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Bridging the Autoimmune Abyss through New Discoveries

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A comprehensive collection of our autoimmunity research done in an effort to help bridge the gap for the large and growing needs of the autoimmune community. This bibliography is a sneak peak at an upcoming white paper for the lonely voices of autoimmune disease.

Topics Include:
Prevalence & Incidence
Immunology
Polyautoimmunity
Current Treatments & Therapies
The Microbiome
Data and Digital Tools
Causes of Autoimmune Disease
Prevention & Lifestyle Modification

Published in: Health & Medicine
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Bridging the Autoimmune Abyss through New Discoveries

  1. 1. © 2015 - All rights reserved. Bonnie Feldman DDS MBA Priya Sahdev Tiffany Simms Bridging the Autoimmune Abyss through New Discoveries
  2. 2. © 2015 - All rights reserved. Bridging the Autoimmune Abyss through New Discoveries +1.310.666.5312 drbonnie360@gmail.com www.drbonnie360.com @DrBonnie360 www.facebook.com/YourAutoimmunityConnection Bonnie Feldman, DDS, MBA Business Development for Digital Health Priya Sahdev, BS UCLA Class of 2016 Microbiology, Immunology, & Molecular Genetics Tiffany Simms, BS UCLA Class of 2015 Anthropology
  3. 3. © 2015 - All rights reserved. The Invisible Epidemic: Incidence & Prevalence • Feldman, Bonnie. “Why is Autoimmune Disease Under-served.” Slideshare (2015). http://bit.ly/1B57pNb • Groza, Tudor et al. “The Human Phenotype Ontology: Semantic Unification of Common and Rare Disease.” The American Journal of Human Genetics (2015). http://www.irdirc.org/the- human-phenotype-ontology-semantic-unification-of-common-and-rare-disease/ • Nakazawa Jackson, Donna. The Autoimmune Epidemic. New York: A Touchstone Book, 2008. Print • “More than 450 Medicines in Development for Rare Diseases.” Medicines in Development (2013). http://phrma.org/Medicines-Development-Rare-Diseases
  4. 4. © 2015 - All rights reserved. Basic Science Foundation for Discovery
  5. 5. © 2015 - All rights reserved. New Discovery Fuels Collaboration: Immunology & Repertoire Sequencing • Burton, Bronwen et al. “Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy.” Nature Communications (2014). http://scholar.qsensei.com/content/1yq4qh • Norman, Jason et al. “Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease.” Cell (2015). http://f1000.com/prime/725326230 • Poletaev et al. “Immunophysiology versus immunopathology: Natural autoimmunity in human health and disease.” Pathophysiology 19.3 (2012): 221- 231.<http://www.researchgate.net/publication/230655913_Immunophysiology_versus_im munopathology_Natural_autoimmunity_in_human_health_and_disease
  6. 6. © 2015 - All rights reserved. New Discovery Fuels Collaboration: Immunology & Repertoire Sequencing • Ramesh, Manish et al. “Clonal and Constricted T cell repertoire in Common Variable Immune Deficiency.” Clinical immunology (Orlando, Fla.) (2015). http://www.bioportfolio.com/resources/pmarticle/1148910/Clonal-and-Constricted-T-cell- repertoire-in-Common-Variable-Immune-Deficiency.html • Robins, Harlan. “Immunosequencing: applications of immune repertoire deep sequencing.” Current Opinion in Immunology 25.5 (2013): 646–52. http://www.researchgate.net/publication/258059445_Immunosequencing_applications_of _immune_repertoire_deep_sequencing
  7. 7. © 2015 - All rights reserved. New Discovery Fuels Collaboration: Immunology & Repertoire Sequencing • Robinson, William. “Sequencing the functional antibody repertoire—diagnostic and therapeutic discovery.” Nature Reviews Rheumatology 11.3 (2015): 171–182. http://www.pubfacts.com/detail/25536486/Sequencing-the-functional-antibody- repertoire-diagnostic-and-therapeutic-discovery • Spreafico, Roberto et al. “A circulating reservoir of pathogenic-like CD4+ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment.” Annals of the Rheumatic Diseases (2014): annrheumdis–2014–206-226. http://www.researchgate.net/publication/269719321_A_circulating_reservoir_of_pathoge nic- like_CD4_T_cells_shares_a_genetic_and_phenotypic_signature_with_the_inflamed_synovi al_micro-environment
  8. 8. © 2015 - All rights reserved. Polyautoimmunity: No Longer Organ Specific • Castiblanco, John, Mauricio Arcos-Burgos, and Juan-Manuel Anaya. “What is next after the genes for autoimmunity?” BMC Medicine 11 (2013): 197. http://www.biomedcentral.com/1741-7015/11/197 • Franco, -S, and -M Anaya. “The autoimmune tautology with a focus on antiphospholipid syndrome.” Lupus 23.12 (2014): 1273-1275. http://www.researchgate.net/publication/265733380_The_autoimmune_tautology_with_a _focus_on_antiphospholipid_syndrome • Groza, Tudor et al. “The Human Phenotype Ontology: Semantic Unification of Common and Rare Disease.” The American Journal of Human Genetics (2015). http://www.irdirc.org/the- human-phenotype-ontology-semantic-unification-of-common-and-rare-disease/
  9. 9. © 2015 - All rights reserved. Polyautoimmunity: No Longer Organ Specific • Greenwood, Veronique. “Disease Networks Show Molecular Connections." Quanta Magazine” (2015). https://www.quantamagazine.org/20150129-networks-reveal-the- connections-of-disease/ • Zippi, Maddalena. “Extraintestinal manifestations in a large series of Italian inflammatory bowel disease patients.” World Journal of Gastroenterology 20.46 (2014): 17463- 17467.http://docrchive.com/document/extraintestinal-manifestations-in-a-large-series-of- italian-inflammatory-bowel-disease-patients-7348008145211277/
