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How Data Drives Personalized Prevention
Genes Are Not Our Destiny
© 2015 - All rights reserved.
@DrBonnie360 Presents:
Judy
diseases US population Top leading
cause of death
in women
less than 64 yrs
The Lonely Voices of Autoimmune Disease
© 2015 - All rights reserved.
© 2015 - All rights reserved.
Genomics
Omics Enables Systems Biology
Epigenomics ProteomicsTranscriptomics Metabolomics
Judy is lost and alone
Judy realizes she’s preautoimmune
© 2014 - All rights reserved.
Judy needs
Personalized Prevention for
Pre-autoimmune
Judy seeks
tailored lifestyle modification
INDIVIDUAL
Yoga
Meditation
Psychologists
Biofeedback
Coaches
GROUP
Family
Friends
Church
MUSCULOSKELETAL
INTEGRITY TEAM
Ph...
Integrated Autoimmune Medicine
© 2014 - All rights reserved.
The Genes You Can’t Take Off: What is the Relationship
between Autoimmunity and Genetics?
• ...
© 2014 - All rights reserved.
Change your Fate: What can Epigenetics do for
Autoimmunity?
• Farh, K. et al. Genetic and ep...
© 2014 - All rights reserved.
Are We What We Eat Or Is What We Eat Who We Are?:
Nutrigenomics and Autoimmunity
• Ferguson,...
Our Genes Are Not Our
Destiny
+1.310.666.5312
drbonnie360@gmail.com
www.drbonnie360.com
@DrBonnie360
www.facebook.com/Your...
Our Genes Are Not Our Destiny: How Data Drives Personalized Prevention
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Our Genes Are Not Our Destiny: How Data Drives Personalized Prevention

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DrBonnie360 brings the Lonely Voices of Autoimmune Disease to #GenomicsFest in SF, highlighting the significance of genetics, epigenetics, nutrigenomics, and big data for autoimmunity.

Published in: Science
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Our Genes Are Not Our Destiny: How Data Drives Personalized Prevention

  1. 1. How Data Drives Personalized Prevention Genes Are Not Our Destiny © 2015 - All rights reserved. @DrBonnie360 Presents:
  2. 2. Judy
  3. 3. diseases US population Top leading cause of death in women less than 64 yrs
  4. 4. The Lonely Voices of Autoimmune Disease
  5. 5. © 2015 - All rights reserved.
  6. 6. © 2015 - All rights reserved.
  7. 7. Genomics Omics Enables Systems Biology Epigenomics ProteomicsTranscriptomics Metabolomics
  8. 8. Judy is lost and alone
  9. 9. Judy realizes she’s preautoimmune
  10. 10. © 2014 - All rights reserved.
  11. 11. Judy needs Personalized Prevention for Pre-autoimmune
  12. 12. Judy seeks tailored lifestyle modification
  13. 13. INDIVIDUAL Yoga Meditation Psychologists Biofeedback Coaches GROUP Family Friends Church MUSCULOSKELETAL INTEGRITY TEAM Physical Therapy Acupuncture Massage Chiropractic Biofeedback FOOD AS MEDICINE TEAM Nutritionists Coaches WELL-BEING TEAM
  14. 14. Integrated Autoimmune Medicine
  15. 15. © 2014 - All rights reserved. The Genes You Can’t Take Off: What is the Relationship between Autoimmunity and Genetics? • Ritchie, M., Holzinger, E., Li, R., Pendergrass, S. & Kim, D. Methods of integrating data to uncover genotype-phenotype interactions. Nature Reviews Genetics (2015). http://www.nature.com/nrg/journal/v16/n2/abs/nrg3868.html • Seldin, MF. The genetics of human autoimmune disease: A perspective on progress in the field and future directions. Journal of autoimmunity (2015). http://www.sciencedirect.com/science/article/pii/S0896841115300330 • Smilek, D. & Clair, W. Solving the puzzle of autoimmunity: critical questions. F1000Prime Reports 7, (2015). http://www.ncbi.nlm.nih.gov/pubmed/25750735
  16. 16. © 2014 - All rights reserved. Change your Fate: What can Epigenetics do for Autoimmunity? • Farh, K. et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 518, 337–43 (2015). http://www.nature.com/nature/journal/v518/n7539/full/nature13835.html • Gupta, B. & Hawkins, D. Epigenomics of autoimmune diseases. Immunol Cell Biol 93, 271–276 (2015). http://www.nature.com/icb/journal/v93/n3/full/icb201518a.html • Jeffries, MA & Sawalha, AH. Autoimmune disease in the epigenetic era: how has epigenetics changed our understanding of disease and how can we expect the field to evolve? Expert review of clinical … (2014). http://www.pubfacts.com/detail/25534978/Autoimmune-disease-in-the-epigenetic-era:- how-has-epigenetics-changed-our-understanding-of-disease-a
  17. 17. © 2014 - All rights reserved. Are We What We Eat Or Is What We Eat Who We Are?: Nutrigenomics and Autoimmunity • Ferguson, LR. Nutrigenetics, nutrigenomics and inflammatory bowel diseases. Expert review of clinical immunology (2013). http://www.ncbi.nlm.nih.gov/pubmed/23971750 • Gibson, PR, Varney, J, Malakar, S & Muir, JG. Food Components and Irritable Bowel Syndrome. Gastroenterology (2015). at http://www.sciencedirect.com/science/article/pii/S0016508515001961 • Minich, D. M. & Bland, J. S. Personalized lifestyle medicine: relevance for nutrition and lifestyle recommendations. The Scientific World Journal 2013, (2013). http://www.ncbi.nlm.nih.gov/pubmed/23878520 • Xie, G, Li, X, Li, H & Jia, W. Toward personalized nutrition: comprehensive phytoprofiling and metabotyping. Journal of proteome research (2013). http://pubs.acs.org/doi/abs/10.1021/pr301222b
  18. 18. Our Genes Are Not Our Destiny +1.310.666.5312 drbonnie360@gmail.com www.drbonnie360.com @DrBonnie360 www.facebook.com/YourAutoimmu nityConnection Bonnie Feldman, DDS, MBA Business Development for Digital Health

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