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Factores de la coagulacion

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Este es un tema super fascinante, me motive a subirlo porque me asignaron este tema para exponerlo y me sorprendio mucho que no encontre material aqui. Asi que los estoy compartiendo con ustedes, espero les sea util.

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Factores de la coagulacion

  1. 1. FACTORES DE LA COAGULACIÓN Cirugía Cardiovascular y Torácica Por Esther Concepción R.
  2. 2. FACTORES ACTIVADORES DE LA COAGULACIÓN <ul><li>Concepto </li></ul><ul><ul><li>Estimulan el proceso de coagulación </li></ul></ul><ul><li>Nomenclatura </li></ul><ul><ul><li>Se nombran con números romanos. </li></ul></ul><ul><ul><li>Cuando está activado al número romano se le añade una “a”. </li></ul></ul><ul><ul><li>Además algunos tienen nombre propio. </li></ul></ul>
  3. 3. FACTORES ACTIVADORES E INHIBIDORES Factor I. Fibrinógeno Factor II. Protrombina Factor III. Tisular, tormboplastina Factor IV. Calcio Factor V. Labil, proacelerina Factor VII. Proconvertina, estable Factor VIII. Antihemofilico A, globulina Factor IX. Christmas, antihemofilico B Factor X. Stuart-Prower Factor XI. Antihemofilico c Factor XII. Hageman Factor XIII. F. estabilizador de la fibrina Quininógeno de alto peso molecular (Fitzgerald Precalicreina. (Fletcher) Proteínas C y S Antitrobina III Macroglobulina, antitripsina y antiplasmina Factor VI Factores activadores de la coagulación Factores inhibidores de la coagulación
  4. 4. CLASIFICACIÓN DE LOS FACTORES Según su naturaleza Según su procedencia Según las influencias a las que son sensibles Según su función
  5. 5. SEGÚN SU NATURALEZA Proteínicos Lípídicos Metálicos Según su naturaleza
  6. 6. SEGÚN SU PROCEDENCIA Según su procedencia Tisulares Plaquetarios Plasmáticos Hepáticos
  7. 7. SEGÚN LAS INFLUENCIAS A QUE SON SENSIBLES Según las influencias a las que son sensibles Vitamina K dependientes Sensibles a la trombina
  8. 8. SEGÚN SU FUNCIÓN Zimógenos o Proenzimas Cofactores Estructurales Desencadenante Según su función
  9. 9. DESCRIPCIÓN DE LOS FACTORES <ul><li>Factor I (Fibrinógeno) </li></ul><ul><li>Proteína estructural </li></ul><ul><li>Concentración plasmática </li></ul><ul><li>PM </li></ul><ul><li>Componentes </li></ul><ul><li>Vida media </li></ul><ul><li>Función </li></ul>
  10. 10. DESCRIPCIÓN DE LOS FACTORES FACTOR NAT. Plasma (mg/dl) COMP. PM (kDa) VM hrs FUNCION II Protrombina Propeptido 10-14 ----------------- 72 72-96 Trombina por el FXa. III F. tisular Proteina de Transmemb. --------- 263 AAs , 219 EC, 23 TM, 21 IC 45 ------- Receptor y cofactor F.VII Activa al F.X IV Calcio Metal 4-5 ---------------- 40 Da ------- Union F 2,7,9, 10 a los Fosf. V. Labil, Proacelerina Glicoprot. 1 Una sola cadena 300 12 Favorece FXa sobre Trombina VII.F. estable (proconvertin) Glicoprot. 0.05 Una cadena 80 12 Junto FIII y Ca q activa FX. VE
  11. 11. DESCRIPCIÓN DE LOS FACTORES FACTOR NAT. PLASMA (Mg/dl ) COMP. PM VM FUNCION VIII AHA Von Willebran Proteina ------- Una cadena >1000 8-10 Facilita al FXa-F X IX Christmas AHB Glicop 0.3 ------------------ 57 18-30 Activa al FX X Stuart Prower Glicop 1 2 cadenas, puents disulfuro 59 24-48 Hidrolis de protrombina XI AHB tromboplastina Proteina 0.5 2 subunidades identicas 160 60 Junto Ca, activa FI
  12. 12. DESCRIPCIÓN DE LOS FACTORES FACTOR NAT. PLASMA (Mg/dl ) COMP. PM VM FUNCION XII F. Hageman Glicoprot -------- 1 cadena polipeptid, 80 50-70 Activa al F XI XIII F. Lakin Lorand Proteína tetramerica 1-2 2 cadenas a 2 cadena b 320 240 Estabilizar la fibrina XIV F. Flitzgerald HMWk Proteína plasmática -------- -------------- 120 35 Junto a la calicreina activan al FXII XV F de Fletcher Igual --------- -------------- 100 35
  13. 13. <ul><li>Plaquetas (F. XVI) </li></ul><ul><li>F. Somocurcio (F. XVII) </li></ul>OTROS FACTORES
  14. 14. Objetivo final Colageno Complejo calicreina-cinina Fosfolipidos Plaquetas
  15. 15. FACTORES INHIBIDORES DE LA COAGULACIÓN <ul><li>Concepto </li></ul><ul><ul><li>La coagulación es activación e inhibición. </li></ul></ul><ul><ul><li>Inhibidores serino proteasas </li></ul></ul><ul><ul><li>Inhibidores de los factores activados </li></ul></ul><ul><li>Descripción </li></ul><ul><ul><li>Proteína C. </li></ul></ul><ul><ul><li>Proteína S. </li></ul></ul>
  16. 16. <ul><ul><li>Antitrombina III (AT III) </li></ul></ul><ul><ul><li>Alfa 1 antitripsina. </li></ul></ul><ul><ul><li>Alfa 2 macroglobulina. </li></ul></ul><ul><ul><li>Alfa 2 antiplasmina. </li></ul></ul><ul><ul><li>C 1 inhibidor </li></ul></ul>FACTORES INHIBIDORES DE LA COAGULACIÓN
  17. 17. BIBLIOGRAFIA http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2003.04333.x/abstract

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