  10. 10. © 2015 - All rights reserved. Personal Trial and Error: Treatments & Therapies • Bot, Adrian et al. “Target discovery for T cell therapy: next steps to advance Immunotherapies.” Journal for Immunotherapy of Cancer (2015). http://www.immunotherapyofcancer.org/content/pdf/s40425-015-0061-5.pdf • Burton, Bronwen et al. “Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy.” Nature Communications (2014). http://research- information.bristol.ac.uk/en/publications/sequential-transcriptional-changes-dictate-safe- and-effective-antigenspecific-immunotherapy(8e1716fd-8874-45eb-84a9- 0dc5540e26a8)/export.html • Chang, Christopher. “Unmet needs in the treatment of autoimmunity: From aspirin to stem cells.” Autoimmunity Reviews 13 (2014). http://www.researchgate.net/publication/259917083_Unmet_Needs_in_the_Treatment_o f_Autoimmunity_From_Aspirin_to_Stem_Cells
  11. 11. © 2015 - All rights reserved. Personal Trial and Error: Treatments & Therapies • Curatola, Gerard. “Oral Microbiome Homeostasis: The New Frontier in Oral Care Therapies.” Symbiosis (2013):1-3. http://www.symbiosisonlinepublishing.com/dentistry-oraldisorders- therapy/dentistry-oraldisorders-therapy05.php • Gertner, Jon. “What’s Lurking In Your Microbiome? Possibly, a Cure for Disease.” Fast Company (2015). http://www.fastcompany.com/3039891/gut-check • Nakazawa Jackson, Donna. The Autoimmune Epidemic. New York: A Touchstone Book, 2008. Print. • Olle, Bernat. “Medicines from microbiota.” Nature Biotechnology 31.4 (2013): 309-315. http://www.researchgate.net/publication/236128149_Medicines_from_microbiota
  12. 12. © 2015 - All rights reserved. Personal Trial and Error: Treatments & Therapies • Petrof et al. “Microbial ecosystems therapeutics: a new paradigm in medicine?” Beneficial microbes 4.1 (2013): 53-65. http://www.researchgate.net/publication/233963283_Microbial_ecosystems_therapeutics _A_new_paradigm_in_medicine • Sabatos-Peyton, Catherine A, Johan Verhagen, and David C Wraith. “Antigen-specific immunotherapy of autoimmune and allergic diseases.” Current opinion in immunology 22.5 (2010): 609–15. http://www.researchgate.net/publication/46305185_Antigen- specific_immunotherapy_of_autoimmune_and_allergic_diseases • Velasquez-Manoff, Moises. An Epidemic of Absence. New York: Scribner, 2012. Print.
  13. 13. © 2015 - All rights reserved. Treatments & Therapies: Fecal Microbiota Transplants • Borody, Thomas, and Alexander Khoruts. “Fecal microbiota transplantation and emerging applications.” Nature Reviews Gastroenterology and Hepatology 9.2 (2011): 88–96. http://www.researchgate.net/publication/51901488_Borody_TJ_Khoruts_A.._Fecal_microb iota_transplantation_and_emerging_applications._Nat_Rev_Gastroenterol_Hepatol_9_88- 96 • Brüssow, Harald. “Microbiota and the human nature: know thyself.” Environmental Microbiology 17.1 (2015): 10–15. http://www.researchgate.net/publication/269727325_Microbiota_and_the_human_nature _know_thyself
  14. 14. © 2015 - All rights reserved. Treatments & Therapies: Fecal Microbiota Transplants • Petrof, Elaine, and Alexander Khoruts. “From stool transplants to next-generation microbiota therapeutics.” Gastroenterology 146.6 (2014): 1573-1582. http://www.researchgate.net/publication/259698247_From_Stool_Transplants_to_Next- generation_Microbiota_Therapeutics • Scher, Jose et al. “Decreased Bacterial Diversity Characterizes the Altered Gut Microbiota in Patients With Psoriatic Arthritis, Resembling Dysbiosis in Inflammatory Bowel Disease.” Arthritis & Rheumatology 67.1 (2015): 128–139. http://www.researchgate.net/publication/266974816_Decreased_Bacterial_Diversity_Char acterizes_the_Altered_Gut_Microbiota_in_Patients_With_Psoriatic_Arthritis_Resembling_ Dysbiosis_in_Inflammatory_Bowel_Disease
  15. 15. © 2015 - All rights reserved. Treatments & Therapies: Prebiotics and Probiotics • Bindels, Laure et al. “Towards a more comprehensive concept for prebiotics.” Nature Reviews Gastroenterology & Hepatology (2015). http://www.researchgate.net/publication/274319084_Towards_a_more_comprehensive_c oncept_for_prebiotics • Derrien, Muriel, and Johan Vlieg. “Fate, activity, and impact of ingested bacteria within the human gut microbiota.” Trends in Microbiology (2015). http://www.researchgate.net/publication/274405159_Fate_activity_and_impact_of_ingest ed_bacteria_within_the_human_gut_microbiota • Vieira, Angélica, Mauro Teixeira, and Flaviano Martins. “The Role of Probiotics and Prebiotics in Inducing Gut Immunity.” Frontiers in Immunology 4 (2013): 445. http://www.researchgate.net/publication/259492313_The_Role_of_Probiotics_and_Prebio tics_in_Inducing_Gut_Immunity
  16. 16. © 2015 - All rights reserved. The Microbiome Lifeline • Ackerman, Jennifer. “The Ultimate Social Network.” Scientific American 306.6 (2012): 36–43. http://www.researchgate.net/publication/225084801_The_ultimate_social_network • Brusca, Samuel, Steven Abramson, and Jose Scher. “Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity.” Current Opinion in Rheumatology (2014). http://www.researchgate.net/publication/258700816_Brusca_S.B._Abramson_S.B.__Scher_J.U. _Microbiome_and_mucosal_inflammation_as_extra- articular_triggers_for_rheumatoid_arthritis_and_autoimmunity._Curr._Opin._Rheumatol._26_1 01-107 • Brüssow, Harald. “Microbiota and the human nature: know thyself.” Environmental Microbiology 17.1 (2015): 10–15. http://www.researchgate.net/publication/269727325_Microbiota_and_the_human_nature_kn ow_thyself
  17. 17. © 2015 - All rights reserved. The Microbiome Lifeline • Garrett, Wendy. “From cell biology to the microbiome: An intentional infinite loop.” The Journal of Cell Biology (2015). http://www.researchgate.net/publication/279862421_From_cell_biology_to_the_microbio me_An_intentional_infinite_loop • Hevia, Arancha et al. “Intestinal Dysbiosis Associated with Systemic Lupus Erythematosus.” mBio (2014). http://www.academia.edu/13411926/Intestinal_dysbiosis_associated_with_systemic_lupus _erythematosus • Kamada, Nobuhiko et al. “Role of the gut microbiota in immunity and inflammatory disease.” Nature Reviews Immunology 13.5 (2013): 321–335. http://www.researchgate.net/publication/236337970_Role_of_gut_microbiota_in_immuni ty_and_inflammatory_disease
