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Transdermal Drug Delivery Systems: Fundamentals, permeation of drugs across the skin, types of TDDS, Materials employed and Evaluation of TDDS.
Transdermal drug delivery system
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Osmotic Drug Delivery System-very imp NDDS
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department of pharmaceutics DELHI INSTITUTE OF PHARMACEUTICAL SCIENCE AND RESEARCH
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GRDDS
Gastro Retentive Drug Delivery System
Gastro Retentive Drug Delivery System
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Mucoadhesive drug delivery system interact with the mucus layer covering the mucosal epithelial surface, & mucin molecules & increase the residence time of the dosage form at the site of the absorption. Mucoadhesive drug delivery system is a part of controlled delivery system. Since the early 1980,the concept of Mucoadhesion has gained considerable interest in pharmaceutical technology. combine mucoadhesive with enzyme inhibitory & penetration enhancer properties & improve the patient complaince. MDDS have been devloped for buccal ,nasal,rectal &vaginal routes for both systemic & local effects. Hydrophilic high mol. wt. such as peptides that cannot be administered & poor absorption ,then MDDS is best choice. Mucoadhesiveinner layers called mucosa inner epithelial cell lining is covered with viscoelasticfluid Composed of water and mucin. Thickness varies from 40 μm to 300 μm General composition of mucus Water…………………………………..95% Glycoproteinsand lipids……………..0.5-5% Mineral salts……………………………1% Free proteins…………………………..0.5-1% The mechanism responsible in the formation of mucoadhesive bond Step 1 : Wetting and swelling of the polymer(contact stage) Step 2 : Interpenetration between the polymer chains and the mucosal membrane Step 3 : Formation of bonds between the entangled chains (both known as consolidation stage) Electronic theory Wetting theory Adsorption theory Diffusion theory Fracture theory Advantages over other controlled oral controlled release systems by virtue of prolongation of residence of drug in GIT. Targeting & localization of the dosage form at a specific site -Painless administration. -Low enzymatic activity & avoid of first pass metabolism If MDDS are adhere too tightlgy because it is undesirable to exert too much force to remove the formulation after use,otherwise the mucosa could be injured. -Some patient suffers unpleasent feeling. -Unfortunately ,the lack of standardized techniques often leads to unclear results. -costly drug delivery system
Mucoadhesive drug delivery system
Mucoadhesive drug delivery system
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CONTROLLED DRUG DELIVERY SYSTEMS
CONTROLLED DRUG DELIVERY SYSTEMS
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Recommended
Transdermal Drug Delivery Systems: Fundamentals, permeation of drugs across the skin, types of TDDS, Materials employed and Evaluation of TDDS.
Transdermal drug delivery system
Transdermal drug delivery system
Arshad Khan
Osmotic Drug Delivery System-very imp NDDS
Osmotic drug delivery system
Osmotic drug delivery system
Dr. Shreeraj Shah
department of pharmaceutics DELHI INSTITUTE OF PHARMACEUTICAL SCIENCE AND RESEARCH
Formulation and evaluation of tdds
Formulation and evaluation of tdds
Pankaj Verma
GRDDS
Gastro Retentive Drug Delivery System
Gastro Retentive Drug Delivery System
Dr Gajanan Sanap
Mucoadhesive drug delivery system interact with the mucus layer covering the mucosal epithelial surface, & mucin molecules & increase the residence time of the dosage form at the site of the absorption. Mucoadhesive drug delivery system is a part of controlled delivery system. Since the early 1980,the concept of Mucoadhesion has gained considerable interest in pharmaceutical technology. combine mucoadhesive with enzyme inhibitory & penetration enhancer properties & improve the patient complaince. MDDS have been devloped for buccal ,nasal,rectal &vaginal routes for both systemic & local effects. Hydrophilic high mol. wt. such as peptides that cannot be administered & poor absorption ,then MDDS is best choice. Mucoadhesiveinner layers called mucosa inner epithelial cell lining is covered with viscoelasticfluid Composed of water and mucin. Thickness varies from 40 μm to 300 μm General composition of mucus Water…………………………………..95% Glycoproteinsand lipids……………..0.5-5% Mineral salts……………………………1% Free proteins…………………………..0.5-1% The mechanism responsible in the formation of mucoadhesive bond Step 1 : Wetting and swelling of the polymer(contact stage) Step 2 : Interpenetration between the polymer chains and the mucosal membrane Step 3 : Formation of bonds between the entangled chains (both known as consolidation stage) Electronic theory Wetting theory Adsorption theory Diffusion theory Fracture theory Advantages over other controlled oral controlled release systems by virtue of prolongation of residence of drug in GIT. Targeting & localization of the dosage form at a specific site -Painless administration. -Low enzymatic activity & avoid of first pass metabolism If MDDS are adhere too tightlgy because it is undesirable to exert too much force to remove the formulation after use,otherwise the mucosa could be injured. -Some patient suffers unpleasent feeling. -Unfortunately ,the lack of standardized techniques often leads to unclear results. -costly drug delivery system
