Content and Visual Design by Tiffany Simms DrBonnie360 presents The Microbiome: Sorting the Hype from the Hope at Cambridge Healthtech Institute's 23rd International Molecular Med TRI-CON 2016 in San Francisco, March 6, 2016. Bringing two scientists from the Sonnenburg and Knight Lab, and four microbiome companies, DrBonnie360 moderates a short course on all you need to know about the microbiome and whether it will be your best friend or your worst enemy. As DrBonnie360's work surrounds autoimmune diseases, the microbiome proves to be one of the lifelines autoimmunity could use to cross the autoimmune abyss. Presented in this slideshare is a carefully curated set of research on autoimmune and the microbiome.

1. Friend or Foe
Bonnie Feldman, DDS, MBA – Your Autoimmunity Connection
www.drbonnie360.com | @DrBonnie360
The Microbiome in Autoimmunity

2. Exploring The Microbiome Lifeline
• Fasano, Alessio. “Leaky Gut and Autoimmune Diseases.” Clinical Reviews in Allergy & Immunology 42.1 (2012) :
71–8. <http://www.ncbi.nlm.nih.gov/pubmed/22109896>.
• Gomez, Andres, David Luckey, and Veena Taneja. “The Gut Microbiome in Autoimmunity: Sex Matters.”Clinical
Immunology 159.2 (2015) : 154–162. <http://www.sciencedirect.com/science/article/pii/S1521661615001576>.
• Kamdar, K et al. “Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and
Drive Progression to Chronic Inflammatory Disease.” Cell Host & Micobe 19.1 (2016) : 21-31.
<http://www.cell.com/cell-host-microbe/pdfExtended/S1931-3128(15)00498-9>.
• McLean, Mairi et al. “Does the Microbiota Play a Role in the Pathogenesis of Autoimmune Diseases?” Gut 64.2
(2014) : gutjnl–2014–308514. <http://gut.bmj.com/content/early/2014/11/28/gutjnl-2014-308514>.
• Waldor, Matthew et al. “Where next for Microbiome Research?” PLoS Biology 13.1 (2015) : e1002050.
<http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002050>.
• Wu, Hao, Valentina Tremaroli, and Fredrik Bäckhed. “Linking Microbiota to Human Diseases: A Systems Biology
Perspective.” Trends in Endocrinology & Metabolism 26.12 (2015) : 758-770.
<http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(15)00194-0>.
Autoimmunity and the Microbiome

3. The Microbiome and Inflammatory Bowel Disease
• De Souza, Heitor, and Claudio Fiocchi. “Immunopathogenesis of IBD: Current State of the Art.” Nature Reviews
Gastroenterology & Hepatology (2015) : 13-27 <http://www.ncbi.nlm.nih.gov/pubmed/26627550>.
• Sartor, R. Balfour. “The Intestinal Microbiota in Inflammatory Bowel Disease.” Nestle Nutrition Institute
Workshop Series 79 (2014) : 29–39.<https://uncch.pure.elsevier.com/en/publications/the-intestinal-microbiota-
in-inflammatory-bowel-diseases>.
• Sartor, RB, and SK Mazmanian. “Intestinal Microbes in Inflammatory Bowel Diseases.” The American Journal of
Gastroenterology … (2012) : 15-21. <http://www.nature.com/ajgsup/journal/v1/n1/abs/ajgsup20124a.html>.
• Wlodarska, Marta, Aleksandar Kostic, and Ramnik Xavier. “An Integrative View of Microbiome-Host Interactions
in Inflammatory Bowel Diseases.” Cell Host & Microbe 17.5 (2015) : 577-591.
<http://www.cell.com/cell-host-microbe/abstract/S1931-3128(15)00166-3>.

4. • Costalonga, M, and MC Herzberg. “The Oral Microbiome and the Immunobiology of Periodontal Disease and
Caries.” Immunology Letters 162.2 (2014) : 22-38.
<http://www.sciencedirect.com/science/article/pii/S0165247814001874>.
The Microbiome and Periodontal Disease
Rheumatoid Arthritis
Systemic Lupus Erythematosus
• Scher, JU, and SB Abramson. “The Microbiome and Rheumatoid Arthritis.” Nature Reviews Rheumatology 7
(2011) : 569-578. <http://www.nature.com/nrrheum/journal/v7/n10/abs/nrrheum.2011.121.html>.
• Mu, Q, H Zhang, and XM Luo. “SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?” Frontiers
in Immunology (2015) : n. pag. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663251/>.

5. Prevention – Diet, Food, & Nutrition
• Tilg, H, and AR Moschen. “Food, Immunity, and the Microbiome.” Gastroenterology 148.6 (2015) : 1107-1119.
<http://www.sciencedirect.com/science/article/pii/S0016508515000128>.
• Zeevi et al. “Personalized Nutrition by Prediction of Glycemic Responses.” Cell. 163.5 (2015) : 1079-1094.
<http://www.cell.com/abstract/S0092-8674(15)01481-6>.
• Zmora, N et al. “Taking It Personally: Personalized Utilization of the Human Microbiome in Health and
Disease.” Cell Host & Microbe 19.1 (2016) : 12-20.
<http://www.cell.com/cell-host-microbe/pdf/S1931-3128(15)00508-9.pdf>.
Prevention – Prebiotics & Probiotics
• Hemarajata, P, and J Versalovic. “Effects of Probiotics on Gut Microbiota: Mechanisms of Intestinal
Immunomodulation and Neuromodulation.” Therapeutic Advances in Gastroenterology. (2012) : 39-51.
<http://tag.sagepub.com/content/early/2012/09/24/1756283X12459294.abstract>.
• Petschow, B et al. “Probiotics, Prebiotics, and the Host Microbiome: The Science of Translation.” Annals of the
New York Academy of Sciences (2013) : 1-17. <http://onlinelibrary.wiley.com/doi/10.1111/nyas.12303/full>.

6. The Microbiome Lifeline
+1.310.666.5312
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www.drbonnie360.com
@DrBonnie360
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Bonnie Feldman, DDS, MBA
DrBonnie360 is helping companies and
entrepreneurs counteract the autoimmune
epidemic.
Through consulting, market research, writing and
speaking, she works with teams using data and
digital tools to reshape research, diagnosis,
treatment and prevention of autoimmune disease.

7. • Autoimmune Disease: An Invisible Epidemic
http://bit.ly/1m0ttsl
• The Serious Health Concern All 20-somethings
Should Know About
http://bit.ly/R9cEgp
• Decoding Autoimmunity – a Summary of the State
of the Art
http://bit.ly/1knzaAQ
• The Lonely Voices of Autoimmune Disease via
Youtube
http://bit.ly/X41mMv
• Believe It or Not – The Real Voices of
Autoimmunity
http://bit.ly/20xRCXO
Your Autoimmunity Exploration