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أساسيات الأدوية في طب الأسنان

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مختصر الأدوية المستعملة في طب الأسنان

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أساسيات الأدوية في طب الأسنان

  1. 1. .‫د‬‫كشحط‬‫ًغخد‬ ‫ح٧دٝ٣ش‬ .‫د‬‫فراس‬ ‫كساب‬ ‫أعخع٤خص‬‫ح٧دٝ٣ش‬ ٢‫ك‬‫هذ‬ٕ‫ح٧ع٘خ‬
  2. 2. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab1 ‫األسنان‬ ‫طب‬ ً‫ف‬ ‫األدوٌة‬ ‫أساسٌات‬ ‫كساب‬ ‫فراس‬ .‫د‬
  3. 3. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab2 : ‫ٓوذٓش‬ ‫هذ‬ ٍ‫ٓـخ‬ ٢‫ك‬ ‫رخ٧خـ‬ ٝ ٢‫حُطز‬ ٍ‫حُٔـخ‬ ٢‫ك‬ ‫رٜخ‬ ‫ح٩كخهش‬ ‫حُقؼذ‬ ِّٞ‫حُؼ‬ ٖٓ ٞٛ ‫ح٧دٝ٣ش‬ ِْ‫ػ‬ ٣ ١‫حُز‬ ٝ ٕ‫ح٧ع٘خ‬ٜ‫حُٞفل‬ ‫ٓٞمٞع‬ ‫ٗغز٤خ‬ ٚ٤‫ك‬ ‫ٔؼ‬ٝ‫أ‬ ٚ‫ر‬ ‫ح٩كخهش‬ ‫ُقؼٞرش‬ ‫آخ‬ ‫حُذٝحث٤ش‬ ‫خص‬ ٢٘‫حُغ‬ ٍ‫حُٔـخ‬ ٢‫ك‬ ‫حُٔٔخسط‬ ‫حُطز٤ذ‬ ٟ‫ُذ‬ ‫ح٧دٝ٣ش‬ ‫ٝفق‬ ٍ‫ٓـخ‬ ‫ُن٤ن‬ّ‫ػذ‬ ‫رغزذ‬ ٠‫كظ‬ ٝ‫أ‬ ‫ٓوش‬ ٢‫ٓذسع‬ ‫ٓؼشكش‬‫أهزخء‬ ٌٕٞٗٞ٣ ‫ٓخ‬ ‫ؿخُزخ‬ ٖ٣‫حُز‬ ٝ ٕ‫ح٧ع٘خ‬ ‫هذ‬ ٍ‫رٔـخ‬ ‫حُق٤ذ٫ٗ٤خص‬ ‫سحص‬ ‫ف٤خدُش‬ ٝ‫أ‬ ٖ٤٣‫رؾش‬ ُ‫ح‬ ‫حُٞفلش‬ ‫رؤعخع٤خص‬ ‫ح٩كخهش‬ َٔ‫حُؼ‬ ‫ٛزح‬ ٍ٬‫خ‬ ٖٓ ‫كخُٝض‬‫حُذٝحث٤ش‬ ‫حُٔؼِٞٓش‬ ‫اخظقخس‬ ٝ ‫ذٝحث٤ش‬ ‫ح٧دٝ٣ش‬ ٖ‫ػ‬ ٚ‫ٓؼشكظ‬ ‫حُٞحؿذ‬ ٠ٗ‫ح٧د‬ ‫حُلذ‬ ٠ُ‫ا‬ ‫رُي‬ ٢‫ك‬ ‫ٝكوض‬ ‫هذ‬ ًٕٞ‫أ‬ ٕ‫أ‬ ٠٘ٔ‫أط‬ ٝ ‫د‬‫ًغخد‬ ‫.كشحط‬ ‫فلش‬1437 ‫ٗٞكٔزش‬2016
  4. 4. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab3 ٟٞ‫حُٔلظ‬ ‫حُقخدحص‬ٕ‫ح٧ع٘خ‬ ‫هذ‬ ٢‫ك‬ ‫حُٔغظخذٓش‬................................................................7 ‫خقخثـ‬‫حُقخد‬١ٞ٤‫حُل‬٢ُ‫حُٔؼخ‬٪ُّ‫عظخذح‬٢٘‫حُغ‬.................................................8 ‫ٓنخدحص‬ْ٤‫حُـشحػ‬‫رحص‬٩‫ح‬ّ‫عظخذح‬‫حُؾخثغ‬٢‫ك‬‫هذ‬.......................................ٕ‫ح٧ع٘خ‬8 ‫حُز٘٤غ٤ِ٤٘خص‬penicillins...................................................................................8 ُ‫ح‬‫غ٤لخُٞعزٞس٣٘خص‬cephalosporins....................................................................9 ‫حُٔخًشُٝ٤ذحص‬macrolides..................................................................................10 ٖ٤‫حٌُِ٤٘ذحٓخ٣غ‬clindamycin.............................................................................10 ‫حُظظشحع٤ٌِ٤٘خص‬tetracyclines............................................................................10 ‫ٓنخدحص‬ْ٤‫حُـشحػ‬‫رحص‬٩‫ح‬‫عظخذحٓخص‬‫حُغ٘٤ش‬..................................‫حُخخفش‬.............11 ٍٝ‫حُٔ٤ظشٝٗ٤ذحص‬metronidazole...........................................................................11 ‫حُز٘٤غ٤ِ٤٘خص‬‫حُٔوخٝٓش‬..................................................................‫ُِز٘٤غ٤ِ٤٘خص‬11 ُ‫ح‬‫ٌ٤ُ٘ٞٞٗخص‬quinolones.................................................................................11 ٩‫ح‬‫ٗظخٗخص‬‫حُلٔٞ٣ش‬‫حُغ٘٤ش‬‫حُؾخثؼش‬ٝ‫حُقخدحص‬‫حُل٤ٞ٣ش‬‫حُٔغظخذٓش‬٢‫ك‬.....‫ٓؼخُلظٜخ‬.....12 ‫ٓنخدحص‬‫ح٩ٗظخٗخص‬‫حُلطش٣ش‬.......................................................................‫حُلٔٞ٣ش‬13 ٖ٤‫حُ٘٤غظخط‬nystatin......................................................................................12 ٍٝ‫حٌُِٞطش٣ٔخص‬clotrimazole.............................................................................13 ٍٝ‫حُٔ٤ٌٞٗخص‬miconazole.................................................................................13 ‫ٓنخدحص‬‫ح٫ُظٜخد‬‫ؿ٤ش‬‫حُغظ٤شٝث٤ذ٣ش‬....................................................................14 ‫حخظ٤خس‬‫ٓنخد‬‫ح٫ُظٜخد‬‫ؿ٤ش‬١‫حُغظ٤شٝث٤ذ‬................................................................14 ‫ٓؾظوخص‬‫كٔل‬‫حُزشٝر٤ٞٗ٤ي‬.............................................................................14 ‫ح٧دٝ٣ش‬‫رحص‬‫حُخٞحؿ‬‫حُٔؾخرٜش‬‫ُٔؾظوخص‬‫كٔل‬‫حُزشٝر٤ٞٗ٤ي‬.....................................15
  5. 5. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab4 ‫طلز٣شحص‬‫ٝطٞف٤خص‬...........................................................................................15 ‫طٞف٤خص‬‫خخفش‬‫رٔؼزطخص‬cox-2‫ح٫ٗظوخث٤ش‬..............................................................16 ٖ٣‫ح٧عزش‬‫ٝحُغخُ٤غ٤٬ص‬aspirin & salicylates..................................................16 ‫ٓغٌ٘خص‬ُْ٧‫ح‬‫ٝخخكنخص‬‫حُلشحسس‬......................................................................18 ‫حُٔغٌ٘خص‬‫ؿ٤ش‬‫ح٧ك٤ٞٗ٤ش‬..................................................................................18 ٖ٣‫ح٧عزش‬aspirin...........................................................................................18 ٍٞٓ‫حُزخسحع٤ظخ‬paracetamol.............................................................................18 ّ‫حُ٘٤لٞرخ‬nefopam.........................................................................................18 ‫ٓنخدحص‬٩‫ح‬‫ُظٜخد‬‫ؿ٤ش‬‫حُغظ٤شٝث٤ذ٣ش‬.....................................................................18 ‫حُٔغٌ٘خص‬‫ح٧ك٤ٞٗ٤ش‬........................................................................................18 ٤‫حٌُٞدث‬ٖcodeine..........................................................................................19 ٖ٤‫حُذ٣ٌغظشٝرشٝرًٞغ٤ل‬dextropropoxyphen.....................................................19 ٍٝ‫حُظشحٓخد‬tramadol........................................................................................19 ‫ٓغظلنشحص‬‫حُٔغٌ٘خص‬‫حُلخٝ٣ش‬٠ِ‫ػ‬‫ٓؾخسًش‬....................................................19 ّ٫‫آ‬٩‫ح‬‫ػظ٬٫ص‬‫حُؼقز٤ش‬....................................................................................20 ‫حُٜٔذثخص‬ٝ‫حُٔ٘ٞٓخص‬......................................................................................21 ‫حُظؤػ٤شحص‬‫حُظ٘خهن٤ش‬paradoxical effects‫ُِٔ٘ٞٓخص‬‫ٝٓض٣٬ص‬‫حُوِن‬............................21 ٩‫ح‬‫ػظٔخد‬dependenceٝ‫حُغلذ‬withdrawal.....................................................21 ‫حُٔ٘ٞٓخص‬hypnotics.......................................................................................22 ‫حُز٘ضٝد٣خص٣ز٤٘خص‬benzodiazepines.....................................................................22 ٍ‫حٌُِٞسح‬ٝٚ‫ٓؾظوخط‬chloral and derivatives......................................................23 ‫ٓنخدحص‬ٖ٤ٓ‫حُٜ٤غظخ‬antihistamines.................................................................23 ‫ٓض٣٬ص‬‫حُوِن‬anxiolytics................................................................................23 ‫حُز٘ضٝد٣خص٣ز٤٘خص‬benzodiazepines....................................................................23
  6. 6. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab5 ‫كخفشحص‬‫ر٤ظخ‬beta blockers.............................................................................24 ‫أدٝ٣ش‬‫حُظوشكخص‬‫حُلٔٞ٣ش‬‫ٝحُظٜخد‬‫حُِؼش‬..................................................................25 ‫حُظوشكخص‬‫حُلٔٞ٣ش‬...........................................................................................25 ‫حُـغٞ٫ص‬‫حُزغ٤طش‬........................................................................................25 ‫حُـغٞ٫ص‬‫حُٔطٜشس‬..........................................................................................25 ‫حُغظ٤شٝث٤ذحص‬‫حُوؾش٣ش‬‫حُٔٞمؼ٤ش‬......................................................................25 ‫حُٔغٌ٘خص‬‫حُٔٞمؼ٤ش‬......................................................................................26 ‫ا‬‫ُظٜخد‬‫حُِؼش‬..................................................................................................26 ُ‫ح‬ٖ٣‫ٌِٞسٛ٤ٌض٣ذ‬chlorhexidine..........................................................................26 ‫حُـغٞ٫ص‬‫حُٔطٜشس‬ٟ‫ح٧خش‬...............................................................................27 ‫ٓنخدحص‬‫حُ٘خٞس‬..............................................................................................28 ‫حُلِٞس٣ذحص‬....................................................................................................28 ‫حُشٓٞص‬‫حُٔغظخذٓش‬٢‫ك‬‫حُٞفلخص‬‫حُذٝحث٤ش‬............................................................29 ‫حُقخدحص‬٢‫ك‬‫هذ‬ٕ‫ح٧ع٘خ‬...............................................................................30 ‫ٓنخدحص‬‫ح٩ُظٜخد‬‫حُ٬عظ٤شٝث٤ذ٣ش‬.......................................................................35 ‫ٓنخدحص‬‫حُلطٞس‬.............................................................................................36 ‫ٓنخدحص‬‫حُل٤شٝعخص‬.......................................................................................38 ‫اػظزخسحص‬‫حُقخدحص‬ٖ٤‫ُِٔقخر‬‫رؤٓشحك‬‫ؿٜخص٣ش‬‫ؽخثؼش‬...............................................40 ْٛ‫أ‬‫ح٧دٝ٣ش‬٢‫حُظ‬‫طخـ‬‫هز٤ذ‬ٕ‫ح٧ع٘خ‬ٝ‫ػ٬هظٜخ‬‫ٓغ‬‫ح٩مطشحرخص‬‫حٌُزذ‬......................43 ‫طق٘٤ق‬‫ح٧دٝ٣ش‬‫ُِٔشأس‬َٓ‫حُلخ‬...........................................................................44 ‫ح٩ػظزخسحص‬‫حُذٝحث٤ش‬‫ُِٔشأس‬‫ح‬َٓ‫ُلخ‬......................................................................45 ‫ح٩ػظزخسحص‬‫حُذٝحث٤ش‬‫ُِٔشأس‬‫حُٔشمغ‬.....................................................................48 ‫طق٘٤ق‬‫حُخطش‬‫ُِلخ٫ص‬‫حُوِز٤ش‬‫حُٔظشحكوش‬‫ٓغ‬‫اُظٜخد‬‫ؽـخف‬‫حُوِذ‬............................50 ٍٝ‫ؿذ‬‫ح٧ٗظٔش‬‫حُٞهخث٤ش‬...................................................................................51
