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By Greg O’Keefe
 Introduction to Neuroethics
 InvolvedTechnology
 Ethical Considerations
 Law, Discrimination/Stigma, Incidental Findings,
Neuromarketing
 Summary and Conclusion
 Emerging field
 Advanced understanding and monitoring of
human thought and behavior
 Brings new ethical, social and legal issues
forward
 Enabled by modern neurotechnologies
 Can now quantify personal behaviors
 Social attitude, value and moral agency
 Akin to modern genetics
 Prediction of disease, privacy, identity
 Must carefully and properly interpret
relationship between brain findings and
concept of self
 Must tackle practical questions in
neuroimaging
 Interpretation is fundamental
 Ethics of genetics are not a sufficient guide
 Not apart of traditional bioethical analysis
 A ScaryTrend
 The Good, the Bad and the AnteriorCingulate
(2002)
 Morals and the Human Brain: AWorking
Model (2003)
 Strategizing the Human Brain (2003)
 The Medial Frontal Cortex and the Rapid
Processing of Monetary Gains and Losses
(2002)
 The Neural Basis of Economic Decision-
Making in the Ultimatum Game (2003)
 How the Mind Reads other Minds (2003)
 Tapping the Mind (2003)
 WhyWe’re So Nice:We’reWired to Cooperate
(2002)
 There’s a Sucker Born in Every Medial
Prefrontal Cortex (2003)
 “Thought maps”
 Quantitative profiles of brain function
 “Thought maps”
 Not restricted to medical research and clinical
neuropsychiatry
 Natural relevance in our daily life
 Introduces many possibilities/desires
 Assessing truth of statements and memory in law
 Profiling prospective employees for professional
and interpersonal skills
 Evaluating students for learning potential
 Selecting investment managers to handle
financial portfolios
 Choosing life partners based on compatible brain
profiles
 Raises a number of epistemological issues
 The study of knowledge
 What is knowledge, how can it be accessed, how can
it be used?
 Proper interpretation
 Scientific level
 Complexity of neuroscience research – integration
and interpretation of neuroimaging data
 Social and cultural level
 Social interpretations, bound by cultural and
anthropological frameworks
 Most prominent tools:
 Electroencephalography (EEG)
 Magnetoencephalography (MEG)
 Positron emission tomography (PET)
 Single photon emission computed tomography
(SPECT)
 Functional Magnetic Resonance Imaging (fMRI)
 1929, Hans Berger
 Invented electroencephalogram
 Relative signal strength and position of electrical
activity generated at level of cerebral cortex
 Measured using electrodes placed on scalp
 Evoked EEG response, “event related potential”
 First tool used to reveal fundamental knowledge
behind the operation of the human brain in real
time
 Other imaging methods took advantage of
brain signals
 Extracranial electromagnetic activity (MEG)
 Metabolic activity and blood flow (PET SPECT)
 Regional blood oxygenation (fMRI)
 All imaging methods use
comparison/subtraction between two
controlled conditions
 All imaging methods use heavy statistical
processing and computer intensive data
reconstruction
 Ultimately produce the familiar and colorful
maps
 Used for diagnosis/intervention
of trauma, dementia, stroke, etc.
 fMRIs will have greatest impact
 Widespread availability of MR scanners
 Imaging approach is non-invasive
 Model for neuroethical discussions
 Relative difference between experimental and
control (baseline) task
 Surplus of oxygenated blood recruited to
relatively active brain regions produces effects
measured by MR
 fMRI used alone or in combo with previously
mentioned techniques in studies
 Lying and deception
 Human cooperation and competition
 Brain differences in violent people
 Genetic influences
 Variability in patterns of brain development
 Investigation of unio mysticia using EEG, fMRI,
and PET
 “Spiritual neuroscience”
 Personal neuroprofiles ripe for bioethical
consideration
 Neuroscience and philosophical questions
 Existence limits
 Meaning of free will
 Distinguishing truth from lies, false memories
from real ones
 Prediction of behavior
Neuroethics presentation
 1985 –Ake v. Oklahoma
 Glen Burton Ake murdered a couple, wounded
their two children
 Acted bizarrely in court, prompted judge to order
psychiatric competency evaluation
 Report resulted in identifying Ake as delusional
▪ Claimed to be ‘Sword ofVengeance’ and will sit at the
left hand of God in heaven
 Diagnosed as probable paranoid schizophrenic
▪ Is he competent to stand trial?
