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Detoxification vs. Maintenance Treatment in Pregnancy – Jessica Young, MD, OB, GYN
1. Opioid Dependence in
Pregnancy: Detoxification
vs. Maintenance
Treatment
Jessica Young, MD MPH
Assistant Professor
Department of Obstetrics and Gynecology
Vanderbilt University Medical Center
3. Objectives
• We will discuss and explore the:
• prevalence of opioid use in pregnancy
• risks of chronic opioid use in pregnancy
• Treatment options
• Detoxification
• Methadone Maintenance
• Buprenorphine Maintenance
• Pregnancy management for these women
• Pain management during labor and delivery
4. A brief history of Opioids
“Presently she cast a drug into
the wine of which they drank to
lull all pain and anger and to
bring forgetfulness of every
sorrow.”
-The Odyssey, Homer, 9th
Century BC
• Sumerians cultivated
poppies ~ 300 BC
• Arab traders brought opium
to India and China ~700 AD
• Manuscripts document
addiction in Europe and
Middle East ~ 1500 AD
• Morphine isolated in 1806
• Heroin produced in 1898
and thought to have no
addictive properties.
6. Controlled Substances in TN
• The top three most prescribed controlled substances in
Tennessee in 2010 are:
• 275.5 million pills of hydrocodone (e.g., Lortab, Lorcet,
Vicodin)
• 116.6 million pills prescribed for alprazolam (e.g., Xanax:
used to treat anxiety)
• 113.5 million pills prescribed for oxycodone (e.g.,
OxyContin, Roxicodone)
• Source: Report to the 2011 107th General Assembly by the
Tennessee Department of Health Controlled Substance
Database Advisory Committee, Board of Pharmacy,
8. The Problem
• Hydrocodone/acetaminophe
n: most commonly
prescribed medication in
any category
• Misuse of prescription
analgesics increased 53%
from 1991-2002. (Blanco, et
al.)
• The misuse of opioids in
young women of
reproductive age continues
to rise.
10. Tip of the Iceberg
• Opioid abuse in Tennessee is escalating.
• 2001: 9,816 admissions for substance abuse treatment
• 762: Opiates
• 2011: 13,409 admissions for substance abuse
treatment
• 4,018: treatment of heroin or opiates
Office of Applied Studies, Substance Abuse and Mental Health Services Administration (SAMHSA). The Treatment
Episode Data Set (TEDS). http://oas.samhsa.gov/dasis.htm#teds2. Accessed April 16, 2012
11. The Problem
• Substance abuse in pregnancy is common (4-16%)
• Prevalence of opioid use in pregnancy ranges from 1-
21%. (Brown, et al.)
• The incidence Neonatal Abstinence Syndrome is
increasing (1.2 to 3.39 per 1000, 2000-2009)
• Over 54,000 pregnancies in the US affected by opioid
abuse. (likely an underestimate) (NIDA)
• Opioid use in first trimester of pregnancy increased
from 8-20% over 2005-2009.
12.
13. Opioid Dependence in
pregnancy
• High risk for unplanned pregnancy
• Lack of prenatal care
• Often chaotic lifestyle with subsequent maternal
and fetal risks
• Higher incidence of abuse, incarceration,
prostitution, exposure to STDs, IV drug use, etc.
• Increased medical costs and utilization of
resources
16. Co-use of opioids and other
drugs
• Tobacco abuse is 4 times
higher compared to other
pregnant women. (Jones,Heil)
• Tobacco exacerbates other
complications of opioid use in
pregnancy.
• Alcohol abuse is seen in 14%
of women with opioid
dependence.
• Unclear what the long-term
cognitive neurobehavioral
outcomes are with concomitant
use.
17. Long-term risks to children of
opioid dependent mothers
• Sudden Infant Death Syndrome
• Higher risk for neurocognitive disorders such as
learning disabilities, ADHD and other behavioral
problems. (Hayford, Epps)
• Long-term risk of addiction
• Unknown whether this is due to opioid exposure
itself
18. Congenital anomalies and
Opioid use
• New data suggesting
association between first
trimester exposure to opioids
and congenital anomalies.
(2011 National Birth Defects
Prevention Study)
• Association with gastroschisis,
spina bifida, and heart defects
• Did not measure degree of
tobacco or ETOH use
• Important to answer this
question due to rapidly
increasing exposure during first
trimester.