  7. 7. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab6 ‫حُظذحخ٬ص‬‫حُذٝحث٤ش‬..........................................................................................52 ‫حُظذحخ٬ص‬‫حُلشً٤ش‬‫حُلخسٓخًُٞٞؿ٤ش‬......................................................................53 ‫ح٩ٓظقخؿ‬٢ٔ‫حُٜن‬........................................................................................53 ‫ح٩ٗظؾخس‬٢‫حُٞػخث‬............................................................................................54 ‫ح٩عظو٬د‬١‫حٌُزذ‬.........................................................................................55 ‫حُطشف‬١ٌُِٞ‫ح‬...............................................................................................57 ‫حُظذحخ٬ص‬‫حُظلخػِ٤ش‬‫حُلخسٓخًُٞٞؿ٤ش‬...................................................................57 ‫حُظظخٛشحص‬‫حُغٔ٤ش‬........................................................................................57 ّ‫ػذ‬‫حُلخػِ٤ش‬‫حُذٝحث٤ش‬.....................................................................................59 َ‫حُظذحخ‬ّ‫رؼذ‬‫حُظٞحكن‬٢‫حُل٤ض٣خث‬-٢‫حٌُ٤ٔخث‬..........................................................59 َٓ‫ػٞح‬ٟ‫أخش‬.................................................................................................60 ْٛ‫أ‬‫ح٩خظ٬هخص‬‫حُذٝحث٤ش‬٢‫ك‬‫هذ‬ٕ‫ح٧ع٘خ‬..........................................................61 ْٛ‫أ‬‫حُٞفلخص‬‫حُذٝحث٤ش‬٢‫ك‬‫هذ‬ٕ‫ح٧ع٘خ‬.............................................................66
  8. 8. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab7 ‫حُقخدحص‬‫حُٔغظخ‬ٕ‫ح٧ع٘خ‬ ‫هذ‬ ٢‫ك‬ ‫ذٓش‬ ٩‫ح‬ ‫٣ؼظٔذ‬٢‫ك‬ ‫حُٔغظخذٓش‬ ‫حُل٤ٞ٣ش‬ ‫ُِقخدحص‬ َ‫ح٧ٓؼ‬ ‫خظ٤خس‬‫حُظؾخ٤ـ‬ ٠ِ‫ػ‬ ‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬ ‫ح٩ٗظخٗخص‬ ‫ٓؼخُـش‬ ،ٕ‫ُ٪ٗظخ‬ ‫حُٔغززش‬ ْ٤‫ُِـشحػ‬ ‫حُقل٤ق‬‫حُل٤ٞ٣ش‬ ‫حُقخدحص‬ ٙ‫طـخ‬ ‫حُخخٓـش‬ ْ٤‫حُـشحػ‬ ‫طلغظ‬ ‫طلذ٣ذ‬ ٠ِ‫ػ‬ ‫رُي‬ ‫ٝ٣ؼظٔذ‬ ْٝ‫٣ظ‬ ٕ‫أ‬ ‫٣ـذ‬ ١‫حُز‬‫رخُٔؼخُـش‬ ‫حُزذء‬ َ‫هز‬ٕ‫أ‬ ‫ؿ٤ش‬ ،‫ط‬ ٫ ‫هذ‬ ‫حُلخدس‬ ‫حُلخ٫ص‬ْ‫٣ظ‬ ٠‫كظ‬ ‫حُٔؼخُـش‬ ‫طؤخ٤ش‬ َٔ‫ظل‬‫طلذ٣ذ‬ ‫حُـشػٞٓ٤ش‬ ‫حُللٞؿ‬ ‫ٗظخثؾ‬ ‫فذٝس‬ ‫٣لظخؽ‬ ‫(هذ‬ ‫حُٔغززش‬ ْ٤‫حُـشحػ‬48‫أًؼش‬ ٝ‫أ‬ ‫عخػش‬)ّٝٞ‫٣و‬‫ا‬١ٞ٤‫حُل‬ ‫حُقخد‬ ‫خظ٤خس‬ ٝ ‫حُٔٔخسط‬ ‫حُطز٤ذ‬ ‫خزشس‬ ٠ِ‫ػ‬ ‫حُلخُش‬ ٙ‫ٛز‬ َ‫ٓؼ‬ ٢‫ك‬ٚ‫ٓؼشكظ‬١ٞ٤‫حُل‬ ‫ٝرخُقخد‬ ٕ‫ُ٪ٗظخ‬ ً‫س‬‫ػخد‬ ‫حُٔغززش‬ ْ٤‫رخُـشحػ‬ ُ‫ح‬ٌٕٞ‫ٝط‬ ،‫حُؼنٞ٣خص‬ ٙ‫ٛز‬ ُٚ ‫طظلغظ‬ ١‫ز‬‫حُغش٣ش٣ش‬ ‫حُ٘خك٤ش‬ ٖٓ ً‫س‬‫ػخد‬ ‫كؼخُش‬ ‫حُٔوخسرش‬ ٙ‫ٛز‬. ٖٓ ‫حُؼذ٣ذ‬ ٖ‫ػ‬ ً‫س‬‫ػخد‬ ‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬ ‫ح٩ٗظخٗخص‬ ‫ط٘ظؾ‬ٝ ّ‫ؿشح‬ ‫ا٣ـخر٤ش‬ ‫حُٜٞحث٤ش‬ ْ٤‫حُـشحػ‬‫عِز٤ش‬ ْ٤‫حُـشحػ‬ ٖٓ َ٤ِ‫حُو‬ ٝ ّ‫ؿشح‬ٖٓ ‫ًز٤شس‬ ‫أػذحد‬ ٖ‫ػ‬ٝ ‫ا٣ـخر٤ش‬ ‫حُ٬ٛٞحث٤ش‬ ْ٤‫حُـشحػ‬٢‫حُظ‬ ّ‫ؿشح‬ ‫عِز٤ش‬ٌَ‫طؾ‬65-75ْ٤‫ؿشحػ‬ ٖٓ % ‫حُ٘ز٤ض‬١ٞٔ‫حُل‬ٝ ،‫ح٩ٗظخ‬ َ٤ٔ‫ط‬‫ر‬ ‫طظظخٛش‬ ٢‫حُظ‬ ‫ٗخص‬‫ب‬٩ َُِٜ‫ح‬ ‫ُظٜخد‬ْ٤‫حُـشحػ‬ ٖٓ ‫أًزش‬ ‫أػذحد‬ ‫كظٞحء‬٢‫ك‬ ،‫حُٜٞحث٤ش‬ ‫حُلٔٞ٣ش‬ ‫ح٩ٗظخٗخص‬ َٔ‫طؾ‬ .‫ٛٞحث٤ش‬ ٫ ‫هز٤ؼش‬ ‫رحص‬ ‫حُخشحؿخص‬ ٌٕٞ‫ط‬ ٖ٤‫ك‬ْ٤‫حُـشحػ‬ ٖٓ ً‫ح‬‫ٓؼوذ‬ ً‫خ‬‫ٓض٣ـ‬ ً‫خ‬‫ؿخُز‬ ‫حُغ٘٤ش‬ ٝ ‫حُٜٞحث٤ش‬‫ك‬ ‫طغ٤طش‬ ‫حُ٬ٛٞحث٤ش‬‫ح٧ٗٞحع‬ ٚ٤‫ر٘غزش‬ ‫حُ٬ٛٞحث٤ش‬1:2. ‫ػ٘ذ‬ ٕ‫ح٧ع٘خ‬ ‫هز٤ذ‬ ٠ِ‫ػ‬ ‫٣ـذ‬‫ا‬ٌٕٞ٣ ٕ‫أ‬ ١ٞ٤‫حُل‬ ‫ُِقخد‬ ٙ‫خظ٤خس‬ٝ ‫ُِذٝحء‬ ْ‫حُـغ‬ ‫ٓؼخِٓش‬ ‫رطش٣وش‬ ً‫خ‬ِِّْٔٓ‫ػ‬ ٠ِ‫ػ‬ ‫حُل٤ٞ٣ش‬ ‫كخُقخدحص‬ ‫حُطز٤ش؛‬ ‫حُٔش٣ل‬ ‫رغ٤شس‬‫ٝؿٞد‬ ٍ‫كخ‬ ٢‫ك‬ ‫حُٔؼخُـش‬ ٢‫ك‬ ّ‫طغظخذ‬ ٫‫أ‬ ‫٣ـذ‬ ١ٌُِٞ‫ح‬ ‫ح٩هشحف‬ ‫رحص‬ َ‫ح٧ه‬ ٠ِ‫ػ‬ ٝ‫أ‬ ١ًِٞ ‫هقٞس‬ٕ‫أ‬ ‫٣ـذ‬ٝ ،‫ح٧دٝ٣ش‬ ٙ‫ٛز‬ ‫ؿشػش‬ ‫ط٘وـ‬ّ‫ػذ‬ ‫٣ـذ‬ ‫ٓؾخرٜش‬ ‫رٔ٘خهؾش‬‫ا‬‫ح٧دٝ٣ش‬ ّ‫عظخذح‬ َ‫طزط‬ ٢‫حُظ‬‫ؽذ٣ذ‬ ١‫ًزذ‬ ‫هقٞس‬ ٖٓ ٕٞٗ‫٣ؼخ‬ ٖ٣‫حُز‬ ٠‫حُٔشم‬ ٟ‫ُذ‬ ‫حٌُزذ‬ ٢‫ك‬ ‫كؼخُ٤ظٜخ‬. ‫حُقخدحص‬ ‫طٞصع‬ ‫رخقخثـ‬ ‫٣ل٤و‬ ٕ‫أ‬ ً‫خ‬‫أ٣ن‬ ٕ‫ح٧ع٘خ‬ ‫هز٤ذ‬ ٠ِ‫ػ‬ ‫٣ـذ‬ٍٞ‫رٞف‬ ‫ٓؾشٝه‬ ‫حُٔؼخُـش‬ ‫ٗـخف‬ ٕ٧ ‫حُل٤ٞ٣ش‬ ٣ٝ‫ح٧د‬ ٙ‫ٛز‬ ٖٓ ‫ًخك٤ش‬ ‫طشحً٤ض‬‫ٓٞمغ‬ ٠ُ‫ا‬ ‫ش‬‫ح٧ٗغـش‬ ٠ُ‫ا‬ ً‫س‬‫ػخد‬ ‫رغُٜٞش‬ ‫حُل٤ٞ٣ش‬ ‫حُقخدحص‬ ‫أؿِذ‬ َ‫طق‬ .ٕ‫ح٩ٗظخ‬ ‫أٓخ‬ ،‫حُلٔٞ٣ش‬ ‫حُٔخخه٤ش‬‫حُقخ‬ ٍٞ‫ٝف‬ ‫٣قؼذ‬ ٢‫حُظ‬ ‫حُٔٞحمغ‬ ٢‫ك‬ ‫ح٩ٗظخٗخص‬ًً٬‫ٓؼ‬ ٢ٔ‫حُؼظ‬ ‫ًخُ٘غ٤ؾ‬ ‫اُ٤ٜخ‬ ‫دحص‬ ‫كظظطِذ‬‫ا‬ٖ٤‫ًخٌُِ٤٘ذحٓخ٣غ‬ ‫حُ٘غ٤ؾ‬ ‫ٛزح‬ ٢‫ك‬ ‫حُظٞصع‬ ‫ؿ٤ذ‬ ١ٞ٤‫ك‬ ‫فخد‬ ‫خظ٤خس‬clindamycin١‫٣زذ‬ ١‫حُز‬‫ا‬‫خظشحه‬ً‫خ‬ ٙ‫طشحً٤ض‬ ‫طلٞم‬ ‫هذ‬ ‫حُؼظٔ٤ش‬ ٙ‫طشحً٤ض‬ ٕ‫أ‬ ٠‫(كظ‬ ٢ٔ‫حُؼظ‬ ‫ُِ٘غ٤ؾ‬ ً‫ح‬‫ٓٔظخص‬ٝ ،)‫حُز٬عٔ٤ش‬‫حخظ٤خس‬ ْ‫٣ظ‬ ٫ ‫حُظظشحع٤ٌِ٤٘خص‬tetracyclines‫ٓغ‬ ‫ٓؼوذحص‬ ٌَ‫طؾ‬ ٢‫حُظ‬ٝ ٢ٔ‫حُؼظ‬ ‫حُ٘غ٤ؾ‬٫ٙ‫ٛز‬ َ‫ُٔؼ‬ ٢ُ‫رخُظخ‬ ‫كؼخُش‬ ٌٕٞ‫ط‬ ٩‫ح‬.‫عظطزخرخص‬ ٩‫ح‬ ٌٖٔ٣ ٫ ٚٗ‫أ‬ ٠ُ‫ا‬ ‫ح٩ؽخسس‬ ‫طـذس‬‫حُقخدحص‬ ٠ِ‫ػ‬ ‫ػظٔخد‬‫حُل‬‫٣لظخؽ‬ ‫ار‬ ،‫ح٩ٗظخٗخص‬ ٠ِ‫ػ‬ ‫حُونخء‬ ٢‫ك‬ ‫ُٞكذٛخ‬ ‫٤ٞ٣ش‬ ‫حُو٤ق‬ ٖٓ ‫ًز٤شس‬ ‫ًٔ٤خص‬ ‫ٝؿٞد‬ٝ‫حُٔظ٘خشس‬ ‫حُ٘غؾ‬ٝ‫ٝؿٞد‬‫ا‬‫ؿش٣ذ‬ ْ‫رـغ‬ ٢ٌ٤ٗ‫ٓ٤ٌخ‬ ‫ٗغذحد‬ٝ‫ٓ٘خهن‬ ‫ٝؿٞد‬ ‫مؼ٤لش‬ ‫خشحؿ٤ش‬،‫حُل٤ٞ٣ش‬ ‫حُقخدحص‬ ٖٓ ‫ًخك٤ش‬ ‫ؿشػخص‬ ْ٣‫طوذ‬ ٠ُ‫ا‬ ‫رخ٩مخكش‬ ١‫كٞس‬ ٢‫ؿشحك‬ ‫طذر٤ش‬ ٠ُ‫ا‬ ‫حُظٞػ٤ش‬‫ًٔخ‬ ‫حُذ‬ ‫ح٧ٗغـش‬ ‫خشحؿخص‬ ‫طلظخؽ‬ٝ ‫حُغ٘٤ش‬ ‫حػٔش‬ٝ ‫حُزسٝس‬ ٍٞ‫ك‬ ‫ٓخ‬ ‫خشحؿخص‬‫ح٩ٗظخٗخص‬ ‫أؿِذ‬٠ُ‫ا‬ ٟ‫ح٧خش‬ ‫حُلٔٞ٣ش‬ ً‫خ‬٤‫ؿشحك‬ َ‫حُظذخ‬ٝ ‫حُخشحؽ‬ ‫ؽن‬ ‫٣غٔق‬ ‫ار‬ ،‫ػذد‬ ‫ربصحُش‬ ‫ؿ٤ذ‬ ٌَ‫رؾ‬ ٚ‫طقش٣ل‬ٝ ‫حُٔغززش‬ ْ٤‫حُـشحػ‬ ٖٓ ‫ًز٤ش‬َ‫هظ‬ ٖ٤‫ُ٨ًٝغـ‬ ‫طؼشمٜخ‬ ‫ٗظ٤ـش‬ ‫حُ٬ٛٞحث٤ش‬ ْ٤‫حُـشحػ‬ٕ‫أ‬ ‫ًٔخ‬ ،ٝ ‫حُٔ٤ظش‬ ‫ح٧ؿضحء‬ ‫ٗضع‬‫حُـشػٞٓ٤ش‬ ‫حُزوخ٣خ‬ٝ ‫(ح٧ؽ٬ء‬ ١ٞ٤‫حُل‬ ‫ُِقخد‬ ‫٣غٔق‬ )‫حُلن٬ص‬ٝ َ‫أكن‬ ٌَ‫رؾ‬ ‫ح٩ٗظخٗ٤ش‬ ‫حُزئس‬ ٠ُ‫ا‬ ٍٞ‫رخُٞف‬٩‫ح‬ٍ‫رذ‬ ‫حُٔٔشمش‬ ْ٤‫رخُـشحػ‬ ‫سطزخه‬ ٩‫ح‬‫سطزخه‬‫حُزشٝط٤٘٤ش‬ ‫رخُٔٞحد‬. ‫كخسؿش‬ ‫ٓؼذس‬ ٠ِ‫ٝػ‬ ْ‫حُل‬ ‫هش٣ن‬ ٖ‫ػ‬ ً‫س‬‫ػخد‬ ‫حُغ٘٤ش‬ ‫حُقخدحص‬ ٠‫طؼط‬(ٝ ‫حُٞؿزش‬ َ‫هز‬ ‫عخػش‬ ٖ‫ػ‬ َ‫طو‬ ٫ ‫ٓذس‬ ٢‫ك‬٫ ٝ )‫رؼذٛخ‬ ٖ٤‫عخػظ‬ ٖ‫ػ‬ َ‫طو‬‫طخشرٜخ‬ ‫ُظـ٘ذ‬ ‫رُي‬‫طشحؿغ‬ ٝ‫أ‬ ١‫حُٔؼذ‬ ‫رخُلٔل‬‫ا‬‫رؼل‬ ٍٝ‫ط٘خ‬ ‫رغزذ‬ ‫ٓظقخفٜخ‬
  9. 9. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab8 ‫ح٧دٝ٣ش‬ ‫رؼل‬ ٢‫طؼخه‬ ٝ‫أ‬ ‫ح٧ؿز٣ش‬٠ِ‫ػ‬ ،‫٣٘وـ‬ ٍ‫حُٔؼخ‬ َ٤‫عز‬‫ا‬ٝ ،‫حُلِ٤ذ‬ ٍٝ‫رظ٘خ‬ ‫حُظظشحع٤ٌِ٤٘خص‬ ‫ٓظقخؿ‬‫ٓنخدحص‬ ‫حُلخٝ٣ش‬ ‫حُلٔٞمش‬،ّٞ٣‫حُٔـ٘٤ض‬ ،ّٞ٤ُ٘ٔ٧‫(ح‬ ‫حُظٌخكئ‬ ‫ػ٬ػ٤ش‬ ٝ‫أ‬ ‫ػ٘خث٤ش‬ ‫ا٣ـخر٤ش‬ ‫ٓؼذٗ٤ش‬ ‫ؽٞحسد‬ ٠ِ‫ػ‬ٌُ‫ح‬،)ّٞ٤‫خُغ‬ ‫حُلذ٣ذ‬ ‫أٓ٬ف‬ ٠ِ‫ػ‬ ‫حُلخٝ٣ش‬ ‫ٝح٧دٝ٣ش‬. ‫حُقخد‬ ‫خقخثـ‬٪ُ ٢ُ‫حُٔؼخ‬ ١ٞ٤‫حُل‬٢٘‫حُغ‬ ّ‫عظخذح‬: ٕ‫أ‬ ‫٣ـذ‬‫حُذٝحث٤ش‬ ‫رخُخٞحؿ‬ ‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬ ‫ح٩ٗظخٗخص‬ ‫ُٔؼخُـش‬ ّ‫حُٔغظخذ‬ ١ٞ٤‫حُل‬ ‫حُقخد‬ ‫٣ظٔظغ‬‫حُظخُ٤ش‬: 1 -َ‫هخط‬ٝ ْ٤‫ُِـشحػ‬‫ُ٪ٗظخٗخص‬ ً‫س‬‫ػخد‬ ‫حُٔغززش‬ ْ٤‫حُـشحػ‬ ‫مذ‬ ‫ؿ٤ذس‬ ‫كؼخُ٤ش‬ ‫٣ِٔي‬‫حُلٔٞ٣ش‬‫حُغ٘٤ش‬. 2 -‫٣ـذ‬‫ٓخ‬ ‫أم٤ن‬ ‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬ ‫ُ٪ٗظخٗخص‬ ً‫س‬‫ػخد‬ ‫حُٔغززش‬ ْ٤‫حُـشحػ‬ ‫مذ‬ ٚ‫كؼخُ٤ظ‬ ‫ه٤ق‬ ٌٕٞ٣ ٕ‫أ‬َ٤ِ‫ُظو‬ ٌٖٔ٣ ‫حُٔز٤نخص‬ ًٞٔ٘( ‫حُؼخٗٞ٣ش‬ ‫ح٩ٗظخٗخص‬ ‫كذٝع‬. ) 3 -‫٣ـذ‬‫ؿشػٞٓ٤ش‬ ‫ٓوخٝٓش‬ ١‫أ‬ ٚٛ‫طـخ‬ ‫طظٜش‬ ٫‫أ‬. 4 -‫ػخرض‬ٝ ،‫حُلٔل‬ ٢‫ك‬٩‫ح‬ ‫ؿ٤ذ‬‫حُل‬ ‫هش٣ن‬ ٖ‫ػ‬ ‫٣ئخز‬ ‫ػ٘ذٓخ‬ ‫ٓظقخؿ‬ٝ ،ْ٢‫ك‬ ّ‫حُطؼخ‬ ‫٣ئػش‬ ٫‫ا‬ٚ‫ٓظقخف‬. 5 -‫ؿ٤ذ‬ٝ ْ‫حُؼظ‬ ٢‫ك‬ ‫حُظٞصع‬ٝ ،‫حُشخٞس‬ ‫ح٧ٗغـش‬( ‫ػخُ٤ش‬ ‫ٗغ٤ـ٤ش‬ ‫طشحً٤ض‬ ٠ُ‫ا‬ ٍٞ‫حُٞف‬ ْ‫٣ظ‬‫رٞمٞف‬ ٠ِ‫أػ‬ٖٓ ‫حُٔغززش‬ ‫ُِؼنٞ٣خص‬ ١‫ح٧فـش‬ َ‫حُوخط‬ ‫حُظشً٤ض‬‫حُذٝحء‬ ٖٓ ‫ٓؼظذُش‬ ‫رـشػخص‬ ). 6 -ٖٓ ‫أًؼش‬ ٚ‫اػطخث‬ ‫طٌشحس‬ ّ‫رؼذ‬ ‫٣غٔق‬ ‫ٓ٘خعذ‬ ٢‫ٗقل‬ ‫رؼٔش‬ ‫٣ظٔظغ‬4‫ٓش‬ّٞ٣/‫حص‬. 7 -َٜ‫ع‬ٝ ‫ح٩هشحف‬ٝ ٕ‫ح٩ٗغخ‬ ‫ُخ٬٣خ‬ ّ‫عخ‬ ‫ؿ٤ش‬ٟ‫ُذ‬ ‫دٝحث٤ش‬ ‫طذحخ٬ص‬ ٝ‫أ‬ ‫ؿخٗز٤ش‬ ً‫ح‬‫آػخس‬ ١‫٣زذ‬ ٫‫حُٔش٣ل‬. 8 -ٖ‫٣لغ‬ٕٞ‫ؿن‬ ٢‫ك‬ ٢٘‫حُغ‬ ٕ‫ح٩ٗظخ‬ ‫كخُش‬5‫ـ‬7َ‫أه‬ ٝ‫أ‬ ّ‫أ٣خ‬. ‫ٓنخدحص‬٩‫ح‬ ‫رحص‬ ْ٤‫حُـشحػ‬ٕ‫ح٧ع٘خ‬ ‫هذ‬ ٢‫ك‬ ‫حُؾخثغ‬ ّ‫عظخذح‬: 1 -‫انثنيسيهيناخ‬penicillins: ٌٖٔ٣‫ؿٔ٤غ‬ ‫ٓؼخُـش‬‫حُل‬ ‫ح٩ٗظخٗخص‬‫ر‬ ٍ‫كؼخ‬ ٌَ‫رؾ‬ ً‫خ‬‫طوش٣ز‬ ‫حُغ٘٤ش‬ ‫ٔٞ٣ش‬‫ب‬‫حُقخدحص‬ ‫أكذ‬ ّ‫عظخذح‬‫حُل٤ٞ٣ش‬ ٝ( ‫حُؾخثؼش‬ ‫حُغ٘٤ش‬ ‫ح٩ٗظخٗخص‬ ‫ط٘ظؾ‬ ‫ار‬ ،‫حُز٘٤غ٤ِ٤٘٤ش‬٢‫حُظ‬ ‫ح٩ٗظخٗخص‬ ‫خخؿ‬ ٌَ‫رؾ‬‫حُ٘خش٣ش‬ ‫ح٥كخص‬ ‫ٗظ٤ـش‬ ‫طظٜش‬) ٝ ّ‫ؿشح‬ ‫ا٣ـخر٤ش‬ ‫ٌٓٞسحص‬ ٖ‫ػ‬‫رٔؼظٜٔخ‬ ‫طظلغظ‬ ‫٫ٛٞحث٤ش‬ ْ٤‫ؿشحػ‬‫ُِز٘٤غ٤ِ٤٘خص‬. ‫أًؼش‬‫حُز٘٤غ‬‫٤ِ٤٘خص‬‫ا‬ٕ‫ح٧ع٘خ‬ ‫هذ‬ ٢‫ك‬ ً‫خ‬ٓ‫عظخذح‬ٖ٤ِ٤‫حُز٘٤غ‬ :V(ٖ٤ِ٤‫ر٘٤غ‬ َ٤‫ٓ٤ظ‬ ٢‫حُل٤ً٘ٞغ‬ phenoxymethylpenicillin)ٖ٤ِ٤‫ح٧ًٓٞغ٤غ‬ ،amoxicillinٖ٤ِ٤‫ح٧ٓز٤غ‬ ،ampicillin، ‫ً٬كٞ٫ٗ٤ي‬ ‫ح٧ًٓٞغ٤غ٤ِ٤ٖ/كٔل‬(‫أًٓٞغ٤ٌ٬ف‬(amoxiclav) ) ٖ٤ِ٤‫حُز٘٤غ‬V:‫٣ؼذ‬ٖ٤ِ٤‫حُز٘٤غ‬V‫حُذٝح‬ ‫حُخ٤خس‬‫رخُؼذ٣ذ‬ ‫٣ظٔظغ‬ ٚٗ٧ ‫حُغ٘٤ش‬ ‫ح٩ٗظخٗخص‬ ‫ٓؼخُـش‬ ٢‫ك‬ ٍٝ٧‫ح‬ ٢‫ث‬ٖٓ ٝ ً‫ش‬‫خخف‬ ٙ٬‫أػ‬ ‫حُٔٞفٞكش‬ ‫حُٔؼخُ٤ش‬ ‫حُخقخثـ‬ْ٤‫حُـشحػ‬ ‫أؿِذ‬ َٔ‫٣ؾ‬ ٚ‫كؼخُ٤ظ‬ ‫ه٤ق‬ ٕ‫أ‬‫ح٩ٗظخٗخص‬ ٖ‫ػ‬ ‫حُٔغئُٝش‬ ٝ ،‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬ٖ٤ِ٤‫حُز٘٤غ‬ ٠ِ‫ػ‬ َ‫٣لن‬ ٞٛG(َ٣‫حُز٘ض‬ٖ٤ِ٤‫ر٘٤غ‬)benzylpenicillin١ٞٔ‫حُل‬ ‫حُطش٣ن‬ ٕ٧ ‫ح‬ ٞٛٝ ً‫خ‬ٗ‫أٓخ‬ ‫ح٧ًؼش‬ ‫ُطش٣ن‬ً‫ش‬ٓ‫ٓ٬ء‬٩ٖ٤ِ٤‫حُز٘٤غ‬ ‫٣خقـ‬ ‫ر٤٘ٔخ‬ ،ٕ‫ح٧ع٘خ‬ ‫هذ‬ ٢‫ك‬ ‫حُل٤ٞ٣ش‬ ‫حُقخدحص‬ ٍ‫عظؼٔخ‬G ‫ُٔؼخُـش‬( ْ‫حُل‬ ‫هش٣ن‬ ٖ‫ػ‬ ‫حُذٝحء‬ ‫اػطخء‬ ‫ك٤ٜخ‬ ٌٖٔ٣ ٫ ٢‫حُظ‬ ‫حُلخ٫ص‬ ٝ‫أ‬ ‫حُؾذ٣ذس‬ ‫ح٩ٗظخٗخص‬‫ُلذٝع‬‫ٝؿٞد‬ ٝ‫أ‬ ‫ه٤خء‬ ‫ح٫ٓظقخؿ‬ ‫ُغٞء‬ ‫ٓظ٬صٓش‬. ) ‫رؼل‬ ‫ٛ٘خى‬‫حُلخ‬ٌٕٞ٣ ٫ ‫٫ص‬‫ا‬ُ‫ح‬ ّ‫عظخذح‬ٖ٤ِ٤‫ز٘٤غ‬V‫حُلٔٞ٣ش‬ ‫ح٩ٗظخٗخص‬ ‫ُٔؼخُـش‬ ً‫خ‬‫ٓ٘خعز‬ ‫ك٤ٜخ‬‫حُغ٘٤ش‬: -‫ط٘ظؾ‬ٝ ،‫ُِز٤ظخ٫ًظخٓخص‬ ‫ٓ٘ظـش‬ ْ٤‫ؿشحػ‬ ٖ‫ػ‬ ‫حُغ٘٤ش‬ ‫ح٩ٗظخٗخص‬ ‫رؼل‬ٙ‫ٛز‬ َ‫ٓؼ‬ ٢‫ك‬ ‫حُٔ٘خعذ‬ ٖٓ ٌٕٞ٣‫حُلخ٫ص‬ ‫ا‬‫حُز٘٤غ٤ِ٤٘٤ش‬ ‫ؿ٤ش‬ ‫حُقخدحص‬ ‫أكذ‬ ٝ‫أ‬ ‫حٌُ٬كٞ٫ٗ٤ي‬ ‫ح٧ًٓٞغ٤غ٤ِ٤ٖ/كٔل‬ ّ‫عظخذح‬ٝ‫أ‬ ٖ٤‫ح٩س٣ؼشٝٓخ٣غ‬ َ‫ٓؼ‬ ‫حٌُِ٤٘ذح‬ٖ٤‫ٓخ٣غ‬.