 Ake’s attorney requested the court appoint a
psychiatrist to evaluate him for purpose of
insanity defense
 Criminal defendants argue this should include
scans like PET and MRI
 What do you guys think? DoesAke get
evaluated?
 The court says, nope!
 Upheld that he had no such right to assistance
 Ake was then tried
 Convicted of 2 counts of murder
 Sentenced to death
 Conviction overturned!
 Ake was not provided a psychiatrist
 Deemed unfair trial
 Found guilty again, this time just life in prison
 Should neuroimaging be used regardless of
offences?
 Do they ‘deserve’ it?
 Burden of the state?
 Unfair advantage?
 Keep in mind: PET previously has shown poor
functioning in prefrontal cortex of criminals
 Locus of impulse control
 PET images have been used to argue that
defendant was biologically predisposed to
committing a crime
 Further argued they should be spared
conviction or death sentence
 1994 – People v. Jones
 Homicide conviction overturned
 State failed to provide brain scans
 1992 – People v.Weinstein
 Accused of strangling his wife to death, throwing
her body from 12th floor
 PET, MRI showed arachnoid cyst, used for insanity
defense
 1992 – People v.Weinstein
 PET scan showed juxtaposition between black
cyst and red/green colored “normal” areas
 Juxtaposition was apparently “profound”,
apparent his brain was not functioning normally
 Convicted of manslaughter
 Thoughts?
 2001 – Langleben et al.
 fMRI study
 Approach to truth verification, “brain fingerprinting”
 Participants with/without playing cards
 Boils down to “lying takes more energy”
 Results consistent with studies done in 1997 and 2003
 Can also determine if deception is premeditated
 Thoughts? Is brain fingerprinting legitimate?
Should it be used in court?
 Brain fingerprinting
 Terry Harrington, convicted of murder of retired
police officer in 1977
▪ Underwent brain fingerprinting in 2000
▪ EEG patterns suggested he was innocent
▪ Original prosecution witness recanted statement when
presented with this evidence
Neuroethics presentation
 Health information is not entirely private
 This can lead to denial of
 Health insurance
 Employment
 Education
 Financial loans
 Neuroimaging provides insights into range of
higher cognitive functions
 Many do not have good animal models
 Studies touch on areas of profound societal
importance and controversy
 Race relations, economic justice, perceived
trustworthiness, moral reasoning, economic
cooperation, social rejection, consumer
brand attachment
 Ability to predict behavior raises many
concerns
 Mind-reading
 Social control
 Novelty and extent of neuroimaging data
gives info on human health, behavior and
cognitive fitness
 Raises concern
 How much of this info will be used to benefit
mankind?
 Can the info be used for harm or purposes
with ill-intent?
 How will neuroimaging affect our daily life?
 Work, education, financial, social interactions
 Prediction of future behavior/pathology
 Screening for team players and weak
decision-makers in the workplace?
 Post-Columbine era
 Screening students for predisposition to unruly or
violent behavior?
 Post 9/11 era
 Screening for terrorists?
 Perhaps a brain scan at the airport?
 Detention of individuals who have not yet
committed a crime
 DSPD – Dangerous Severe Personality Disorder
 Type I and II errors – statistical threshold
 Cost vs. detaining past sentence (which can be legal)
 Pedophiles
 January 22nd, 2002 – US Supreme Court states:
▪ Can confine violent sexual offenders beyond their prison term
▪ Only if shown they have mental/personality disorder making
it difficult to control behavior
 Very likely future imaging studies will be used to
determine felon’s ability to control behavior
 More effective than behavioral test
 So, back to pedophiles!
