5. NGS Shift Toward Downstream Analytics
Source: Sboner et. all. "The Cost of Sequencing: Higher Than You Think!" Genome Biology 2011, 12:125
5
6. Multifactorial Compute Implications to
Epigenomic Analysis
Source: Kohane IS, Kho AT, Butte AJ. Microarrays for an
Integrative Genomics. (The MIT Press; Cambridge, MA;
2003), p. 11.
6
7. Data intensive Genome Analytics
Collecting and integrating large‐scale, diverse data types
Transforming Genomic data into
biological information to enable
inference and network logic analysis
7
11. Architecture for Discovery
• Seamlessly solve your most important problems of any scale
Intel® Xeon® processor
• Ground-breaking real-world application performance
• Industry-leading energy efficiency
• Meet HPC challenges and scale for growth
Intel® Xeon Phi™ product family
• Based on Intel® Many Integrated Core (MIC) architecture
• Leading performance for highly parallel workloads
• Common Intel Xeon programming model
• Seamlessly increases developer productivity
11
12. The Foundation of High-performance
Computing
Intel® Xeon® Processor E5-2600 Family
Up to 73% performance
boost vs. prior gen1 on HPC
suite applications
Over 2X improvement on key
industry benchmarks
Up to 4 channels
DDR3 1600 memory
Significantly reduce
compute time on large,
Up to 8 cores complex data sets with Intel®
Up to 20 MB cache
Advanced Vector Extensions
Integrated
PCI Express* Integrated I/O
cuts latency while
adding capacity & bandwidth
1 Over previous generation Intel® processors. Intel internal estimate. For more legal information on performance forecasts go to http://www.intel.com/performance
12
13. Delivers on Today’s HPC Challenges
Intel Xeon processor
E5-4600 product family
Most FLOPS per server - up to 1.7x
compared to Intel Xeon processor E5-
2600 product family1
Excellent 4-socket performance per
watt
Up to 70% better density at
rack level1,2
More compute capacity with up to
1.5TB memory & 160 lanes PCIe* 3.0
Results that have been estimated based on internal Intel analysis and are provided for informational purposes only. Any difference in system hardware or software design or configuration may affect actual performance.
Software and workloads used in performance tests may have been optimized for performance only on Intel microprocessors. Performance tests, such as SYSmark and MobileMark, are measured using specific computer
systems, components, software, operations and functions. Any change to any of those factors may cause the results to vary. You should consult other information and performance tests to assist you in fully evaluating your
contemplated purchases, including the performance of that product when combined with other products. Configuration Details: Please reference back up slides. For more information go to http://www.intel.com/performance
1 Intel internal assessment compared to Intel Xeon processor E5-2600 product family; see backup for configuration details
2 Assumed max density for 2S platforms achieved in 1U form factor; max density for 4S platforms achieved in 2U form factor
13 * Other names and brands may be claimed as the property of others
14. Intel’s Many Core and Multi-core Engines
Intel® Xeon® processor:
• Intel’s Foundation of HPC Performance
• Suited for full scope of workloads
• Industry leading performance/watt for serial
& highly parallel workloads.
Multi-core Intel® Xeon® processor at 2.0-3.5 GHz
Intel® Xeon Phi™ coprocessor:
• Optimized for highly parallelized compute
intensive workloads
• Common programming model & S/W tools
with Xeon processors, enabling efficient app
readiness and performance tuning
• Launching on 22nm with >50 cores and
Many Core Intel® Xeon® Phi™ coprocessor at 1-1.5 GHz required b/w to provide outstanding
performance for highly parallel HPC uses
• Die Size not to scale
14 Copyright Intel Corporation 2011-12
15. Broad Ecosystem Support
Other brands and names are the property of their respective owners.
