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IN
DENTISTRY
DENTAL PHARMACOLOGY
DRUGS SPECIFICALLY USED
12/26/2018 PATKI 1
PART2
12/26/2018 PATKI 2
ASTRINGENTS IN DENTISTRY
โ€ข Precipitate proteins on the surface. Used as
hemostats and mummifying agents.
โ€ข Tannic acid,30% used in mouthwashes
โ€ข Zinc chloride- Gingivitis, pyorrhoea.
โ€ข Zinc sulphate
โ€ข Copper sulphate
โ€ข Alum
12/26/2018 PATKI 3
Bleeching agnets
โ€ข Remove the pigments
โ€ข Oxidizing agent-
Perhydrol, sodium
peroxide, Chlorinated
lime.
โ€ข Reducing agents-
Sodium thiosulphate,
Silver, iodine
โ€ข Ultravoilet rays.
12/26/2018 PATKI 4
MUMMIFYING AGENTS
โ€ข Used to harden and dry tissues during
rootcanal. Pulp can be hardened.
โ€ข Tannic acid used with glycerine
โ€ข Paraform-zinc oxide and creosate, liberates
formaldehyde.
โ€ข Idoform-iodine release
โ€ข Toothache drops- Benzocaine, clove oil
12/26/2018 PATKI 5
Styptics
Stop bleeding
12/26/2018 PATKI 6
Styptics
โ€ข Local hemostatics used to arrest bleeding.
Cotton gauze
โ€ข Gelatin sponge
โ€ข Fibrin foam
โ€ข Human or bovine thrombin
โ€ข Adrenalin
โ€ข Astrigents, Tranexamic acid. Ethamsylate
12/26/2018 PATKI 7
MOUTH WASHES
โ€ข Aqueous solution used for swishing the oral
cavity.
โ€ข 15-30 ml per rinse
โ€ข Therapeutic mouth wash-reduce dental
plaque, dental caries, gingivitis,stomatitis.
โ€ข Cosmetic mouthwashes- halitosis, dental
whiteness.
12/26/2018 PATKI 8
Mouth washes
โ€ข Alcohol,
โ€ข Humactants- Glycerine
and sorbitol
โ€ข Surfactants-
Polyetheline
derivatives.
โ€ข Sodium lauryl sulphate
โ€ข Cetyl
โ€ข Flavouring agents-
peppermintoil, menthol
โ€ข Coloring agents-
methylene blue,
magenta
โ€ข Medicated-pilocarpine,
antimicrobials, etc
12/26/2018 PATKI 9
FLUORIDES
IN DENTISTRY
12/26/2018 PATKI 10
Fluorides
โ€ข In 1940 relationship between fluoride deficiency
and caries teeth was established.
โ€ข Dental fluorosis is related to concentration of
fluoride in water. Optimal- 1.0 ppm.
โ€ข Fluoride added to drinking water reduced caries.
Widespread use of fluoride in toothpaste .
โ€ข Excess of fluorides leads to ADRs.
โ€ข Topical 2% fluoride in dentifrices reduces caries
by 30%
12/26/2018 PATKI 11
Prevention of caries
โ€ข Fluoride
โ€ข Avoid colds, carbohydrate drinks
โ€ข Regular teethcare,
โ€ข Use of mouthwashes. Antiplaque agents
โ€ข Deflossing.
12/26/2018 PATKI 12
fluorides
โ€ข Stannous fluoride
โ€ข Sodium fluoride
โ€ข Sodium
monoflurophosphate
โ€ข Amine fluoride
โ€ข Fluoride toxicity-mottling
of teeth, discolor,
osteosclerosis, joint pain.
โ€ข Fluoride prophylactically
โ€ข Prevent decalcification of
tooth by inhibiting
bacterial enzymes
producing lactic acid.
โ€ข Prevent enamel weakness
โ€ข Remineralise enamel.
โ€ข Therapeutically- 2% is
applied locally on teeth.
12/26/2018 PATKI 13
Dental
desensitizers
12/26/2018 PATKI 14
Dental sensitivity
โ€ข Common, mechanical, chemical or thermal
stimuli lead to sensitivity problems.
โ€ข Loss of enamel and nerve exposure
โ€ข Drugs used-Potassium nitrate, Potassium
oxalate, Formaldehyde
โ€ข Potassium nitrate in mouthwash or dentifrices
can minimize sensitivity in 4-5 weeks.