 Megan’s Law
 Information on sex offenders available to public
 What if brain scans can be used to identify
potential pedophiles among non-criminal
persons
 Who should scan? How should the data be used?
Should identified persons be registered? Should it be
made available to employers?
Neuroethics presentation
 Incidental findings
 “Observations of potential clinical significance
and unexpectedly discovered and unrelated to the
purpose of variables of the study”
 Found in up to 10% of neuroimaging research
 How should they be handled? In what way?
What should be done?
 Abide by legal and ethical principles in
research/medicine
 Risks
 Emotional burden, possible unnecessary
procedures
 Benefits
 Early detection of something that can be
treated/prevented
 How about opportunity to waive right to
receive info on incidental findings?
 Case Study!
 FE is 65 yo female fMRI volunteer
 Study is for osteoarthritic knee pain
 Found to have ischemic changes in left temporal
lobe during brain scan
 She had no neurological deficit, did not complain
of discomfort
 What would you do?
 What actually happened
 PI was clinician, decided to disclose findings
 With her permission contacted physician for follow
up
 FE developed neurological deficits 24 hours
later, underwent repeat neuroimaging and
treatment
 Diagnosis of ischemic temporal lobe
 Survived after treatment
 Afterwards, PI and team felt distressed and
unequipped in dealing with incidental
findings
 Wished for clear documentation of whether
patient wanted to be informed
 Addressed lack of standard guidelines, protocol,
training, knowledge regarding legal and ethical
principles
 Canada – all known foreseeable risks (even rare
and remote) must be disclosed to research
participants or surrogate decision-maker
 Guided by Halushka v. University of Saskatchewan and
Weiss v. Solomon
 No mention of whether foreseeable incidental
findings should be regarded as potential risks/harms
 No clear guidelines as to when and what to disclose in
best interests of the patient
 Thoughts?
Neuroethics presentation
 Goal of marketing is to match products with
people
 Guide design and presentation of products to
increase compatibility with consumers
 Facilitating choice process of customer
 Neuroeconomics – incorporating
neuroimaging into decision-making sciences
 Hope among marketers neuroimaging will
streamline marketing processes while saving
money
 Obtain customer information that cannot be
acquired using conventional methods
 Some companies market neuromarketing
itself
 More accurately indicate underlying
preferences than standard market data
 Remains insensitive to biases
 Efficiently allocate resources
 Product concepts tested rapidly
 Unpromising concepts eliminated early
 Can now focus on promising products
 Banned in France
 Eye-tracking, galvanic skin response still legal
 Misinterpretation and over-interpretation an
issue
 Video:
http://www.youtube.com/watch?v=Ajg0ypD
D7i0
 Unsettling?Creepy?
 Is it ethical?
 Need to respect autonomy, confidentiality,
privacy
 Informed consent? Full disclosure of risk or harm
▪ How invasive are the procedures?
 What exactly can the data be used for?
 Protecting the vulnerable
 Children, psychiatric patients, prisoners
 Can be easily influenced
▪ Easily deceived and/or experience negative affected
 Commercial use of data from these groups
 Is it justified? Can it be defended?
 Baylor College of Medicine
 Pepsi vs. Coca-Cola
 fMRI showed consumers prefer Pepsi
▪ 5x the response in ventral putamen
 When repeated unblind…
▪ Nearly all participants prefer Coca-Cola
▪ Medial prefrontal cortex was activated – linked to sense
of self
▪ Brand is so attractive its overriding our taste buds?
 Are you comfortable with neuromarketing?
 Should lines be drawn?Where?
 What can the information be used for?
 Do the risks outweigh the benefits?
 Do we care that much about finding products that
suit us?
