Note: ACTIVE LINKS begin on PAGE 4. DrBonnie360 joins the Cambridge HealthTech Institute to present at the 2nd Annual Targeting the Microbiome Conference on September 20, 2016. Working to bridge the autoimmune abyss, DrBonnie360 gives to you a carefully curated list of the latest research on the microbiome and autoimmune disease. Included is research on the influence of the microbiome in autoimmunity, Inflammatory Bowel Disease, Celiac Disease, Multiple Sclerosis, Rheumatoid Arthritis, Systemic Lupus Erythematosus, and how we can personalize nutrition.

1. Your Personal Microbial Garden
Balancing your Immune System
Your Autoimmunity ConnectionSecond Annual Targeting the Microbiome September 20-21, 2016 Bonnie Feldman DDS, MBA @DrBonnie360

2. Your Personal Microbial Garden
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Bonnie Feldman, DDS, MBA
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3. “I may be small and unknown
today, but I have big ambitions
for tomorrow”
– Author Unknown

4. • Barin, Jobert, Lawrence Tobias, and Daniel Peterson. “The Microbiome and Autoimmune Disease:
Report from a Noel R. Rose Colloquium.” Clinical Immunology 159, no. 2 (2015): 183–188.
doi:10.1016/j.clim.2015.05.009 <http://www.ncbi.nlm.nih.gov/pubmed/26003843>
• Bitar, Khalil, and Elie Zakhem. “Bioengineering the Gut: Future Prospects of Regenerative Medicine.”
Nature Reviews Gastroenterology & Hepatology (2016). doi:10.1038/nrgastro.2016.124
<http://www.ncbi.nlm.nih.gov/pubmed/27507104>
• Cusick, Matthew, Jane Libbey, and Robert Fujinami. “Molecular Mimicry as a Mechanism of
Autoimmune Disease.” Clinical Reviews in Allergy & Immunology 42, no. 1 (2012): 102–111.
doi:10.1007/s12016-011-8294-7.
<http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266166/>
• Fasano, Alessio. “Leaky Gut and Autoimmune Diseases.” Clinical Reviews in Allergy &
Immunology 42.1 (2012) : 71–8.
<http://www.ncbi.nlm.nih.gov/pubmed/22109896>
Autoimmunity and the Microbiome

5. • Gomez, Andres, David Luckey, and Veena Taneja. “The Gut Microbiome in Autoimmunity: Sex
Matters.”Clinical Immunology 159.2 (2015) : 154–162.
<http://www.sciencedirect.com/science/article/pii/S1521661615001576>.
• Kamdar, K et al. “Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the
Microbiota and Drive Progression to Chronic Inflammatory Disease.” Cell Host & Micobe 19.1 (2016) :
21-31.
<http://www.cell.com/cell-host-microbe/pdfExtended/S1931-3128(15)00498-9>.
• McLean, Mairi et al. “Does the Microbiota Play a Role in the Pathogenesis of Autoimmune
Diseases?” Gut 64.2 (2014) : gutjnl–2014–308514.
<http://gut.bmj.com/content/early/2014/11/28/gutjnl-2014-308514>.
• Opdenakker, Ghislain, Paul Proost, and Jo Damme. “Microbiomic and Posttranslational Modifications
as Preludes to Autoimmune Diseases.”Trends in Molecular Medicine (2016).
doi:10.1016/j.molmed.2016.07.002. <http://www.cell.com/trends/molecular-medicine/abstract/S1471-
4914(16)30077-
6?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1471491416300776
%3Fshowall%3Dtrue>
Autoimmunity and the Microbiome