19. Identification of women at
risk for substance use
Options
• Universal Screening
• Validated screening tool
• Routine UDS as part of
prenatal labs
(controversial and not
recommended without
consent)
Validated tools for
Pregnancy
• T-ACE (Tolerance, Annoyance,
Cut down, Eye-opener)
• AUDIT-C (Alcohol Use Disorders
Identification Test)
)
• TWEAK (Tolerance, Worry about
drinking, Eye-opener, Amnesia,
K/Cut down)
• TQDH (Ten Question Drinking
History)
20. Universal Screening
• 4P’s Plus Modified Screening Tool
• Parents: Did any of your parents have
a problem with alcohol or other drug
use?
• Partner: Does your partner have a
problem with alcohol or drug use?
• Past: In the past, have you had
difficulties in your life because of
alcohol or other drugs, including
prescription medications?
• Present: In the past month have you
drunk any alcohol or used other
drugs?
• Opioid abuse, dependence, and addiction in pregnancy.
Committee Opinion No. 524. American College of Obstetricians
and Gynecologists. Obstet Gynecol 2012;119:1070–6.
• First ob visit and L&D
• Eliminates provider
bias and assumptions
• Allows for early
intervention and
education
21.
22.
23. Treatment of opioid
dependent women
• Comprehensive treatment
program
• Ob, Psychiatry, Social Work,
Case Managers,
Anesthesiology
• Importance and challenge of
therapeutic alliance
• Improved outcomes for women
who receive integrated prenatal
care and substance abuse
treatment.(Goler, et al.)
• Importance of education of
ancillary staff.
24. Treatment of opioid
dependence
• Opioid maintenance is standard of care. (ACOG)
• Detoxification is often not successful with 29%
resuming use of street drugs. (outpatient setting)
• 12% opted for methadone maintenance after
detoxification.
• 25% of detox patients had withdrawal which
precipitated active labor. (Kaltenbach)
25. Opioid Detoxification
• Inpatient
• Taper with methadone or buprenorphine
(Methadone or Buprenorphine assisted
withdrawal)
• Outcomes are better for women in a residential
treatment program. (Haabrecke, 2014)
26. The obstetrical and neonatal
impact of maternal opioid
detoxification in pregnancy
• Retrospective study, AJOG 2013
• 95 women
• 53 women successfully detoxed
• 5% vs. 33% treated for withdrawal (p 0.001)
• Average LOS for success-> 25 days
• Exclusion criteria: prior unsuccessful detox, IUGR,
oligohydramnios, significant maternal psychiatric
illness
Stewart, et al;. AJOG 2013
27. Benefits of Detoxification
• Greatly reduces risk of NAS
• Theoretically reduces long-term effects of opioid
exposure
• Considered by many to be “ true recovery”
• Decreases risk of child protective services and
legal action
28. Disadvantagesof
Detoxification
• Lack of evidence based protocols
• Risk of relapse
• Shortage of drug treatment programs
• Risk of withdrawal symptoms including preterm
labor, fetal demise
• Requires large degree of financial and institutional
commitment
29. Barriers to Residential
Programs
• Lack of programs
• Cost
• Lack of insurance coverage
• Few programs allow children
• Few programs allow families
30. Methadone Maintenance
• Gold standard with decades of experience
• Increases adherence to prenatal care
• Improves pregnancy outcomes
• Decreases severity of NAS
• Decreased foster home placement
(Winklebaur et al; Kaltenback, et al.)
31. Methadone Maintenance
• For women on methadone prior to pregnancy,
continue current dosing. May need increase dose
in 3rd trimester due to increased plasma volume.
• Initiation of methadone: Start at 10-20mg and
titrate to eliminate withdrawal symptoms without
producing intoxication.
• Preferably done as inpatient
32. Methadone
disadvantages
• Daily visit to treatment center
• Cost
• Stigma
• Continued exposure to others who are using
• Incidence of NAS is still 50-66%
33. Buprenorphine maintenance
• Partial mu opioid agonist and full kappa opioid agonist
• Neonatal outcomes similar to methadone (MOTHER
trial)
• Less severe NAS with shorter hospitalization and less
morphine requirement.
• Office-based treatment
• More insurance coverage
• Feels less like being “on something.”
34. Buprenorphine Maintenance
• If on Suboxone, change to buprenorphine (Subutex).
• Little data on appropriate way to initiate buprenorphine
during pregnancy.