  10. 10. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab9 -‫هذ‬ّ‫ؿشح‬ ‫ٝعِز٤ش‬ ّ‫ؿشح‬ ‫ا٣ـخر٤ش‬ ْ٤‫ؿشحػ‬ ٖ‫ػ‬ ‫حُغ٘٤ش‬ ‫حُذحػٔش‬ ‫حُ٘غؾ‬ ‫اٗظخٗخص‬ ‫رؼل‬ ‫ط٘ظؾ‬ٝ ،ٌٕٞ٣‫حُخ٤خس‬ ‫ه٤ق‬ ٖٓ ‫أٝعغ‬ ْ٤‫ُِـشحػ‬ ‫ٓنخد‬ ‫ه٤ق‬ ١‫ر‬ ١ٞ٤‫ك‬ ‫فخد‬ ‫اػطخء‬ ٞٛ ‫حُلخُش‬ ٙ‫ٛز‬ ٢‫ك‬ ٢‫حُؼ٬ؿ‬ٖ٤ِ٤‫حُز٘٤غ‬Vَ‫ٓؼ‬ ٖ٤ِ٤‫ح٧ًٓٞغ٤غ‬. -‫طضدحد‬ٖ٤ِ٤‫ُِز٘٤غ‬ ‫حُٔوخٝٓش‬ ‫كٞحدع‬V‫أٗٞحع‬ ٢‫ك‬‫حُؼقٞحٗ٤خص‬Bacteroidesٝ‫حُؼوذ٣ش‬ ‫حٌُٔٞسحص‬ Streptococcusٝ ،‫حُغ٘٤ش‬ ‫ح٩ٗظخٗخص‬ ٢‫ك‬ ‫حُٔؾظشًش‬ٙ‫ٛز‬ َ‫ٓؼ‬ ٢‫ك‬ ٖ٤ِ٤‫ح٧ًٓٞغ٤غ‬ ٌٕٞ٣ً٬٣‫رذ‬ ‫حُلخ٫ص‬ ٖ٤ِ٤‫ُِز٘٤غ‬ ً‫خ‬‫ٓ٘خعز‬V‫ٓ٘ظـش‬ ‫ؿ٤ش‬ ْ٤‫حُـشحػ‬ ٙ‫ٛز‬ ‫ًخٗض‬ ‫ارح‬‫ُِز٤ظخ٫ًظخٓخص‬. -‫٣لظخؽ‬٤‫ٝهخث‬ ‫ٓؼخُـش‬ ٕٞ‫٣ظِو‬ ٖ٣‫حُز‬ ٠‫حُٔشم‬‫رخُز‬ ‫ٓذ٣ذس‬ ‫ش‬ٖٓ ‫ُِٞهخ٣ش‬ ٖ٤ِ٤‫٘٤غ‬‫ا‬‫حُوِذ‬ ‫ؽـخف‬ ‫ُظٜخد‬٠ُ‫ا‬ ‫ا‬٢٘‫ع‬ ‫اؿشحء‬ ٠ُ‫ا‬ ٕٞ‫ع٤خنؼ‬ ‫ًخٗٞح‬ ‫ارح‬ ‫آخش‬ ١ٞ٤‫ك‬ ‫فخد‬ ّ‫عظخذح‬. ٖ٤ِ٤‫ٝح٧ٓز٤غ‬ ٖ٤ِ٤‫ح٧ًٓٞغ٤غ‬:ٖ٤ِ٤‫حُز٘٤غ‬ ‫كؼخُ٤ش‬ ‫ه٤ق‬ ٖٓ ‫أٝعغ‬ ‫كؼخُ٤ش‬ ‫رط٤ق‬ ٕ‫٣ظٔظؼخ‬Vٝ٢‫ك‬ ٕ‫٣غظخذٓخ‬ ‫ٓؼخُـش‬‫حُٜٞحث٤ش‬ ْ٤‫حُـشحػ‬ ‫ك٤ٜخ‬ ‫طؾظشى‬ ٢‫حُظ‬ ‫حُٔخظِطش‬ ‫حُغ٘٤ش‬ ‫ح٩ٗظخٗخص‬ٝ ‫ا٣ـخر٤ش‬ّ‫ؿشح‬ ‫عِز٤ش‬ْٝ٤‫حُـشحػ‬ ٝ ‫حُ٬ٛٞحث٤ش‬‫حُِٔظٞ٣خص‬Spirochetesٝ‫طظطِذ‬ ٢‫حُظ‬‫ا‬‫ٝحعغ‬ ٖ٤ِ٤‫ر٘٤غ‬ ّ‫عظخذح‬.‫حُط٤ق‬ ٍٝ٧‫ح‬ ٢‫حُذٝحث‬ ‫حُخ٤خس‬ ٖ٤ِ٤‫ح٧ٓز٤غ‬ ٝ‫أ‬ ٖ٤ِ٤‫ح٧ًٓٞغ٤غ‬ ٌٕٞ٣ ٕ‫أ‬ ‫حُٞحهغ‬ ٢‫ك‬ ‫٣لظشك‬‫حُلٔٞ٣ش‬ ‫ح٩ٗظخٗخص‬ ‫ٓؼخُـش‬ ٢‫ك‬ ٝ ١‫ؿِذ‬ ‫ُطلق‬ ‫اكذحػٜٔخ‬ ‫آٌخٗ٤ش‬ ٫ُٞ ‫حُغ٘٤ش‬‫اٗظ‬‫خٗخص‬‫ه٤ق‬ ‫(رغزذ‬ ١ٞ‫حُٔؼ‬ ١‫حُٔؼذ‬ ‫ٝح٧ٗزٞد‬ َ‫حُٜٔز‬ ٢‫ك‬ ‫ػخٗٞ٣ش‬ ْ٤‫حُـشحػ‬ ‫مذ‬ ‫حُٞحعغ‬ ‫حُلؼخُ٤ش‬ٖ٤ِ٤‫حُز٘٤غ‬ ٖٓ ٠ِ‫أػ‬ ‫ر٘غذ‬ )ّ‫ؿشح‬ ‫عِز٤ش‬ ‫حُٜٞحث٤ش‬V ‫حٌُ٬كٞ٫ٗ٤ي‬ ‫ح٧ًٓٞغ٤غ٤ِ٤ٖ/كٔل‬:‫رلذ‬ ْ٤‫ُِـشحػ‬ ‫ٓنخدس‬ ‫كؼخُ٤ش‬ ١‫رؤ‬ ‫حٌُ٬كٞ٫ٗ٤ي‬ ‫كٔل‬ ‫٣ظٔظغ‬ ٫،ٚ‫رحط‬ ٓ‫حُز٤ظخ٫ًظخ‬ ‫أٗض٣ٔخص‬ ‫٣ؼزو‬ ٌُٚ٘ٝ‫مذ‬ ‫كؼخُ٤ش‬ ‫أًؼش‬ ٖ٤ِ٤‫ح٧ًٓٞغ٤غ‬ َ‫٣ـؼ‬ ‫ٓٔخ‬ ‫خص‬‫حُٔغززش‬ ْ٤‫حُـشحػ‬ ٖٓ ‫حُؼذ٣ذ‬ ‫(حُؼقٞحٗ٤خص‬ ‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬ ‫ُ٪ٗظخٗخص‬Bacteroides،‫حُٜنٔٞٗ٤ش‬ ‫حُؼوذ٣ش‬ ‫حٌُٔٞسحص‬Peptostreptococcus، ‫حُٜنٔٞٗ٤ش‬ ‫ٝحٌُٔٞسحص‬Peptococcus)ٝ‫حُز٤ظخ٫ًظخ‬ ْ٣‫أٗض‬ ‫ربٗظخؽ‬ ٖ٤ِ٤‫ُ٨ًٓٞغ٤غ‬ ‫ٓوخٝٓش‬ ‫أفزلض‬ ٢‫حُظ‬‫ٓخص‬. 2 -‫انسيفانىسثىريناخ‬cephalosporins: ‫طظٔظغ‬َ‫ٓؼ‬ ً‫خ‬٣ٞٔ‫ك‬ ‫حُلؼخُش‬ ٢ٗ‫حُؼخ‬ َ٤‫حُـ‬ ‫ع٤لخُٞعزٞس٣٘خص‬ ‫رؼل‬‫حُغ٤لخًِٞس‬cefaclorْ٤‫حُـشحػ‬ ‫مذ‬ ‫رلؼخُ٤ش‬ ‫ا٣ـخر٤ش‬ ‫حُٜٞحث٤ش‬ٝٝ ّ‫ؿشح‬ ‫عِز٤ش‬‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬ ‫ح٩ٗظخٗخص‬ ٢‫ك‬ ‫حُٔؾظشًش‬ ‫حُ٬ٛٞحث٤ش‬ ْ٤‫حُـشحػ‬ ٖٓ ‫حُؼذ٣ذ‬ٝ‫طل٤ذ‬ ‫ُِز‬ َ‫ًزذحث‬ٖ٤ِ٤‫٘٤غ‬Vٟ‫ُذ‬ ْ٤‫حُـشحػ‬ ٙ‫ٛز‬ ‫اٗظخٗخص‬ ‫ٓؼخُـش‬ ٢‫ك‬ ٖ٤ِ٤‫ح٧ًٓٞغ٤غ‬ ٝ‫أ‬‫ُِلغخع٤ش‬ ‫ع٤شس‬ ‫ٝؿٞد‬ ‫حُز٘٤غ٤ِ٤٘خص‬ ٙ‫طـخ‬. ‫طل٤ذ‬‫حُلٔٞ٣ش‬ ٍٝ٧‫ح‬ َ٤‫حُـ‬ ‫ع٤لخُٞعزٞس٣٘خص‬(ٖ٣‫حُغ٤لشحد‬cephradine،ٖ٤‫حُغ٤لخٌُغ‬cephalexin، َ٤‫حُغ٤لخدسًٝغ‬cefadroxil)َٝ٤‫حُـ‬ ‫ع٤لخُٞعزٞس٣٘خص‬‫حُلٔٞ٣ش‬ ‫حُؼخُغ‬(ُ‫ح‬ْ٤‫غ٤لزٞدًٝغ‬cefpodoxime) َ‫ًزذحث‬ٖ‫ػ‬ ‫حُ٘خطـش‬ ‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬ ‫ح٩ٗظخٗخص‬ ‫ٓؼخُـش‬ ٢‫ك‬ )ٖ٤ِ٤‫(ًخ٧ًٓٞغ٤غ‬ ‫ُِز٘٤غ٤ِ٤٘خص‬‫ٛٞحث٤ش‬ ْ٤‫ؿشحػ‬ ‫حُط٤ق‬ ‫ٝحعغ‬ ١ٞ٤‫ك‬ ‫فخد‬ ‫اػطخء‬ ‫حُلخُش‬ ‫طظطِذ‬ ‫ػ٘ذٓخ‬ )‫حُلخد‬ َُِٜ‫ح‬ ‫(ًخُظٜخد‬َ‫كؼ‬ ‫ُشدٝد‬ ‫ع٤شس‬ ‫ٝؿٞد‬ ‫ٓغ‬ ‫مؼق‬ ٕ‫أ‬ ٫‫ا‬ ،‫حُز٘٤غ٤ِ٤٘خص‬ ٙ‫طـخ‬ ‫ٓظؤخشس‬ ‫طلغغ٤ش‬‫مذ‬ ‫كؼخُ٤ظٜخ‬‫كخثذطٜخ‬ ٖٓ ‫٣لذ‬ ‫حُ٬ٛٞحث٤ش‬ ‫حُلٔٞ٣ش‬ ْ٤‫حُـشحػ‬ ‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬ ‫ح٩ٗظخٗخص‬ ‫ٓؼخُـش‬ ٢‫ك‬‫رؼل‬ ّ‫طغظخذ‬ ‫رُي‬ ‫ٓغ‬ ،)‫حُزسٝس‬ ٍٞ‫ك‬ ‫ٓخ‬ ‫(ًخشحؿخص‬ ٟ‫ح٧خش‬ ُ‫ح‬٢‫ك‬ ٍٝ٧‫ح‬ َ٤‫حُـ‬ ‫غ٤لخُٞعزٞس٣٘خص‬ٝ ،‫حُغ٘خ٤ش‬ ‫حُغ٘٤ش‬ ‫ًخُخشحؿخص‬ ‫حُغ٘٤ش‬ ‫ح٩ٗظخٗخص‬ ‫ٓؼخُـش‬‫كؼخُ٤ظٜخ‬ ٟ‫طؼض‬ ‫حُلخ٫ص‬ ٙ‫ٛز‬ ٢‫ك‬٠ُ‫ا‬‫هظ‬ ٢‫ك‬ ‫دٝسٛخ‬‫ر‬ ّٞ‫طو‬ ٢‫حُظ‬ ‫حُٜٞحث٤ش‬ ْ٤‫حُـشحػ‬ َ‫ب‬ٝ ‫حُٞعو‬ ٖٓ ٖ٤‫ح٧ًٝغـ‬ ‫عظ٘لخر‬‫طغٔق‬ ‫حُ٬ٛٞحث٤ش‬ ْ٤‫حُـشحػ‬ ٞٔ٘‫ر‬. ‫طل٤ذ‬ ٫‫حُِٔظٞ٣خص‬ ٖ‫ػ‬ ‫حُ٘خطـش‬ ‫ح٩ٗظخٗخص‬ ‫ٓؼخُـش‬ ٢‫ك‬ ‫حُغ٤لخُٞعزٞس٣٘خص‬Spirochetesً‫ب‬‫ُظٜخد‬٢‫حُظوشك‬ ‫حُِؼش‬ ‫حُلخد‬ ٢‫حُٔٞحط‬. ‫ػذد‬ ‫٣زِؾ‬‫حُظشحً٤ض‬ ‫حُغ٤لخُٞعزٞس٣٘خص‬ ٖٓ‫رخُـشػخص‬ ‫اػطخثٜخ‬ ‫رؼذ‬ ‫حُؼظٔ٤ش‬ ‫حُ٘غؾ‬ ٢‫ك‬ ‫حُؼ٬ؿ٤ش‬٩‫ح‬‫ػظ٤خد٣ش‬ ٝ ْ‫حُؼظ‬ ‫اٗظخٗخص‬ ٢‫ك‬ ‫ٓل٤ذس‬ ‫ح٧دٝ٣ش‬ ٙ‫ٛز‬ ٌٕٞ‫ٝط‬‫طغززٜخ‬ ٢‫حُظ‬ َ‫حُٔلخف‬،‫حُلغخعش‬ ‫حُذه٤وش‬ ‫حُؼنٞ٣خص‬
  11. 11. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab11 ْ‫حُؼظ‬ ٢‫ك‬ ٙ‫طشً٤ض‬ َ‫٣ق‬ ٍ‫حُٔؼخ‬ َ٤‫عز‬ ٠ِ‫ػ‬ ٖ٤‫كخُغ٤لخُ٤ٌغ‬ٖٓ ‫ُؼذد‬ ١‫ح٧فـش‬ َ‫حُوخط‬ ‫حُظشً٤ض‬ ٠ُ‫ا‬ ٢‫حُغ٘خ‬ ‫حُٜٞحث٤ش‬ ْ٤‫حُـشحػ‬ّ‫ؿشح‬ ‫ا٣ـخر٤ش‬‫حُغ٘٤ش‬ ‫ح٩ٗظخٗخص‬ ٢‫ك‬ ‫حُٔؾظشًش‬. ‫طـذس‬ٖٓ ً‫ش‬‫ًِل‬ ٠ِ‫أػ‬ ً‫خ‬٣ٞٔ‫ك‬ ‫حُلؼخُش‬ ٢ٗ‫حُؼخ‬ َ٤‫حُـ‬ ‫ع٤لخُٞعزٞس٣٘خص‬ ٕ‫أ‬ ٠ُ‫ا‬ ً‫ح‬‫أخ٤ش‬ ‫ح٩ؽخسس‬ٖ٤‫ح٩س٣ؼشٝٓخ٣غ‬ ‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬ ‫ح٩ٗظخٗخص‬ ‫ٓؼخُـش‬ ٢‫ك‬ ً‫س‬‫ػخد‬ ٖ٤ُ‫حُلؼخ‬ ٖ٤‫ٝحٌُِ٤٘ذحٓخ٣غ‬‫حُ٬ٛٞحث٤ش‬. 3 -‫انماكرونيذاخ‬macrolides: ‫٣ق٘ق‬‫ح‬ٖ٤‫٩س٣ؼشٝٓخ٣غ‬erythromycin‫حُٔشطزش‬ ٖٓ ٢‫دٝحث‬ ‫ًخ٤خس‬‫ح٩ٗظخٗخص‬ ‫ٓؼخُـش‬ ٢‫ك‬ ‫حُز٘٤غ٤ِ٤٘خص‬ ‫رؼذ‬ ‫حُؼخٗ٤ش‬ ‫مذ‬ ٍ‫كؼخ‬ ٜٞ‫ك‬ ،‫حُؾخثؼش‬ ‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬‫حُلٔٞ٣ش‬ ‫ُ٪ٗظخٗخص‬ ‫حُٔغززش‬ ّ‫ؿشح‬ ‫ا٣ـخر٤ش‬ ‫حُٜٞحث٤ش‬ ْ٤‫حُـشحػ‬ ‫أؿِذ‬ ٝ ‫حُغ٘٤ش‬ْ٤‫حُـشحػ‬ٝ ،‫حُلٔٞ٣ش‬ ‫حُ٬ٛٞحث٤ش‬٘‫ُِز‬ ً‫خ‬‫ٓ٘خعز‬ ً٬٣‫رذ‬ ‫٣ؼذ‬ٙ‫طـخ‬ ‫كغخع٤ش‬ ‫ٝؿٞد‬ ٟ‫ُذ‬ ٖ٤ِ٤‫٤غ‬‫ح٧خ٤ش‬. ّ‫طغظخذ‬‫فخدحص‬ٖ٤‫حٌُ٬س٣ؼشٝٓخ٣غ‬clarythromycinٖ٤‫ٝح٧ص٣ظشٝٓخ٣غ‬azithromycin‫ح٩ٗظخٗخص‬ ‫ٓؼخُـش‬ ٢‫ك‬ ‫حُلٔٞ٣ش‬‫ًخٗض‬ ٕ‫ٝا‬ ٖ٤‫رخ٩س٣ؼشٝٓخ٣غ‬ ‫حُٔؼخُـش‬ ‫ػ٘ذ‬ ‫ٓؼٞ٣ش‬ ‫ٓؼذ٣ش‬ ‫حمطشحرخص‬ ‫كذٝع‬ ٍ‫كخ‬ ٢‫ك‬ ‫حُغ٘٤ش‬‫ح٧دٝ٣ش‬ ٙ‫ٛز‬ ‫ًِلش‬ ٠ِ‫أػ‬. ّ‫٣غظخذ‬٣‫حُغز٤شحٓخ‬ٖ٤‫غ‬spiramycin‫ح٩ٗظخٗخص‬ ‫ٓؼخُـش‬ ٢‫ك‬ ً‫خ‬‫أ٣ن‬ٝ ‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬‫ا‬ٝ ،‫حُِؼش‬ ‫ُظٜخد‬‫٣ؾخسى‬ ‫ح٩ٗظخٗخص‬ ‫ُٔؼخُـش‬ ٍٝ‫حُٔ٤ظشٝٗ٤ذحص‬ ‫ٓغ‬ ً‫س‬‫ػخد‬ٝ ‫حُٜٞحث٤ش‬ ْ٤‫حُـشحػ‬ ٖ‫ػ‬ ‫حُ٘خطـش‬ ‫حُٔخظِطش‬ ‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬‫حُ٬ٛٞحث٤ش‬. 4 -‫انكهينذامايسين‬clindamycin: ‫٣ؼذ‬ُٔ‫ح‬ ‫ح٧دٝ٣ش‬ ٖٓ ٖ٤‫حٌُِ٤٘ذحٓخ٣غ‬َٔ‫٣ؾ‬ ‫ار‬ ،‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬ ‫ح٩ٗظخٗخص‬ ‫رؼل‬ ‫ُٔؼخُـش‬ ‫٬ثٔش‬‫أؿِذ‬ ٚ‫ه٤ل‬ ٝ ‫حُٜٞحث٤ش‬ ْ٤‫حُـشحػ‬،‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬ ‫ح٩ٗظخٗخص‬ ٢‫ك‬ ‫حُٔقخدكش‬ ‫حُ٬ٛٞحث٤ش‬٢‫ك‬ ‫حُؼخُؼش‬ ‫حُٔشطزش‬ ٖٓ ‫ًخ٤خس‬ ‫٣ق٘ق‬ ٞٛٝ ‫طغززٜخ‬ ٢‫حُظ‬ ‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬ ‫ح٩ٗظخٗخص‬ ‫ٓؼخُـش‬‫حُ٬ٛٞحث٤ش‬ ْ٤‫حُـشحػ‬ ٝ‫أ‬ ّ‫ؿشح‬ ‫ا٣ـخر٤ش‬ ‫حٌُٔٞسحص‬‫عِز٤ش‬ ٝ‫أ‬ ‫ا٣ـخر٤ش‬ ‫حُٔظلغغش‬ ّ‫ؿشح‬ٝ ‫حُٔضٓ٘ش‬ ‫ح٩ٗظخٗخص‬ ‫ػ٬ؽ‬ ٢‫ك‬ ‫ٝ٣ل٤ذ‬ ،‫ُِذٝحء‬‫حُٔغظـ٤زش‬ ‫ؿ٤ش‬ ‫حُ٬ٛٞحث٤ش‬ ‫ح٩ٗظخٗخص‬ ‫ٝحُٔخًشُٝ٤ذحص‬ ‫ُِز٘٤غ٤ِ٤٘خص‬. َ‫٣ق‬‫رظشحً٤ض‬ ٖ٤‫حٌُِ٤٘ذحٓخ٣غ‬‫ر‬ ‫٣غٔق‬ ‫ٓخ‬ ‫ٝٛزح‬ ّ‫حُؼظخ‬ ٠ُ‫ا‬ ‫ػخُ٤ش‬‫ب‬٢‫ك‬ ُٚ‫عظؼٔخ‬‫ا‬ْ‫حُؼظ‬ ‫ُظٜخد‬‫ؿ٤شٛخ‬ ٝ‫أ‬ ٢‫حُو٤ل‬ ٤ٔ‫حُؼظ‬ ‫ح٩ٗظخٗخص‬ ٖٓ‫أٗٞحع‬ َ‫(ٓؼ‬ ‫حُ٬ٛٞحث٤ش‬ ْ٤‫حُـشحػ‬ ‫طغززٜخ‬ ٢‫حُظ‬ ‫ش‬‫حُؼقٞحٗ٤خص‬Bacteroides. ) 5 -‫انتتراسيكهيناخ‬tetracyclines: ‫طق٘ق‬‫حُظظشحع٤ٌِ٤٘خص‬(ٖ٤ٌِ٤‫حُظظشحع‬tetracyclineٖ٤ٌِ٤‫حُٔ٤٘ٞع‬ ،minocyclineٖ٤ٌِ٤‫ع‬ ٢‫حُذًٝغ‬ ، doxycycline)ٖٓ ٢‫دٝحث‬ ‫ًخ٤خس‬ ٍ‫ح٧كٞح‬ ٖ‫رؤكغ‬٢‫ك‬ ‫حُخخٓغش‬ ‫حُٔشطزش‬‫حُلخدس‬ ‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬ ‫ح٩ٗظخٗخص‬ ‫ػ٬ؽ‬ ‫حُز٘٤غ٤ِ٤٘خص‬ ‫رؼذ‬ٝ ،ٖ٤‫ٝحٌُِ٤٘ذحٓخ٣غ‬ ‫ٝحُغ٤لخُٞعزٞس٣٘خص‬ ‫ٝحُٔخًشُٝ٤ذحص‬ٖٓ ‫ؿ٤شٛخ‬ ٠ِ‫ػ‬ َ‫طلن‬ ‫ٌُٜ٘خ‬ ٝ ،‫حُغ٘٤ش‬ ‫حُذحػٔش‬ ‫حُ٘غؾ‬ ‫أٓشحك‬ ‫ٓؼخُـش‬ ٢‫ك‬ ‫حُل٤ٞ٣ش‬ ‫حُقخدحص‬‫طظٞحؿذ‬ ‫أٜٗخ‬ ٠ُ‫ا‬ ‫رُي‬ ‫٣ؼٞد‬٢‫ك‬ ‫ػخُ٤ش‬ ‫رظشحً٤ض‬ ‫حُِؼٞ٣ش‬ َ‫حُغٞحث‬ٝ ،ُ‫ر‬ ‫٣غخػذ‬‫حُٔوخٝٓش‬ ْ٤‫حُـشحػ‬ ٠ِ‫ػ‬ ‫حُونخء‬ ٢‫ك‬ ‫ي‬ٌٖٔ٣ ٢‫حُظ‬ ‫حُظظشحع٤ٌِ٤٘خص‬ ‫ُظشحً٤ض‬ ‫حُز٬عٔخ‬ ٢‫ك‬ ً‫س‬‫ػخد‬ ‫اُ٤ٜخ‬ ٍٞ‫حُٞف‬. ‫طظٔ٤ض‬ّ‫ُِٞس‬ ‫حُٔقخكزش‬ ‫حُٔؾؼؾؼش‬ ْ٤‫ؿشحػ‬ ‫مذ‬ ً‫ح‬‫ؿذ‬ ‫كؼخُش‬ ‫رؤٜٗخ‬ ‫حُظظشحع٤ٌِ٤٘خص‬Actinobacillus actinomycetemocomitans٩ ‫حُٔغززش‬ٝ ٢‫حُؾزخر‬ ‫حُذحػٔش‬ ‫حُ٘غؾ‬ ‫ُظٜخد‬‫أ‬ ٝ‫٣زذ‬‫طٞهق‬ ‫ٜٗخ‬٢ٔ‫حُؼظ‬ ‫حُن٤خع‬ ‫حُٔشك‬ ‫ٓغ‬ ‫حُٔظشحكن‬ ‫حُٔغظٔش‬. ‫طؾ٤ش‬ٝ ٖ٤ٌِ٤‫حُظظشحع‬ ٠ِ‫ػ‬ ‫أؿش٣ض‬ ٢‫حُظ‬ ‫حُذسحعخص‬ٕ‫أ‬ ٠ُ‫ا‬ ٖ٤ٌِ٤‫ع‬ ٢‫حُذًٝغ‬‫ا‬‫حُٔشًزخص‬ ٙ‫ٛز‬ ّ‫عظخذح‬‫٣ؼضص‬ ٝ ‫حُغ٘٤ش‬ ‫حُذحػٔش‬ ‫حُ٘غؾ‬ ْ٤ٓ‫طش‬‫ٌٗظ‬ ٖٓ ٢‫٣و‬‫ا‬ٟ‫ُذ‬ ‫حُغ٘٤ش‬ ‫حُذحػٔش‬ ‫حُ٘غؾ‬ ‫ُظٜخد‬‫حُخطٞسس‬ ١ٝ‫ر‬ ٠‫حُٔشم‬ ٝ ،‫حُؼخُ٤ش‬‫ؿضث‬ ‫ٛزح‬ ٟ‫٣ؼض‬‫حُٔؼزو‬ ‫حُظظشحع٤ٌِ٤٘خص‬ ‫طؤػ٤ش‬ ٠ُ‫ا‬ ً‫خ‬٤ٝ ٢‫حُ٘غ٤ـ‬ ‫ٌُِٞ٫ؿ٤٘خص‬‫حُٔ٤ضحد‬ ٢‫ك‬ ‫٣٬كع‬ ١‫حُز‬ ٠ُ‫ا‬ ‫ح٧دٝ٣ش‬ ٙ‫ٛز‬ ٍٞ‫ٝف‬ ‫ٗظ٤ـش‬ ١ٞ‫حُِؼ‬‫ػخُ٤ش‬ ‫رظشحً٤ض‬ ٢‫حُٔ٤ضحر‬ َ‫حُغخث‬.