  18. 18. © 2015 - All rights reserved. The Microbiome Lifeline • Proal, Amy, Paul Albert, and Trevor Marshall. “Inflammatory disease and the human microbiome.” Discovery medicine 17.95 (2014): 257–65. http://www.researchgate.net/publication/262782132_Inflammatory_disease_and_the_hu man_microbiome • “Modern Medicine: Microbes Maketh Man." The Economist, (2012). http://www.economist.com/node/21560559 • Waldor, Matthew et al. “Where next for microbiome research?” PLoS biology 13.1 (2015). http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002050 • Yurkovetskiy, Leonid, Joseph Pickard, and Alexander Chervonsky. “Microbiota and Autoimmunity: Exploring New Avenues.” Cell Host & Microbe (2015). http://scifeeds.com/journal-article/microbiota-and-autoimmunity-exploring-new-avenues/
  19. 19. © 2015 - All rights reserved. The Microbiome Lifeline: Gut As An Organ of Immunity • Campbell, Andrew. “Autoimmunity and the Gut.” Autoimmune Diseases 2014 (2014): 152-428. http://www.researchgate.net/publication/262886119_Autoimmunity_and_the_Gut • Goldszmid, Romina, and Giorgio Trinchieri. “The price of immunity.” Nature Immunology 13.10 (2012): 932–8. http://www.researchgate.net/publication/230879962_The_price_of_immunity • Kamada, Nobuhiko et al. “Role of the gut microbiota in immunity and inflammatory disease.” Nature Reviews Immunology 13.5 (2013): 321–335. http://www.researchgate.net/publication/236337970_Role_of_gut_microbiota_in_immunity_a nd_inflammatory_disease • Kohn, David. “Joint Pain, From the Gut.” The Atlantic (2015). http://www.theatlantic.com/health/archive/2015/01/joint-pain-from-the-gut/383772/
  20. 20. © 2015 - All rights reserved. The Microbiome Lifeline: Gut As An Organ of Immunity • Mowat, Allan, and William Agace. “Regional specialization within the intestinal immune system.” Nature Reviews Immunology 14.10 (2014): 667–85. http://www.researchgate.net/publication/265862048_Regional_specialization_within_the_ intestinal_immune_system • Sorini, Chiara, and Marika Falcone. “Shaping the (auto)immune response in the gut: the role of intestinal immune regulation in the prevention of type 1 diabetes.” American journal of clinical and experimental immunology 2.2 (2013): 156–71. http://www.researchgate.net/publication/251876845_Shaping_the_(auto)immune_respon se_in_the_gut_the_role_of_intestinal_immune_regulation_in_the_prevention_of_type_1_ diabetes
  21. 21. © 2015 - All rights reserved. The Microbiome Lifeline: Gut As An Organ of Immunity • Strober, Warren. “Impact of the gut microbiome on mucosal inflammation.” Trends in Immunology (2013). http://www.researchgate.net/publication/255984931_Impact_of_the_gut_microbiome_on _mucosal_inflammation • Yurkovetskiy, Leonid, Joseph Pickard, and Alexander Chervonsky. “Microbiota and Autoimmunity: Exploring New Avenues.” Cell Host & Microbe (2015). http://www.researchgate.net/publication/276358904_Microbiota_and_Autoimmunity_Expl oring_New_Avenues
  22. 22. © 2015 - All rights reserved. The Microbiome Lifeline: Gut-Brain Axis • Alcock, Joe, Carlo Maley, and Athena Aktipis. “Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms.” BioEssays (2014). https://ucsf.box.com/shared/static/pdz2z4b5fdvwlpr9hfdh.pdf • Brod, Samuel et al. “‘As above, so below’ examining the interplay between emotion and the immune system.” Immunology 143.3 (2014): 311–8. http://www.researchgate.net/publication/263291162_As_above_so_below_Examining_the _interplay_between_emotion_and_the_Immune_System • Forsythe, Paul et al. “Mood and gut feelings.” Brain, Behavior, and Immunity (2010). http://www.journals.elsevier.com/brain-behavior-and-immunity/
  23. 23. © 2015 - All rights reserved. The Microbiome Lifeline: Gut-Brain Axis • Foster, Jane, and Karen-Anne Neufeld. “Gut–brain axis: how the microbiome influences anxiety and depression.” Trends in Neurosciences (2013). http://www.researchgate.net/publication/235404335_Gut- brain_axis_How_the_microbiome_influences_anxiety_and_depression • Hadhazy, Adam. “Think Twice: How the Gut’s ‘Second Brain’ Influences Mood and Well- Being." Scientific American (2010). http://www.scientificamerican.com/article/gut-second- brain/ • Mayer, Emeran et al. “Gut Microbes and the Brain: Paradigm Shift in Neuroscience.” The Journal of Neuroscience (2014). http://www.researchgate.net/publication/268233441_Gut_Microbes_and_the_Brain_Para digm_Shift_in_Neuroscience
  24. 24. © 2015 - All rights reserved. The Microbiome Lifeline: Gut-Brain Axis • O’Mahony et al. “Serotonin, tryptophan metabolism and the brain-gut-microbiome axis.” Behavioural Brain Research 277 (2015): 3248. http://www.researchgate.net/publication/264389028_Serotonin_Tryptophan_Metabolism_ and_the_Brain-Gut-_Microbiome_Axis • Steenbergen, Laura et al. “A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood.” Brain, Behavior, and Immunity (2015). http://www.researchgate.net/publication/274781872_A_randomized_controlled_trial_to_t est_the_effect_of_multispecies_probiotics_on_cognitive_reactivity_to_sad_mood
  25. 25. © 2015 - All rights reserved. The Microbiome Lifeline: Fixing Your Leaky Gut is Key • Derrien, Muriel, and Johan Vlieg. “Fate, activity, and impact of ingested bacteria within the human gut microbiota.” Trends in Microbiology (2015). http://www.researchgate.net/publication/274405159_Fate_activity_and_impact_of_ingested_ bacteria_within_the_human_gut_microbiota • Fasano, Alessio. “Leaky gut and autoimmune diseases.” Clinical reviews in allergy & immunology 42.1 (2012): 71–8. http://www.researchgate.net/publication/51823457_Leaky_gut_and_autoimmune_diseases • Ghosh, Subrata et al. “New tools and approaches for improved management of inflammatory bowel diseases.” Journal of Crohn’s and Colitis 8.10 (2014): 1246–53. http://www.researchgate.net/publication/261756210_New_tools_and_approaches_for_improv ed_management_of_inflammatory_bowel_diseases