6. • Tamburini, Sabrina, Nan Shen, Han Wu, and Jose Clemente. “The Microbiome in Early Life:
Implications for Health Outcomes.” Nature Medicine 22, no. 7 (2016): 713–722. doi:10.1038/nm.4142.
<http://www.ncbi.nlm.nih.gov/pubmed/27387886>
• Waldor, Matthew et al. “Where next for Microbiome Research?” PLoS Biology 13.1 (2015) : e1002050.
<http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002050>.
• Wu, Hao, Valentina Tremaroli, and Fredrik Bäckhed. “Linking Microbiota to Human Diseases: A
Systems Biology Perspective.” Trends in Endocrinology & Metabolism 26.12 (2015) : 758-770.
<http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(15)00194-0>.
• Rao, Meenakshi, and Michael Gershon. “The Bowel and beyond: The Enteric Nervous System in
Neurological Disorders.” Nature Reviews Gastroenterology & Hepatology (2016).
doi:10.1038/nrgastro.2016.107.
<http://www.nature.com/nrgastro/journal/vaop/ncurrent/full/nrgastro.2016.107.html>
Autoimmunity and the Microbiome
The Gut is Where it’s At – Brain-Gut Axis

7. A Life Balance – Inflammatory Bowel Disease
• DeFilippis, Ersilia, Robbyn Sockolow, and Elaine Barfield. “Health Care Maintenance for the Pediatric
Patient With Inflammatory Bowel Disease.” Pediatrics (2016). doi:10.1542/peds.2015-1971.
<http://pediatrics.aappublications.org/content/early/2016/08/01/peds.2015-1971>
• De Souza, Heitor, and Claudio Fiocchi. “Immunopathogenesis of IBD: Current State of the Art.” Nature
Reviews Gastroenterology & Hepatology (2015) : 13-27
<http://www.ncbi.nlm.nih.gov/pubmed/26627550>.
• Sartor, R. Balfour. “The Intestinal Microbiota in Inflammatory Bowel Disease.” Nestle Nutrition Institute
Workshop Series 79 (2014) : 29–39.<https://uncch.pure.elsevier.com/en/publications/the-intestinal-
microbiota-in-inflammatory-bowel-diseases>.
• Sartor, RB, and SK Mazmanian. “Intestinal Microbes in Inflammatory Bowel Diseases.” The American
Journal of Gastroenterology … (2012) : 15-21.
<http://www.nature.com/ajgsup/journal/v1/n1/abs/ajgsup20124a.html>.

8. A Life Balance – Celiac Disease
• Cenit, María, Marta Olivares, Pilar Codoñer-Franch, and Yolanda Sanz. “Intestinal Microbiota and
Celiac Disease: Cause, Consequence or Co-Evolution?” Nutrients 7, no. 8 (2015): 6900–6923.
doi:10.3390/nu7085314.
<http://www.mdpi.com/2072-6643/7/8/5314/htm>
• Leonard, Maureen M, Stephanie Camhi, Tania B Huedo-Medina, and Alessio Fasano. “Celiac Disease
Genomic, Environmental, Microbiome, and Metabolomic (CDGEMM) Study Design: Approach to the
Future of Personalized Prevention of Celiac Disease.” Nutrients 7, no. 11 (November 2015): 9325–36.
doi:10.3390/nu7115470.
<http://www.mdpi.com/2072-6643/7/11/5470/htm>
• Wlodarska, Marta, Aleksandar Kostic, and Ramnik Xavier. “An Integrative View of Microbiome-Host
Interactions in Inflammatory Bowel Diseases.” Cell Host & Microbe 17.5 (2015) : 577-591.
<http://www.cell.com/cell-host-microbe/abstract/S1931-3128(15)00166-3>.

9. • Glenn, Justin, and Ellen Mowry. “Emerging Concepts on the Gut Microbiome and Multiple
Sclerosis.”Journal of Interferon & Cytokine Research : The Official Journal of the International
Society for Interferon and Cytokine Research 36, no. 6 (2016): 347–357. doi:10.1089/jir.2015.0177.
http://www.ncbi.nlm.nih.gov/pubmed/27145057
• Jangi, Sushrut, Roopali Gandhi, Laura Cox, Ning Li, Felipe von Glehn, Raymond Yan, Bonny Patel,
et al. “Alterations of the Human Gut Microbiome in Multiple Sclerosis.” Nature Communications 7
(2016): 12015. doi:10.1038/ncomms12015.
http://www.nature.com/ncomms/2016/160628/ncomms12015/full/ncomms12015.html
Beyond the Gut – Multiple Sclerosis
• Costalonga, M, and MC Herzberg. “The Oral Microbiome and the Immunobiology of Periodontal
Disease and Caries.” Immunology Letters 162.2 (2014) : 22-38.
<http://www.sciencedirect.com/science/article/pii/S0165247814001874>.