 Neuroethics is still young
 Many unaddressed situations
 Neuroscience “boomed” in early 21st century
 Utilizes neuroimaging
 EEG, MEG, PET, SPECT, fMRI
 Massive impact on bioethics
 Law, Discrimination/Stigma, Incidental findings,
Neureconomics/Neuromarketing, etc.
 However, brain imaging is extremely useful
 Understanding how our brain functions, diagnosis
of disease, detecting abnormalities
 Interpretation is the key issue
 Scientific and social level
 Should lines be drawn?Where do we draw
the line?
 Illes, J., & Racine, E. (2005). Imaging or Imagining?A Neuroethics
Challenge Informed by Genetics. The AmericanJournal of Bioethics :
AJOB, 5(2), 5–18. doi:10.1080/15265160590923358
 Illes, J., & Bird, S. (2006, July 21). Neuroethics:A modern context for
ethics in neuroscience. Retrieved February 12, 2015, from
http://neuroethics.stanford.edu/documents/TINSarticle.pdf
 Scanning the social brain. (n.d.). Retrieved February 12, 2015, from
http://www.nature.com/neuro/journal/v6/n12/full/nn1203-1239.html
 Canli,T., & Amin, Z. (2002, December 3). Neuroimaging of emotion and
personality: Scientific evidence and ethical considerations. Retrieved
February 12, 2015, from
http://www.sciencedirect.com.ezpxy.fanshawec.ca/science/article/pii/S0
278262602005171
 Lawrence Leung, “Incidental Findings in Neuroimaging: Ethical and
MedicolegalConsiderations,”Neuroscience Journal, vol. 2013, Article ID
439145, 7 pages, 2013. doi:10.1155/2013/439145
 Ariely, D., & Berns, G. S. (2010). Neuromarketing: the hope and hype of
neuroimaging in business. Nature Reviews. Neuroscience, 11(4), 284–292.
doi:10.1038/nrn2795
 Yesim Isil Ulman,Tuna Cakar & GokcenYildiz, Ethical Issues in
Neuromarketing: “I Consume,Therefore I am!”, Science and Engineering
Ethics, ISSN 1353-3452, Sci Eng Ethics, DOI 10.1007/s11948-014-9581-5

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Neuroethics presentation

  • 2.  Introduction to Neuroethics  InvolvedTechnology  Ethical Considerations  Law, Discrimination/Stigma, Incidental Findings, Neuromarketing  Summary and Conclusion
  • 4.  Advanced understanding and monitoring of human thought and behavior  Brings new ethical, social and legal issues forward  Enabled by modern neurotechnologies
  • 5.  Can now quantify personal behaviors  Social attitude, value and moral agency  Akin to modern genetics  Prediction of disease, privacy, identity  Must carefully and properly interpret relationship between brain findings and concept of self
  • 6.  Must tackle practical questions in neuroimaging  Interpretation is fundamental  Ethics of genetics are not a sufficient guide  Not apart of traditional bioethical analysis
  • 8.  The Good, the Bad and the AnteriorCingulate (2002)  Morals and the Human Brain: AWorking Model (2003)  Strategizing the Human Brain (2003)  The Medial Frontal Cortex and the Rapid Processing of Monetary Gains and Losses (2002)  The Neural Basis of Economic Decision- Making in the Ultimatum Game (2003)
  • 9.  How the Mind Reads other Minds (2003)  Tapping the Mind (2003)  WhyWe’re So Nice:We’reWired to Cooperate (2002)  There’s a Sucker Born in Every Medial Prefrontal Cortex (2003)
  • 10.  “Thought maps”  Quantitative profiles of brain function  “Thought maps”  Not restricted to medical research and clinical neuropsychiatry  Natural relevance in our daily life
  • 11.  Introduces many possibilities/desires  Assessing truth of statements and memory in law  Profiling prospective employees for professional and interpersonal skills  Evaluating students for learning potential  Selecting investment managers to handle financial portfolios  Choosing life partners based on compatible brain profiles
  • 12.  Raises a number of epistemological issues  The study of knowledge  What is knowledge, how can it be accessed, how can it be used?  Proper interpretation  Scientific level  Complexity of neuroscience research – integration and interpretation of neuroimaging data  Social and cultural level  Social interpretations, bound by cultural and anthropological frameworks