Mucoadhesive drug delivery system
Mucoadhesive drug delivery system
Anita Duduskar
CONTROLLED DRUG DELIVERY SYSTEMS
CONTROLLED DRUG DELIVERY SYSTEMS
Sonam Gandhi
Niosome
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Nasopulmonary Drug Delivery System
Nasopulmonary Drug Delivery System
Nasopulmonary Drug Delivery System
Dr. Prashant L. Pingale GES's Sir Dr. M. S. Gosavi College of Pharmacy, Nashik
Pulmonary route used to treat different respiratory diseases from last decade. The inhalation therapies involved the use of leaves from plants, vapours from aromatic plants, balsams, and myhrr. Pulmonary drug delivery is primarily used to treat conditions of the airways, delivering locally acting drugs directly to their site of action. Delivery of drugs directly to their site of action reduces the dose needed to produce a pharmacological effect.
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Helpful to understand the overview of mechanism of enhancing the skin penetration with their examples.
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I have tried to include almost all details in superficially, and have been supported a lot by my ma'm SHITAL ACHARYA. Thanks to her
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TDDS are topically administered medicaments in the form of patches that deliver drugs for systemic effects at predetermined and controlled rate.
Transdermal Drug Delivery System (TDDS)
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mucosal drug delivery is a developing system nowadays due to its several advantages including patient compliance and for sustained delivery
Mucosal drug delivery system
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Oral route is the most acceptable route for drug administration. Apart from conventional dosage forms several other forms were developed in order to enhance the drug delivery for prolonged time period and for delivering drug to a particular target site. Gastro-retentive drug delivery system (GRDDS) has gainned immense popularity in the field of oral drug delivery recently. it is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. different innovative approaches are being applied to fabricate GRDDS. Gastroretentive drug delivery is an approach to prolong gastric residence time, there by targeting site-specific drugs release in the upper gastrointestinal tract (GIT) for local or systemic effects. It is obtained by retaining dosage form into stomach and by releasing the in controlled manner.
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Dr. Prashant L. Pingale GES's Sir Dr. M. S. Gosavi College of Pharmacy, Nashik
Pulmonary route used to treat different respiratory diseases from last decade. The inhalation therapies involved the use of leaves from plants, vapours from aromatic plants, balsams, and myhrr. Pulmonary drug delivery is primarily used to treat conditions of the airways, delivering locally acting drugs directly to their site of action. Delivery of drugs directly to their site of action reduces the dose needed to produce a pharmacological effect.
Pulmonary drug delivery system [PDDS]
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Helpful to understand the overview of mechanism of enhancing the skin penetration with their examples.
Penetration enhancer with their examples
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I have tried to include almost all details in superficially, and have been supported a lot by my ma'm SHITAL ACHARYA. Thanks to her
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TDDS are topically administered medicaments in the form of patches that deliver drugs for systemic effects at predetermined and controlled rate.
Transdermal Drug Delivery System (TDDS)
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PRABU12345678
mucosal drug delivery is a developing system nowadays due to its several advantages including patient compliance and for sustained delivery
Mucosal drug delivery system
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Pranali Palandurkar
TRANSDERMAL DRUG DELIVERY SYSTEM, TDDS,
Factors affecting TRANSDERMAL DRUG DELIVERY SYSTEM
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Siddu K M
NDDS
Nasal drug delivery system
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Pravin Chinchole
Polymers in controlled release Drug Delivery System
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Nasal drug delivery system
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