Cultivation of KODO MILLET . made by Ghanshyam pptx
Obstructive jaundice
1.
2.
3. Anatomy of the biliary tree
Physiology of bile formation
Pathophysiology of jaundice
Etiology
Clinical features
Diagnostic investigations
Treatment modalities
4.
5.
6.
7. INTRAHEPATIC BILE DUCTS
Anterior superior lobe duct
Anterior inferior lobe duct Anterior
segmental duct
Posterior superior duct
Posterior inferior duct Posterior
segmental duct
Right caudate lobe duct
RIGHT HEPATIC DUCT
8. Lateral superior lobe duct
Lateral inferior lobe duct Lateral
segmental duct
Medial superior lobe duct
Medial inferior lobe duct Medial
segmental duct
Left caudate lobe duct
LEFT HEPATIC DUCT
9.
10. Common Hepatic Duct
• Formed 0.25 – 2.5cm from the surface of liver
• 1.5 – 3.5cm long
Cystic Duct
• 2 – 4 cm long, 3mm diameter
• Variable cysto hepatic junction
12. 5 – 16 cm in Length
Four parts
• Supraduodenal
• Retroduodenal
• Pancreatic
• Intra duodenal
13. BOUNDARIES
Right- cystic duct
Left – common hepatic duct
Superiorly- inferior margin of right lobe of liver
CONTENTS
Right hepatic artery
Cystic artery
Lymph node of lund
Abberant or accessory bile duct
14.
15. 500-1000ml per day
Secreted in 2 phases
Hepatocytes- rich in bile acids, cholesterol,
other organic constituents
Ductal epithelial cells- mainly watery solution
of sodium and bicarbonate ions.
16.
17.
18.
19. Normal volume: 30-60 ml
Functions as a reservoir storing as much as
12hours of bile
Absorption of sodium by active transport
Absorption of chloride, water by secondary
diffusion
Bile is concentrated 5 – 20 fold
23. Parenchymal secretion- BILE ACIDS
Secretion by the ductal epithelial cells-
SECRETIN
Emptying of gall bladder-
CHOLECYSTOKININ, Vagal stimulation
24. Functions-
› Emulsification of fat particles in food and
facilitate the function of lipases
› Absorption of digested fat through the intestinal
mucosa
› Excretion of waste ( Cholesterol, Bilirubin)
25.
26. Conjugated hyperbilirubinemia occurs
Levels increase by 25- 45 micromol/L/day
Normal secretory pressures in the biliary tree
– 15- 25cm H2O
At pressures above 35cm of H2O the bile flow
is suppressed
27. Obstruction to outflow of bile
Increased pressure within biliary tree
Loss of hepatocyte polarity
Disruption of tight junctions between hepatocytes and
bile duct cells
Hepatocyte necrosis
Rupture of dilated biliary canaliculi into hepatic
sinusoids
Cholangiovenous and cholangiolymphatic reflux
28. Bile Reflux
Neutrophil Infiltration
Increased Fibrinogenesis
Reticular Fibre Deposition In Portal Triad
Collagen Type 1 Deposition
Hepatic Fibrosis
Obstruction Of Sinusoids
Secondary Biliary Cirrhosis
Portal Hypertension
29. BILIRUBIN LEVELS PLATEAU IN
CHRONIC CASES
Increased excretion of bile pigments other than
bilirubin by the kidney, which do not give the
diazo reaction
Increased levels of conjugated bilirubins leads to
binding with albumin by covalent bonds forming
DELTA BILIRUBIN which is not measurable by
routine techniques
30. On CVS-
• Bile salts act on SA node- bradycardia
• Decreased cardiac contractility
• Decreased left ventricular pressures
• Decreases peripheral vascular resistance
Overall there is hypotension and
exaggerated hypotensive response to blood
loss. Patient is thus more prone to shock
intraoperatively
31. Decreased cardiac function
Hypovolemia
Bile salts causing increased PGE2 levels
Endotoxemia
Renal vasoconstriction
Shunting of blood from renal cortex
Complement activation in glomeruli
RENAL FAILURE
32. COAGULATION ABNORMALITIES
• Increased prothrombin time
• Decreased absorption of fat soluble vitamins A, D, E,
K
• Endotoxin induced alteration in coagulation factors XI,
XII, platelets
33. ITCHING
• Due to increased bile salts, but levels poorly correlate
• May be due to endogenous opiate peptides which
cause central opioid mediated scatching activity
POOR WOUND HEALING
• Due to decreased propyl hydroxylase enzyme in skin
leading to formation of defective collagen
• Increased risk of wound dehiscence
34.