  26. 26. © 2015 - All rights reserved. The Microbiome Lifeline: Fixing Your Leaky Gut is Key • Kostic, Aleksandar, Ramnik Xavier, and Dirk Gevers. “The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead.” Gastroenterology 146.6 (2014): 1489–99. http://www.researchgate.net/publication/260374207_The_Microbiome_in_Inflammatory_Bow el_Diseases_Current_Status_and_the_Future_Ahead • Strober, Warren. “Impact of the gut microbiome on mucosal inflammation.” Trends in Immunology (2013). http://www.researchgate.net/publication/255984931_Impact_of_the_gut_microbiome_on_mu cosal_inflammation • Wlodarska, Marta, Aleksandar Kostic, and Ramnik Xavier. “An Integrative View of Microbiome- Host Interactions in Inflammatory Bowel Diseases.” Cell Host & Microbe (2015). http://www.researchgate.net/publication/276359033_An_Integrative_View_of_Microbiome- Host_Interactions_in_Inflammatory_Bowel_Diseases
  27. 27. © 2015 - All rights reserved. The Microbiome Lifeline: Fixing Your Leaky Gut is Key • Zippi, Maddalena. “Extraintestinal manifestations in a large series of Italian inflammatory bowel disease patients.” World Journal of Gastroenterology 20.46 (2014): 17463-17467. http://docrchive.com/document/extraintestinal-manifestations-in-a-large-series-of-italian- inflammatory-bowel-disease-patients-7348008145211277/
  28. 28. © 2015 - All rights reserved. The Microbiome Lifeline: Health Starts in the Mouth • Atanasova, Kalina, and Özlem Yilmaz. “Prelude to oral microbes and chronic diseases: past, present and future.” Microbes and Infection (2015). http://www.researchgate.net/publication/274258034_Prelude_to_Oral_Microbes_and_Chronic _Diseases_Past_Present_and_Future • Costalonga, Massimo, and Mark Herzberg. “The oral microbiome and the immunobiology of periodontal disease and caries.” Immunology Letters (2014). http://www.researchgate.net/publication/268079979_The_oral_microbiome_and_the_immun obiology_of_periodontal_disease_and_caries • He, Jinzhi et al. “The oral microbiome diversity and its relation to human diseases.” Folia Microbiologica (2014). http://www.researchgate.net/publication/264987867_The_oral_microbiome_diversity_and_its _relation_to_human_diseases
  29. 29. © 2015 - All rights reserved. The Microbiome Lifeline: Health Starts in the Mouth • Marsh, P, and D Bradshaw. “Dental plaque as a biofilm.” Journal of Industrial Microbiology 15.3 (1995): 169–175. http://www.researchgate.net/publication/14678794_Dental_plaque_as_a_biofilm._J_Ind_ Microbiol • Schwarzberg, Karen et al. “The Personal Human Oral Microbiome Obscures the Effects of Treatment on Periodontal Disease.” PLoS ONE 9.1 (2014). http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086708 • Steinberg, Doron. “Dental Chatter: Bacterial Cross‐Talk in the Biofilm of the Oral Cavity.” Israel Journal of Chemistry (2015). http://onlinelibrary.wiley.com/doi/10.1002/ijch.201400143/abstract
  30. 30. © 2015 - All rights reserved. The Microbiome Lifeline: Health Starts in the Mouth • Struzycka, Izabela. “The oral microbiome in dental caries.” Polish journal of microbiology / Polskie Towarzystwo Mikrobiologów = The Polish Society of Microbiologists 63.2 (2014): 127–35. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086708 • Warinner, Christina, Camilla Speller, and Matthew Collins. “A new era in palaeomicrobiology: prospects for ancient dental calculus as a long-term record of the human oral microbiome.” Philosophical Transactions of the Royal Society of London B: Biological Sciences 370.1660 (2015). http://www.pubfacts.com/detail/25487328/A-new- era-in-palaeomicrobiology:-prospects-for-ancient-dental-calculus-as-a-long-term-record-of- the-
  31. 31. © 2015 - All rights reserved. The Microbiome Lifeline: Health Starts in the Mouth • Zarco, Vess, and Ginsburg. “The oral microbiome in health and disease and the potential impact on personalized dental medicine.” Oral Diseases 18.2 (2012): 109–120. http://www.researchgate.net/publication/51628583_The_oral_microbiome_in_health_and _disease_and_the_potential_impact_on_personalized_dental_medicine • Zhang, Xuan et al. “The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment.” Nature Medicine (2015). http://www.researchgate.net/publication/280036160_The_oral_and_gut_microbiomes_ar e_perturbed_in_rheumatoid_arthritis_and_partly_normalized_after_treatment
  32. 32. © 2015 - All rights reserved. Data as an Enabling Tool: Getting Closer to Precision Medicine
  33. 33. © 2015 - All rights reserved. Big Data: Top-Down Bottom-Up Convergence • Dove, Edward, Vural Özdemir, and Yann Joly. “Harnessing Omics Sciences, Population Databases, and Open Innovation Models for Theranostics‐Guided Drug Discovery and Development.” Drug Development Research (2012). http://www.researchgate.net/publication/263060822_Harnessing_Omics_Sciences_Population_Dat abases_and_Open_Innovation_Models_for_TheranosticsGuided_Drug_Discovery_and_Developmen t • Farh, Kyle et al. “Genetic and epigenetic fine mapping of causal autoimmune disease variants.” Nature 518.7539 (2015): 337–43. http://www.researchgate.net/publication/267753091_Genetic_and_epigenetic_fine_mapping_of_c ausal_autoimmune_disease_variants • Greene, Casey et al. “Understanding multicellular function and disease with human tissue-specific networks.” Nature Genetics (2015). http://www.researchgate.net/publication/275525447_Understanding_multicellular_function_and_d isease_with_human_tissue-specific_networks