  12. 12. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab11 ‫ٓغخٝة‬ ٖٓ‫ا‬ّٞ٤‫ًخُغ‬ ‫ـ‬ ٖ٤ٌِ٤‫طظشحع‬ ‫ٓؼوذ‬ ٌَ‫ُظؾ‬ ّٞ٤‫حٌُخُغ‬ ‫ٓغ‬ ‫طشطزو‬ ‫أٜٗخ‬ ‫حُظظشحع٤ٌِ٤٘خص‬ ّ‫عظخذح‬ ٝ ّ‫حُؼظخ‬ ٢‫ك‬ ‫أٝسػٞكٞعلخص‬‫حُ٘خؽو‬ ‫حُظٌِظ‬ ‫كظشس‬ ٍ٬‫خ‬ ٕ‫ح٧ع٘خ‬ٖ٤ٌِ٤‫حُظظشحع‬ ‫٣ظؤًغذ‬ ‫ك٤غ‬ ،ٝ ‫حُٞهض‬ ‫ٓغ‬ ٌَ‫رؾ‬ ٕ‫ح٧ع٘خ‬ ِٕٞ‫ط‬ ُِٕٞ‫ح‬ ‫ر٘٤ش‬ ‫ٓخدس‬ ٠ُ‫ا‬ ‫ُِنٞء‬ ‫حُظؼشك‬ ‫ٗظ٤ـش‬ْ‫دحث‬. ٌٖٔ٣ُٞٔ٘‫ح‬ ٢‫ك‬ ً‫خ‬‫طؼز٤ط‬ ‫٣لذع‬ ٕ‫أ‬ ٖ٤٘‫حُـ‬ ٟ‫ُذ‬ ٢ٔ‫حُؼظ‬ ٌَ٤ُٜ‫ح‬ ٢‫ك‬ ‫حُظظشحع٤ٌِ٤٘خص‬ ‫ُظٞمغ‬ٝ ،٢ٔ‫حُؼظ‬ٌٖٔ٣ ‫كظ‬ ٍ٬‫خ‬ ‫ػخُ٤ش‬ ‫رـشػخص‬ ‫٩ػطخثٜخ‬ٝ‫أ‬ ‫حُِز٘٤ش‬ ٕ‫ح٧ع٘خ‬ )‫(طٌِظ‬ ‫ططٞس‬ ‫شس‬،‫حُٔ٤٘خء‬ ‫ط٘غؾ‬ ٢‫ك‬ ً‫خ‬‫ٗوق‬ ‫٣لذع‬ ٕ‫أ‬ ‫حُذحثٔش‬ ‫ك٤ٜخ‬ ‫(رٔخ‬ ‫حُ٘خطـش‬ ‫حُٔ٤٘خء‬ ‫ػ٤ٞد‬ ‫ٝطظشحكن‬ٝ ‫حُٞٛذس‬ ‫ػ٤ٞد‬‫ُلذٝع‬ ‫حُلغخع٤ش‬ ‫ص٣خدس‬ ‫ٓغ‬ )ٖ‫حُغ‬ ‫كذرش‬ ‫ػ٤ٞد‬ ‫حُ٘خٞس‬‫رظـ٘ذ‬ ٠‫٣ٞف‬ ‫ُزُي‬ ،ٕٝ‫د‬ ٍ‫ُ٨هلخ‬ ‫حُظظشحع٤ٌِ٤٘خص‬ ‫اػطخء‬8‫(ر‬ ٕ‫ح٧ع٘خ‬ ٕ‫ط٤ـخ‬ ٌٕٞ‫ط‬ ‫ار‬ ‫ع٘ٞحص‬‫ب‬‫عظؼ٘خء‬ ٠‫حُشك‬٠ُٝ٧‫ح‬‫حُؼٔش‬ ‫ٛزح‬ َ‫هز‬ ‫ٓظٌِغش‬ ‫ؿ٤ش‬ ). ‫طـ٘ذ‬ ‫٣ـذ‬‫ا‬ٝ ّ٧‫ح‬ ٟ‫ُذ‬ ‫ًزذ٣ش‬ ‫أر٣ش‬ ‫ططٞس‬ ‫آٌخٗ٤ش‬ ‫رغزذ‬ َٔ‫حُل‬ ٍ٬‫خ‬ ‫حُظظشحع٤ٌِ٤٘خص‬ ّ‫عظخذح‬ًَ‫ٓؾخ‬٢‫ك‬ ٖ٤٘‫حُـ‬ ٟ‫ُذ‬ ٢ٔ‫حُؼظ‬ ‫حُظ٘غؾ‬‫طـ٘ذ‬ ‫٣ـذ‬ ‫ًٔخ‬ ،‫ا‬‫افخرش‬ ‫ٝؿٞد‬ ‫ػ٘ذ‬ ٖ٤ٌِ٤‫حُظظشحع‬ ّ‫عظخذح‬‫٧ٜٗخ‬ ١ٌُِٞ‫ح‬ ‫رخُوقٞس‬ ‫حُل‬ ْ‫طلخه‬ ٠ُ‫ا‬ ١‫طئد‬‫خُش‬. ‫ٓنخدحص‬‫ر‬ ْ٤‫حُـشحػ‬٩‫ح‬ ‫حص‬‫حُخخفش‬ ‫حُغ٘٤ش‬ ‫عظخذحٓخص‬: 1 -‫انميترونيذازول‬metronidazole: ‫مؼق‬ ٕ‫ا‬‫حُٔ٤ظشٝٗ٤ذحص‬ ‫كؼخُ٤ش‬ٖٓ ‫٣لذ‬ ‫حُٜٞحث٤ش‬ ْ٤‫حُـشحػ‬ ‫مذ‬ ٍٝ‫ا‬َ‫ح٧ه‬ ٠ِ‫ػ‬ ‫ٓلشد‬ ٌَ‫رؾ‬ ٚٓ‫عظخذح‬‫أؿِذ‬ ٢‫ك‬ ‫حُغ٘٤ش‬ ‫ح٩ط٘خٗخص‬ٝ ‫حُٔـزشس‬ ‫حُ٬ٛٞحث٤ش‬ ْ٤‫رخُـشحػ‬ ٚ‫كؼخُ٤ظ‬ ‫ه٤ق‬ ‫٣٘لقش‬ ‫ار‬ ،ُٞٛ‫ػ٬ؽ‬ ٢‫ك‬ ّ‫٣غظخذ‬ ‫زُي‬‫ا‬‫ُظٜخد‬ ّ‫حُٔظوذ‬ ‫حُغ٘٤ش‬ ‫حُذحػٔش‬ ‫حُ٘غؾ‬ٝ ،٠ِ‫ػ‬ ‫حُونخء‬ ٢‫ك‬ ‫٣ل٤ذ‬‫حُٜؾش‬ ‫حُؼقٞحٗ٤ش‬ ‫طغززٜخ‬ ٢‫حُظ‬ ‫ح٩ٗظخٗخص‬ Bacteroides fragilisٝ‫طؼشك‬ ‫رؼذ‬ ‫طظٜش‬ ٢‫حُظ‬ٝ ،‫ٌُِغش‬ ٢ِ‫حُغل‬ ‫حُلي‬ ْ‫ػظ‬‫حُِز٤ش‬ ‫ح٩ٗظخٗخص‬ ‫ػ٬ؽ‬ ٢‫ك‬ ٝ‫ا‬٢‫حُظوشك‬ ‫حُِؼش‬ ‫ُظٜخد‬٢‫حُٔٞحط‬. 2 -‫انثنيسيهيناخ‬‫نهثنيسيهيناز‬ ‫انمقاومح‬: ّ‫حعظخذح‬ ‫٣خقـ‬ًٌُِٞ‫ح‬‫غ‬ٖ٤ِ٤‫خع‬cloxacillinًًِِٞٞ‫ٝحُل‬‫غ‬ٖ٤ِ٤‫خع‬flucloxacillin‫حُ٘خؿٔش‬ ‫ح٩ٗظخٗخص‬ ‫ُٔؼخُـش‬ ‫حُزٛز٤ش‬ ‫حُؼ٘وٞد٣ش‬ ‫حٌُٔٞسحص‬ ٖ‫ػ‬staphylococcus aureusٝ ،‫ُِز٘٤غ٤ِ٤٘خص‬ ‫حُٔ٘ظـش‬‫ٗغزش‬ ‫ُنآُش‬ ً‫ح‬‫ٗظش‬ ٌُٖ ْ٤‫حُـشحػ‬ ٖ٤‫ر‬ ْ٤‫حُـشحػ‬ ٙ‫ٛز‬ ‫ٝؿٞد‬ٝ‫حُٔؼض‬ٖٓ َ‫(أه‬ ‫حُغ٘٤ش‬ ‫ُ٪ٗظخٗخص‬ ‫حُٔغززش‬ ‫ُش‬1%٠ُ‫ا‬ ‫كخؿش‬ ٫ ٚٗ‫كب‬ ) ‫ا‬ٍ‫عظؼٔخ‬ًٌُِٞ‫ح‬‫غ‬ًًِِٞٞ‫ٝحُل‬ ٖ٤ِ٤‫خع‬‫غ‬ٕ‫ح٧ع٘خ‬ ‫هذ‬ ٢‫ك‬ ٖ٤ِ٤‫خع‬. 3 -‫انكينىنىناخ‬quinolones: ٖ٤‫ر‬ ُٖٓ‫ح‬ٌٖٔ٣ ‫حٌُ٤ُ٘ٞٞٗ٤ش‬ ‫حُل٤ٞ٣ش‬ ‫قخدحص‬‫ا‬ّ‫عظخذح‬ٖ٤‫حُغ٤زشٝكًِٞغخع‬ciprofloxacinٖ٤‫ٝح٧ٝكًِٞغخع‬ ofloxacin٘‫ح٧ع‬ ‫هذ‬ ٢‫ك‬ٕ‫خ‬. ‫٣ظٔظغ‬‫ر‬ ٖ٤‫حُغ٤زشٝكًِٞغخع‬‫ب‬ٝ ٕ‫ح٧ع٘خ‬ ‫هذ‬ ٢‫ك‬ ‫ٝك٤ذ‬ ٢‫ػ٬ؿ‬ ٍ‫عظؼٔخ‬‫حُلٔٞ٣ش‬ ‫حُٔؼخُـش‬ ٢‫ك‬ ‫رُي‬‫ُ٪ٗظخٗخص‬ ‫حُضٝحثق‬ ْ٤‫ؿشحػ‬ ٖ‫ػ‬ ‫حُ٘خطـش‬ ‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬Pseudomonas،‫ُِذٝحء‬ ‫حُٔظلغغش‬ٌٖٔ٣ ‫رُي‬ ‫ٓغ‬‫ا‬٢‫ك‬ ٚٓ‫عظخذح‬ ٝ ‫حُٜٞحث٤ش‬ ْ٤‫حُـشحػ‬ ٖ‫ػ‬ ‫حُ٘خؿٔش‬ ‫ح٩ٗظخٗخص‬ ‫ٓؼخُـش‬‫حُٔخ٤شس‬ُ‫ح‬َٔ‫طؾ‬ ٢‫ظ‬َ‫٣لن‬ ‫هذ‬ .‫حُلٔٞ٣ش‬ ٠٘‫حُز‬‫ا‬ٍ‫عظؼٔخ‬ ‫ح٩ٗظخٗخص‬ ‫ٓؼخُـش‬ ٢‫ك‬ ٖ٤‫ح٧ٝكًِٞغخع‬‫حُ٬ٛٞحث٤ش‬ ْ٤‫حُـشحػ‬ ‫مذ‬ ‫أٝعغ‬ ٚ‫كؼخُ٤ظ‬ ‫ه٤ق‬ ٕ٧ ً‫ح‬‫ٗظش‬ ‫حُغ٘٤ش‬ ‫حُلٔٞ٣ش‬ ‫حُلٔٞ٣ش‬. ‫ٓ٬كظش‬:‫حُؼخٓش‬ ٝ ‫حُخخفش‬ ‫ح٩عظطزخرخص‬ ٝ ‫حُذٝحث٤ش‬ ‫حُـشػخص‬ ٝ ‫حُظشحً٤ض‬ ٝ ‫ح٧ف٘خف‬ ‫ُٔؼشكش‬ ‫حُٔشكوش‬ ٍٝ‫حُـذح‬ ‫سحؿغ‬ ‫حُظؤػ٤شح‬ ‫ٓغ‬‫حُـخٗز٤ش‬ ‫ص‬
  13. 13. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab12 ‫في‬ ‫انمستخذمح‬ ‫انذيىيح‬ ‫وانصاداخ‬ ‫انشائعح‬ ‫انسنيح‬ ‫انفمىيح‬ ‫االنتاناخ‬‫معانذتها‬ ‫انناجمح‬ ‫اإلنتاناخ‬‫عن‬‫انصاداخ‬‫انذيىيح‬ ‫انخيار‬‫األول‬‫انخياراخ‬‫انثذيهح‬ ‫انممرضح‬‫انعىامم‬‫انشائعح‬‫انفمىيح‬‫داخم‬ ‫خشحؽ‬‫حُزسٝس‬ ٍٞ‫ك‬ ‫ٓخ‬ ٖ٤ِ٤‫حُز٘٤غ‬V(ً‫خ‬٣ٞٔ‫ك‬) ٖ٤ِ٤‫ح٧ًٓٞغ٤غ‬ * ً‫حُٔخ‬‫شُٝ٤ذحص‬ ‫حُغ٤لخُٞعزٞس٣٘خص‬ ٖ٤‫حٌُِ٤٘ذحٓخ٣غ‬ * ٖ٤ِ٤‫ح٧ٓز٤غ‬ ّ‫٣غظخذ‬ ٢‫ك‬ّ‫حعظخذح‬ ‫ٓٞحمغ‬ ٖ٤ِ٤‫ح٧ًٓٞغ٤غ‬ ‫خشحؽ‬ٖ‫حُغ‬ ٍٞ‫ك‬ ‫ٓخ‬ ‫ا‬٢‫حُو٤ل‬ ‫حُِذ‬ ‫ُظٜخد‬‫حُلخد‬ ‫ا‬٢ٔ‫حُغ‬ َُِٜ‫ح‬ ‫ُظٜخد‬ ‫حُظخُ٤ش‬ ٝ‫أ‬ ‫ُِـشحكش‬ ‫حُظخُ٤ش‬ ‫ح٩ٗظخٗخص‬‫ُِشمٞف‬ ‫حٌُز٤شس‬ ‫حُِؼخر٤ش‬ ‫حُـذد‬ ‫اٗظخٗخص‬‫حُٔو٤لش‬ ‫ُٞدٝ٣ؾ‬ ‫ررلش‬Ludwig ‫حُلٔٞ٣ش‬ ٝ‫أ‬ ‫ح٧ٗل٤ش‬ ‫حُلٔٞ٣ش‬ ‫حُ٘ٞحع٤ش‬‫ٓغ‬ ‫حُٔظشحكوش‬ ‫حُـ٤ز٤ش‬‫ا‬‫ُظٜخد‬ ‫حُـ٤ٞد‬ ٠‫حُٔشم‬ ٟ‫ُذ‬ ‫حُٔخخه٤ش‬ ‫ح٧ؿؾ٤ش‬ ‫اٗظخٗخص‬‫هقٞس‬ ٝ‫أ‬ ‫رخُلوخع‬ ٖ٤‫حُٔقخر‬ ‫حُٔن٤ق‬ ٟ‫ُذ‬ ‫حُذكخػ٤ش‬ ‫ح٥ُ٤خص‬ ٢‫ك‬ ‫ا‬‫ٓغ‬ ‫حُٔظشحكن‬ ‫حُظخؽ‬ ٍٞ‫ك‬ ‫ٓخ‬ ‫ُظٜخد‬‫ا‬‫ُظٜخد‬ٝ َُِٜ‫ح‬ٝ ٠ٔ‫ك‬‫طٞػي‬ ‫ا‬٢‫حُو٤ل‬ ْ‫حُؼظ‬ ‫ُظٜخد‬ ‫انذقيقح‬‫انعضىياخ‬‫(انفريذج‬‫اننىعيح‬( ‫ا‬٢‫حُؾزخر‬ ‫حُغ٘٤ش‬ ‫حُذحػٔش‬ ‫ح٧ٗغـش‬ ‫ُظٜخد‬‫حُٔظٞمغ‬ ‫حُظظشحع٤ٌِ٤٘خص‬ ٖ٤ِ٤‫ح٧ًٓٞغ٤غ‬* ‫ٓغ‬ ٍٝ‫حُٔ٤ظشٝٗ٤ذحص‬ ‫ا‬ٖٓ‫حُٔض‬ ‫حُذحػٔش‬ ‫ح٧ٗغـش‬ ‫ُظٜخد‬‫حُٔؼ٘ذ‬ٖ٤ٌِ٤‫ع‬ ٢‫حُذًٝغ‬‫حُظظشحع٤ٌِ٤٘خص‬ٟ‫ح٧خش‬ ‫ٓغ‬ ٍٝ‫حُٔ٤ظشٝٗ٤ذحص‬ ٧‫ح‬ٖ٤ِ٤‫ًٓٞغ٤غ‬* ٝ‫أ‬ٚٗٝ‫رذ‬ ‫ا‬٢‫حُظوشك‬ ‫حُِؼش‬ ‫ُظٜخد‬٢‫حُٔٞحط‬ٖ٤ِ٤‫حُز٘٤غ‬V(ً‫خ‬٣ٞٔ‫ك‬)‫حُٔخًشُٝ٤ذحص‬ ٍٝ‫حُٔ٤ظشٝٗ٤ذحص‬ ٖ٤ِ٤‫ح٧ًٓٞغ٤غ‬* ‫حُظظشحع٤ٌِ٤٘خص‬ ٖ٤ِ٤‫ُِز٘٤غ‬ ‫حُٔوخٝٓش‬ ‫ح٩ٗظخٗخص‬V‫ؿ٤ش‬ ‫ٓخظِطش‬ ْ٤‫ؿشحػ‬ ٖ‫ػ‬ ‫حُ٘خؿٔش‬ ‫ٓ٘ظـش‬‫٫ًظخٓخص‬ ‫ُِز٤ظخ‬ ٖ٤ِ٤‫ح٧ًٓٞغ٤غ‬* ‫حُٔخًشُٝ٤ذحص‬ ٣‫حٌُِ٤٘ذحٓخ‬ٖ٤‫غ‬ ‫حُغ٤لخُٞعزٞس٣٘خص‬ ٖ٤ِ٤‫ُِز٘٤غ‬ ‫حُٔوخٝٓش‬ ٕ‫ح٩ٗظخ‬V‫ٓ٘ظـش‬ ‫ٓخظِطش‬ ْ٤‫ؿشحػ‬ ٖ‫ػ‬ ‫حُ٘خؿٔش‬ ‫ُِز٤ظخ‬‫٫ًظخٓخص‬ ‫ٝكٔل‬ ٖ٤ِ٤‫ح٧ًٓٞغ٤غ‬ ‫حٌُ٬كٞ٫ٗ٤ي‬ ‫حُٔخًشُٝ٤ذحص‬ ٖ٤‫حٌُِ٤٘ذحٓخ٣غ‬ ‫حُ٬ٛٞحث٤ش‬ ْ٤‫حُـشحػ‬ ٖ‫ػ‬ ‫حُ٘خؿٔش‬ ‫ح٩ٗظخٗخص‬ّ‫ؿشح‬ ‫ٝعِز٤ش‬ ‫ا٣ـخر٤ش‬ ٖ٤ِ٤‫حُز٘٤غ‬ ٠ِ‫ػ‬ ‫حُٔؼ٘ذس‬ ‫حٌُِ٤٘ذحٓخ‬ٖ٤‫٣غ‬‫حُغ٤لخُٞعزٞس٣٘خص‬َ٤‫(حُـ‬٢ٗ‫حُؼخ‬( ٖ٤‫حٌُ٬س٣ؼشٝٓخ٣غ‬ ٍٝ‫حُٔ٤ظشٝٗ٤ذحص‬ ‫حُظظشحع٤ٌِ٤٘خص‬
  14. 14. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab13 ‫حُلٔٞ٣ش‬ ‫حُلطش٣ش‬ ‫ح٩ٗظخٗخص‬ ‫ٓنخدحص‬ ‫دحء‬ ‫٣ؼذ‬‫حُٔز٤نخص‬candidiasisً‫خ‬‫ؽ٤ٞػ‬ ‫حُلٔٞ٣ش‬ ‫حُلطش٣ش‬ ‫ح٩ٗظخٗخص‬ ‫أٗٔخه‬ ‫أًؼش‬ٝ ،‫ُٔؼخُـش‬ ‫طظٞكش‬‫أدٝ٣ش‬ ‫حُلخُش‬ ٙ‫ٛز‬ ‫ػ‬ ‫رٜخ‬ ‫حُٔؼخُـش‬ ‫طٔظذ‬ ‫ٓخظِلش‬ٖ٤‫أعزٞػ‬ ‫ٓذس‬ ً‫س‬‫خد‬. ٌٕٞ٣‫انكهىتريمازول‬clotrimazole٢‫ك‬ ً‫ح‬‫ؿذ‬ ً٫‫كؼخ‬ ‫ٓـ‬ ‫كزٞد‬ ٌَ‫رؾ‬ ّ‫حُٔوذ‬‫حُٔز٤نخص‬ ‫دحء‬ ‫كخ٫ص‬ ‫أؿِذ‬ ٝ ،١ٞٔ‫حُل‬ٚ‫رِؼ‬ ‫ػ٘ذ‬ ‫٣غزذ‬ ‫هذ‬ ٌُٖ‫ا‬‫حُظشحً٤ض‬ ٢‫ك‬ ً‫خ‬‫سطلخػ‬ٝ ‫حٌُزذ٣ش‬ ‫ُ٨ٗض٣ٔخص‬ ‫حُز٬عٔ٤ش‬‫كخ٫ص‬ ٢‫ك‬ ‫٣لذع‬ ‫هذ‬ ‫ٗخدسس‬‫ا‬ً‫خ‬٣‫ًزذ‬ ً‫خ‬‫ُظٜخر‬َ‫٣لن‬ ‫ُزح‬ ،‫أ‬ ‫ٓـ‬ ‫كزٞد‬ ‫اػطخء‬ٖٓ ‫كٔٞ٣ش‬ ‫ؿغٞ٫ص‬ ٝ‫اننيستاتين‬nystatinٕ‫ًخ‬ ‫ارح‬ ‫ًزذ٣ش‬ ‫عٔ٤ش‬ ‫ُلذٝع‬ ‫ًز٤ش‬ ‫خطش‬ ٚ٣‫ُذ‬ ٝ‫أ‬ ١‫ًزذ‬ ‫ٓشك‬ ٖٓ ٢ٗ‫٣ؼخ‬ ‫حُٔش٣ل‬. ٢‫ك‬‫ح٩٣ذص‬ ٠‫ٓشم‬ ٟ‫ُذ‬ ٍ‫حُلخ‬ ٞٛ ‫ًٔخ‬ ‫حُقؼزش‬ ‫حُلخ٫ص‬ ٝ‫أ‬ ‫حُٔز٤نخص‬ ‫دحء‬ ٖٓ ‫حُٔ٘ظؾشس‬ ‫حُلخ٫ص‬ْ٣‫طوذ‬ ٌٖٔ٣ ٝ ،‫ُِلطٞس‬ ‫ٓنخدس‬ ‫ؿٜخص٣ش‬ ‫ٓؼخُـش‬‫حُلخُش‬ ٙ‫ٛز‬ ٢‫ك‬ ٠‫٣ؼط‬‫انكيتىك‬‫ىنازول‬ketoconazole‫رـشػش‬ ً‫خ‬٣ٞٔ‫ك‬200 ٝ ّٞ٣/‫ِٓؾ‬ٖ٤‫حُ٘٤غظخط‬ ‫ٓغ‬ ٚ‫ٓؾخسًظ‬ ٌٖٔ٣ٝ ،‫ح٧ٓش‬ ّ‫ُض‬ ‫ارح‬ ٢‫حُٔٞمؼ‬،‫ًزذ٣ش‬ ‫عٔ٤ش‬ ‫رلذٝع‬ ‫٣ظغزذ‬ ‫هذ‬ ٌُٚ٘ ‫٣ل٤ذ‬ ‫ٝهذ‬‫انفهىكىنازول‬fluconazole‫رـشػش‬ ً‫خ‬٣ٞٔ‫ك‬ ّ‫حُٔوذ‬100‫ـ‬200٢‫ك‬ ّٞ٣/‫ِٓؾ‬‫حُٔز٤نخص‬ ‫دحء‬ ‫ٓؼخُـش‬ ٝ ١ٞٔ‫حُل‬٣‫ًزذ‬ ‫ػ٤ٞد‬ ‫كذٝع‬ ‫خطش‬ ٌٕٞ٣‫ػ٘ذ‬ ٚ٘ٓ َ‫أه‬ ٚ‫ر‬ ‫حُٔؼخُـش‬ ‫ػ٘ذ‬ ‫ش‬ٝ ،ٍٝ‫رخٌُ٤ظًٞٞٗخص‬ ‫حُٔؼخُـش‬ٕ‫ًخ‬ ‫ارح‬ ٌٕٞ٣ ‫ح٧دٝ٣ش‬ ٙ‫رٜز‬ ‫ُِٔؼخُـش‬ ً‫خ‬ٓٝ‫ٓوخ‬ ٕ‫ح٩ٗظخ‬‫اإليتراكىنازول‬itraconazole‫رـشػش‬200ً‫خ‬‫ٓ٘خعز‬ ً٬٣‫رذ‬ ّٞ٣/‫ِٓؾ‬. (‫سحؿغ‬ٍٝ‫ؿذح‬‫حُلطٞس‬ ‫ٓنخدحص‬) ٖٓٝ ،‫حُٔ٘زغو‬ ‫حُلضحص‬ ‫ٓغ‬ ‫حُلٔٞ٣ش‬ ‫حُٔز٤نخص‬ ‫دحء‬ ‫ظٜٞس‬ ‫حُؾخثغ‬٣‫حُلخ٫ص‬ ٙ‫ٛز‬ َ‫ٓؼ‬ ٢‫ك‬ ‫طزن‬ٓ ١‫كطش‬ ‫ٓنخد‬‫غ‬ ً‫خ‬٤‫ٓٞمؼ‬ ١‫عظ٤شٝث٤ذ‬ ‫ٓشًذ‬‫ٝهذ‬ ،‫ا‬‫عظ٤شٝث٤ذ‬ ‫ٓغ‬ ٍٝ‫حٌُِٞطش٣ٔخص‬ ‫اػطخء‬ ‫هظشف‬‫رخُلضحص‬ ٖ٤‫حُٔقخر‬ ٠‫ُِٔشم‬ ٢‫ٓٞمؼ‬ ‫حُٔز٤نخص‬ ‫دحء‬ ٖٓ ‫ُِٞهخ٣ش‬ ١ٞٔ‫حُل‬ ‫حُٔ٘زغو‬. ،ً‫ح‬‫أخ٤ش‬‫حُٔز٤نخص‬ ‫دحء‬ ٢‫ك‬ ‫ػ٬ؿ٤ش‬ ‫كٞحثذ‬ ً‫خ‬‫أ٣ن‬ ‫حُلٔٞ٣ش‬ ٖ٣‫حٌُِٞسٛ٤ٌض٣ذ‬ ‫ُـغٞ٫ص‬ ٌٕٞ٣ ‫هذ‬‫ح‬١ٞٔ‫ُل‬. ‫اننيستاتين‬nystatin:٢‫حُٔٞمؼ‬ ٖ٤‫حُ٘٤غظخط‬ ‫٣ؼذ‬٢‫ك‬ ‫حُٔز٤نخص‬ ‫اٗظخٗخص‬ ‫ُٔؼخُـش‬ ‫حُٔغظخذٓش‬ ‫ح٧دٝ٣ش‬ ‫أًؼش‬ ‫حُطٞه٤خص‬ ‫(دحء‬ ١ٞٔ‫حُل‬ ‫حُظـٞ٣ق‬،‫حُغ٬م‬ ،١ٞٔ‫حُل‬ ‫حُز٤ل‬‫ا‬ٕ‫ح٧ع٘خ‬ ‫رذ٫ص‬ ٖ‫ػ‬ ‫حُ٘خطؾ‬ ْ‫حُل‬ ‫ُظٜخد‬ٝ ،)ّ‫٣غظخذ‬ ٟ‫ُذ‬ ‫ُِٞهخ٣ش‬‫حُٔ٘خػش‬ ٢‫ٓ٘وٞف‬ ٠‫حُٔشم‬. ٔ‫ط‬ ٠ِ‫ػ‬ ‫حُٔلخكظش‬ ‫٣ـذ‬‫حُٔقخرش‬ ْ‫حُل‬ ‫ؿٞحٗذ‬ ٠ِ‫ػ‬ ٖ٤‫حُ٘٤غظخط‬ ‫خط‬‫ُٔذس‬5‫حُٔغظلنش‬ ‫رِغ‬ َ‫هز‬ ‫دهخثن‬ ٝ٩‫ح‬‫ُٔذس‬ ‫رخُٔؼخُـش‬ ‫عظٔشحس‬10٠ُ‫ا‬ ٝ‫أ‬ َ‫ح٧ه‬ ٠ِ‫ػ‬ ّ‫أ٣خ‬‫رؼذ‬ ‫ٓخ‬‫ا‬‫رـ‬ ‫حُغش٣ش٣ش‬ ‫ح٧ػشحك‬ ‫خظلخء‬48‫عخػش‬. ‫انكهىتريمازول‬clotrimazole:ٝ ً٫‫كؼخ‬ ً٬٣‫رذ‬ ‫٣ؼذ‬‫أًؼش‬‫ا‬‫ُٔؼخُـش‬ ً‫خ‬٤‫ٓٞمؼ‬ ‫٣طزن‬ ،ٖ٤‫حُ٘٤غظخط‬ ٖٓ ‫عظغخؿش‬‫دحء‬ ٌَ‫رؾ‬ ٢ٓٞ‫حُزِؼ‬ ١ٞٔ‫حُل‬ ‫حُٔز٤نخص‬‫ٓـ‬ ‫أهشحؿ‬‫ر‬ ‫حُزط٢ء‬ َ‫حُل‬ ‫٣غٔق‬ ‫ار‬ ،‫ب‬‫حُلٔٞ٣ش‬ ‫رخُٔخخه٤ش‬ ‫حُذٝحء‬ ‫سطزخه‬ ٌَ‫رؾ‬ ‫ٜٓ٘خ‬ ‫ُ٤ظلشس‬ٝ ٢‫طذس٣ـ‬‫ٓؼخُـش‬ ٢‫ك‬ ‫حُٔخظخس‬ ‫حُذٝحء‬ ٍٝ‫حٌُِٞطش٣ٔخص‬ ‫٣ؼذ‬ .‫ُِلطٞس‬ ‫حُٔنخدس‬ ٚ‫كؼخُ٤ظ‬ ‫٣ٔخسط‬ ‫ح٩٣ذص‬ ٠‫ٓشم‬ ٟ‫ُذ‬ ‫حُٔز٤نخص‬ ‫دحء‬. ‫انميكىنازول‬miconazole:‫ح‬ ٖٓ‫ػ٬ؽ‬ ٢‫ك‬ ‫حُلؼخُش‬ ‫٧دٝ٣ش‬،٢‫حُٔٞمؼ‬ ‫رخُظطز٤ن‬ ‫حُلٔٞ٣ش‬ ‫حُلطش٣ش‬ ‫ح٩ٗظخٗخص‬ ‫رخُظذُ٤ي‬ ‫حُٔٞمؼ٤ش‬ ٚ‫ٓغظلنشحط‬ ّ‫ٝطغظخذ‬‫حُٔ٘طوش‬ ‫ٓغ‬ ‫طٔخط‬ ٠ِ‫ػ‬ ‫ربروخثٜخ‬ ٝ‫أ‬ ‫حُٔقخرش‬ ‫حُٔ٘طوش‬ ٠ِ‫ػ‬ ‫حُِط٤ق‬ ‫كظشس‬ ٍٞ‫أه‬ ‫حُٔقخرش‬ٝ ،‫ٌٓٔ٘ش‬٪ُ َ‫هخر‬ ٖ٤‫حُ٘٤غظخط‬ ‫خ٬ف‬ ٠ِ‫ػ‬ ٞٛ٩‫ح‬ ٢‫٣غظذػ‬ ١‫حُز‬ ‫ح٧ٓش‬ ‫ٓظقخؿ‬٠ُ‫ا‬ ٙ‫ٗظزخ‬ ‫دٝحث٤ش‬ ‫طذحخ٬ص‬ ‫كذٝع‬ ‫آٌخٗ٤ش‬) ‫حُذٝحث٤ش‬ ‫حُظذحخ٬ص‬ ‫سحؿغ‬ (‫ُٔذس‬ ّ‫ح٫عظخذح‬ ‫ػ٘ذ‬ ً٫‫اعٜخ‬ ‫حُذٝحء‬ ‫٣غزذ‬ ‫هذ‬ . ‫هٞ٣ِش‬.
  15. 15. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab14 ٩‫ح‬ ‫ٓنخدحص‬‫ُظٜخد‬‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ٩‫ح‬ ‫ٓنخدحص‬ ‫طظٔ٤ض‬ٟ‫ُذ‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬‫ا‬‫عظخذحٜٓخ‬‫ٓؾخرٜش‬ ُْ٨ُ ‫ٓغٌ٘ش‬ ‫رلؼخُ٤ش‬ ‫ٓلشدس‬ ‫رـشػخص‬ ‫حُزخسح‬ ‫ُلؼخُ٤ش‬‫ؿشػخطٜخ‬ ‫أٓخ‬ ،ٍٞٓ‫ع٤ظخ‬‫حُٔغٌ٘ش‬ ‫طؤػ٤شحطٜخ‬ ‫ؿخٗذ‬ ٠ُ‫ا‬ ‫كظِٔي‬ ‫حُٔ٘ظظٔش‬ ‫حٌُخِٓش‬‫ٓنخدس‬ ‫كؼخُ٤ش‬ ٪ُٝ ‫ُظٜخد‬‫ٓخ‬ ‫ٛزح‬‫طذر‬ ٢‫ك‬ ً‫خ‬٤‫ػ٬ؿ‬ ً‫ح‬‫خ٤خس‬ ‫ٜٓ٘خ‬ َ‫٣ـؼ‬٩‫ح‬ ‫ٓغ‬ ‫حُٔظشحكن‬ ‫حُٔغظٔش‬ ُْ٧‫ح‬ ‫٤ش‬ٝ ،‫ُظٜخد‬‫أًؼش‬ٖٓ ً‫ش‬٤ُ‫كؼخ‬ ‫حُٔلقِ٤ش‬ ‫ح٫ُظٜخرخص‬ ‫ػ٬ؽ‬ ٢‫ك‬ ‫ح٧ك٤ٞٗ٤ش‬ ‫حُٔغٌ٘خص‬ ٝ‫أ‬ ٍٞٓ‫حُزخسحع٤ظخ‬‫(ا‬ٝ )٢ٗ‫حُشػ٤خ‬ َ‫حُٔلخف‬ ‫ُظٜخد‬‫كخ٫ص‬ ‫رؼل‬ ٍٞٓ‫حُزخسحع٤ظخ‬ ٕ‫أ‬ ‫(ٓغ‬ ‫حُٔظوذٓش‬ ٢ٔ‫حُؼظ‬ ٍ‫حُلقخ‬٣٩‫ح‬ ٢‫ك‬ ُْ٧‫ح‬ ٠ِ‫ػ‬ ‫ًخك٤ش‬ ‫ع٤طشس‬ ٖٓ‫ئ‬‫حُؼظٔ٤ش‬ ‫ُظٜخرخص‬ ٝ ،)‫حُٔلقِ٤ش‬ٙ‫ٛز‬ ‫طل٤ذ‬ ‫هذ‬ُٔ‫ح‬ٝ ‫حُظٜش٣ش‬ ّ٫٥‫ح‬ ‫طخل٤ق‬ ٢‫ك‬ ‫شًزخص‬‫ا‬‫حُشخٞس‬ ‫حُ٘غؾ‬ ‫مطشحرخص‬. ‫ا‬٩‫ح‬ ‫ٓنخد‬ ‫خظ٤خس‬١‫حُغظ٤شٝث٤ذ‬ ‫ؿ٤ش‬ ‫ُظٜخد‬: ٫‫٣ٞؿذ‬‫ا‬٬‫خظ‬٩‫ح‬ ‫ٓنخدحص‬ ‫أكشحد‬ ٖ٤‫ر‬ ‫ؿٞٛش٣ش‬ ‫كخص‬ٝ ،‫حُلؼخُ٤ش‬ ‫ك٤غ‬ ٖٓ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬ٌُٖ‫ٛ٘خى‬ ‫ا‬ٝ َٔ‫حُظل‬ ‫دسؿخص‬ ٢‫ك‬ ‫ٛخٓش‬ ‫خظ٬كخص‬٩‫ح‬‫حُلشد٣ش‬ ‫عظـخرش‬. ْ‫٣ظ‬‫حُٔؼخُـش‬ ٖٓ ‫أعزٞع‬ ٍ٬‫خ‬ ُْ٨ُ ‫حُٔغٌ٘ش‬ ‫حُظؤػ٤شحص‬ َٓ‫ًخ‬ ٠ِ‫ػ‬ ٍٞ‫حُلق‬‫طظطِذ‬ ‫ر٤٘ٔخ‬ ،ٛ‫حُٔظخ‬ ‫ٓ٬كظش‬‫ش‬ ٤‫ُِظؤػ‬ ‫حُغش٣ش٣ش‬٪ُ ‫حُٔنخدس‬ ‫شحص‬٢ُ‫كٞح‬ ‫ُظٜخد‬3ٝ ،‫أعخر٤غ‬ْ‫٣ظ‬ ُْ ‫ارح‬٩‫ح‬ ٠ِ‫ػ‬ ٍٞ‫حُلق‬‫خ‬ ‫حُٔطِٞرش‬ ‫عظـخرخص‬ٍ٬ ٩‫ح‬ ‫ٓنخد‬ ‫طـ٤٤ش‬ ‫٣ـذ‬ ‫حُٔذس‬ ٙ‫ٛز‬‫ؿ٤ش‬ ‫ُظٜخد‬١‫حُغظ٤شٝث٤ذ‬. ٖٔ‫طظن‬٩‫ح‬٩‫ح‬ ‫ٓنخدحص‬ ٖ٤‫ر‬ ‫حُشث٤غ٤ش‬ ‫خظ٬كخص‬‫حُـخٗز٤ش‬ ‫ح٥ػخس‬ ‫ٗٔو‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬‫حُذٝحء‬ ‫٣غززٜخ‬ ٢‫حُظ‬ ٝ ،‫كذٝػٜخ‬ ‫ٝطٞحطش‬ٖ٤‫ر‬ ‫حُٔٞحصٗش‬ ٠ِ‫ػ‬ ً‫ء‬‫ر٘خ‬ ً‫س‬‫ػخد‬ ‫حُذٝحء‬ ‫ٝفق‬ ْ‫٣ظ‬ٝ ٚ‫كؼخُ٤ظ‬‫حُٔلظِٔش‬ ‫حُـخٗز٤ش‬ ٙ‫آػخس‬. ‫طخظِق‬٩‫ح‬ ‫ٓنخدحص‬ُ٢‫ك‬ ً‫خ‬‫أ٣ن‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ظٜخد‬‫ا‬‫٧ٗض٣ٔخص‬ ‫حُٔؼزو‬ ‫طؤػ٤شٛخ‬ ‫ٗظوخث٤ش‬‫حُغ٤ٌِٞأًٝغ٤ـ٤٘خص‬ cyclo-oxygenaseٝ ،‫ط‬٩‫ح‬ ‫حُٔؼزطخص‬ ٕ‫أ‬ ٠ُ‫ا‬ ‫حُذسحعخص‬ ‫ؾ٤ش‬‫ٗظوخث٤ش‬‫ُِغ٤ٌِٞأًٝغ٤ـ٤٘خصـ‬2(cox-2)‫طظٔظغ‬ َ‫أكن‬ ١ٞ‫ٓؼ‬ ١‫ٓؼذ‬ َٔ‫رظل‬. ‫انثروتيىنيك‬ ‫دمض‬ ‫مشتقاخ‬: ٖ‫ح٩٣زٞرشٝك‬ibuprofen:‫ٓغٌ٘ش‬ ‫خٞحؿ‬ ٖ‫ح٩٣زٞرشٝك‬ ‫٣ِٔي‬ٝ ُْ٨ُ٪ُ ‫ٓنخدس‬ٝ ‫ُظٜخد‬ٝ ،‫ُِلشحسس‬ ‫خخكنش‬‫٣ظٔ٤ض‬ ٖ‫ػ‬ ‫حُ٘خطـش‬ ‫حُـخٗز٤ش‬ ‫ح٥ػخس‬ ٕ‫رؤ‬‫ا‬‫ع‬٩‫ح‬ ‫ٓنخدحص‬ ٖٓ ٙ‫ؿ٤ش‬ ٖٓ َ‫أه‬ ُٚ‫ظؼٔخ‬٫‫ا‬ ،‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬ٙ‫طؤػ٤ش‬ ٕ‫أ‬ ‫حُٔنخد‬٪ُ‫أمؼق‬ ‫ُظٜخد‬ٝ ،ْ‫ٓ٬ث‬ ‫ؿ٤ش‬ ‫٣ؼذ‬٩‫ح‬ ‫ك٤ٜخ‬ ٌٕٞ٣ ٢‫حُظ‬ ‫حُلخ٫ص‬ ‫ُؼ٬ؽ‬ً‫خ‬‫ٝحمل‬ ‫ُظٜخد‬ٝ٢‫ك‬ ‫ًٔخ‬ ً‫ح‬‫ٓغ٤طش‬ ‫حُلخد‬ ‫حُ٘وشط‬. ٖ٤‫حُ٘خرشًٝغ‬naproxen:‫حُؼ٬ؿ٤ش‬ ‫حُخ٤خسحص‬ ٖٔ‫م‬ ‫٣ق٘ق‬٩‫ح‬ ‫طخل٤ق‬ ٢‫ك‬ ٠ُٝ٧‫ح‬٪ُ ‫حُٔشحكوش‬ ‫ُظٜخرخص‬‫مطشرخص‬ ٝ ‫حُٔلقِ٤ش‬ٚٗ٧ ‫حُٜ٤ٌِ٤ش‬ ‫حُؼنِ٤ش‬ٔ‫٣ظ‬ٝ ‫ؿ٤ذس‬ ‫رلؼخُ٤ش‬ ‫ظغ‬‫حُـخٗز٤ش‬ ‫ُ٦ػخس‬ ‫ٓ٘خلنش‬ ‫كٞحدع‬ ‫ر٘غزش‬. ٖ‫حٌُ٤ظٞرشٝك‬ketoprofen:‫حُخٞحؿ‬ ٢‫ك‬ ٖ‫ح٩٣زٞرشٝك‬ َ‫٣ٔخػ‬٪ُ ‫حُٔنخدس‬‫ؿخٗز٤ش‬ ‫رآػخس‬ ‫٣ظشحكن‬ ُٚ‫حعظؼٔخ‬ ٕ‫أ‬ ٫‫ا‬ ‫ُظٜخد‬ ‫أًؼش‬. ‫حُظ٤خرشٝك٤٘٤ي‬ ‫كٔل‬tiaprofenic acid:(Surgam)ٚ‫كؼخُ٤ظ‬ َ‫طٔخػ‬ٖ٤‫حُ٘خرشًٝغ‬ ‫كؼخُ٤ش‬ٝ ،‫آ‬ ‫طلٞم‬‫حُـخٗز٤ش‬ ٙ‫ػخس‬ ٖ‫ح٩٣زٞرشٝك‬ ٍ‫حعظؼٔخ‬ ‫طشحكن‬ ٢‫حُظ‬ ‫طِي‬(‫ؽذ٣ذ‬ ‫ٓؼخٗش‬ ‫حُظٜخد‬ ‫كذٝع‬ ٖ‫ػ‬ ‫طوخس٣ش‬ ‫عـِض‬. )