15 Copyright Intel Corporation 2011-12
16. Intel Development Tools extend to
Intel® Xeon Phi™ Coprocessors
Leading developer tools for performance on nodes and clusters
Advanced Performance Distributed Performance
C++ and Fortran Compilers, MKL/IPP MPI Cluster Tools with C++ and Fortran
Libraries & Analysis Tools for Windows*, Compiler, MKL Libraries and Analysis Tools for
Linux* developers on Windows*, Linux* developers on
IA based multi-core node IA based clusters
16 Copyright Intel Corporation 2011-12
18. Intel in the Datacenter
Intel®: Helping Simplify and Save in the Datacenter
Building blocks that scale + a commitment to help
Server Cloud
Deploying the latest generation of Get help implementing a flexible
Intel® Xeon® servers can reduce your and scalable cloud infrastructure
total cost of ownership by up to 66%1 IT Center: Data Center Cloud Design
Intelligent Storage Big Data
Use Intel® Xeon®-based
storage to Learn about new solutions that help
reduce storage footprints up to 50%2 turn big data into intelligence
Intel IT Center: Big Data Analytics
Network
Replace older 1GbE with Intel® 10GbE
Manufacturing Leadership
An increasing advantage delivering
to reduce power cost 45% and cabling
the benefits of Moore’s Law to IT
80% while doubling the bandwidth3
Intel Manufacturing Innovation
Security Ecosystem Choice
Create a hardened foundation for
The broadest range of solutions
computing with Intel® and McAfee
from the widest choice of vendors
security technologies
Orchestration Intel(R) Learn More for exclusive, real-
Your main source
Manage server power usage and see IT world tested information and advice
power savings up to 30%4 Center from Intel® and Industry experts
1. Over older generation Intel® processors. See TCO backup foil for details. For more legal info. on performance forecasts go to http://www.intel.com/performance
2. Source for savings claims: IT@Intel Whitepaper “Solving Intel IT’s Data Storage Challenges”. December 2011
3. Intel 10GbE ROI Calculator. http://www.event-management-online.de/LAD/calculator.aspx. See back up foil “IT Savings with Unified Network“ for more details.
18 4. 30% savings: http://www.intel.com/content/www/us/en/data-center-efficiency/data-center-efficiency-xeon-oracle-changing-the-game-study.html
19. Intel in the Datacenter
Intelligent Scale-out Storage Simplifies and Saves
Intel® Xeon® powers today’s compute intensive storage strategies2
Many organizations have data
Allocated&
Unused Available
growth of 40%-100% per year—
Data
Storage
mostly unstructured data
Allocated&
Data
Unused
Data Data Scale-out systems required
Data Deduplication
accommodate this growth by
Thin Provisioning
more simply adding more capacity
and compute as needed
Flash/SSDs
FC Drives
Reduce total storage footprint by
>50% with storage refresh
SATADrives
Storage Virtualization Storage Tiering Reduce storage device capacity
growth by 25% via thin provisioning
Improve storage efficiency by up
to 25% with data de-duplication
Intel® High Performance SSDs3
Encryption Large scale analytics Increased Performance
Datacenter Endurance
New Safety Features
up to 2X TCO Savings4
1. Source for savings claims: IT@Intel Whitepaper “Solving Intel IT’s Data Storage Challenges”. December 2011
2. Intel Xeon is the storage industry’s processor of choice--Xeon MSS is 80% (2011); Source: : IDC Quarterly Storage Tracker Q4’11. Intel(R) SSD Datacenter Total
3. Intel enterprise SSDs. Intel® 710 series SSD—SATA; Intel® 910 series SSD--PCIe
19 4. SSD TCO generated from SNIA* (Storage Networking Industry Association). TCO model for Solid-State Storage. Calculations
Cost of Ownership calculator
based on 4K random, 65/35 read writes. 3.5” SAS 15K HDD 48 drives, 73GB RAID 5. TCO model can be found at: www.snia.org.
20. Intel in the Datacenter
Simplify with Intel® 10GbE
The #1 Selling Ethernet Adapter1
Simplify2 Fibre Channel
Over Ethernet Unify
Unify your storage
10X 1GbE
Server Connections
2X 10GbE
Server Connections up to 20% and data networks
Lower Total
Infrastructure costs3
>50% of IT shops have >2 storage networks4
27% have over five4
Better
45% 80% 15% 2x
Reduction in
Power per Rack
Reduction in
Cables and
Reduction in
Infra-structure
Improved
Bandwidth
Intel® Ethernet X540
Server 10GbE Adapter Together
Switch ports Costs per Server Intel® Xeon® E5 2600
brings up to 3X more I/O
bandwidth vs.. prior gen.5
Intel® Xeon® E5 2600 Unleash the full I/O
Utilize Intel Advanced I/O Technologies: SR-IOV, VMDq, and Integrated I/O and Intel
capabilities of Xeon® E5
Data Direct I/O
Intelligent Data Path offload architecture with Intel® 10GbE
1. Intel® 82599 10 Gigabit Controller and Intel® Ethernet X520 Server Adapter; Intel® 10GbE Adapter: #1 MSS per Dell’Oro Group Q1’12 Ethernet Report
2. Intel 10GbE ROI Calculator. http://www.event-management-online.de/LAD/calculator.aspx. See back up foil “IT Savings with Unified Network“ for more details.