  34. 34. © 2015 - All rights reserved. Big Data: Top-Down Bottom-Up Convergence • Groza, Tudor et al. “The Human Phenotype Ontology: Semantic Unification of Common and Rare Disease.” The American Journal of Human Genetics (2015). http://www.researchgate.net/publication/279631558_The_Human_Phenotype_Ontology_Sem antic_Unification_of_Common_and_Rare_Disease • Ramos-Casals, Manuel et al. “Google-driven search for big data in autoimmune geoepidemiology: Analysis of 394,827 patients with systemic autoimmune diseases.” Autoimmunity Reviews (2015). http://www.researchgate.net/publication/274513423_Google- driven_search_for_big_data_in_autoimmune_geoepidemiology_Analysis_of_394827_patients_ with_systemic_autoimmune_diseases
  35. 35. © 2015 - All rights reserved. Big Data: Top-Down Bottom-Up Convergence • Stanberry, Larissa et al. “Integrative Analysis of Longitudinal Metabolomics Data from a Personal Multi-Omics Profile.” Metabolites (2013). http://www.researchgate.net/publication/256413714_Integrative_Analysis_of_Longitudinal _Metabolomics_Data_from_a_Personal_Multi-Omics_Profile • Xu et al. “Comprehensive serological profiling of human populations using a synthetic human virome.” Science (2015). http://www.researchgate.net/publication/277778734_Viral_immunology._Comprehensive_ serological_profiling_of_human_populations_using_a_synthetic_human_virome
  36. 36. © 2015 - All rights reserved. Systems Biology and Personal Data • Kim, Ho-Youn, Hae-Rim Kim, and Sang-Heon Lee. “Advances in Systems Biology Approaches for Autoimmune Diseases.” Immune Network 14.2 (2014): 73–80. http://www.pubfacts.com/detail/24851096/Advances-in-systems-biology-approaches-for- autoimmune-diseases • Leung, Elaine et al. “Network-based drug discovery by integrating systems biology and computational technologies.” Briefings in Bioinformatics 14.4 (2013): 491–505. http://www.researchgate.net/publication/230644421_Network- based_drug_discovery_by_integrating_systems_biology_and_computational_technologies • Schork, and Nicholas. “Personalized medicine: Time for one-person trials.” Nature News (2015). http://www.researchgate.net/publication/275668184_Personalized_medicine_Time_for_o ne-person_trials
  37. 37. © 2015 - All rights reserved. Systems Biology and Personal Data • Smarr, Larry. “Quantifying your body: A how‐to guide from a systems biology perspective.” Biotechnology Journal 7.8 (2012): 980–991. http://www.researchgate.net/publication/230658785_Quantifying_your_body_A_how- to_guide_from_a_systems_biology_perspective
  38. 38. © 2015 - All rights reserved. Predictive Modeling • Ahmed, Usman et al. “Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health.” Scientific Reports (2015). http://www.researchgate.net/publication/273781983_Biomarkers_of_early_stage_osteoart hritis_rheumatoid_arthritis_and_musculoskeletal_health • Chopra, Monika, Kulwinder Singh, and Neelam Verma. “AUTOIMMUNE AND INFLAMMATORY DISEASES BIOMARKERS.” International Journal of Biomedical and Advance Research (2012). http://www.researchgate.net/publication/272761554_AUTOIMMUNE_AND_INFLAMMATO RY_DISEASES_BIOMARKERS
  39. 39. © 2015 - All rights reserved. Predictive Modeling • Dagan, Amir, and Shaye Kivity. "Cutting edge data in autoimmunity: as presented in the 9th international congress of autoimmunity." Cutting Edge in Autoimmunity 61.1 (2015): 1-3. Web http://www.researchgate.net/publication/269177309_Cutting_edge_data_in_autoimmunit y_as_presented_in_the_9th_international_congress_of_autoimmunity • Jaberi‐Douraki, Majid et al. “Autoimmune responses in T1DM: quantitative methods to understand onset, progression, and prevention of disease.” Pediatric Diabetes 15.3 (2014): 162–174. http://www.researchgate.net/publication/262339657_Autoimmune_responses_in_T1DM_ quantitative_methods_to_understand_onset_progression_and_prevention_of_disease
  40. 40. © 2015 - All rights reserved. Predictive Modeling • Lee, James, and Kenneth Smith. “Prognosis in autoimmune and infectious disease: new insights from genetics.” Clinical & Translational Immunology 3.5 (2014): 15. http://www.researchgate.net/publication/269715667_Prognosis_in_autoimmune_and_infectio us_disease_new_insights_from_genetics • Norman, Jason et al. “Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease.” Cell (2015). http://www.researchgate.net/publication/271448551_Disease- Specific_Alterations_in_the_Enteric_Virome_in_Inflammatory_Bowel_Disease • Stanberry, Larissa et al. “Integrative Analysis of Longitudinal Metabolomics Data from a Personal Multi-Omics Profile.” Metabolites (2013). http://www.researchgate.net/publication/256413714_Integrative_Analysis_of_Longitudinal_M etabolomics_Data_from_a_Personal_Multi-Omics_Profile •
  41. 41. © 2015 - All rights reserved. Autoimmunity: Sorting through the Multiple Causes
  42. 42. © 2015 - All rights reserved. Causes of Autoimmunity: Genetics & Genomics • Archer, Nassif, and O’Brien. “Genetic variants of SLC11A1 are associated with both autoimmune and infectious diseases: systematic review and meta-analysis.” Genes and Immunity (2015). http://www.researchgate.net/publication/274724921_Genetic_variants_of_SLC11A1_are_ass ociated_with_both_autoimmune_and_infectious_diseases_systematic_review_and_meta- analysis • Dieli-Crimi, Romina, Carmen Cénit, and Concepción Núñez. “The genetics of celiac disease: A comprehensive review of clinical implications.” Journal of Autoimmunity (2015). http://www.mdlinx.com/allergy-immunology/medical-news-article/2015/07/21/celiac- disease-epigenetics-gene-expression-hla/6248457/ • Farh, Kyle et al. “Genetic and epigenetic fine mapping of causal autoimmune disease variants.” Nature 518.7539 (2015): 337–43. http://www.nature.com/nature/journal/v518/n7539/full/nature13835.html
