Fructose & galactose metabolism
โข
36 likesโข14,540 views
Metabolism of Fructose and Galactose for medical student
Recommended
More Related Content
What's hot
What's hot (20)
Viewers also liked
Viewers also liked (20)
Similar to Fructose & galactose metabolism
Similar to Fructose & galactose metabolism (20)
More from Dhiraj Trivedi
More from Dhiraj Trivedi (20)
Recently uploaded
Recently uploaded (20)
Fructose & galactose metabolism
- 1. Fructose metabolism โข Dietary source is sucrose โข Fruits and honey are other sources of fructose โข Absorption is not dependent on insulin โข It gets absorbed by GLUT 2 and GLUT 5 receptors โข Fructose is metabolized separately in liver and muscle โข Too much of fructose leads to hyperlipidemia
- 2. Metabolism of fructose in muscle and extra hepatic tissue Fructose Fructose -6-phosphate Glucose 6 Phosphate ATP ADP Hexokinase Pyruvate Glycolysis Glycogen F1,6 BP Phosphohexose isomerase
- 3. Metabolism of fructose in Liver Fructose Fructose -1- phosphate Glyceraldehyde ATP ADP Fructokinase TAG Glycero phospholipid Aldolase B DHAP Glycerol 3 P Alcohol DH Glycerol NAD NAD H + H Glycero kinase ATP ADP Glycolysis Gluconeogenesis 1 2 3 4 5 6
- 4. Inborn error involved in Metabolism of fructose Fructose Fructose -1- phosphate Glyceraldehyde ATP ADP Fructokinase Aldolase B DHAP Glycolysis / Gluconeogenesis 1 2 3 Deficiency of fructokinase Result in essential Fructosuria Deficiency of Aldolase B Result in accumulation of F1P Condition โ Fructose intolerance
- 6. Metabolism of Galactose โข Major dietary source of galactose is Lactose โข Lactose is digested by ฮฒ-galactosidase (lactase) enzyme in intestine โข Galactose uptake by cell is not influenced by Insulin โข Galactose is required for glycoprotein, glycolipid and GAG synthesis โข Lactose synthesis takes place in Mammary gland
- 7. Source of Galactose Lactose Galactose Lactase Lactase deficiency Intestinal mucosal cell Lactose intolerance Diarrhoea, Vomiting, Nausea of milk Glucose
- 8. Phosphorylation of Galactose Galactose Galactose 1 Phosphate Galactokinase ATP ADP Mg+2 Galactokinase deficiency Rare Autosomal recessive disorder Increased Galactose in Blood Excretion of Galactose in Urine Galactitol NADP+ NADPH + H+ Aldose reductase
- 9. Reduction of Galactose Galactose When Galactose levels increases Galactose is reduced Increased level of Galactitol causes CATARACT Galactitol NADP+ NADPH + H+ Aldose reductase Aldose reductase is present in Liver, Kidney, Retina Lens, Nervous tissue, Seminal ves Ovaries
- 10. Synthesis of UDP-Galactose Galactose 1 Phosphate Galactose-1-P Uridyltransferase UTP PPi UDP- Galactose Classic Galactosemia Deficiency of Galactose 1-P Uridyl transferase Causes Galactosemia, Galactosuria, Vomiting, Diarrhoea, Jaundice Galactose
- 11. Synthesis of UDP-Galactose Galactose 1 Phosphate Galactose-1-P Uridyltransferase UTP PPi UDP- GalactoseLactose Glycoprotein Glycolipid GAG UDP Glucose GlucoseUDP Lactose synthase UDP Hexose 4 epimerase Prolactin +
- 12. Galactosemia โข Enzyme defect: Galactose 1 P Uridyltransferase or Galactokinase โข Inheritance : Autosomal recessive โข Age : Child โข Biochemical finding: Accumulation of Galactose in NT & Lens Galactosemia , Galactosuria, Hypoglycemia, โข Clinical finding: Failure to thrive on milk Liver disease, Mental retardation and CATARACT โข Diagnosis: Reducing sugar in urine but GOD negative, Chromatography, Increased level of blood galactose โข Treatment: Galactose free diet