  • 13.  Most prominent tools:  Electroencephalography (EEG)  Magnetoencephalography (MEG)  Positron emission tomography (PET)  Single photon emission computed tomography (SPECT)  Functional Magnetic Resonance Imaging (fMRI)
  • 14.  1929, Hans Berger  Invented electroencephalogram  Relative signal strength and position of electrical activity generated at level of cerebral cortex  Measured using electrodes placed on scalp  Evoked EEG response, “event related potential”  First tool used to reveal fundamental knowledge behind the operation of the human brain in real time
  • 15.  Other imaging methods took advantage of brain signals  Extracranial electromagnetic activity (MEG)  Metabolic activity and blood flow (PET SPECT)  Regional blood oxygenation (fMRI)  All imaging methods use comparison/subtraction between two controlled conditions
  • 16.  All imaging methods use heavy statistical processing and computer intensive data reconstruction  Ultimately produce the familiar and colorful maps  Used for diagnosis/intervention of trauma, dementia, stroke, etc.
  • 17.  fMRIs will have greatest impact  Widespread availability of MR scanners  Imaging approach is non-invasive  Model for neuroethical discussions  Relative difference between experimental and control (baseline) task  Surplus of oxygenated blood recruited to relatively active brain regions produces effects measured by MR
  • 18.  fMRI used alone or in combo with previously mentioned techniques in studies  Lying and deception  Human cooperation and competition  Brain differences in violent people  Genetic influences  Variability in patterns of brain development  Investigation of unio mysticia using EEG, fMRI, and PET  “Spiritual neuroscience”
  • 19.  Personal neuroprofiles ripe for bioethical consideration  Neuroscience and philosophical questions  Existence limits  Meaning of free will  Distinguishing truth from lies, false memories from real ones  Prediction of behavior
  • 21.  1985 –Ake v. Oklahoma  Glen Burton Ake murdered a couple, wounded their two children  Acted bizarrely in court, prompted judge to order psychiatric competency evaluation  Report resulted in identifying Ake as delusional ▪ Claimed to be ‘Sword ofVengeance’ and will sit at the left hand of God in heaven  Diagnosed as probable paranoid schizophrenic ▪ Is he competent to stand trial?
  • 22.  Ake’s attorney requested the court appoint a psychiatrist to evaluate him for purpose of insanity defense  Criminal defendants argue this should include scans like PET and MRI  What do you guys think? DoesAke get evaluated?
  • 23.  The court says, nope!  Upheld that he had no such right to assistance  Ake was then tried  Convicted of 2 counts of murder  Sentenced to death
  • 24.  Conviction overturned!  Ake was not provided a psychiatrist  Deemed unfair trial  Found guilty again, this time just life in prison
  • 25.  Should neuroimaging be used regardless of offences?  Do they ‘deserve’ it?  Burden of the state?  Unfair advantage?  Keep in mind: PET previously has shown poor functioning in prefrontal cortex of criminals  Locus of impulse control
  • 26.  PET images have been used to argue that defendant was biologically predisposed to committing a crime  Further argued they should be spared conviction or death sentence
  • 27.  1994 – People v. Jones  Homicide conviction overturned  State failed to provide brain scans  1992 – People v.Weinstein  Accused of strangling his wife to death, throwing her body from 12th floor  PET, MRI showed arachnoid cyst, used for insanity defense
  • 28.  1992 – People v.Weinstein  PET scan showed juxtaposition between black cyst and red/green colored “normal” areas  Juxtaposition was apparently “profound”, apparent his brain was not functioning normally  Convicted of manslaughter  Thoughts?