  43. 43. © 2015 - All rights reserved. Causes of Autoimmunity: Genetics & Genomics • Gupta, Bhawna, and David Hawkins. “Epigenomics of autoimmune diseases.” Immunology and Cell Biology 93.3 (2015): 271–276. http://www.nature.com/icb/journal/v93/n3/full/icb201518a.html • Lee, James, and Kenneth Smith. “Prognosis in autoimmune and infectious disease: new insights from genetics.” Clinical & Translational Immunology 3.5 (2014). http://www.nature.com/cti/journal/v3/n5/full/cti20148a.html • Marson, Alexander, William Housley, and David Hafler. “Genetic basis of autoimmunity.” Journal of Clinical Investigation (2015). http://www.ncbi.nlm.nih.gov/pubmed/26030227 • McGarvey, Peter et al. “In silico analysis of autoimmune diseases and genetic relationships to vaccination against infectious diseases.” BMC Immunology 15.1 (2014): 61. http://www.researchgate.net/publication/267753091_Genetic_and_epigenetic_fine_mapping_ of_causal_autoimmune_disease_variants
  44. 44. © 2015 - All rights reserved. Causes of Autoimmunity: Genetics & Genomics • Mikacenic, Carmen et al. “Cutting edge: Genetic variation in TLR1 is associated with Pam3CSK4- induced effector T cell resistance to regulatory T cell suppression.” Journal of immunology (Baltimore, Md. : 1950) 193.12 (2014): 5786–90. http://www.researchgate.net/publication/267931277_Cutting_Edge_Genetic_Variation_in_TLR 1_Is_Associated_with_Pam(3)CSK(4)- Induced_Effector_T_Cell_Resistance_to_Regulatory_T_Cell_Suppression • “NIH researchers reveal link between powerful gene regulatory elements and autoimmune diseases.” National Institutes Into Health (2015). http://www.nih.gov/news/health/feb2015/niams-17.htm • Oftedal, Bergithe et al. “Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases.” Immunity (2015). http://www.researchgate.net/publication/278792204_Dominant_Mutations_in_the_Autoimmu ne_Regulator_AIRE_Are_Associated_with_Common_Organ-Specific_Autoimmune_Diseases
  45. 45. © 2015 - All rights reserved. Causes of Autoimmunity: Genetics & Genomics • Parkes, Miles et al. “Genetic insights into common pathways and complex relationships among immune-mediated diseases.” Nature Reviews Genetics (2013). http://www.researchgate.net/publication/255689274_Genetic_insights_into_common_pat hways_and_complex_relationships_among_immune-mediated_diseases._Nat_Rev_Genet • Richardson, Bruce, and Dipak Patel. “Epigenetics in 2013: DNA methylation and miRNA— key roles in systemic autoimmunity.” Nature Reviews Rheumatology 10.2 (2014): 72–74. http://www.researchgate.net/publication/255689274_Genetic_insights_into_common_pat hways_and_complex_relationships_among_immune-mediated_diseases._Nat_Rev_Genet
  46. 46. © 2015 - All rights reserved. Causes of Autoimmunity: Genetics & Genomics • Ritchie, Marylyn et al. “Methods of integrating data to uncover genotype-phenotype interactions.” Nature Reviews Genetics (2015). http://www.researchgate.net/publication/270910379_Methods_of_integrating_data_to_u ncover_genotype-phenotype_interactions • Wang, Xuefeng, Eric Xing, and Daniel Schaid. “Kernel methods for large-scale genomic data analysis.” Briefings in bioinformatics 16.2 (2015): 183–92. http://www.researchgate.net/publication/264164029_Kernel_methods_for_large- scale_genomic_data_analysis • Yang, Chin-An, and Bor-Luen Chiang. “Inflammasomes and human autoimmunity: A comprehensive review.” Journal of Autoimmunity (2015). http://www.researchgate.net/publication/49688650_Inflammasomes_and_autoimmunity
  47. 47. © 2015 - All rights reserved. Causes of Autoimmunity: Environment • Ballantyne, Sarah. The Paleo Approach. Las Vegas: Victory Belt Publishing Inc, 2013. Print. • Blum, Susan. The Immune System Recovery Plan. New York: Scribner, 2013. Print. • Bogdanos, Dimitrios et al. “Infectome: A platform to trace infectious triggers of autoimmunity.” Autoimmunity Reviews 12.7 (2013): 726740. http://www.researchgate.net/publication/233983999_Infectome_A_platform_to_trace_infec tious_triggers_of_autoimmunity • Campbell, Andrew. “Autoimmunity and the Gut.” Autoimmune Diseases 2014 (2014): 152428. http://www.researchgate.net/publication/262886119_Autoimmunity_and_the_Gut • Horton, Daniel et al. “Antibiotic Exposure and Juvenile Idiopathic Arthritis: A Case–Control Study” Rutgers University (2015). http://www.sciencedaily.com/releases/2015/07/150720092257.htm
  48. 48. © 2015 - All rights reserved. Causes of Autoimmunity: Environment • Javierre, Hernando, and Ballestar. “Environmental triggers and epigenetic deregulation in autoimmune disease.” (2011). http://www.researchgate.net/publication/51976993_Environmental_triggers_and_epigene tic_deregulation_in_autoimmune_disease • Nakazawa Jackson, Donna. The Autoimmune Epidemic. New York: A Touchstone Book, 2008. Print. • Obregon-Tito, Alexandra et al. “Subsistence strategies in traditional societies distinguish gut microbiomes.” Nature Communications 6 (2015). http://www.researchgate.net/publication/274071457_Subsistence_strategies_in_traditiona l_societies_distinguish_gut_microbiomes
  49. 49. © 2015 - All rights reserved. Causes of Autoimmunity: Environment • Terato, Kuniaki, Christopher Do, and Hiroshi Shionoya. “Slipping through the Cracks: Linking Low Immune Function and Intestinal Bacterial Imbalance to the Etiology of Rheumatoid Arthritis.” Autoimmune Diseases 2015 (2015). http://www.hindawi.com/journals/ad/2015/636207/ • Velasquez-Manoff, Moises. An Epidemic of Absence. New York: Scribner, 2012. Print. • Vojdani, Aristo. “A Potential Link between Environmental Triggers and Autoimmunity.” Autoimmune Diseases 2014 (2014). http://www.researchgate.net/publication/273894696_Slipping_through_the_Cracks_Linking_Low _Immune_Function_and_Intestinal_Bacterial_Imbalance_to_the_Etiology_of_Rheumatoid_Arthri tis • Vojdani, Aristo, Michael Pollard, and Andrew Campbell. “Environmental Triggers and Autoimmunity.” Autoimmune Diseases 2014 (2014): 798029. http://www.researchgate.net/publication/271221861_Environmental_Triggers_and_Autoimmunit y
  50. 50. © 2015 - All rights reserved. Causes of Autoimmunity: Hormones • Blum, Susan. The Immune System Recovery Plan. New York: Scribner, 2013. Print. • Perlmutter, David. Grain Brain. New York: Little, Brown and Company, 2013. Print.