• Must be in moderate withdrawal which is risky in
pregnancy. Great care must be taken not to precipitate
severe withdrawal.
• Must be at least 6 hours since last dose of short-acting
opioid.
• Start with (2-4mg) and titrate for relief of withdrawal
symptoms.
35. Buprenorphine
Disadvantages
• No rigorous studies on initiation during pregnancy
• Often not effective for women using high doses of
IV opiates.
• Higher drop out rate than methadone in MOTHER
trial (33% vs. 18%) (P>0.05)
• Higher relapse rate
• Physician must obtain waiver to write rx.
36. Chronic pain in pregnancy
• Limited data
• Some studies suggest that NAS is less severe in this
population.
• 11% NAS compared to 59% in methadone
maintenance group. (Sharpe, et al.)
• Case series of women maintained on opioids for pain:
NAS 38% (Hadi, da Silva, et al)
• Treatment plans must be individualized and if tapering
is done must be done with caution.
37. Intrapartum Pain Management:
Vaginal Delivery
Methadone
• Continue current dose
• Regional anesthesia
• Avoid stadol/nubaine
• PP: Schedule NSAIDS
Buprenorphine
• d/c buprenorphine +/-
methadone OR continue
buprenorphine OR divide
dose by 25% and give q6h
• Regional anesthesia
• Avoid stadol/nubaine
• PP: Schedule NSAIDS
38. Intrapartum Pain Management:
Cesarean Delivery
Methadone
• Continue current dose
• Regional anesthesia
• Local anesthetics
• PP: NSAIDS and short-acting
opioids with
monitoring for respiratory
depression.
Buprenorphine
• Continue buprenorphine
OR d/c buprenorphine +/-
methadone OR divide
buprenorphine dose q6h.
• Regional anesthesia
• Local anesthetics
• PP: NSAIDS and short-acting
opioids
39. Intrapartum Pain Management
for Detoxed Patient
• Vaginal delivery: No change in standard of care
• Avoid Narcotics post-partum
• Cesarean Delivery: May still require increased
doses of narcotics post-op due to low pain
tolerance and high opioid tolerance.
• Important to discuss with patient her plans and
goals for post-op pain.
40. Postpartum
Considerations
• Plan for continued addiction treatment or pain
management.
• Discourage detoxification in the immediate PP
period unless in a residential program.
• High risk for PP depression.
• May get financially detoxed from methadone
treatment facility.
• Social work assistance for placement may be
needed.
41. Breastfeeding
• Breastfeeding is safe for women who are
maintained on methadone or buprenorphine and
should be supported unless contraindicated.
• Breastfeeding decreases severity of NAS.
• Promotes mother-infant bonding
• Increases maternal self-esteem.
(Abdel-Latif, et al.)
42. Vanderbilt Obstetric Drug
Dependency Clinic
• Integrated prenatal and
addiction care
• Psychiatry
• Ob
• Social Services
• Nursing
• Weekly case conference
• Weekly visits until
stabilization
• Biweekly visits
• Addiction group
• Counseling
• Serial growth scans
43. References
• Abdel-Latif ME, Pinner J, Clews S, et al. Effects of breast milk on the severity and outcome of neonatal abstinence syndrome among infants of drug-dependent
moth- ers. Pediatrics 2006;117(6):e1163–9.
• Baron D; Garbely J, Boyd RL, Evaluation and Management of Substance Abuyse Emergencies Primary Psychiatry. Vulume 16, 2009
• Blanco, C., et al., Changes in the prevalence of non-medical prescription drug use and drug use disorders in the United States: 1991–1992 and 2001–
2002. Drug and Alcohol Dependence, 2007. 90(2-3): p. 252-260.
• Brown HL, B.K., Mahaffey D, Brizendine E, Hiert AK, Turnquest MA, Methadone maintenance in Pregnancy: a reappraisal. American Journal of
Obstetrics and Gynecology, 1998. 179: p. 459-63.
• Goler N, Armstrong MA, Taillac CJ, et al. Substance abuse treatment linked with prenatal visits improves perinatal outcomes: a new standard. J
Perinatol 2008;28(9): 597– 603.
• Jones HE, Heil SH, O’Grady KE, et al. Smoking in pregnant women screened for an opioid agonist medication study compared to related pregnant and
non-pregnant patient samples. Am J Drug Alcohol Abuse 2009;35(5):375– 80.