  • 29.  2001 – Langleben et al.  fMRI study  Approach to truth verification, “brain fingerprinting”  Participants with/without playing cards  Boils down to “lying takes more energy”  Results consistent with studies done in 1997 and 2003  Can also determine if deception is premeditated  Thoughts? Is brain fingerprinting legitimate? Should it be used in court?
  • 30.  Brain fingerprinting  Terry Harrington, convicted of murder of retired police officer in 1977 ▪ Underwent brain fingerprinting in 2000 ▪ EEG patterns suggested he was innocent ▪ Original prosecution witness recanted statement when presented with this evidence
  • 32.  Health information is not entirely private  This can lead to denial of  Health insurance  Employment  Education  Financial loans
  • 33.  Neuroimaging provides insights into range of higher cognitive functions  Many do not have good animal models  Studies touch on areas of profound societal importance and controversy  Race relations, economic justice, perceived trustworthiness, moral reasoning, economic cooperation, social rejection, consumer brand attachment
  • 34.  Ability to predict behavior raises many concerns  Mind-reading  Social control  Novelty and extent of neuroimaging data gives info on human health, behavior and cognitive fitness  Raises concern
  • 35.  How much of this info will be used to benefit mankind?  Can the info be used for harm or purposes with ill-intent?  How will neuroimaging affect our daily life?  Work, education, financial, social interactions
  • 36.  Prediction of future behavior/pathology  Screening for team players and weak decision-makers in the workplace?  Post-Columbine era  Screening students for predisposition to unruly or violent behavior?
  • 37.  Post 9/11 era  Screening for terrorists?  Perhaps a brain scan at the airport?  Detention of individuals who have not yet committed a crime  DSPD – Dangerous Severe Personality Disorder  Type I and II errors – statistical threshold  Cost vs. detaining past sentence (which can be legal)
  • 38.  Pedophiles  January 22nd, 2002 – US Supreme Court states: ▪ Can confine violent sexual offenders beyond their prison term ▪ Only if shown they have mental/personality disorder making it difficult to control behavior  Very likely future imaging studies will be used to determine felon’s ability to control behavior  More effective than behavioral test
  • 39.  So, back to pedophiles!  Megan’s Law  Information on sex offenders available to public  What if brain scans can be used to identify potential pedophiles among non-criminal persons  Who should scan? How should the data be used? Should identified persons be registered? Should it be made available to employers?
  • 41.  Incidental findings  “Observations of potential clinical significance and unexpectedly discovered and unrelated to the purpose of variables of the study”  Found in up to 10% of neuroimaging research  How should they be handled? In what way? What should be done?  Abide by legal and ethical principles in research/medicine
  • 42.  Risks  Emotional burden, possible unnecessary procedures  Benefits  Early detection of something that can be treated/prevented  How about opportunity to waive right to receive info on incidental findings?
  • 43.  Case Study!  FE is 65 yo female fMRI volunteer  Study is for osteoarthritic knee pain  Found to have ischemic changes in left temporal lobe during brain scan  She had no neurological deficit, did not complain of discomfort  What would you do?
  • 44.  What actually happened  PI was clinician, decided to disclose findings  With her permission contacted physician for follow up  FE developed neurological deficits 24 hours later, underwent repeat neuroimaging and treatment  Diagnosis of ischemic temporal lobe  Survived after treatment
  • 45.  Afterwards, PI and team felt distressed and unequipped in dealing with incidental findings  Wished for clear documentation of whether patient wanted to be informed  Addressed lack of standard guidelines, protocol, training, knowledge regarding legal and ethical principles
  • 46.  Canada – all known foreseeable risks (even rare and remote) must be disclosed to research participants or surrogate decision-maker  Guided by Halushka v. University of Saskatchewan and Weiss v. Solomon  No mention of whether foreseeable incidental findings should be regarded as potential risks/harms  No clear guidelines as to when and what to disclose in best interests of the patient  Thoughts?