3. Intel IT Proof of Concept with 10GbE and FCoE. See back up foil “IT Savings with Unified Network“ for more details.
20 4. Storage Magazine Survey published Dec ’11 Link to Storage Magazine article
5. Max. I/O R/W bandwidth Intel® Xeon® E5-2680 vs.. Intel® Xeon® X5670. See backup slide “Xeon® Processor Performance Leadership Claims” for details
21. Isolate Enforce Encrypt
Server Security Technologies
Intel® Technologies: Server Security
Establishing the Foundation for More Secure Computing
Isolate Enforce Encrypt
Intel® VT and Intel® TXT Intel® AES-NI
Intel® TXT
Delivers built-in
Protects VM isolation and Establishes “trusted” status
encryption acceleration
provides a more secure foundation for security policy-
for better data
platform launch based workload control
protection
Mf.
VM1 VM2 Policy VM2 VM3
VM1
VMM VMM VMM
21
22. Server Security Technologies
Intel® Cloud Builder
Security Reference Architectures Provide the “How To”
Support and/ Support and/or
or Reference
Accelerate your ability to Implementatio
Architectures deploy key technologies that n White Papers
Featuring: enhance cloud security Featuring:
For the latest Intel® Cloud Builder Security Reference Architectures, go to:
Cloud Builder: Enhance Cloud Security
† Not all features and capabilities will be supported by all listed providers
*Other names and brands may be claimed as the property of others
22
23. Connect and enrich the lives of every person on earth
through seamless and pervasive computing
Intel in the Datacenter Intel’s datacenter vision
Intel®: Helping Simplify and Save in the Datacenter
More than just a data center technology supplier
Technology that Scales Solutions and Insights Standards that Ensure
that Accelerate Adoption Choice and Flexibility
Server
Networking
Y Data
Cloud
Big Scale-out
Storage
Storage Unified
Network Mission Reference arch.
Datacenter Critical
& POCs ROI/Refresh As the leading supplier of industry
Modernization
calculators building blocks
Solution briefs
Expert and IT Intel plays a key role in industry
Software IT@Intel insights peer discussions
standards bodies
Whitepapers Podcasts Including developing open
standards for the cloud
Devices Intel® IT Center
The Data Stack Online community of Intel experts and IT practitioners. IT@Intel Insights from Intel’s own IT department
Intel(R) Cloud Builders Proven guidance to build and optimize cloud infrastructure
Other useful links Intel(R) Server Refresh Estimator Estimate your possible Xeon-based server refresh savings with this online estimator
23 Intel IT Center--Big Data Analytics information Learn how big data analytics delivers fresh insights
www.mcafee.com/datacenter Optimizing security in the next-generation data center
24. Next-Gen Sequencing Big Data Analytics Personalized Medicine
Cloud-Based Analytics
& Precision Medicine
24
26. Big Data In Context
Intel Value in Solution Provisioning For Insight
Rich and deep visualization
Decision Support Application Layer for applications – Connect &
Interact with your data
Efficiency, Trust, Secure Efficient Capturing and Ordering
Data Delivery
Storage of Data
Governance, Tools
Data Integration,
Performance Algorithms for Data
Management Analysis,
Processing and Transformation
Transformation
Xeon enabled in-
Infrastructure & Compute, storage and IO architecture
memory & storage
Services that balances performance and capacity
EcoSystem
26
27. Big Data In Context
Intel and Big Data Methods
Performance and Scale
Efficiencies
Data Delivery Data Usage
Data Management
Business
Intelligence
Decision
Support – Business Strategy
CRM- ETL
ERP,OLTP, KPI’s
Batch
Data LOB Reporting
Marts
SOURCE – ETL
Big Data
Intel® Identity
In-Memory
Protection
Reliability, Availability &
Power Management & Security Rich Visualization
Serviceability (RAS)
27
28. Big Data In Context
Managing the Data and Driving Insight
Life Sciences
Database and compute infrastructure Analytics engines Workloads & Solutions
Relational
VOLTDB
EXALYTICS
Nonrelational
Open Source:
BLAST, FASTA,
ClustalW, HMMER,
Darwin, etc.