  16. 16. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab15 . ‫حُلخدس‬ ‫حُٞرٓخص‬ ٢‫ك‬ ‫ػِ٤ٜخ‬ ‫ح٩ػظٔخد‬ ٌٖٔ٣ ‫ُِٞرٓش‬ ‫ٓنخدس‬ ‫خٞحؿ‬ ‫حُظ٤خرشٝك٤٘٤ي‬ ‫كٔل‬ ‫٣ٔظِي‬ ٖ‫حُلِٞسر٤زشٝك‬flurbiprofen:‫ٓضح٣خ‬ ١‫رؤ‬ ‫حُذٝحء‬ ‫٣ظٔظغ‬ ٫،ٖ‫رخ٩٣زٞرشٝك‬ ً‫ش‬ٗ‫ٓوخس‬ ‫امخك٤ش‬ٖٓ ٚ٤ِ‫ػ‬ ‫٣ظلٞم‬ ٚٗ‫أ‬ ‫ؿ٤ش‬ ‫كؼخُ٤ش‬ ٕ‫ا‬ ‫ار‬ ،‫حُلؼخُ٤ش‬ ‫ك٤غ‬50‫ـ‬100‫كؼخُ٤ش‬ ٍ‫طؼخد‬ ٖ‫حُلِٞسر٤زشٝك‬ ٖٓ ‫ِٓؾ‬400ٖٓ ‫ِٓؾ‬ٖ‫ح٩٣زٞرشٝك‬. ‫دمض‬ ‫نمشتقاخ‬ ‫انمشاتهح‬ ‫انخىاص‬ ‫راخ‬ ‫األدويح‬‫انثروتيىنيك‬: ‫حُذ٣ٌِٞك٤٘خى‬diclofenac:ٝ ٙ‫طؤػ٤ش‬ ٢‫ك‬ َ‫٣ٔخػ‬ٙ‫آػخس‬ٖ٤‫حُ٘خرشًٝغ‬ ‫حُـخٗز٤ش‬. ٖ٤‫ح٧ٗذٝٓ٤ظخع‬indomethacin:‫٣لٞم‬ ٝ‫أ‬ ٍ‫٣ؼخد‬ ٙ‫طؤػ٤ش‬ٝ ،ٖ٤‫حُ٘خرشًٝغ‬ ‫طؤػ٤ش‬‫٣ظشحكن‬‫ا‬٠ِ‫أػ‬ ‫رلٞحدع‬ ٚٓ‫عظخذح‬ ،‫ًخُقذحع‬ ‫حُـخٗز٤ش‬ ‫ُ٦ػخس‬ٝٝ ،‫حُذٝحس‬٫‫ح‬‫ا‬‫حُٔؼٞ٣ش‬ ‫حُٔؼذ٣ش‬ ‫مطشحرخص‬. ‫حٌُ٤ظٞسٝ٫ى‬ketorolac:‫ح٧ٓذ‬ ‫هق٤ش‬ ‫حُظذر٤ش‬ ٢‫ك‬ ّ‫٣غظخذ‬.‫ُِـشحكش‬ ٢ُ‫حُظخ‬ ‫حُٔظٞعو‬ ٠ُ‫ا‬ ‫حُخل٤ق‬ ُْ٨ُ ٕٝ‫رٞطخص‬ َ٤٘‫حُل‬phenylbutazone:ٚ‫كؼخُ٤ظ‬ ٖٓ ْ‫حُشؿ‬ ٠ِ‫ػ‬ٕ‫كب‬‫ا‬ً‫ح‬‫ٗظش‬ ٢‫حُٔؾخك‬ ٠ِ‫ػ‬ ً‫خ‬٤ُ‫كخ‬ ‫٣وظقش‬ ُٚ‫عظؼٔخ‬ ٕ‫أ‬ ٌٖٔ٣ ٢‫حُظ‬ ‫حُخط٤شس‬ ‫حُـخٗز٤ش‬ ‫ُ٦ػخس‬ٝ‫حُذ‬ َٔ‫٣غظؼ‬ .‫٣غززٜخ‬‫ُٔؼخُـش‬ ‫حء‬‫ا‬ٝ ،٢ٗ‫حُشػ٤خ‬ ‫حُلوخس‬ ‫ُظٜخد‬ٖٓ ٌٕٞ٣ ‫هذ‬ ١‫حُنشٝس‬‫ا‬ٝ ،‫هٞ٣ِش‬ ‫ُلظشس‬ ُٚ‫عظؼٔخ‬٠ُ‫ا‬ ‫٣ِـؤ‬ ٫ ٌُٖ‫ا‬‫كؾ‬ ٍ‫كخ‬ ٢‫ك‬ ٫‫ا‬ ٚٓ‫عظخذح‬‫ح٧دٝ٣ش‬ ‫ؿٔ٤غ‬ َٟ‫ح٧خش‬. ‫حُغُٞ٤٘ذحى‬sulindac:‫ك٤غ‬ ٖٓ ٖ٤‫حُ٘خرشًٝغ‬ ٚ‫٣ؾخر‬َٔ‫حُظل‬. ّ‫حُٔ٤ًِٞغ٤ٌخ‬meloxicam:‫حُٔؼخُـش‬ ٢‫ك‬ ّ‫حُٔ٤ًِٞغ٤ٌخ‬ َ‫أدخ‬ٝ ٢ٔ‫حُؼظ‬ ٍ‫ُِلقخ‬ ‫ح٧ٓذ‬ ‫هق٤شس‬‫حُٔؼخُـش‬ ٩ ‫ح٧ٓذ‬ ‫هٞ٣ِش‬ٝ ،٢ٗ‫حُشػ٤خ‬ َ‫حُٔلخف‬ ‫ُظٜخد‬ٞٛ‫ٓؼزو‬‫ا‬ْ٣‫٧ٗض‬ ٢‫ٗظوخث‬cox-2. ّ‫حُز٤شًٝغ٤ٌخ‬piroxicam:‫ُلؼخُ٤ش‬ ‫ٓؾخرٜش‬ ‫رلؼخُ٤ش‬ ‫٣ظٔظغ‬ٝ ،ٖ٤‫حُ٘خرشًٝغ‬‫حُطٞ٣ِش‬ ٙ‫طؤػ٤ش‬ ‫كظشس‬ ‫طغٔق‬ ‫ر‬‫ب‬‫كوو‬ ‫ٝحكذس‬ ‫٣ٞٓ٤ش‬ ‫رـشػش‬ ٚٓ‫عظخذح‬ٕ‫أ‬ ٫‫ا‬ ،‫حُٔؼذ٣ش‬ ‫حُـخٗز٤ش‬ ‫حُلٞحدع‬ ‫ٗغذ‬ٖ‫ػ‬ ‫حُ٘خطـش‬ ‫حُٔؼٞ٣ش‬‫ا‬ّ‫عظخذح‬ ‫حُ٘غذ‬ ‫طلٞم‬ ‫حُذٝحء‬ٖ‫ػ‬ ‫حُ٘خطـش‬‫ا‬ٖ٤٘‫حُٔغ‬ ٠‫حُٔشم‬ ٟ‫ُذ‬ ً‫ش‬‫خخف‬ ٖ‫ح٩٣زٞرشٝك‬ ٍ‫عظؼٔخ‬. ٤‫حُظ٤ً٘ٞغ‬ّ‫ٌخ‬tenoxicam:ٝ ٚ‫كؼخُ٤ظ‬ ٢‫ك‬ ٚ‫٣ؾخر‬ِٚٔ‫طل‬ٝ ،ٖ٤‫حُ٘خرشًٝغ‬َ٣ٞ‫حُط‬ ٙ‫ػٔش‬ ‫ٗقق‬ ‫٣غٔق‬ ‫ر‬‫ب‬ّٞ٤ُ‫ح‬ ٢‫ك‬ ‫كوو‬ ‫ٝحكذس‬ ‫ٓشس‬ ٚٓ‫عظخذح‬. ‫حُشٝك٤ًٌٞغ٤ذ‬rofecoxib‫ٝحُغ٤ِ٤ًٌٞغ٤ذ‬celecoxib:ٖٓ٩‫ح‬ ‫حُٔؼزطخص‬ْ٣‫٧ٗض‬ ‫ٗظوخث٤ش‬cox-2ٝ ،ٕ‫٣ظٔظؼخ‬ ،‫حُذ٣ٌِٞك٤٘خى‬ ‫ُلؼخُ٤ش‬ ‫ٓؾخرٜش‬ ‫رلؼخُ٤ش‬ٝ‫ر‬ ‫ٓغ‬ ٕ‫٣ؾظشًخ‬٩‫ح‬ ‫ٓنخدحص‬ ‫و٤ش‬‫ح٥ػخس‬ ٢‫ك‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬ ٝ ،‫حُـخٗز٤ش‬ٕ‫٣ظٔ٤ضح‬َ‫أه‬ ٌٕٞ٣ ‫حُٔؼٞ٣ش‬ ‫حُٔؼذ٣ش‬ ‫حُو٘خس‬ ٖٓ ١ِٞ‫حُؼ‬ ْ‫حُوغ‬ ٢‫ك‬ ‫حُؾذ٣ذس‬ ‫حُلٞحدع‬ ‫خطش‬ ٕ‫رؤ‬، ٌُٖٝ‫ٓ٘خلنش‬ ‫رـشػخص‬ ً‫خ‬٘ٓ‫ٓضح‬ ً‫خ‬‫ػ٬ؿ‬ ٕٞ‫٣ظِو‬ ٖ٣‫حُز‬ ٠‫حُٔشم‬ ٟ‫ُذ‬ ‫ه٤ٔش‬ ١‫أ‬ ‫حُٔ٤ضس‬ ٙ‫ُٜز‬ ‫٣ؼٞد‬ ٫ٖ٣‫ح٧عزش‬ ٖٓ. ‫طلز٣شحص‬‫ٝط‬‫ٞف٤خص‬: -‫٣ـذ‬‫طـ٘ذ‬‫ا‬٩‫ح‬ ‫ٓنخدحص‬ ّ‫عظخذح‬‫ُلشه‬ ‫ٓشم٤ش‬ ‫ع٤شس‬ ‫ٝؿٞد‬ ٍ‫كخ‬ ٢‫ك‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬‫حُلغخع٤ش‬ ‫طـخ‬٩‫ح‬ ‫ٓنخدحص‬ ٖٓ ٍّّ١‫أ‬ ٝ‫أ‬ ٖ٣‫ح٧عزش‬ ٙ‫(كذٝع‬ ٟ‫ح٧خش‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬ٝ‫أ‬ ،ٟ‫ؽش‬ ،ٞ‫سر‬ ،‫ٝػخث٤ش‬ ‫ٝرٓش‬ ‫ا‬‫رظـ٘ذ‬ ٠‫٣ٞف‬ ‫ًٔخ‬ ،)‫أٗق‬ ‫ُظٜخد‬‫ا‬ٌَ‫رؾ‬ ‫ح٧دٝ٣ش‬ ٙ‫ٛز‬ ّ‫عظخذح‬‫ح‬ ٟ‫ُذ‬ ‫ٓطِن‬‫ٛنٔ٤ش‬ ‫روشكخص‬ ٖ٤‫حُٔقخر‬ ٠‫ُٔشم‬ ٝ ،‫ٗخؽطش‬‫عخروش‬ ‫افخرخص‬ ‫ٝؿٞد‬ ٟ‫ُذ‬ ‫طـ٘زٜخ‬ َ‫٣لن‬‫ٓؼٞ٣ش‬ ‫ٓؼذ٣ش‬ ‫ٗضٝف‬ ٝ‫أ‬ ‫روشكخص‬ ‫كخُ٤ش‬ ٝ‫أ‬ٝ ،‫علذ‬ ‫٣ـذ‬ ‫ٓؼذ٣ش‬ ‫آكخص‬ ‫ططٞس‬ ٟ‫ُذ‬ ‫ح٧دٝ٣ش‬ ٙ‫ٛز‬‫ٓؼٞ٣ش‬. -َ‫٣لن‬ً‫خ‬ٔ‫دحث‬‫ا‬٩‫ح‬ ‫ٓنخدحص‬ ّ‫عظخذح‬‫ُظٜٞس‬ ‫ٓ٘خلل‬ ‫رخطش‬ ‫حُٔظشحكوش‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬‫ؿخٗز٤ش‬ ‫طؤػ٤شحص‬ ٓ٣ٞ‫ٓؼ‬ ‫ؼذ٣ش‬‫ش‬ٝ ،،‫ٌٓٔ٘ش‬ ‫كؼخُش‬ ‫ؿشػش‬ َ‫رؤه‬ ‫حُٔؼخُـش‬ ‫رذء‬ّٝ‫ػذ‬‫ا‬ّ‫عظخذح‬‫ٓنخدحص‬ ٖٓ ‫ٝحكذ‬ ‫ٓشًذ‬ ٖٓ ‫أًؼش‬ ٩‫ح‬٢‫ك‬ ‫حُلٔٞ٣ش‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬‫حُٞهض‬ ‫ٗلظ‬.
  17. 17. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab16 -٠‫٣ٞف‬‫ػلـ٤ش‬ ‫ٓؼذ٣ش‬ ‫هشكش‬ ‫ُلذٝع‬ ٕٞ‫حُٔئٛز‬ ٠‫حُٔشم‬ٝ‫رٔنخدحص‬ ً‫خ‬ٔ‫دحث‬ ً‫خ‬‫ػ٬ؿ‬ ٕٞ‫٣لظخؿ‬ ٖ٣‫حُز‬٩‫ح‬‫ؿ٤ش‬ ‫ُظٜخد‬ ‫ر‬ ‫حُغظ٤شٝث٤ذ٣ش‬‫ب‬‫عظ‬ْ٣‫٧ٗض‬ ‫حُٔؼزطش‬ ‫ح٧دٝ٣ش‬ ‫أكذ‬ ٍ‫ؼٔخ‬cox-2‫أكذ‬ ٝ‫أ‬٩‫ح‬ ‫ٓنخدحص‬‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬ ‫ُِٔؼذس‬ ‫ٝحه٤ش‬ ‫ٓؼخُـش‬ ‫ٓغ‬ ‫حُٔؼ٤خس٣ش‬. -َٔ‫طغظؼ‬ٝ ،٢‫حُوِز‬ ‫حُوقٞس‬ ‫كخ٫ص‬ ٢‫ك‬ ‫رلزس‬ ‫ح٧دٝ٣ش‬ ٙ‫ٛز‬ٝ ،١‫حٌُزذ‬ ‫حُوقٞس‬ٝ ،١ٌُِٞ‫ح‬ ‫حُوقٞس‬‫٣ـذ‬‫ٓشحػخس‬ ‫ا‬ٝ ‫كؼخُش‬ ‫ؿشػخص‬ َ‫أه‬ ّ‫عظخذح‬٣ٌُِٞ‫ح‬ ‫حُٞظ٤لش‬ ‫ٓشحهزش‬١‫حُز‬ ‫حُظشحؿغ‬ ‫خطش‬ ‫ُظـ٘ذ‬ ‫ش‬ٙ‫ٛز‬ ٚ‫طلذػ‬ ٕ‫أ‬ ٌٖٔ٣ ‫حُٞظ٤لش‬ ٙ‫ٛز‬ ٢‫ك‬ ‫حُٔشًزخص‬. -‫هذ‬٩‫ح‬ ‫ٓنخدحص‬ ‫طلذع‬ْٜ٣‫ُذ‬ ٖ٣‫حُز‬ ٠‫حُٔشم‬ ٟ‫ُذ‬ ً‫ش‬‫خخف‬ ً‫خ‬٣ًِٞ ً٬‫كؾ‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬٢‫ك‬ ‫عخرن‬ ‫مؼق‬ ٝ ،‫حٌُِٞ٣ش‬ ‫حُٞظ٤لش‬‫حُٔشحكن‬ ٢ُ٬‫حُخ‬ ‫حُظِ٤ق‬ ٝ‫أ‬ ٢ٔ٤ِ‫حُل‬ ‫حُظ٘خش‬ ١‫٣ئد‬ ‫هذ‬٩٩‫ح‬ ‫ٓنخدحص‬ ّ‫عظخذح‬‫ُظٜخ‬‫ؿ٤ش‬ ‫د‬ َ‫كؾ‬ ٠ُ‫ا‬ ‫ٗخدسس‬ ‫كخ٫ص‬ ٢‫ك‬ ‫حُغظ٤شٝث٤ذ٣ش‬١ًِٞ. -‫٣ـذ‬ً‫ح‬‫ٗظش‬ ٖ٤٘‫حُٔغ‬ ٠‫حُٔشم‬ ٟ‫ُذ‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ح٫ُظٜخد‬ ‫ٓنخدحص‬ ّ‫حعظخذح‬ ٟ‫ُذ‬ ‫حُلزس‬ ٢‫طٞخ‬‫ُخطٞسس‬ ‫حُؼٔش٣ش‬ ‫حُلجش‬ ٙ‫ٛز‬ ٟ‫ُذ‬ ‫حُٔٔ٤ظش‬ ‫ٝٓؾخًِٜخ‬ ‫حُـخٗز٤ش‬ ‫آػخسٛخ‬. -‫٣ـذس‬٩‫ح‬ ‫ٓنخدحص‬ ٕ‫أ‬ ٠ُ‫ا‬ ٚ٤‫حُظ٘ز‬‫هذ‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬ٞ‫حُشر‬ ‫كخُش‬ ‫طذٛٞس‬ ٠ُ‫ا‬ ١‫طئد‬،٢‫طٞخ‬ ‫٣ـذ‬ ‫ُزح‬ ٠‫ُٔشم‬ ‫ٝفلش‬ ٕٝ‫د‬ ‫فشكٜخ‬ ٝ‫أ‬ ‫ح٧دٝ٣ش‬ ٙ‫ٛز‬ ‫ٝفق‬ ٟ‫ُذ‬ ‫حُلزس‬ٞ‫حُشر‬. ** ‫ٓنخدحص‬ ٖٓ ‫ُغزؼش‬ ٢‫حُ٘غز‬ ٕ‫ح٧ٓخ‬ ٍٞ‫ك‬ ‫حُلذ٣ؼش‬ ‫حُذسحعخص‬ ‫ٗظخثؾ‬ ‫أظٜشص‬٩‫ح‬‫ُظٜخد‬‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ٝؿٞد‬ ‫حُلٔٞ٣ش‬‫ا‬ْ‫حُوغ‬ ٍ‫ططخ‬ ٢‫حُظ‬ ‫حُـخٗز٤ش‬ ‫ح٥ػخس‬ ‫خطٞسس‬ ٢‫ك‬ ‫خظ٬كخص‬‫ح‬ِ‫ُؼ‬‫ك٤غ‬ ،٢ٔ‫حُٜن‬ َ٤‫حُغز‬ ٖٓ ١ٞ ‫طشحكن‬‫ا‬ٕٝ‫ح٥صحرشٝرخص‬ ٍ‫عظؼٔخ‬azapropazoneٖ٤‫ر‬ ٖٟٓ‫حٌُزش‬ ‫رخُخطٞسس‬ ‫حُٔذسٝعش‬ ‫حُغزؼش‬ ‫ح٧كشحد‬ٕ‫ًخ‬ ‫ر٤٘ٔخ‬ ، ،ً‫س‬‫خطٞس‬ َ‫ح٧ه‬ ٖ‫ح٩٣زٞرشٝك‬ٝ‫طشحكن‬‫ا‬ٖٓ ًَ ٍ‫عظؼٔخ‬،ٖ٤‫ح٧ٗذٝٓ٤ظخع‬ ،ٖ‫حٌُ٤ظٞرشٝك‬ ،ّ‫حُز٤شًٝغ٤ٌخ‬ : ٖ٤‫حُ٘خرشًٝغ‬‫رخطٞس‬ ‫ٝحُذ٣ٌِٞك٤٘خى‬ٞ‫ٓظ‬ ‫س‬ٟ‫ُذ‬ ٠ِ‫ح٧ػ‬ ‫ُلذٛخ‬ ‫ٝفِض‬ ‫عطش‬‫ا‬ٝ ،ّ‫حُز٤شًٝغ٤ٌخ‬ ّ‫عظخذح‬٫‫طظٞكش‬ ٌ‫ُظ‬ ‫ًخك٤ش‬ ‫ٓؼِٞٓخص‬٩‫ح‬ ‫ٓنخدحص‬ ‫رخقٞؿ‬ ‫ٝحملش‬ ‫ٗظ٤ـش‬ ٖ٣ٞ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬ٟ‫ح٧خش‬. ‫طٞف٤خص‬‫رٔؼزطخص‬ ‫خخفش‬cox-2‫ح٫ٗظوخث٤ش‬: -‫٣ـذ‬ّ‫ػذ‬‫ا‬‫رؾ‬ ‫ح٧دٝ٣ش‬ ٙ‫ٛز‬ ّ‫عظخذح‬‫ر‬ ٖ٤‫حُٔقخر‬ ٠‫حُٔشم‬ ٟ‫ُذ‬ ٢٘٤‫سٝط‬ ٌَ‫ب‬‫حُٔلخف‬ ‫ُظٜخد‬٢ٗ‫حُشػ٤خ‬ َٝ‫أ‬ ٢ٔ‫حُؼظ‬ ٍ‫حُلقخ‬. -َ‫٣لن‬‫ا‬‫ٓؼزطخص‬ ّ‫عظخذح‬cox-2٩‫ح‬٩‫ح‬ ‫ٓنخدحص‬ ٠ِ‫ػ‬ ‫ٗظوخث٤ش‬‫حُٔؼ٤خس٣ش‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬‫ٝؿٞد‬ ٍ‫كخ‬ ٢‫ك‬ ٤‫ع‬٩‫ح‬ ٝ‫أ‬ ‫حُؼلـ٤ش‬ ‫حُٔؼذ٣ش‬ ‫ُِوشكش‬ ‫شس‬ٝ ،١ٞ‫حُٔؼ‬ ١‫حُٔؼذ‬ ‫حُ٘ضف‬ ٝ‫أ‬ ‫ٗؼوخد‬ٌُّْٖ٤‫٣و‬ ٕ‫أ‬ ‫٣ـذ‬‫ا‬‫رذهش‬ ‫عظخذحٜٓخ‬ ‫حُلخ٫ص‬ ٙ‫ٛز‬ ٢‫ك‬ ٠‫كظ‬. -َ‫٣لن‬‫ا‬‫عظ‬‫ٓؼزطخص‬ ّ‫خذح‬cox-2٩‫ح‬٩‫ح‬ ‫ٓنخدحص‬ ٠ِ‫ػ‬ ‫ٗظوخث٤ش‬‫حُٔؼ٤خس٣ش‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬‫ٝؿٞد‬ ٟ‫ُذ‬ ً‫خ‬‫أ٣ن‬ ‫كٞم‬ ٠‫(حُٔشم‬ ‫ؽذ٣ذس‬ ‫ٛنٔ٤ش‬ ‫ؿخٗز٤ش‬ ‫آػخس‬ ‫ُظٜٞس‬ ‫ػخُ٤ش‬ ‫خطٞسس‬65،ً‫خ‬ٓ‫ػخ‬‫رؤدٝ٣ش‬ ‫ُٔؼخُـش‬ ٕٞ‫حُخخمؼ‬ ٠‫حُٔشم‬ ،‫حُٔؼٞ٣ش‬ ‫حُٔؼذ٣ش‬ ‫حُظؤػ٤شحص‬ ‫خطش‬ ٖٓ ‫طض٣ذ‬ ٟ‫أخش‬٠‫حُٔشم‬ ٝ‫أ‬ ،ُٕٞ٘ٛٞٔ‫ح‬ ٠‫حُٔشم‬‫هٞ٣ِش‬ ‫ٓؼخُـش‬ ٕٞ‫٣ظِو‬ ٖ٣‫حُز‬ ٖٓ ‫أػظٔ٤ش‬ ‫رـشػخص‬ ‫ح٧ٓذ‬‫حُٔؼ٤خس٣ش‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ح٫ُظٜخد‬ ‫ٓنخدحص‬. ) -‫ُ٤ظ‬‫طزشس‬ ‫أدُش‬ ‫ٛ٘خى‬‫ا‬‫ٓؼزطخص‬ ‫ٓغ‬ ٖٓ‫ٓظضح‬ ٌَ‫رؾ‬ ‫ُِٔؼذس‬ ‫حُٞحه٤ش‬ ‫ح٧دٝ٣ش‬ ّ‫عظخذح‬cox-2٩‫ح‬‫رٜذف‬ ‫ٗظوخث٤ش‬ ‫رقٞسس‬ ‫حُٔؼٞ٣ش‬ ‫حُٔؼذ٣ش‬ ‫حُـخٗز٤ش‬ ‫ح٥ػخس‬ ‫اٗوخؿ‬‫امخك٤ش‬.