12/26/2018 PATKI 15
Dental sensitivity
โ€ข Dental tubule closure- Potassium nitrate 5%
โ€ข Calcium hydroxide
โ€ข Tubule sealants-Glass ionomers
โ€ข Capping
12/26/2018 PATKI 16

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Dental pharmacology

  • 3. ASTRINGENTS IN DENTISTRY โ€ข Precipitate proteins on the surface. Used as hemostats and mummifying agents. โ€ข Tannic acid,30% used in mouthwashes โ€ข Zinc chloride- Gingivitis, pyorrhoea. โ€ข Zinc sulphate โ€ข Copper sulphate โ€ข Alum 12/26/2018 PATKI 3
  • 4. Bleeching agnets โ€ข Remove the pigments โ€ข Oxidizing agent- Perhydrol, sodium peroxide, Chlorinated lime. โ€ข Reducing agents- Sodium thiosulphate, Silver, iodine โ€ข Ultravoilet rays. 12/26/2018 PATKI 4
  • 5. MUMMIFYING AGENTS โ€ข Used to harden and dry tissues during rootcanal. Pulp can be hardened. โ€ข Tannic acid used with glycerine โ€ข Paraform-zinc oxide and creosate, liberates formaldehyde. โ€ข Idoform-iodine release โ€ข Toothache drops- Benzocaine, clove oil 12/26/2018 PATKI 5
  • 7. Styptics โ€ข Local hemostatics used to arrest bleeding. Cotton gauze โ€ข Gelatin sponge โ€ข Fibrin foam โ€ข Human or bovine thrombin โ€ข Adrenalin โ€ข Astrigents, Tranexamic acid. Ethamsylate 12/26/2018 PATKI 7
  • 8. MOUTH WASHES โ€ข Aqueous solution used for swishing the oral cavity. โ€ข 15-30 ml per rinse โ€ข Therapeutic mouth wash-reduce dental plaque, dental caries, gingivitis,stomatitis. โ€ข Cosmetic mouthwashes- halitosis, dental whiteness. 12/26/2018 PATKI 8
  • 9. Mouth washes โ€ข Alcohol, โ€ข Humactants- Glycerine and sorbitol โ€ข Surfactants- Polyetheline derivatives. โ€ข Sodium lauryl sulphate โ€ข Cetyl โ€ข Flavouring agents- peppermintoil, menthol โ€ข Coloring agents- methylene blue, magenta โ€ข Medicated-pilocarpine, antimicrobials, etc 12/26/2018 PATKI 9
  • 11. Fluorides โ€ข In 1940 relationship between fluoride deficiency and caries teeth was established. โ€ข Dental fluorosis is related to concentration of fluoride in water. Optimal- 1.0 ppm. โ€ข Fluoride added to drinking water reduced caries. Widespread use of fluoride in toothpaste . โ€ข Excess of fluorides leads to ADRs. โ€ข Topical 2% fluoride in dentifrices reduces caries by 30% 12/26/2018 PATKI 11
  • 12. Prevention of caries โ€ข Fluoride โ€ข Avoid colds, carbohydrate drinks โ€ข Regular teethcare, โ€ข Use of mouthwashes. Antiplaque agents โ€ข Deflossing. 12/26/2018 PATKI 12
  • 13. fluorides โ€ข Stannous fluoride โ€ข Sodium fluoride โ€ข Sodium monoflurophosphate โ€ข Amine fluoride โ€ข Fluoride toxicity-mottling of teeth, discolor, osteosclerosis, joint pain. โ€ข Fluoride prophylactically โ€ข Prevent decalcification of tooth by inhibiting bacterial enzymes producing lactic acid. โ€ข Prevent enamel weakness โ€ข Remineralise enamel. โ€ข Therapeutically- 2% is applied locally on teeth. 12/26/2018 PATKI 13
  • 15. Dental sensitivity โ€ข Common, mechanical, chemical or thermal stimuli lead to sensitivity problems. โ€ข Loss of enamel and nerve exposure โ€ข Drugs used-Potassium nitrate, Potassium oxalate, Formaldehyde โ€ข Potassium nitrate in mouthwash or dentifrices can minimize sensitivity in 4-5 weeks. 12/26/2018 PATKI 15
  • 16. Dental sensitivity โ€ข Dental tubule closure- Potassium nitrate 5% โ€ข Calcium hydroxide โ€ข Tubule sealants-Glass ionomers โ€ข Capping 12/26/2018 PATKI 16