Orchestration of DB Variants – Modernization on Xeon Architecture
28
30. Use Case: NEXTBIO
Patient Correlation Data
Novel Discoveries
Biomarkers
Disease Mechanism
Drug Indications
Clinical trial parameters
Patient Care options
Large content repository of public and private genomic data
combined with proprietary and patented correlation engine
30
32. Clinical Decision Support requires
extensive Medical Knowledge Graph
Existing Public Documents Knowledge Graph
Ontologies
(e.g. ICD9, RxNorm,
Diabetes Type
SNOMED)
Retinal Eye
ICD 250.xx
Glucose
Exam
Echo
A1c
1
Diabetes Type
1
Dictionary Extraction Diabetes Type
& Association Discovery 2
Glucose
Hemoglobin
A1c
Retinal Eye
Exam
Clinical Echo
Documents
9/6/2012 32 www.apixio.com
33. High Performance Analytics for Scalability
& Real-Time Results
Queries Job Queue Results
Patient Data Store Patient Data Store Patient Data Store
Analytics Engine Analytics Engine Analytics Engine
Patient Objects Patient Objects Patient Objects
Hadoop & Cassandra
9/6/2012 33 www.apixio.com
35. Where would you like to be in two years?
• your codes optimized for our architecture – which ones??
• commercial tools, open-source, Hadoop, visualization tools,
sw optimization tools, federated query/analytics?
• community-identified bioinformatics workloads, algorithms,
frameworks and tools?
• alignment on informatics standards supporting clinical
care/research interoperability requisite for personalized
medicine?
• data management, data lifecycle for life sciences?
• infrastructure & solutions optimized for your changing
workloads?
35
36. You are the Experts…
Tell us what you need to –
• Accelerate results
• Identify gaps in the industry, and
• Ensure our architecture is optimized for
your workloads
36
37. Additional Information:
• Intel Software Optimization Tools – www.software.intel.com
• Intel® Cloud Builders
• Open Data Center Alliance (ODCA)
• Cloud Security Alliance (CSA)
• European Network and Information Security Agency (ENISA)
• Healthcare Blogs – Intel® Healthcare IT Professionals
• Whitepapers
– CARESTREAM* Increasing the Scalability of Medical Imaging Solutions
– Secure Healthcare Cloud (TXT whitepaper)
– VMware* and Intel® 10GbE Best Practices
– Securing the Enterprise with Intel® AES-NI
– Enhanced Cloud Security with HyTrust* & VMware*
– Taking Control of the Cloud for your Enterprise
– Unified Networking with Cisco* Virtualized Multi-Tenant Data Center*
• Videos
– Cloud Security: Built from the Ground Up
– Trusted Execution Technology
– Virtualization Demo/Animation
37
38. Big Data/Analytics References
Intel® Big Data and Analytics
Blogs – Intel® Healthcare IT Professionals
Big Data and Hadoop
• http://software.intel.com/en-us/articles/intel-benchmark-
install-and-test-tool-intel-bitt-tools/
• http://www.scribd.com/doc/43871872/Intel-White-Paper-
Optimizing-Hadoop-Deployments
• http://www.cloudera.com/videos/hw10_video_optimizing_h
adoop_workloads
• http://hadoop.apache.org/
Intel Hadoop Reference Architectures
• http://www.intelcloudbuilders.com/docs/Intel_Cloud_Builde
rs_Hadoop.pdf
38
39. Intel Technologies
• Intel® Scale-out Storage – Tackle your data center’s challenges with enterprise
storage solutions powered by the world’s most advanced multi-core architecture
• Intel® Solid State Drives – High performance, Self-Encrypting Solid State Drives for
protecting sensitive data at rest
• Intel Unified Networking – Unified Networking enables cost-effective connectivity to
the LAN and the SAN on the same Ethernet fabric
• Intel® Virtualization Technology (Intel® VT) – Provides flexibility and maximum
system utilization by consolidating multiple environments into a single server,
workstation, or PC
• Intel® Trusted Execution Technology (Intel® TXT) – Protect confidentiality and
integrity of business data against software-based attacks.