  18. 18. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab17 ‫األسثرين‬‫وانسانيسيالخ‬aspirine & salicylates: ٕ‫ًخ‬‫حُظو‬ ‫حُخ٤خس‬ ٖ٣‫ح٧عزش‬٪ُ ‫ٝٓنخد‬ ُْ٨ُ ٌٖ‫ًٔغ‬ ٍٝ٧‫ح‬ ١‫ِ٤ذ‬‫ح٧هزخء‬ ْ‫ٓؼظ‬ ٕ‫أ‬ ٫‫ا‬ ،‫ُظٜخد‬‫حُٞهض‬ ٢‫ك‬ ِٕٞ‫٣لن‬ ‫ٓن‬ ٖٓ ٟ‫أخش‬ ‫رؤكشحد‬ ‫حُٔؼخُـش‬ ‫رذء‬ ٖٛ‫حُشح‬٩‫ح‬ ‫خدحص‬‫ؿ٤ش‬ ‫ُظٜخد‬ٌٕٞ‫ط‬ ‫هذ‬ ٢‫حُظ‬ ‫حُغظ٤شٝث٤ذ٣ش‬َ‫هز‬ ٖٓ ً٬ٔ‫طل‬ ‫أًؼش‬ ْ‫سؿ‬ ‫حُٔش٣ل‬‫ا‬‫ح‬ ‫ٓظ٬ى‬‫حُؼخُ٤ش‬ ‫ُـشػخص‬ٝ٧‫ح‬ ٖٓ ‫حُ٘ظخٓ٤ش‬٪ُ ‫ٓنخدس‬ ‫ٌٓخكجش‬ ‫ُظؤػ٤شحص‬ ٖ٣‫عزش‬‫ُظٜخد‬. ّ‫٣غظخذ‬٣ ‫رـشػخص‬ ٖ٣‫ح٧عزش‬ٖ‫ػ‬ َ‫طو‬ ٫ ‫ٞٓ٤ش‬3.6‫ٓؼخُـش‬ ٢‫ك‬ ‫ؽ‬‫ا‬ٝ ،‫حُ٘خؽو‬ َ‫حُٔلخف‬ ‫ُظٜخد‬ٌٕٞ‫ط‬‫حُظؤػ٤شحص‬ ٪ُ ‫حُٔنخدس‬‫ػ٘ذ‬ ‫ٓلذٝدس‬ ‫ُظٜخد‬‫ا‬ٖ‫ػ‬ َ‫طو‬ ‫ؿشػخص‬ ّ‫عظخذح‬3‫ؽ‬. ‫٣ظشحكن‬‫ا‬‫ػ٬ؿ‬ ‫ؿشػش‬ ١‫رؤ‬ ٖ٣‫ح٧عزش‬ ّ‫عظخذح‬ٕ‫ًخُـؼ٤خ‬ ‫حُٜنٔ٤ش‬ ‫حُـخٗز٤ش‬ ‫ح٥ػخس‬ ٖٓ ‫ػذد‬ ‫رظٜٞس‬ ‫٤ش‬ْٝ‫حُٜن‬ ‫ػغش‬ ٝٝ ،‫حُٔؼٞ٣ش‬ ‫حُٔؼذ٣ش‬ ‫حُ٘ضٝف‬ٟ‫ُذ‬ ‫حُـخٗز٤ش‬ ‫ح٥ػخس‬ ٙ‫ٛز‬ ‫كذٝع‬ ‫ٗغزش‬ ‫طضدحد‬‫ا‬٪ُ ‫حُٔنخدس‬ ‫حُـشػخص‬ ّ‫عظخذح‬‫ُظٜخد‬ ‫طغزذ‬ ٕ‫أ‬ ٌٖٔ٣ ٢‫حُظ‬ً‫خ‬‫أ٣ن‬‫ا‬ً‫خ‬٘ٓ‫ٓض‬ ً‫خ‬ٓ‫ٗغٔخ‬ٝ ‫رذٝحس‬ ‫٣ظظخٛش‬ ‫رخُغخُ٤غ٤٬ص‬ٝ ٖ٤٘‫ه‬ٝ ،ْٔ‫ف‬‫خلل‬ ‫٣غٔق‬ ‫حُـ‬‫ح٧ػشحك‬ ٠ِ‫ػ‬ ‫رخُغ٤طشس‬ ‫شػش‬‫حُغخروش‬.
  19. 19. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab18 ُْ٧‫ح‬ ‫ٓغٌ٘خص‬‫حُلشحسس‬ ‫ٝخخكنخص‬ ٝ ٍٞٓ‫حُزخسحع٤ظخ‬ َ‫ٓؼ‬ ‫ح٧ك٤ٞٗ٤ش‬ ‫ؿ٤ش‬ ‫حُٔغٌ٘خص‬ ‫طؼذ‬ٖ٣‫ح٧عزش‬ٝ٩‫ح‬ ‫ٓنخدحص‬‫ٓ٘خعزش‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬ ‫حُٜ٤ٌِ٤ش‬ ‫حُؼنِ٤ش‬ ّ٫٥‫ح‬ ٖ٤ٌ‫ُظغ‬‫ر٤٘ٔخ‬ ،٤ٌ‫ُظغ‬ ‫ٓ٘خعزش‬ ‫ح٧ك٤ٞٗ٤ش‬ ‫حُٔغٌ٘خص‬ ‫طؼذ‬٠ُ‫ا‬ ‫حُٔظٞعطش‬ ّ٫٥‫ح‬ ٖ ٝ ‫حُؾذ٣ذس‬‫خخؿ‬ ٌَ‫رؾ‬١ٞ‫حُلؾ‬ ‫حُٔ٘ؾؤ‬ ‫رحص‬ ّ٫٥‫ح‬. ‫غير‬ ‫انمسكناخ‬‫األفيىنيح‬: ٖ٣‫ح٧عزش‬aspirine:‫٣ٞفق‬،٠ٔ‫ٝحُل‬ ‫حُطٔغ‬ ‫ٝػغش‬ ‫حُؼخرشس‬ ‫حُٜ٤ٌِ٤ش‬ ‫حُؼنِ٤ش‬ ّ٫٥‫ٝح‬ ‫حُقذحع‬ ‫ُؼ٬ؽ‬ ٖ٣‫ح٧عزش‬ ‫أٓخ‬٩‫ح‬ ‫ُِلخ٫ص‬ ‫حُٔشحكوش‬ ّ٫٥‫ح‬٤‫ُظٜخر‬٘٤ٌ‫رظغ‬ ‫ح٧هزخء‬ ْ‫ٓؼظ‬ ‫ك٤٘قق‬ ‫ش‬‫ر‬ ‫ٜخ‬‫ب‬‫آخش‬ ‫ٓشًذ‬ ّ‫عظخذح‬‫ٓنخدحص‬ ٖٓ ٩‫ح‬ٝ ‫أًزش‬ َٔ‫رظل‬ ‫٣ظٔظغ‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬َ‫هز‬ ٖٓ َ‫أكن‬ ‫ٓطخٝػش‬‫حُٔش٣ل‬. ٌَ‫٣ؾ‬ٖ٣‫ح٧عزش‬ ُٕٞٝ‫٣ظ٘خ‬ ٖ٣‫حُز‬ ‫ح٧ؽخخؿ‬ ٟ‫ُذ‬ ‫ٛخٓش‬ ‫ٓؾٌِش‬ ١‫حُٔؼذ‬ ‫حُظٜ٤ؾ‬ٝ ،‫ٛزح‬ ٖٓ ‫حُلذ‬ ٌٖٔ٣‫حُظٜ٤ؾ‬ ‫رؼذ‬ ‫حُـشػش‬ ‫أخز‬ ٝ‫أ‬ ‫حُلٔٞمش‬ ‫ٓنخدحص‬ ‫ٓغ‬ ٖ٣‫ح٧عزش‬ ‫رٔؾخسًش‬ّ‫حُطؼخ‬. ٍٞٓ‫حُزخسحع٤ظخ‬paracétamol:ٝ ُْ٧‫ح‬ ٖ٤ٌ‫طغ‬ ٢‫ك‬ ٖ٣‫ح٧عزش‬ ‫ُلؼخُ٤ش‬ ‫ٓؾخرٜش‬ ‫كؼخُ٤ش‬ ٍٞٓ‫حُزخسحع٤ظخ‬ ‫٣ِٔي‬ٌُٚ٘ ‫٣ِٔي‬ ٫٪ُ ‫ٓنخدس‬ ‫ِٓلٞظش‬ ‫كؼخُ٤ش‬ٝ ،‫ُظٜخد‬َ‫٣لن‬ ‫ُزح‬ ‫ُِٔؼذس‬ ً‫خ‬‫طٜ٤٤ـ‬ َ‫أه‬ ٞٛ‫ا‬٠ِ‫ػ‬ ٚٓ‫عظخذح‬ً‫ش‬‫خخف‬ ٖ٣‫ح٧عزش‬ ٖ٤٘‫حُٔغ‬ ٠‫حُٔشم‬ ٟ‫ُذ‬. ‫طؼذ‬ٍٞٓ‫حُزخسحع٤ظخ‬ ٖٓ ‫حُضحثذس‬ ‫حُـشػخص‬‫طظٜش‬ ٫ ‫هذ‬ ‫ًزذ٣ش‬ ‫أر٣ش‬ ‫كذٝع‬ ٠ُ‫ا‬ ١‫طئد‬ ‫٧ٜٗخ‬ ‫خطشس‬‫رؼذ‬ ٫‫ا‬4-6ّ‫أ٣خ‬. ّ‫حُ٘٤لٞرخ‬nefopam:ّ‫٣غظخذ‬‫ؿ٤ش‬ ُْ٧‫ح‬ ‫ٓغٌ٘خص‬ ٖٓ ٙ‫ُـ٤ش‬ ‫حُٔغظـ٤زش‬ ‫ؿ٤ش‬ ‫حُٔؼ٘ذس‬ ّ٫٥‫ح‬ ‫ػ٬ؽ‬ ٢‫ك‬ ‫ح٧ك٤ٞٗ٤ش‬. ‫٣ظغزذ‬ ٫ٝ( ٢‫ط٘لغ‬ ‫طؼز٤و‬ ‫رلذٝع‬ ّ‫حُ٘٤لٞرخ‬ٝ ،)ً‫ح‬‫ؿذ‬ ً‫خ‬‫مؼ٤ل‬ ‫حُظؼز٤و‬ ‫ٛزح‬ ٌٕٞ٣ ‫كذع‬ ٕ‫ا‬ٖ‫ػ‬ ‫٣٘ظؾ‬‫ا‬ٚٓ‫عظخذح‬ ٝ ‫حُٞد٣ش‬ ‫حُـخٗز٤ش‬ ‫ح٥ػخس‬ ‫رؼل‬ٖ٣‫ُِٔغٌخس‬ ‫حُٔنخدس‬. ٩‫ح‬ ‫ٓنخدحص‬‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬:‫ٓقلٞرش‬ ‫ٓضٓ٘ش‬ ‫رؤٓشحك‬ ٖ٤‫حُٔقخر‬ ٠‫حُٔشم‬ ٟ‫ُذ‬ ‫ح٧دٝ٣ش‬ ٙ‫ٛز‬ ّ‫طغظخذ‬ ُْ٧‫رخ‬٩‫ٝح‬ٝ ،‫ُظٜخد‬٠ُ‫ا‬ ‫حُخل٤لش‬ ّ٫٦ُ ‫ح٧ٓذ‬ ‫هق٤ش‬ ‫حُؼ٬ؽ‬ ٢‫ك‬ ‫ح٧دٝ٣ش‬ ٙ‫ٛز‬ ‫رؼل‬ ّ‫٣غظخذ‬‫ك٤ٜخ‬ ‫رٔخ‬ ‫حُٔظٞعطش‬ ٫٥‫ح‬ٌِ٤ُٜ‫ح‬ ‫حُؼنِ٤ش‬ ّ‫أكنِ٤ش‬ ٖٓ ْ‫حُشؿ‬ ٠ِ‫ػ‬ ‫حُؼخرشس‬ ‫٤ش‬‫ا‬ّ‫عظخذح‬٠‫حُٔشم‬ ٟ‫ُذ‬ ً‫ش‬‫خخف‬ ‫ػِ٤ٜخ‬ ٍٞٓ‫حُزخسحع٤ظخ‬ ٖ٤٘‫حُٔغ‬. ‫طل٤ذ‬٩‫ح‬ ‫ٓنخدحص‬ٝ ‫حُطٔغ‬ ‫ػغش‬ ّ٫‫آ‬ ‫طخل٤ق‬ ٢‫ك‬ ً‫خ‬‫أ٣ن‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬ّ‫ح٧ٝسح‬ ّ٫‫آ‬ٝ ‫حُؼخٗٞ٣ش‬ ‫حُؼظٔ٤ش‬ ‫ر‬ ‫طظغزذ‬ ٢‫حُظ‬‫ب‬ٝ ّ‫حُؼظخ‬ ٍ٬‫ٗل‬.‫حُزشٝعظخؿ٬ٗذ٣٘خص‬ ‫طلشس‬ ّ‫طغظخذ‬٩‫ح‬ ‫ٓنخدحص‬‫حٌُ٤ظٞسٝ٫ى‬ ‫ك٤ٜخ‬ ‫رٔخ‬ ً‫خ‬‫أ٣ن‬ ‫حُغظ٤شٝث٤ذ٣ش‬ ‫ؿ٤ش‬ ‫ُظٜخد‬ketorolacٖ٤ٌ‫ُظغ‬‫حُلظشس‬ ٢‫ك‬ ُْ٧‫ح‬ ٢‫حُـشحك‬ َٔ‫رخُؼ‬ ‫حُٔل٤طش‬. ‫انمسكناخ‬‫األفيىنيح‬: ّ‫طغظخذ‬،١ٞ‫حُلؾ‬ ‫حُٔ٘ؾؤ‬ ‫رحص‬ ّ٫٥‫ح‬ ‫خخفش‬ ‫حُؾذ٣ذس‬ ٠ُ‫ا‬ ‫حُٔظٞعطش‬ ّ٫٥‫ح‬ ٖ٤ٌ‫ُظغ‬ ‫حُٔشًزخص‬ ٙ‫ٛز‬ٝ‫هذ‬ ٩‫ح‬ ٌٕٞ٣ُ٘ٔ‫ح‬ ّ‫عظخذح‬ّ٫٥‫ح‬ ٖ٤ٌ‫ُظغ‬ ً‫خ‬‫ٓ٘خعز‬ ‫حُوٞ٣ش‬ ‫ح٧ك٤ٞٗ٤ش‬ ‫حُٔغٌ٘خص‬ ‫٧كذ‬ ْ‫ظظ‬‫٣ـذ‬ .‫حُخز٤ؼش‬ ‫ؿ٤ش‬ ‫حُٔضٓ٘ش‬
  20. 20. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab19 ٢‫حُطز‬ ‫ح٩ؽشحف‬ ‫طلض‬ ‫ح٧ك٤ٞٗ٤ش‬ ‫رخُٔغٌ٘خص‬ ‫حُٔؼخُـش‬ ْ‫طظ‬ ٕ‫أ‬٩‫ح‬ ٕ٧‫حُٔظٌش‬ ّ‫عظخذح‬٠ُ‫ا‬ ١‫٣ئد‬ ‫ح٧دٝ٣ش‬ ٙ‫ُٜز‬ ‫س‬ ٩‫ح‬ ‫ططٞس‬‫ػظٔخد‬َٝٔ‫حُظل‬. ٖ٤‫حٌُٞدث‬codéine:٢‫ك‬ ٍ‫كؼخ‬ُ‫ح‬ ٠ُ‫ا‬ ‫حُخل٤لش‬ ّ٫٥‫ح‬ ‫ػ٬ؽ‬ٗ‫أ‬ ٫‫ا‬ ‫ؾذ٣ذس‬‫ػ٘ذ‬ ‫ؽذ٣ذ‬ ‫آغخى‬ ‫رلذٝع‬ ‫٣ظغزذ‬ ٚ ٩‫ح‬ّ‫عظخذح‬‫هٞ٣ِش‬ ‫ُٔذس‬. ٖ٤‫حُذ٣ٌغظشٝرشٝرًٞغ٤ل‬dextropropoxyphen:ً‫خ‬ٌ٘‫ٓغ‬ ً٬‫كؼ‬ ٙ‫رٔلشد‬ ٚ‫اػطخث‬ ‫ػ٘ذ‬ ‫حُٔشًذ‬ ‫ٛزح‬ ‫٣ٔخسط‬ً‫خ‬‫خل٤ل‬ ٖ٤‫حٌُٞدث‬ ٖٓ ‫كؼخُ٤ش‬ َ‫أه‬ ٌٕٞ٣ٝٝ‫أ‬ ٍٞٓ‫حُزخسحع٤ظخ‬ ‫ٓغ‬ ٚ‫ٓؾخسًظ‬ ٕ‫أ‬ ٖ٤‫ك‬ ٢‫ك‬ ،‫أه‬ ً‫خ‬ٌ٘‫ٓغ‬ ً٬‫كؼ‬ ّ‫طوذ‬ ٖ٣‫ح٧عزش‬ٟٞ ‫حُٔؾخسًش‬ ٙ‫ٛز‬ ‫ٓغخٝة‬ ٟ‫اكذ‬ .‫كذس‬ ٠ِ‫ػ‬ ٖ٤ٌ٘‫حُٔغ‬ ٬ً ٖٓٝ ‫حُـشػش‬ ‫ص٣خدس‬ ٖ‫ػ‬ ‫حُ٘خطـش‬ ‫حُٔنخػلخص‬ ٞٛ٢‫حُظ‬ ٠ُ‫ا‬ ‫حُؼخثذ‬ ٢‫حُظ٘لغ‬ ‫رخُظؼز٤و‬ َ‫طظٔؼ‬ٝ ٖ٤‫حُذ٣ٌغظشٝرشٝرًٞغ٤ل‬٩‫ح‬ٍٞٓ‫حُزخسحع٤ظخ‬ ٠ُ‫ا‬ ‫حُؼخثذ‬ ١‫حٌُزذ‬ ّ‫ٗغٔخ‬ ٖ٤‫حُلخُظ‬ ‫(ًِٝظخ‬ً‫خ‬‫عش٣ؼ‬ ً‫خ‬‫ػ٬ؿ‬ ٕ‫طغظٞؿزخ‬)‫حُذٝحث‬ ‫حُغٞم‬ ٖٓ ‫علذ‬ () ‫ٓلخؿت‬ ‫هِذ‬ ‫طٞهق‬ ٚ‫٩كذحػ‬ ‫٤ش‬. ٍٝ‫حُظشحٓخد‬tramadol:ٝٞٛٝ ،‫حُلذ٣ؼش‬ ‫ح٧ك٤ٞٗ٤ش‬ ‫حُٔغٌ٘خص‬ ٖٓ‫حُؾخد‬ ‫حُظؤػ٤ش‬ ٍ٬‫خ‬ ٖٓ ٌٖ‫حُٔغ‬ ٙ‫طؤػ٤ش‬ ‫٣ٔخسط‬ ٝ ‫ح٧ك٤ٞٗ٤ش‬ ‫ُِٔغظوز٬ص‬ٝ ٖ٤ٗٞ‫حُغ٤شٝط‬ ‫هزو‬ ‫٩ػخدس‬ ‫حُٔؼزو‬ ‫حُظؤػ٤ش‬ٖ٣‫حُ٘ٞسار٤٘لش‬ٌٕٞ‫ط‬ .