraction.
3. Lie transverse: Correct by external version or internal
version to cephalic or podalic.

Page 38
Indication of urgent delivery of second baby:
– Severe vaginal bleeding,
– Cord prolapse
– Inadvertent use of IV ergometrine with the delivery of
anterior shoulder of the first baby,
– First baby delivered under general anesthesia,
– Appearance of fetal distress.

Page 39
Delay in the birth of second twin
• Birth of second twin should be completed within 45
minute of the first twin being born but with close
monitoring can be extended if there are no signs of fetal
compromise.
• The risk of delays:
– intrauterine hypoxia,
– birth asphyxia,
– sepsis

Page 40
Management of third stage
• Routine administration of 0.2mg
delivery of anterior shoulder.
methergin IV with
• Deliver placenta by CCT
• Continue oxytocin drip for at least
delivery of second baby.
one hour, following
• The patient is to be carefully watched for about 2 hours
after delivery.

Indications of caesarean section
Page 41
Obstetric causes:
– Placenta previa
– Severe preeclampsia
– Previous caesarean section
– Cord prolapse of the first baby
– Abnormal uterine contractions
– Contracted pelvis
• For twins: Both fetuses or even first fetus with non-
cephalic presentation,
twins;• Twins with complications: IUGR, conjoint
Monoamniotic twins, monochorionic twins with TTS

Management of difficult cases of
twins
Interlocking
f first baby getting locked
by.
hins of the fetuses
), pushing up decapitated
nd baby and lastly, delivery
• Commonest:
with forecomi
• Vaginal manip
• Decapitation o
head, followed
of decapitated
Aftercoming head o
ng head of second ba
ulation to separate c
f first baby (dead
by delivery of seco
head.
• Occasionally, two heads of both vertex get locked at the
pelvic brim preventing engagement of either of the head.
• Disengagement of the higher head: Under general
anesthesia, If fails, caesarean section is the alternative
Page 42

Management of difficult cases of
twins contd..
Page 43
Conjoined twins
• Extremely rare.
• Often diagnosed during delivery
• Presence of a bridge of tissue between the fetuses on
vaginal examination confirms the diagnosis.
• Antenatal diagnosis is important.
• Benefits are: reduces maternal trauma and
morbidity, improves fetal survival, helps to plan method
of delivery, allows time to organize pediatric surgical
team.

Postnatal period
Page 44
Care of the babies
• Immediate care
• Maintenance of body temperature,
• Use of overhead heaters,
• Parents given the opportunity to check the identity tag
and cuddle them.
Breastfeeding
regarding different• Provide knowledge to mother
positions for breastfeeding, along with advantages,
attachment, positioning timing.

Postnatal period contd..
Page 45
Nutrition
• Expressed breast milk is best (for small babies), they may need to
be fed intravenously or by nasogastric tube or cup-fed, depending
on their size and general condition.
• Careful monitoring of weight gain, regular capillary blood glucose
estimations
• Reassure her that lactation responds to the demands made by
babies sucking at the breast.
• At feeding times, mother must be provided support and advised on
positioning and fixing babies.
Care of the mother
• Slow involution of uterus, increased ‘After pains’ so analgesia
should be offered.
• High calorie diet.
• Teach extra support to handle twin babies

Management and Nursing
Interventions
Page 46
• Nutrition counseling
• Fetal evaluation
• Evaluate woman for signs and symptoms of obstetrical
complications
• PTL prevention: explain for hospitalization
– Encourage bed rest and hydration.
– Institute fetal monitoring and assist with tocolytic therapy, if
ordered.
• Explain to the woman that mode for delivery depends on
the presentation of the twins, maternal and fetal status,
and gestational age

Page 53
Management and nursing interventions contd…
Intrapartum management
• Establish I.V. access
– Provide for electronic fetal monitoring for each fetus.
– Double setup is recommended for delivery.
• Availability of two units of crossmatched whole blood.
• I.V. access with large bore catheter.
• Surgical suite immediately available.
• An obstetrician and assistant experienced in vaginal births of twins.
• Best choice of anesthesia: epidural.
• Anesthesia provider capable of administering general anesthesia.
• Neonatal team for each neonate present at birth for neonatal
resuscitation.
– Pitocin induction/augmentation may be required secondary to
hypotonic labor.
– Postpartum hemorrhage may occur due to uterine atony.
• Emotional support.

Nursing diagnoses
Page 48
• Anxiety
• Deficient Knowledge Regarding High-risk Situation/Preterm
Labor
• Risk for Imbalanced Nutrition: Less/More than Body
Requirements
• Risk for Fetal Injury
• Risk for Maternal Injury
• Risk for Deficient Fluid Volume
• Risk for Impaired Gas Exchange
• Risk for Activity Intolerance
• Risk for Ineffective/Compromised Family Coping
• Risk for Interrupted Family Process.

Nursing diagnoses contd…
Page 49
For Cesarean Delivery
• Deficient Knowledge Regarding Surgical Procedure, and
Postoperative Regimen
• Anxiety (Specify Level)
• Powerlessness
• Risk for Acute Pain
• Risk for Infection
• Risk for Impaired Fetal Gas Exchange
• Risk for Maternal Injury
• Risk for Decreased Cardiac Output

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