  51. 51. © 2015 - All rights reserved. Causes of Autoimmunity: Pathogenesis • Blum, Susan. The Immune System Recovery Plan. New York: Scribner, 2013. Print. • Brady, David M. "Molecular Mimicry, the Hygiene Hypothesis, Stealth Infections and Other Examples of Disconnect between Medical Research and the Practice of Clinical Medicine in Autoimmune Disease" Open Journal of Rheumatology and Autoimmune Disease (2013): 33-39. Web. http://www.researchgate.net/publication/262068728_Molecular_Mimicry_the_Hygiene_Hypothesis _Stealth_Infections_and_Other_Examples_of_Disconnect_between_Medical_Research_and_the_Pr actice_of_Clinical_Medicine_in_Autoimmune_Disease> • Brusca, Abramson, and Scher. “Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity.” (2014). http://www.researchgate.net/publication/258700816_Brusca_S.B._Abramson_S.B.__Scher_J.U._Mic robiome_and_mucosal_inflammation_as_extra- articular_triggers_for_rheumatoid_arthritis_and_autoimmunity._Curr._Opin._Rheumatol._26_101- 107
  52. 52. © 2015 - All rights reserved. Causes of Autoimmunity: Pathogenesis • Craft, Joe, and Saeed Fatenejad. “Self antigens and epitope spreading in systemic autoimmunity.” Arthritis & Rheumatism 40.8 (1997): 1374–1382. http://onlinelibrary.wiley.com/doi/10.1002/art.1780400803/abstract • Cusick, Libbey, and Fujinami. “Molecular mimicry as a mechanism of autoimmune disease” (2012). http://www.ncbi.nlm.nih.gov/pubmed/22095454 • Farh, Kyle et al. “Genetic and epigenetic fine mapping of causal autoimmune disease variants.” Nature 518.7539 (2015): 337–43. http://www.nature.com/nature/journal/v518/n7539/full/nature13835.html#close • McLean, Mairi et al. “Does the microbiota play a role in the pathogenesis of autoimmune diseases?” Gut (2014). http://www.researchgate.net/publication/268790142_Does_the_microbiota_play_a_role_in_th e_pathogenesis_of_autoimmune_diseases
  53. 53. © 2015 - All rights reserved. Causes of Autoimmunity: Pathogenesis • Roederer, Mario et al. “The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis.” Cell 161.2 (2015): 387–403. http://www.cell.com/cell/abstract/S0092-8674(15)00247-0?rss=yes • Rosenblum, Michael D., Kelly A. Remedios, and Abul K. Abbas. "Mechanisms of Human Autoimmunity." The Journal of Clinical Investigation 125.6 (2015): 2228-2233. Web. http://www.researchgate.net/publication/275217316_Mechanisms_of_human_autoimmu nity • Smilek, Dawn, and William Clair. “Solving the puzzle of autoimmunity: critical questions.” F1000Prime Reports 7 (2015). http://www.ncbi.nlm.nih.gov/pubmed/25750735
  54. 54. © 2015 - All rights reserved. Causes of Autoimmunity: Pathogenesis • Theofilopoulos, Argyrios, Wolfgang Dummer, and Dwight Kono. “T cell homeostasis and systemic autoimmunity.” Journal of Clinical Investigation 108.3 (2001): 335-340. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC209358/ • Wen, Haitao, Edward Miao, and Jenny Ting. “Mechanisms of NOD-like Receptor-Associated Inflammasome Activation.” Immunity 39.3 (2013). http://www.sciencedirect.com/science/article/pii/S1074761313003890
  55. 55. © 2015 - All rights reserved. Causes of Autoimmunity: Microbiome Diet • Lerner, Aaron, and Torsten Matthias. “Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease.” Autoimmunity Reviews (2015). http://www.researchgate.net/publication/272186939_Changes_in_intestinal_tight_junctio n_permeability_associated_with_industrial_food_additives_explain_the_rising_incidence_ of_autoimmune_disease • Manzel, Arndt et al. “Role of ‘Western Diet’ in Inflammatory Autoimmune Diseases.” Current Allergy and Asthma Reports 14.1 (2013): 404. http://www.researchgate.net/publication/259335985_Role_of_Western_Diet_in_Inflamma tory_Autoimmune_Diseases • Perlmutter, David. Grain Brain. New York: Little, Brown and Company, 2013. Print.
