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OVERVIEW OF GASTROINTESTINAL FUNCTION & REGULATION   簡介 胃腸功能及其調節      黃士哲  (Shih-Che Huang)  ,[object Object]
Understand gastrointestinal function ,[object Object]
major gastrointestinal secretions  胃腸分泌
major hormones, peptides, and neurotransmitters  荷爾蒙 生肽 神經傳導物質
enteric nervous system and splanchnic circulation  腸神經系統 內臟循環
胃腸構造 Organization of the wall of the intestine into functional layers
腸構造 structure of intestinal villi  絨毛 and crypts  窩
Regulation of salivary secretion  唾液分泌   parasympathetic nervous system 副交感神經 ACh, acetylcholine.
Anatomy of the stomach 胃
Structure of a gastric gland  胃腺  from the fundus  底部  and body  體部 of the stomach
ECL (enterochromaffin-like) cells  腸親色素細胞 ,[object Object],[object Object]
G cells, S cells, etc. ,[object Object]
Contents of Normal Gastric Juice 胃液 (Fasting State 禁食 ) ,[object Object]
Anions: Cl–, HPO4 2–, SO4 2–
Pepsins  胃蛋白酶
Lipase  脂肪酶
Mucus  黏液
Intrinsic factor  內因子
Intrinsic factor  內因子 absorption  吸收  of vitamin B12
Regulation of gastric acid 胃酸 and pepsin 胃蛋白酶  secretion (SST somatostatin  體抑制素 )
Parietal cell  壁細胞 receptors  受體
Ion transport  離子運輸 proteins of parietal cells 壁細胞
Clinical Box –1  Peptic Ulcer Disease  消化性潰瘍 ,[object Object],[object Object]
Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) 消炎止痛藥 ,[object Object]
decrease mucus and HCO3 – secretion
Clinical Box –1 Peptic Ulcer Disease  消化性潰瘍 ,[object Object],[object Object],[object Object]
NSAID 消炎止痛藥 -induced ulcers ,[object Object]
PANCREATIC SECRETION 胰臟分泌
Principal Digestive Enzymes  酵素 ( 酶 ) ,[object Object]
Pepsins 胃蛋白酶  Proteins     Polypeptides  多生肽 ,[object Object]
Trypsin  胰蛋白酶  Proteins    Polypeptides
Lipase  脂肪酶  Triglycerides    Monoglycerides, fatty acids
Amylase  澱粉酶  Starch    Dextrins, maltotriose, maltose
Liver, gallbladder  膽 , and pancreas 胰
Human bile acids 膽汁酸
Lipid digestion  脂質消化  and passage to intestinal mucosa  腸黏膜
circulation of bile acids  膽汁酸循環
Daily Water Turnover (mL) in the Gastrointestinal Tract ,[object Object]
Endogenous secretions  分泌  7000 ,[object Object]
Stomach  2500
Pancreas  1500 ,[object Object]

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