35. Type 1 ( complete
obstruction)
• Primary or secondary liver
tumors
• Iatrogenic ligation of CBD
• Pancreatic tumors,
cholangiocarcinoma
Type 2 ( intermittent
obstruction)
• Choledocholithiasis
• Periampullary tumor
• Choledochal cyst
• Bile duct papilloma
• Hemobilia
• Duodenal diverticula
Type 3 ( chronic
complete obstruction)
• Bile duct stricture
• Biliary atresia
• Post radiotherapy
• Chronic pancreatitis
• Cystic fibrosis
Type 4 ( segmental
obstruction)
• Sclerosing cholangitis
• Traumatic
• Hepatolithisis
42. Routine blood investigations
Serum bilirubin
Serum albumin
Albumin: globulin ( A:G) ratio
Prothrombin time
Serum Alkaline Phosphatase (ALP)
SGOT/ AST
SGPT/ ALT
Gamma Glutamyl Transferase (GGT)
5’- Nucleotidase
43. Normal levels- 44 to 147 IU/L
Raised in all cases of biliary obstruction
except in intermittent obstruction
Raise by atleast 3 times the upper limit is
diagnostic of biliary obstruction
44. Normal levels AST 5-40 IU/L
Normal level of ALT 7-56IU/L
Elevated levels are indicative of hepatocellular damage.
AST is less specific but more sensitive for liver function.ALT
can confirm the hepatic origin of AST.
In extra hepatic obstruction usually AST levels are not
elevated(< 10 times the upper reference limit)
45. Most sensitive indicator of biliary tract
disease especially in children.
Helpful in the diagnosis of acute biliary tract
obstruction.
Correlates with ALP level but ALP levels take
longer duration to increase.
46. This is particularly helpful in children,
pregnant women and patients who may have
bone disease resulting in rise of ALP
Confirms the hepatic origin of ALP
It is more useful than ALP/GGT in detecting
hepatic metastasis
49. Most calculi in biliary tract are radioluscent
Seagull/ Benz sign may be seen
occasionally
Helps to exclude other causes of RUQ pain
50. Sensitive, inexpensive, but operator dependent
Able to identify calculous disease accurately
Finding of dilated bile duct (>8mm) in setting of
jaundice suggests obstruction to the biliary tract
Also malignant lesions such as carcinoma GB,
cholangiocarcinoma may be identified
51. Assesment of distal bile duct and the
ampulla
Assesment of vascular invasion by the
tumors
Radial echoendoscope- for tomographic
evaluation
Linear echoendoscope for guiding
interventions
52. Triple phase CT is especially useful
Provides superior anatomical detail on the
biliary tree as well as other abdominal
organs
Important especially in preoperative planning
53. Invasive test
Useful in imaging the biliary and pancreatic
ducts
Diagnostic and therapeutic in most benign
biliary conditions
Able to provide tissue samples in malignant
condtions
Complication rate upto 10%
o Cholangitis
o Pancreatitis
o Duodenal injury of perforation
o Sphincter stenosis
54. Non invasive modality to image biliary and pancreatic
ducts.
Technique uses the fluid present in the biliary and
pancreatic ducts as a contrast agent highlighting them in
heavily T2 weighted sequences.
Provides multiplanar 3D reconstructions.
Only diagnostic.
Indicated in cases where ERCP is not feasible.
55. Biliary scintigraphy
Radioisotope such as Tc99 labelled HIDA,
PIPIDA, BRIDA are used
These are actively taken up by hepatocytes
and also secreted into the biliary canaliculi
Failure to fill the gall bladder within 2hrs of
administration indicates obstruction in the
tract
CCK enhanced emptying of gall bladder may
also be demonstrated
58. PERCUTANEOUS TRANSHEPATIC
CHOLANGIOGRAPHY
Indications-
Failure of ERCP
High biliary strictures
Klatskin tumor
Can be used in severe obstructive jaundice to
also decompress the dilated biliary tree
59.
60. Correction of fluid and electrolyte imbalance
Inj vit K, fresh frozen plasma
Lactulose, oral neomycin
Mannitol
Broad spectrum antibiotics
Decompression of biliary tree
Management of the cause of obstruction
61. Inflammatory obliteration of intrahepatic and
extrahepatic biliary ducts
Associated with splenic abnormalities, absent IVC,
intestinal malformation.
ETIOLOGY
• Immune mediated inflammatory reaction
• Viral insult
• HLA- B12 association
• CFC1 gene mutation
62.
63. CLINICAL FEATURES
Jaundice- persisting
beyond 14days age
Pale stools
Dark urine
Failure to thrive
Hepatomegaly
Ascitis
INVESTIGATIONS
Liver function tests
TORCH screening
Ultrasound
HIDA scan
MRCP
ERCP
LIVER BIOPSY
64.
65.