  56. 56. © 2015 - All rights reserved. Causes of Autoimmunity: Microbiome Diet • Sonnenburg, Erica, and Justin Sonnenburg. “Starving our Microbial Self: The Deleterious Consequences of a Diet Deficient in Microbiota-Accessible Carbohydrates.” Cell Metabolism (2014). http://www.researchgate.net/publication/265055722_Starving_our_Microbial_Self_The_D eleterious_Consequences_of_a_Diet_Deficient_in_Microbiota-Accessible_Carbohydrates • Youm, Yun-Hee et al. “The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease.” Nature Medicine 21.3 (2015): 263–9. http://www.researchgate.net/publication/272354552_The_ketone_metabolite_- hydroxybutyrate_blocks_NLRP3_inflammasomemediated_inflammatory_disease
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  58. 58. © 2015 - All rights reserved. Prevention and Lifestyle Modifications • “Translating the Science of Wellness and Healing.” Samueli Institute. 2011. https://www.samueliinstitute.org/File%20Library/About%20Us/SP11_lowres.pdf
  59. 59. © 2015 - All rights reserved. Prevention and Lifestyle Modifications: Food • Ballantyne, Sarah. The Paleo Approach. Las Vegas: Victory Belt Publishing Inc, 2013. Print. • Blum, Susan. The Immune System Recovery Plan. New York: Scribner, 2013. Print. • Charlebois, Ashley, Greg Rosenfeld, and Brian Bressler. “The Impact of Dietary Interventions on the Symptoms of Inflammatory Bowel Disease: A Systematic Review.” Critical Reviews in Food Science and Nutrition (2015). http://www.researchgate.net/publication/270651195_The_Impact_of_Dietary_Interventions _on_the_Symptoms_of_Inflammatory_Bowel_Disease_A_Systematic_Review • Clarke, and Mullin. “A Review of Complementary and Alternative Approaches to Immunomodulation.” Nutrition in Clinical Practice 23.1 (2008): 49–62. http://www.researchgate.net/publication/5647579_A_review_of_complementary_and_alter native_approaches_to_immunomodulation
  60. 60. © 2015 - All rights reserved. Prevention and Lifestyle Modifications: Food • Halmos, Emma, and Peter Gibson. “Dietary management of IBD—insights and advice.” Nature Reviews Gastroenterology & Hepatology 12.3 (2015): 133–146. http://www.researchgate.net/publication/272083767_Dietary_management_of_IBDinsights_a nd_advice • LeBlanc et al. “Bacteria as vitamin suppliers to their host: a gut microbiota perspective” (2013). http://www.researchgate.net/publication/230782474_Bacteria_as_vitamin_suppliers_to_their _host_A_gut_microbiota_perspective • Mullin, Gerard and Kathie Swift. The Inside Tract. New York: Rodale, 2011. Print. • Nakazawa Jackson, Donna. The Autoimmune Epidemic. New York: A Touchstone Book, 2008. Print. • Perlmutter, David. Grain Brain. New York: Little, Brown and Company, 2013. Print.
  61. 61. © 2015 - All rights reserved. Prevention and Lifestyle Modifications: Food • Sanfilippo, Diane. Practical Paleo: a customized approach to health and a whole-foods lifestyle. Las Vegas: Victory Belt Publishing Inc, 2012. Print. • Subramanian, Sathish et al. “Cultivating Healthy Growth and Nutrition through the Gut Microbiota.” Cell (2015). http://www.researchgate.net/publication/274259147_Cultivating_Healthy_Growth_and_N utrition_through_the_Gut_Microbiota
  62. 62. © 2015 - All rights reserved. Prevention and Lifestyle Modifications: Exercise • Brourman, Sherry, and Randy Rodman. Walk Yourself Well. www.SherryBrourman.com. 2005. Print. • Perlmutter, David. Grain Brain. New York: Little, Brown and Company, 2013. Print.
  63. 63. © 2015 - All rights reserved. Prevention and Lifestyle Modifications: Meditation • Blum, Susan. The Immune System Recovery Plan. New York: Scribner, 2013. Print. • Nakazawa Jackson, Donna. The Autoimmune Epidemic. New York: A Touchstone Book, 2008. Print.
  64. 64. © 2015 - All rights reserved. Prevention and Lifestyle Modifications: Digital Health • Altshuler, David and et al. "Creating a Global Alliance to Enable Responsible Sharing of Genomic and Clinical Data." 2013 June 3. http://genomicsandhealth.org/about-the-global- alliance/key-documents/white-paper-creating-global-alliance-enable-responsible-shar • Cnossen, Rick, Wendy Nilsen, et al. "White Paper: Data Collection and Mobile Technologies." Precision Medicine Meeting (2014): 1-13 Web http://www.nih.gov/precisionmedicine/whitepapers/Data-Collection-Mobile- Technologies.pdf • Elenko, Eric, Lindsay Underwood, and Daphne Zohar. “Defining digital medicine.” Nature Biotechnology (2015). http://www.researchgate.net/publication/276208474_Defining_digital_medicine
  65. 65. © 2015 - All rights reserved. Prevention and Lifestyle Modifications: Digital Health • Housman, Dan. "Marketing Research: Collaboration Proclamation." Medical Marketing & Media (2015): 36- 37. Web. http://www.mmm-online.com/features/marketing-research- collaboration-proclamation/article/400196/ • Maecker, Holden, Tamsin M. Lindstrom, and et al. "New Tools for Classification and Monitoring of Autoimmune Diseases." Nature Reviews Rheumatology. 8.1 (2012): 317-328. Web http://www.researchgate.net/publication/225078353_New_tools_for_classification_and_ monitoring_of_autoimmune_diseases
  66. 66. © 2015 - All rights reserved. Prevention and Lifestyle Modifications: Digital Health • Margolis, Peter, Laura Peterson, and Michael Seid. “Collaborative Chronic Care Networks (C3Ns) to transform chronic illness care.” Pediatrics 131.Supplement 4 (2013): S219–S223. http://www.researchgate.net/publication/269912722_Collaborative_Chronic_Care_Networ ks_(C3Ns)_to_Transform_Chronic_Illness_Care • Milani, Richard, and Carl Lavie. “Health care 2020: reengineering health care delivery to combat chronic disease.” The American journal of medicine 128.4 (2014): 337–43. http://www.researchgate.net/publication/268692852_Health_Care_2020_Reengineering_ Health_Care_Delivery_to_Combat_Chronic_Disease • Topol, Eric. The Patient Will See You Now. New York: Basic Books, 2015. Print.
  67. 67. © 2015 - All rights reserved. Bridging the Autoimmune Abyss through New Discoveries +1.310.666.5312 drbonnie360@gmail.com www.drbonnie360.com @DrBonnie360 www.facebook.com/YourAutoimmunityCon nection Bonnie Feldman, DDS, MBA Business Development for Digital Health

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