• Intel® AES New Instructions (Intel® AES-NI) – The Advanced Encryption Standard
(AES) algorithm is now widely used across the software ecosystem to protect network
traffic, personal data, and corporate IT infrastructures
• Intel® Cloud Access 360 – Protection Enterprise Access to Cloud and Protecting
Enterprise Applications in the Cloud
• Intel® Expressway Service Gateway – High performance security, xml acceleration
and routing. Cross-domain service mediation, threat prevention, policy enforcement.
Interoperable ESB gateway
• McAfee Cloud Security Platform* – Consistent security policies, reporting, and threat
intelligence across all cloud traffic—now available from a single platform
39
41. Risk Factors
The above statements and any others in this document that refer to plans and expectations for the first quarter, the year and the
future are forward-looking statements that involve a number of risks and uncertainties. Words such as “anticipates,” “expects,”
“intends,” “plans,” “believes,” “seeks,” “estimates,” “may,” “will,” “should” and their variations identify forward-looking statements.
Statements that refer to or are based on projections, uncertain events or assumptions also identify forward-looking statements.
Many factors could affect Intel’s actual results, and variances from Intel’s current expectations regarding such factors could cause
actual results to differ materially from those expressed in these forward-looking statements. Intel presently considers the following
to be the important factors that could cause actual results to differ materially from the company’s expectations. Demand could be
different from Intel's expectations due to factors including changes in business and economic conditions, including supply
constraints and other disruptions affecting customers; customer acceptance of Intel’s and competitors’ products; changes in
customer order patterns including order cancellations; and changes in the level of inventory at customers. Uncertainty in global
economic and financial conditions poses a risk that consumers and businesses may defer purchases in response to negative
financial events, which could negatively affect product demand and other related matters. Intel operates in intensely competitive
industries that are characterized by a high percentage of costs that are fixed or difficult to reduce in the short term and product
demand that is highly variable and difficult to forecast. Revenue and the gross margin percentage are affected by the timing of Intel
product introductions and the demand for and market acceptance of Intel's products; actions taken by Intel's competitors, including
product offerings and introductions, marketing programs and pricing pressures and Intel’s response to such actions; and Intel’s
ability to respond quickly to technological developments and to incorporate new features into its products. Intel is in the process of
transitioning to its next generation of products on 22nm process technology, and there could be execution and timing issues
associated with these changes, including products defects and errata and lower than anticipated manufacturing yields. The gross
margin percentage could vary significantly from expectations based on capacity utilization; variations in inventory valuation,
including variations related to the timing of qualifying products for sale; changes in revenue levels; product mix and pricing; the
timing and execution of the manufacturing ramp and associated costs; start-up costs; excess or obsolete inventory; changes in unit
costs; defects or disruptions in the supply of materials or resources; product manufacturing quality/yields; and impairments of long-
lived assets, including manufacturing, assembly/test and intangible assets. The majority of Intel’s non-marketable equity
investment portfolio balance is concentrated in companies in the flash memory market segment, and declines in this market
segment or changes in management’s plans with respect to Intel’s investments in this market segment could result in significant
impairment charges, impacting restructuring charges as well as gains/losses on equity investments and interest and other. Intel's
results could be affected by adverse economic, social, political and physical/infrastructure conditions in countries where Intel, its
customers or its suppliers operate, including military conflict and other security risks, natural disasters, infrastructure disruptions,
health concerns and fluctuations in currency exchange rates. Expenses, particularly certain marketing and compensation expenses,
as well as restructuring and asset impairment charges, vary depending on the level of demand for Intel's products and the level of
revenue and profits. Intel’s results could be affected by the timing of closing of acquisitions and divestitures. Intel's results could be
affected by adverse effects associated with product defects and errata (deviations from published specifications), and by litigation or
regulatory matters involving intellectual property, stockholder, consumer, antitrust and other issues, such as the litigation and
regulatory matters described in Intel's SEC reports. An unfavorable ruling could include monetary damages or an injunction
prohibiting us from manufacturing or selling one or more products, precluding particular business practices, impacting Intel’s ability
to design its products, or requiring other remedies such as compulsory licensing of intellectual property. A detailed discussion of
these and other factors that could affect Intel’s results is included in Intel’s SEC filings, including the report on Form 10-Q for the
quarter ended Oct. 1, 2011.
Rev. 1/19/12
41