66. Roux -en- y hepato-
portoenterostomy
Does not cure
Delays need for a liver
transplant by atleast 10yrs
73. Treatment-
• Excision of cyst
• Reconstruction with roux- en- y
hepaticojejunostomy
• Enucleation of cyst
74. Supersaturation of secreted bile(lithogenic bile)
Concentration of bile in GB
Crystal nucleation
Gall bladder dysmotility
Stone formation
75. Types of stones
Pure cholesterol stones (cholesterol solitaire)-
usually single, rare (6%)
Pigment stones- green or black coloured, usually
multiple, tiny, seen in hemolytic conditions
Mixed- 90% of the gall bladder stones, multiple,
composed of cholesterol, calcium phosphates,
carbonates, palmitates. Characteristically multi-
faceted.
76. CBD stones ( CHOLEDOCHOLITHIASIS)
TYPES-
PRIMARY- formed de novo in the bile duct.
Brown stones are common and usually
multiple
SECONDARY- stones formed in the gall
bladder and pass into the bile ducts
78. USG- dilated bile duct >8mm in setting of
jaundice
ERCP-
› Cholangitis
› Biliary pancreatitis
› Limited expertise with CBD exploration
› Morbid patient
MRCP-
79. ERCP- sphincterotomy
Laparoscopic CBD exploration
Open CBD exploration
› Transduodenal sphincteroplasty
› Choledocho duodenostomy
› Roux en y choledocho jejunostomy
Percutaneous drainage and stone extraction
80. Compression of Common hepatic or common
bile duct by a stone impacted in the cystic
duct or hartmans pouch leading to formation
of cholecysto-choledochal fistula.
Often a large cholesterol solitaire
Classification ( csendes )
81. Type 1- extrinsic compression of CBD
Type 2- stone eroding through less than
1/3rd the circumference of CBD
Type 3- Fistula involving upto 2/3rd the
circumference of CBD
Type 4- Cholecysto choledochal fistula with
destruction of the CBD
82. Usually diagnosed on CT or intraoperatively
Cholecystectomy ( partial or complete) with
intra operative cholangiogram, and T- tube
insertion.
Reconstruction with hepaticojejunostomy
may be required in type 4
83.
84. Autoimmune process involving intra and extra
hepatic biliary tree
Associated with riedles thyroiditis, ulcerative
colitis
Inflammation, scarring of bile ducts causing
progressive cholestasis
Elevated ALP, p ANCA
ERCP- diffuse multifocal dilatations and
stricturres of the biliary tree
Biopsy- onion skin concentric periductal fibrosis
90. Based on location of tumor
Proximal lesions- perihilar (klatskin tumor),
intrahepatic
Lesions in the middle third
Distal lesions- periampullary carcinoma
Based on pathologic subtypes
Sclerosing
Nodular
Papillary
91.
92.
93.
94.
95. INVESTIGATIONS
Triple phase CT- assesment of resectability,
preoperative planning, metastases.
Cholangiography- to determine the proximal
extent of resection
Tissue diagnosis- only important in patients
with unresectable disease
96. R0 resection is the only strategy that affords
possibility of cure
Contraindications for resection
Bilobar intrahepatic metastases
Extrahepatic disease
Encasement of the portal vein
Bilateral hepatic lobar artery involvement
Lobar atrophy with contralateral portal vein or
biliary radical involvement
97. Distal lesions- pancreatico-duodenectomy
Proximal lesions-en bloc resection of common
bile duct with hepatic parenchyma and regional
nodal tissue
Type 1- common duct resection , cholecystectomy, 5-
10mm margin
Type 2- partial hepatic resection including the
caudate lobe
Types 3 and 4- complex resection up to secondary
biliary radicals, and reconstruction of hepatic artery,
portal vein
Biliary drainage is provided by Roux en Y
hepaticojejunostomy, transanastomotic stenting
98. Endoscopic or percutaneous drainage
according to site of lesion
Analgesia
IV narcotics
Percutaneous ablation of celiac plexus
Endoscopic duodenal stenting
99. RISK FACTORS-
Chronic inflammatory conditions
Gall stones larger than 3cm
Choledochal cyst
PSC
Porcelain gall bladder
Gall bladder polyp larger than 10mm
100.
101. USG- irregularly thickened gall bladder wall ,
polyp >10mm size, heterogenous mass in
gall bladder
Triphasic CT- to delineate hepatic artery and
portal venous involvement
102. Pre operative suspicion-
Extended liver resections, including segments IV, V,
VIII
Right trisegmentectomy
Following cholecystectomy
› T1b lesion- extended cholecystectomy including
draining nodal basins, cystic duct, excision of CBD
with Roux en y reconstruction
› T2 lesions- radical cholecystectomy
103. Carcinoma head of pancreas or
periampullary- Whipples operation, ERCP
stenting
Parasites- Endoscopic removal
Intra ductal papillomas- wide local excision
and reconstruction