  • 48.  Goal of marketing is to match products with people  Guide design and presentation of products to increase compatibility with consumers  Facilitating choice process of customer  Neuroeconomics – incorporating neuroimaging into decision-making sciences
  • 49.  Hope among marketers neuroimaging will streamline marketing processes while saving money  Obtain customer information that cannot be acquired using conventional methods  Some companies market neuromarketing itself
  • 50.  More accurately indicate underlying preferences than standard market data  Remains insensitive to biases  Efficiently allocate resources  Product concepts tested rapidly  Unpromising concepts eliminated early  Can now focus on promising products
  • 51.  Banned in France  Eye-tracking, galvanic skin response still legal  Misinterpretation and over-interpretation an issue  Video: http://www.youtube.com/watch?v=Ajg0ypD D7i0
  • 52.  Unsettling?Creepy?  Is it ethical?  Need to respect autonomy, confidentiality, privacy  Informed consent? Full disclosure of risk or harm ▪ How invasive are the procedures?  What exactly can the data be used for?
  • 53.  Protecting the vulnerable  Children, psychiatric patients, prisoners  Can be easily influenced ▪ Easily deceived and/or experience negative affected  Commercial use of data from these groups  Is it justified? Can it be defended?
  • 54.  Baylor College of Medicine  Pepsi vs. Coca-Cola  fMRI showed consumers prefer Pepsi ▪ 5x the response in ventral putamen  When repeated unblind… ▪ Nearly all participants prefer Coca-Cola ▪ Medial prefrontal cortex was activated – linked to sense of self ▪ Brand is so attractive its overriding our taste buds?
  • 55.  Are you comfortable with neuromarketing?  Should lines be drawn?Where?  What can the information be used for?  Do the risks outweigh the benefits?  Do we care that much about finding products that suit us?
  • 56.  Neuroethics is still young  Many unaddressed situations  Neuroscience “boomed” in early 21st century  Utilizes neuroimaging  EEG, MEG, PET, SPECT, fMRI  Massive impact on bioethics  Law, Discrimination/Stigma, Incidental findings, Neureconomics/Neuromarketing, etc.
  • 57.  However, brain imaging is extremely useful  Understanding how our brain functions, diagnosis of disease, detecting abnormalities  Interpretation is the key issue  Scientific and social level  Should lines be drawn?Where do we draw the line?
  • 58.  Illes, J., & Racine, E. (2005). Imaging or Imagining?A Neuroethics Challenge Informed by Genetics. The AmericanJournal of Bioethics : AJOB, 5(2), 5–18. doi:10.1080/15265160590923358  Illes, J., & Bird, S. (2006, July 21). Neuroethics:A modern context for ethics in neuroscience. Retrieved February 12, 2015, from http://neuroethics.stanford.edu/documents/TINSarticle.pdf  Scanning the social brain. (n.d.). Retrieved February 12, 2015, from http://www.nature.com/neuro/journal/v6/n12/full/nn1203-1239.html  Canli,T., & Amin, Z. (2002, December 3). Neuroimaging of emotion and personality: Scientific evidence and ethical considerations. Retrieved February 12, 2015, from http://www.sciencedirect.com.ezpxy.fanshawec.ca/science/article/pii/S0 278262602005171
  • 59.  Lawrence Leung, “Incidental Findings in Neuroimaging: Ethical and MedicolegalConsiderations,”Neuroscience Journal, vol. 2013, Article ID 439145, 7 pages, 2013. doi:10.1155/2013/439145  Ariely, D., & Berns, G. S. (2010). Neuromarketing: the hope and hype of neuroimaging in business. Nature Reviews. Neuroscience, 11(4), 284–292. doi:10.1038/nrn2795  Yesim Isil Ulman,Tuna Cakar & GokcenYildiz, Ethical Issues in Neuromarketing: “I Consume,Therefore I am!”, Science and Engineering Ethics, ISSN 1353-3452, Sci Eng Ethics, DOI 10.1007/s11948-014-9581-5