3. AND NOW…
EQUIPMENT
PATIENT PREPARATION
RELEVANT ANATOMY
CATHETERS and PLACEMENT
BASIC INTERVALS
TESTS OF SN FUNCTION
ATRIAL and VENTRICULAR EXTRASTIMULUS
TESTING
REFRACTORY PERIODS
‘GAP’
INCREMENTAL PACING
MINIMUM PROTOCOL FOR DIAGNOSTIC EPS
5. 5
Drive train with a single extra stimulus
S1 S1 S1 S1 S1 S1 S1 S1 S2Sensed
PAUSEDRIVETRAIN
S1-S2
Interval
Sense-S1
Interval
8 paced beat drive train – EP steady state
Extrastimulus
(Coupling interval)
6. Extra stimuli
S 1 S 1 S 1 S 1 S 1 S 1 S 1 S 1 S 2Sensed
DRIVETRAIN
S 3 S 4
S1 S1 S1 S1 S1 S1 S1 S1 S2Sensed
DRIVETRAIN
S 1 S 1 S 1 S 1 S 1 S 1 S 1 S 1 S2Sensed
DRIVETRAIN
S3
Single
Double
Triple
8. Atrial Extrastimulus testing
• Dynamic properties of AVN and HPS
conduction
• AVN and RA refractory periods
• Dual AVN physiology
9. Atrial Extrastimulus testing
• Dynamic properties of AVN and HPS
conduction
• AVN and RA refractory periods
• Dual AVN physiology
• Arrhythmia induction
10. S2 with long coupling interval
Conduction at
fairly constant
velocity
A2H2 equal or
slightly more than
A1H1
11. A1H1 80 ms ~ A2H2 95 ms
S1A1 ~ S2A2 ~ 55 ms
H1V1 ~ H2V2 ~ 50 ms
12. S2 with short coupling interval
Slowing of
Conduction
A1H1 < A2H2
19. H buried in V
V1A1 almost equal to V2A2
Earliest atrial
activation in HBE
Atleast 30 ms
before HRA
Proximal-to-distal
CS activation
CONCENTRIC
ATRIAL
ACTIVATION
22. S2 with short coupling interval with
short drive cycle length
Blocked VES at AVN
VA block
Differs with
– ES coupling interval
– Drive cycle length
23. S2 with short coupling interval
Tissue latency in
local evoked
response
Occurs just above
the tissue refractory
period
24. Even shorter coupling interval
Blocked VES locally at
RV apex
Loss of ventricular
capture
25. Ventricular Extrastimulus testing
• Other ‘Normal’ responses
– No VA conduction at all
• Atropine, Isoprenaline
• No VA conduction despite drugs
26. Ventricular Extrastimulus testing
• Other ‘Normal’ responses
– No VA conduction at all
• Atropine, Isoprenaline
• No VA conduction despite drugs
– Retrograde exit site from AV node maybe near CS
ostium rather than HBE – earliest atrial activation
at Proximal CS
27. Ventricular Extrastimulus testing
• Other ‘Normal’ responses
– No VA conduction at all
• Atropine, Isoprenaline
• No VA conduction despite drugs
– Retrograde exit site from AV node maybe near CS
ostium rather than HBE – earliest atrial activation
at Proximal CS
• Maneuvers to prove accessory pathway
31. EFFECTIVE Refractory Period
• ERP of a tissue (or a structure) is the LONGEST
coupling interval that fails to capture the
tissue
32. EFFECTIVE Refractory Period
• ERP of a tissue (or a structure) is the LONGEST
coupling interval that fails to capture the
tissue (or be conducted over the structure)
33. FUNCTIONAL Refractory Period
• FRP of a tissue (or a structure) is the
SHORTEST ‘output’ coupling interval that can
be elicited from a tissue (or structure) by any
‘input’ interval
34. FUNCTIONAL Refractory Period
• FRP of a tissue (or a structure) is the
SHORTEST ‘output’ coupling interval that can
be elicited from a tissue (or structure) by any
‘input’ interval
S1-A1-H1-V1 S2-A2-H2-V2
AVN
HPS
AV conduction system
35. RELATIVE Refractory Period
• RRP of a tissue (or a structure) is the ‘input’
interval at which the ‘output’ interval just
begins to differ from ‘input’ interval
36. RELATIVE Refractory Period
• RRP of a tissue (or a structure) is the ‘input’
interval at which the ‘output’ interval just
begins to differ from ‘input’ interval
• This is the point at which Latency or
Decremental conduction begins to occur
• Least commonly measured
37. • In all tissues, ERP and FRP are ‘length-
dependent’
• So, measured using atleast 2 different drive
cycle lengths
42. Normal range of refractory periods (ms)
ERP Atria ERP AVN FRP AVN ERP HPS ERP V
150-350 230-430 330-530 330-450 190-290
*Denes, Akhtar, Durrer, Josephsen series