‫حُ٘خطـش‬ ‫حُـخٗز٤ش‬ ‫ح٥ػخس‬ ٖٓ َ‫أه‬ ‫حُذٝحء‬ ٖ‫ػ‬ٖٓ ٙ‫ؿ٤ش‬ ٖ‫ػ‬ ‫حُ٘خطـش‬ ‫حُـخٗز٤ش‬ ‫ح٥ػخس‬َ‫أه‬ ‫ح٩ٓغخى‬ ‫(كٞحدع‬ ‫ح٧ك٤ٞٗ٤ش‬ ‫حُٔغٌ٘خص‬‫حُظؼز٤و‬ ، ‫ِٓلٞظ‬ ٌَ‫رؾ‬ َ‫أه‬ ٢‫حُظ٘لغ‬ٝ ،ٕ‫ح٩دٓخ‬ٝ ،)ً‫خ‬٤‫ٗغز‬ َ‫أه‬‫حُ٘لغ٤ش‬ َ‫حُلؼ‬ ‫سدٝد‬ ‫رؼل‬ ‫ُِذٝحء‬ ‫عـِض‬ ‫هذ‬. : ‫انمسكناخ‬ ‫في‬ ‫انمشاركح‬ *ٕ‫أ‬ ٌٖٔ٣٤‫رغ‬ ٌٖ‫ٓغ‬ ٖٓ ‫ٓؾخسًش‬ ٠ِ‫ػ‬ ‫حُٔغٌ٘خص‬ ‫ٓغظلنشحص‬ ١ٞ‫طلظ‬‫ٓغ‬ ٍٞٓ‫حُزخسحع٤ظخ‬ ٝ‫أ‬ ٖ٣‫ًخ٧عزش‬ ‫و‬ ٝ ،٢ٗٞ٤‫أك‬ ٌٖ‫ٓغ‬‫حُٔخظِلش‬ ‫حُؾذحص‬ ‫رحص‬ ّ٫٥‫ح‬ ٖ٤ٌ‫طغ‬ ٢‫ك‬ ‫طل٤ذ‬ ٢ٛ. *ّ‫طغظخذ‬‫ٓ٘خلنش‬ ‫ؿشػش‬ ‫ٓغ‬ ٍٞٓ‫حُزخسحع٤ظخ‬ ٝ‫أ‬ ٖ٣‫ح٧عزش‬ ٖٓ ‫ٓؾخسًش‬ ٠ِ‫ػ‬ ‫حُلخٝ٣ش‬ ‫حُٔغظلنشحص‬ ً‫س‬‫ػخد‬ٖٓ ٖ٤‫حٌُٞدث‬ ‫كٞعلخص‬ ً٬‫(ٓؼ‬ ‫ح٧ك٤ٞٗ٤ش‬ ‫حُٔغٌ٘خص‬ ‫أكذ‬codéine phosphate‫رـشػش‬8‫ِٓؾ‬، )ٖٝٓ ْ‫حُشؿ‬ ٠ِ‫ػ‬ ‫ًخك٤ش‬ ٌٕٞ‫ط‬ ‫هذ‬ ‫أٜٗخ‬ ٫‫ا‬ ‫حُٔغظلنشحص‬ ٙ‫ٛز‬ ٢‫ك‬ ٢ٗٞ٤‫ح٧ك‬ ٌٖ‫حُٔغ‬ ‫ؿشػش‬ ‫فـش‬‫حُخخفش‬ ‫حُـخٗز٤ش‬ ‫ح٥ػخس‬ ‫ُظٜٞس‬ )‫ح٩ٓغخى‬ ‫خخؿ‬ ٌَ‫(رؾ‬ ‫حُٔغٌ٘خص‬ ‫رظِي‬َ‫طـؼ‬ ‫أٜٗخ‬ ‫ًٔخ‬ ،ٝ ،ً‫ح‬‫ٓؼوذ‬ ً‫ح‬‫أٓش‬ ‫حُـشػش‬ ‫كشه‬ ‫ػ٬ؽ‬‫حُٞهض‬ ٢‫ك‬ ٢ٛ ً‫خ‬‫ِٓلٞظ‬ ً‫خ‬٤‫امخك‬ ً‫خ‬‫طخل٤ل‬ ّ‫طوذ‬ ٫ ٚ‫ٗلغ‬‫أ‬ .ُْ٨ُٖ٤‫حٌُٞدث‬ ‫(كٞعلخص‬ ‫ح٧ك٤ٞٗ٤ش‬ ‫حُٔغٌ٘خص‬ ٖٓ ‫حٌُخِٓش‬ ‫حُـشػخص‬ ‫ٓخ‬ ‫رـشػش‬60‫ِٓؾ‬)‫ٓغظلن‬ ٢‫ك‬٠ُ‫ا‬ ١‫طئد‬ ‫هذ‬ ‫كبٜٗخ‬ ‫حُٔؾخسًش‬ ‫شحص‬‫ا‬‫طظغزذ‬ ‫أٜٗخ‬ ٫‫ا‬ ‫حُٔغٌ٘ش‬ ‫حُلؼخُ٤ش‬ ‫صد٣خد‬ ٝ ،ٕ‫حُـؼ٤خ‬ َ‫ٓؼ‬ ‫حُـخٗز٤ش‬ ‫ح٥ػخس‬ ٖٓ ‫ًز٤ش‬ ‫ه٤ق‬ ‫رظٜٞس‬ٝ ،‫حُو٤خء‬،‫حُؾذ٣ذ‬ ‫ح٩ٓغخى‬ٝٝ ،‫حُ٘ؼخط‬،٢‫حُظ٘لغ‬ ‫حُظؼز٤و‬ ٝ٩‫ح‬‫ر‬ ‫ػظٔخد‬٩‫ح‬ ‫ؼذ‬ٝ ،‫هٞ٣ِش‬ ‫ُٔذس‬ ّ‫عظخذح‬‫ح٥ػخس‬ ٙ‫ٛز‬ ‫طظٜش‬ْٛ‫اػطخإ‬ ‫٣ـذ‬ ‫ُزح‬ ٖ٤٘‫حُٔغ‬ ٟ‫ُذ‬ ‫خخؿ‬ ٌَ‫رؾ‬ ‫حُٔغظلنشحص‬ ٙ‫ٛز‬ ٖٓ َ‫أه‬ ‫ؿشػخص‬. *‫٣ظٔظغ‬ٖ٤‫حٌُخكج‬caféineٝ ‫مؼ٤لش‬ ‫ٓ٘زٜش‬ ‫رخٞحؿ‬‫حُٔغظلنشحص‬ ٢‫ك‬ ‫فـ٤شس‬ ‫رـشػخص‬ ً‫س‬‫ػخد‬ ّ‫٣غظخذ‬ ٝ ،‫حُٔغٌ٘ش‬‫حُظؤ‬ ٖٓ ‫طض٣ذ‬ ‫هذ‬ ٖ٤‫حٌُخكج‬ ‫امخكش‬ ٕ‫أ‬ َ‫عـ‬ ‫هذ‬ٌٖ‫حُٔغ‬ ‫ػ٤ش‬‫٣ظشحكن‬ ‫رُي‬ ٕ‫أ‬ ٫‫ا‬ ،‫طؤػ٤شحص‬ ‫رظٜٞس‬ ٩‫ًخ‬ ‫امخك٤ش‬ ‫ؿخٗز٤ش‬ٝ ‫حُخل٤ق‬ ‫ػظٔخد‬‫حُقذحع‬ ‫اػخسس‬‫حُـشػخص‬ ٕ‫أ‬ ٖ‫ػ‬ ‫ٗخٛ٤ي‬ ،ُٚٝ‫ط٘خ‬ ‫ا٣وخف‬ ٝ‫أ‬ ٖ٤‫حٌُخكج‬ ٖٓ ‫حُضحثذس‬ ً‫خ‬‫أ٣ن‬ ‫حُقذحع‬ ‫طغزذ‬. *‫طؾخسى‬ٖ٤ٓ‫حُذ٣ل٤ٜ٘٤ذسح‬ َ‫ٓؼ‬ ‫حُٜٔذثش‬ َٓ‫حُؼٞح‬ ‫ٓغ‬ ‫حُٔغظلنشحص‬ ‫رؼل‬ ٢‫ك‬ ‫ح٧ك٤ٞٗ٤ش‬ ‫ؿ٤ش‬ ‫حُٔغٌ٘خص‬ diphenhydramineٝ ،ٝ ُْ٧‫ح‬ ٖ٤ٌ‫ُظغ‬ ‫حُٔؾخسًخص‬ ٙ‫ٛز‬ ّ‫طغظخذ‬،‫حُٔئهض‬ ٢ِ٤ُِ‫ح‬ ‫ح٧سم‬ ‫ٓؼخُـش‬ٝ‫ش‬ َّ‫لغ‬‫ط‬ ً‫خ‬‫أ٣ن‬ ‫ح٧سم‬ ٖٓ ٌٞ‫٣ؾ‬ ‫ٓخ‬ ً‫خ‬‫ؿخُز‬ ُْ٧‫ح‬ ٖٓ ٢ٗ‫٣ؼخ‬ ١‫حُز‬ ‫حُٔش٣ل‬ ٕ‫رؤ‬ ‫كؼخُ٤ظٜخ‬.‫رحص‬ ‫حُٔغظلنشحص‬ ٙ‫ٛز‬ ٌَ‫طؾ‬ ٝ ٌٖ‫حُٔغ‬ ‫حُذٝحء‬ ‫٩ػطخء‬ ‫ٓ٬ثٔش‬ ‫ٝع٤ِش‬ ‫حُؼخرظش‬ ‫حُـشػش‬‫حُذٝحء‬٢‫ك‬ ‫حُٜٔذة‬‫ٗخك٤ش‬ ٖٓ ‫ٌُٜ٘خ‬ ،‫ٝحكذس‬ ‫ٝفلش‬ ‫حُٔظ٘ٞػش‬ ‫حٌُٔٞٗخص‬ ‫ؿشػش‬ َ٣‫طؼذ‬ َ‫طـؼ‬ ٟ‫أخش‬‫آٌخٗ٤ش‬ ٖٓ ‫طض٣ذ‬ ‫ًٔخ‬ ،‫حُظلو٤ن‬ ‫فؼذ‬ ً‫ح‬‫أٓش‬ ‫حُلشد٣ش‬ ‫ُِلخؿخص‬ ً‫خ‬‫طزؼ‬ ‫حُظذحخ٬ص‬ ‫كذٝع‬‫حُـخٗز٤ش‬ ‫ٝح٥ػخس‬ ‫حُذٝحث٤ش‬.
  21. 21. ‫األسنان‬ ‫طب‬ ‫في‬ ‫األدوية‬ ‫أساسيات‬ Dr. Firas Kassab21 ‫آالو‬‫انعصثيح‬ ‫االعتالالخ‬: ٙ‫ٛز‬ ‫ط٘ظؾ‬ٝ ٢‫حُؼقز‬ ‫حُ٘غ٤ؾ‬ ٢‫ك‬ ‫أر٣ش‬ ٖ‫ػ‬ ّ٫٥‫ح‬ٖٔ‫طظن‬: ّ٫٥‫ح‬‫(مٔٞس‬ ‫حُٔؼوذ‬ ٢‫حُٔ٘طو‬ ُْ٧‫ح‬ ‫ٓظ٬صٓش‬ ،٢‫حُؾزل‬ ‫حُطشف‬ ُْ‫أ‬ ،٨‫ُِل‬ ‫حُظخُ٤ش‬ ‫حُؼقز٤ش‬ُ‫ح‬ ١‫حُٞد‬،‫ٔ٘ؼٌظ‬ ٩‫ح‬ ،)١ٝ‫حٌُخ‬ ٢‫حُؼقز‬ ُْ٧‫ح‬٩‫ح‬ ‫حُؼقز٤ش‬ ‫ػظ٬٫ص‬٩‫ح‬ ،‫ٗنـخه٤ش‬‫ػظ٬٫ص‬ُ‫ح‬ ‫(حُذحء‬ ‫حُٔل٤ط٤ش‬ ‫حُؼقز٤ش‬‫ح٧ٓشحك‬ ،١‫غٌش‬ ،‫حُخز٤ؼش‬ ‫حُذٓٞ٣ش‬‫ا‬،١ٞ‫حُشػ‬ َ‫حُٔلخف‬ ‫ُظٜخد‬‫عٞء‬ ،‫حٌُلُٞ٤ش‬‫ا‬ٍ‫عظؼٔخ‬َ‫(ٓؼ‬ ‫حُٔشًض٣ش‬ ّ٫٥‫ح‬ ،‫حُشمٞف‬ ،)‫ح٧دٝ٣ش‬ ٢ُ‫حُظخ‬ ُْ٧‫ح‬‫حُ٘خخع‬ ‫طٌٜق‬ ،٢ًٞ‫حُؾ‬ َ‫حُلز‬ ‫أر٣ش‬ ،‫ُِغٌظش‬ٝ ،)‫حُزحط٤ش‬ ‫حُؼقز٤ش‬ ‫ح٧ٓشحك‬. ‫طؼخُؾ‬٩‫ح‬ ٖ‫ػ‬ ‫حُ٘خطـش‬ ّ٫٥‫ح‬‫ر‬ ّ‫ػخ‬ ٌَ‫رؾ‬ ‫حُؼقز٤ش‬ ‫ػظ٬٫ص‬‫ب‬٩‫ح‬ ‫ٓنخدحص‬ ّ‫عظخذح‬‫ػ٬ػ٤ش‬ ‫ًظجخد‬ٝ ‫حُلِوخص‬‫رؼل‬ ٝ ،‫حُخخفش‬ ‫حُقشع‬ ‫ٓنخدحص‬٩‫ح‬ ‫مؼ٤لش‬ ٌٕٞ‫ط‬‫حُٔغٌ٘ش‬ ‫ُ٨دٝ٣ش‬ ‫عظـخرش‬ٝ ،ٌٖٔ٣‫ر‬ ‫ٓؼخُـظٜخ‬‫ب‬ٍٝ‫حُظشحٓخد‬ ّ‫عظخذح‬ ٝ‫حُٔؼخُـش‬ ‫هشم‬ َ‫كؾ‬ ٍ‫كخ‬ ٢‫ك‬ ٖ٤‫حُذ٣ٌغظشٝرشٝرًٞغ٤ل‬ٟ‫ح٧خش‬. ً‫خ‬‫ؿخُز‬ٖ٤ِ٤‫ح٧ٓ٤ظش٣زظ‬ ّ‫٣غظخذ‬ ‫ٓخ‬amitriptyline‫ُ٤ِ٤ش‬ ‫رذث٤ش‬ ‫رـشػش‬10‫ـ‬25‫ص٣خدطٜخ‬ ٌٖٔ٣ ‫ِٓؾ‬٠‫كظ‬ ً‫خ‬٤‫طذس٣ـ‬75 ‫طؼط‬ ٕ‫أ‬ ‫ٓشحػخس‬ ‫ٓغ‬ ،‫حُلخؿش‬ ‫ػ٘ذ‬ ّٞ٣/‫ِٓؾ‬‫طلض‬ ‫حُؼخُ٤ش‬ ‫حُـشػخص‬ ٠‫اػطخء‬ ‫ًزُي‬ ٌٖٔ٣ .٢‫حُطز‬ ‫ح٩ؽشحف‬ ٖ٤ِ٤‫حُ٘ٞسطش٣زظ‬nortriptyline(ٖٝ‫ػ‬ ‫ٗخطؾ‬ ٞٛ‫ا‬‫عظو٬د‬‫ُ٤ِ٤ش‬ ‫رذث٤ش‬ ‫رـشػش‬ )ٖ٤ِ٤‫ح٧ٓ٤ظش٣زظ‬10‫ـ‬25ٝ ،‫ِٓؾ‬‫ح٥ػخس‬ ٖ‫ػ‬ ‫حُ٘خطـش‬ ‫حُـخٗز٤ش‬‫ا‬ّٞ٣‫حُقٞد‬ ‫كخُزشٝحص‬ ‫أٓخ‬ .َ‫أه‬ ٌٕٞ‫ط‬ ٚٓ‫عظخذح‬sodium valproateٖٝ٤‫حُل٤٘٤ظٞث‬phenytoin ٪ُ ّ‫ػخ‬ ٌَ‫رؾ‬ ‫كظخقـ‬٢‫حُطز‬ ‫ح٩ؽشحف‬ ‫طلض‬ ٍ‫عظؼٔخ‬. ‫سخـ‬‫ا‬ٖ٤‫حٌُخرغخ٣غ‬ ّ‫عظخذح‬capsaicin‫حُؾذ٣ذ‬ ‫حُٔلشم‬ ‫حُلظ‬ ٌُٖ ،‫حُؼقز٤ش‬ ّ٫٥‫ح‬ ‫ُٔؼخُـش‬‫٣غ‬ ١‫حُز‬ٚ‫زز‬ ٖٓ ‫٣لذ‬ ‫هذ‬ ‫حُٔؼخُـش‬ ‫رذء‬ ٟ‫ُذ‬‫ا‬ٚٓ‫عظخذح‬. ‫طل٤ذ‬ ‫هذ‬‫حُوؾش٣ش‬ ‫حُغظ٤شٝث٤ذحص‬corticosterois٢‫ك‬ ‫حُنـو‬ ‫طخل٤ق‬ ٢‫ك‬‫ا‬‫ح٧ػقخد‬ ‫ػظ٬٫ص‬٩‫ح‬٢ُ‫ٝرخُظخ‬ ‫ٗنـخه٤ش‬ ُْ٧‫ح‬ ‫طخل٤ق‬. ْ‫حُظٞحث‬ ‫ٓؼِغ‬ ‫حُؼقذ‬ ُْ‫أ‬trigeminal neuralgia: ٖ‫ػ‬ ْ‫حُظٞحث‬ ‫ٓؼِغ‬ ‫حُؼقذ‬ ُْ‫أ‬ ‫٣٘ؾؤ‬ٖ‫ػ‬ ‫٣خظِق‬ ٚ٤ِ‫ػ‬ ‫حُغ٤طشس‬ ‫أعِٞد‬ ٌُٖ ،٢‫حُؼقز‬ ‫حُ٘غ٤ؾ‬ ‫ٝظ٤لش‬ ٢‫ك‬ َِ‫خ‬ ّ٫٥‫ح‬ ٖٓ ٙ‫ؿ٤ش‬ٝ ،٠‫حُٔشم‬ ٖٓ ‫ًؼ٤ش‬ ٟ‫ُذ‬ َ‫ح٧ٓؼ‬ ‫حُخ٤خس‬ ‫حُـشحكش‬ ٌٕٞ‫ط‬ ‫كوذ‬ ‫حُؼقز٤ش؛‬‫طخ‬ ٌٖٔ٣‫كذس‬ ‫ل٤ق‬ ٖ٤‫حٌُخسرخٓخص٣ز‬ ‫ربػطخء‬ ‫حُلخدس‬ َ‫حُٔشحك‬ ٢‫ك‬ ُْ٧‫ح‬ ‫ٛـٔخص‬carbamazipineٝ‫٣ـذ‬ ٌُٖ‫حُظشحً٤ض‬ ‫ٓشحهزش‬ ٝ ‫ػخُ٤ش‬ ‫رـشػخص‬ ٢‫أػط‬ ‫ٓخ‬ ‫ارح‬ ‫ُِذٝحء‬ ‫حُز٬عٔ٤ش‬‫ر‬ ‫حُزذء‬ ‫٣ـذ‬‫ب‬ٚٓ‫عظخذح‬‫ح٥ػخس‬ ‫ظٜٞس‬ ١‫ُظلخد‬ ‫فـ٤شس‬ ‫رـشػخص‬ ٖ٤‫حُ٬ٓٞطش٣ـ‬ ‫اػطخء‬ ٌٖٔ٣ .‫حُذٝخش‬ َ‫ٓؼ‬ ‫حُـخٗز٤ش‬lamotrigine‫ًذ‬،‫ٓشخـ‬ ‫ؿ٤ش‬ ‫ح٫عظطزخد‬ ‫ٛزح‬ ٕ‫أ‬ ‫ؿ٤ش‬ َ٣‫رذ‬ ‫ٝحء‬ ٝ‫حُلخ٫ص‬ ‫رؼل‬ ‫طغظـ٤ذ‬ ‫هذ‬ٖ٤‫رخُل٤٘٤ظٞث‬ ‫ُِٔؼخُـش‬phenytoin. ٨‫ُِل‬ ٢ُ‫حُظخ‬ ٢‫حُؼقز‬ ُْ٧‫ح‬postherpetic neuralgia: ٖ٤٘‫حُٔغ‬ ٟ‫ُذ‬ ‫ٝخخفش‬ ٢‫حُ٘طخه‬ ٨‫رخُل‬ ‫حُلخدس‬ ‫ح٩فخرش‬ ً‫س‬‫ػخد‬ ُْ٧‫ح‬ ‫ٛزح‬ ٢ِ٣ٝ‫ر‬ ً‫س‬‫ػخد‬ ‫٣ؼخُؾ‬‫ب‬ّ‫عظخذح‬ ٖ٤ِ٤‫ح٧ٓ٤ظش٣زظ‬amitriptylineٝ ،‫طشخ٤ـ‬ ْ‫ط‬ ‫هذ‬‫ا‬ّ‫عظخذح‬٠ِ‫ػ‬ ‫حُلخٝ٣ش‬ ُْ٨ُ ‫حُٔغٌ٘ش‬ ‫حُٔٞمؼ٤ش‬ ‫حُٔغظلنشحص‬ ٖ٤‫حٌُخرغخ٣غ‬capsaicin‫رظشً٤ض‬0.075ٝ ،٠‫حُٔشم‬ ‫رؼل‬ ٟ‫ُذ‬ ‫حُٔٞمؼ٤ش‬ ‫حُٔخذسحص‬ ‫ططز٤ن‬ ‫٣ل٤ذ‬ ‫هذ‬.

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