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SLIDE‹#›
EnablingDigitalDiagnostics
WithaDataSciencePlatform
WadeL.Schulz,MD,PhD
DepartmentofLaboratoryMedicine
RichardTorres,MD,MS
DepartmentofLaboratoryMedicine
SLIDE‹#›
Overview
•HealthcareDataandDataSources
•Yale/YNHHDataSciencePlatform
•TheDataScienceJourney:ComputationalHealthcareUseCase
–Question
–Data
–Architecture
–Implementation
•OtherUseCasesinHealthcare
SLIDE‹#›
Healthcare(Big?)Data
SLIDE‹#›
Healthcare(Big?)Data
SLIDE‹#›
TheDreamforBigDatainHealthcare
SLIDE‹#›
TheDataSciencePlatform
K
er
b
er
iz
e
d
SLIDE‹#›
DataScienceJourney
SLIDE‹#›
CreatingDataScienceQuestions
•Definethequestion/hypothesis
•Assessthedatasource,cleanasnecessary
•Iterativelytesttheexperimentandimplementation
DescriptiveDiagnosticPredictivePrescriptive
SLIDE‹#›
ClinicalLaboratoryUseCase
•AdvancedAnalyticsforLaboratoryDiagnostics(Yale-NewHaven)
–~10millionlaboratorytests
–~46millionresultsperyear
–Significantnumberrequirephysicianinterpretation
–Labbasedexample
•Analogoustoanatomic(tissue)pathology
•Applicablebeyond
SLIDE‹#›
GeneralProblemDefinition
•Canweusebigdataandmachinelearningtoimproveourdiagnosticreproducibilityandthroughput
forlaboratorytesting?
•Hypothesis:TheuseofaMLalgorithmandreal-timedataprocessingpipelinewillimproveour
turnaroundtimeandinterpretivereproducibility.Quantitativeresultswillimprovediagnostic
accuracy.

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