• Haabrekke KJ1, Slinning K, Walhovd KB, Wentzel-Larsen T, Moe V. The perinatal outcome of children born to women with substance
dependence detoxified in residential treatment during pregnancy. J Addict Dis. 2014;33(2):114-23. doi: 10.1080/10550887.2014.909698
• Hayford S, Epps R, Dahl-Regis M. Behavior and development patterns in children born to heroin-addicted and methadone-addicted mothers. J Natl
Med Assoc 1988; 80(11):1197–200.
• Heil SH, Jones HE, Arria A, et al. Unintended pregnancy in opioid-abusing women. J Subst Abuse Treat 2011;40(2):199–202.
• KaltenbachK,BerghellaV,FinneganL.Opioiddependenceduringpregnancy.Effects and management. Obset Gynecol Clin North Am, 1998;25(1):139 –51.
44. References
• Kaltenbach K, Silverman N, Wapner R. Methadone maintenance during pregnancy. In: State methadone treatment guidelines, Center for Substance
Abuse Treatment 1992. Rockville (MD): US Department of Health and Human Services; 1992. p. 85–93.
• National Pregnancy and Health Survey: Drug use among women delivering live births: 1992, 1996, National Institute on Drug Abuse.
• Office of Applied Studies, Substance Abuse and Mental Health Services Administration (SAMHSA). The Treatment Episode Data Set
(TEDS). http://oas.samhsa.gov/dasis.htm#teds2. Accessed April 16, 2012
• Opioid abuse, dependence, and addiction in pregnancy. Committee Opinion No. 524. American College of Obstetricians and Gynecologists. Obstet
Gynecol 2012;119:1070–6.
• Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM. Neonatal abstinence syndrome and associated health care
expenditures: United States, 2000-2009 [published online April 30, 2012]. JAMA. 2012;307(18):joc1200141934-1940
• Sharpe C, Kuschel. Outcomes of infants born to mothers receiving methadone for pain management in pregnancy Arch
Dis Child Fetal Neonatal Ed 2004;89:1 F33-F36 doi:10.1136/fn.89.1.F33
• Stewart RD1, Nelson DB, Adhikari EH, McIntire DD, Roberts SW, Dashe JS, Sheffield JS. The obstetrical and neonatal impact of maternal opioid detoxification in pregnancy. Am
J Obstet Gynecol. 2013 Sep;209(3):267.e1-5. doi: 10.1016/j.ajog.2013.05.026. Epub 2013 May 29.
• Winklbaur B, Kopf N, Ebner N, et al. Treating pregnant women dependent on opioids is not the same as treating pregnancy and opioid dependence: a
knowledge synthesis for better treatment for women and neonates. Addiction 2008;103:1429–40.
• Young JL, Martin PR, Treatment of Opioid Dependence in the Setting of Pregnancy. Psychiatr Clin N Am 35 (2012) 441– 460
Initially used only in religious ceremonies and along with Hemlock to put people painlessly to death. Eventually used medicinally.
Named after Morpheus “ God of dreams”
The 1900’s saw development of other opioids –each with the promise of being less addictive.
Charles Dickens, Florence Nightingale, Janis Joplin, Billie Holiday, Cory Monteith, Kurt Cobain
51 pills of hydrocodone for EVERY Tennessean above the age of 12
22 pills of alprazolam for EVERY Tennessean above the age of 12
21 pills of oxycodone for EVERY Tennessean above the age of 12
9
51 pills of hydrocodone for EVERY Tennessean above the age of 12
22 pills of alprazolam for EVERY Tennessean above the age of 12
21 pills of oxycodone for EVERY Tennessean above the age of 12
9
2005, 100 million hydrocodone/acetaminophen rx
27% of 3,403 women listed prescription opioids as their primary substance of abuse.
Tenncare database
Withdrawal symtpoms: GI hypermotility, nausea, vomiting, runny nose, piloerection, dilated pupils, shaky, jittery, abdominal cramping, body aches, hot and cold flashes
Complicating factors: Chaotic home environment, prematurity, other drug exposure
Prenatal scheduled doesn’t change: Serial growth scans
Likely needs more frequent visits due to psychiatric issues
Detox successful in only 59%
Patient must be counseled appropriately.
Infants were normally grown but had significant morbidity from prematurity.
Canada: small study: long and short-acting, normal growth parameters
Pain contract, UDS q visit, and check CSMD