10. Rheumatoid Arthritis
Systemic Lupus Erythematosus
• Terato, Kuniaki, Christopher T Do, and Hiroshi Shionoya. “Slipping through the Cracks: Linking Low
Immune Function and Intestinal Bacterial Imbalance to the Etiology of Rheumatoid
Arthritis.”Autoimmune Diseases 2015 (January 04, 2015): 636207. doi:10.1155/2015/636207.
http://www.hindawi.com/journals/ad/2015/636207/
• Scher, JU, and SB Abramson. “The Microbiome and Rheumatoid Arthritis.” Nature Reviews
Rheumatology 7 (2011) : 569-578.
<http://www.nature.com/nrrheum/journal/v7/n10/abs/nrrheum.2011.121.html>.
• Mu, Q, H Zhang, and XM Luo. “SLE: Another Autoimmune Disorder Influenced by Microbes and
Diet?” Frontiers in Immunology (2015) : n. pag.
<http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663251/>.
Beyond the Gut

11. Tailor-Made – Personalizing Nutrition
• Biesalski, Hans. “Nutrition Meets the Microbiome: Micronutrients and the Microbiota.” Annals of the
New York Academy of Sciences 1372, no. 1 (2016): 53–64. doi:10.1111/nyas.13145.
http://www.ncbi.nlm.nih.gov/pubmed/27362360
• Moelling, Karin. “Nutrition and the Microbiome.” Annals of the New York Academy of Sciences 1372,
no. 1 (2016): 3–8. doi:10.1111/nyas.13039.
http://onlinelibrary.wiley.com/doi/10.1111/nyas.13039/abstract
• Tilg, H, and AR Moschen. “Food, Immunity, and the Microbiome.” Gastroenterology 148.6 (2015) :
1107-1119. <http://www.sciencedirect.com/science/article/pii/S0016508515000128>.
• Wasielewski, Helen, Joe Alcock, and Athena Aktipis. “Resource Conflict and Cooperation between
Human Host and Gut Microbiota: Implications for Nutrition and Health.” Annals of the New York
Academy of Sciences 1372, no. 1 (May 2016): 20–8. doi:10.1111/nyas.13118
http://onlinelibrary.wiley.com/doi/10.1111/nyas.13118/full

12. • Zeevi et al. “Personalized Nutrition by Prediction of Glycemic Responses.” Cell. 163.5 (2015) : 1079-
1094. <http://www.cell.com/abstract/S0092-8674(15)01481-6>.
• Zmora, N et al. “Taking It Personally: Personalized Utilization of the Human Microbiome in Health and
Disease.” Cell Host & Microbe 19.1 (2016) : 12-20.
<http://www.cell.com/cell-host-microbe/pdf/S1931-3128(15)00508-9.pdf>.
Prebiotics & Probiotics
• Hemarajata, P, and J Versalovic. “Effects of Probiotics on Gut Microbiota: Mechanisms of Intestinal
Immunomodulation and Neuromodulation.” Therapeutic Advances in Gastroenterology. (2012) : 39-
51.
<http://tag.sagepub.com/content/early/2012/09/24/1756283X12459294.abstract>.
• Petschow, B et al. “Probiotics, Prebiotics, and the Host Microbiome: The Science of
Translation.” Annals of the New York Academy of Sciences (2013) : 1-17.
<http://onlinelibrary.wiley.com/doi/10.1111/nyas.12303/full>.
Tailor-Made – Personalizing Nutrition

13. • Autoimmune Disease: An Invisible Epidemic http://bit.ly/1m0ttsl
• The Serious Health Concern All 20-somethings Should Know About http://bit.ly/R9cEgp
• Decoding Autoimmunity – a Summary of the State of the Art http://bit.ly/1knzaAQ
• The Lonely Voices of Autoimmune Disease via Youtube http://bit.ly/X41mMv
• Believe It or Not – The Real Voices of Autoimmunity http://bit.ly/20xRCXO
Your Autoimmunity Exploration