5. Inotropes
ā¢ Agents that affect myocardial contraction
ā¢ Positive Inotropes
ā Cardiac glycosides
ā Bypyridine derivatives (Milrinone)
ā PDE-I (Theophylline)
ā Catecholamines
ā¢ Negative Inotropes
ā BB
ā CCB
ā Class IA & IC anti-arrhythmics
6. Class Participation Question #1
Which of the following is an
example of a positive inotrope?
a) Docusate
b) Digoxin
c) HCTZ
d) Propranolol
e) Nitroglycerin
7. Class Participation Question #1
Which of the following is an
example of a positive inotrope?
a) Docusate
b) Digoxin
c) HCTZ
d) Propranolol
e) Nitroglycerin
10. Digoxin (contād)
ā¢ Indications/dosage:
ā Afib & HF
ā¢ LD: 10-15 mcg/kg IV or PO, given in 3 divided doses every
6-8 hrs, with the first dose equalling approximately 1/2 the
total
ā¢ MD: 125-350 mcg PO or IV per day, depending on CrCl,
given in 1-2 divided doses
ā¢ CrCL < 60 requires renal adjustment
ā¢ Monitoring
ā ECG
ā serum Ca
ā Scr/BUN
ā serum Mg
11. Class Participation Question 2:
AJ is a 54 year old male weighing 50kg who
has class III heart failure. AJās doctor will
be starting him on Digoxin therapy.
Calculate the Digoxin LOADING dose.
12. Class Participation Question 2:
AJ is a 54 year old male weighing 50kg who has
class III heart failure. AJās doctor will be starting
him on Digoxin therapy. Calculate the Digoxin
LOADING dose.
ā¢ Recall
ā LD: 10-15 mcg/kg IV or PO, given in 3 divided doses
every 6-8 hrs, with the first dose equalling
approximately 1/2 the total
13. Class Participation Question 2:
ā¢ TOTAL dose
100 kg x 10 mcg = 1000 mcg total
kg
ā¢ 1st
dose is Ā½ the total dose
1000 mcg / 2 = 500 mg
ā¢ 2nd
& 3rd
dose
500 mg / 2 = 250 mg
14. Class Participation Question 2:
ā¢ Answer:
ā 500 mcg IV or PO initially
ā followed by 250 mcg IV or PO every 6 hours x
2 doses
15. Latest News on Digoxin
On April 28, 2008, Actavis Totowa LLC notified
healthcare professionals of a Class I nationwide
recall of all strengths of Digitekā¢.
The products are distributed by Mylan
Pharmaceuticals Inc. under a Bertek label and
by UDL Laboratories, Inc. under a UDL label.
16. Digitalis Toxicity
ā¢ Visual changes (unusual)
ā¢ Confusion
ā¢ Loss of appetite
ā¢ Nausea, vomiting, diarrhea
ā¢ Palpitations
ā¢ Irregular pulse
ā¢ Additional symptoms that may be associated
with digitalis toxicity include:
ā¢ Decreased urine output
ā¢ Excessive nighttime urination
ā¢ Overall swelling
ā¢ Decreased consciousness
ā¢ Difficulty breathing when lying down
21. Atropine (contād)
ā¢ MOA
ā competitive inhibitor at autonomic postganglionic
cholinergic receptors
ā¢ Clinical effects
ā āanti-SLUDā
ā ā in salivary bronchial, & sweat gland secretions;
mydriasis; cycloplegia; changes in heart rate;
contraction of the bladder detrusor muscle and of
the GI smooth muscle; ā gastric secretion; and ā GI
motility
22. Atropine Dosing
ā¢ Bradycardia
ā 0.5-1 mg IV push; repeat if needed every 5 min up to 2 mg
ā¢ Aspiration prophylaxis
ā po: 2 mg PO 30-60 min prior to anesthesia
ā parental: ā„ 20 kg: 0.2-1 mg (the usual dose is 0.4 mg) IV, IM or
SC 30-60 min prior to anesthesia
ā¢ IBS
ā po: 0.3-1.2 mg PO every 4-6 hours
ā¢ Organophosphate insecticide toxicity
ā 1-2 mg IM or IV initially; repeat if needed every 20-30 min as
needed until symptoms dissipate. Adjunct nerve agent &
insecticide poisoning
ā¢ Mydriasis
ā Opthalmic: drop of 1% solution instilled in eye 1 hour prior to
procedure or, 0.3-0.5 cm of 1% ointment placed in conjunctival
sac up to tid
ā¢ Note: Lab monitoring not necessary
26. Nitrites/Nitrates
ā¢ Previously known as ācoronary dilatorsā
ā¢ Main effect: to produce general
vasodilation of systemic vein & arteries
ā āpreload & āafterload
ā ā cardiac work & oxygen consumption
ā¢ 2 main uses
ā Angina attacks
ā Angina prophylaxis
27. Class Participation Question #3:
Which is the PREFERRED route for
nitroglycerin during angina attacks?
a) Topical (ointment 2%)
b) IV infusion
c) Transdermal
d) SL
e) Extended release tablets/capsules
28. Class Participation Question #3:
Which is the PREFFERED route for
nitroglycerin during angina attacks?
a) Topical (ointment 2%)
b) IV infusion
c) Transdermal
d) SL
e) Extended release tablets/capsules
29. Drug
(Trade Name)
Common
Dosage
Onset Duration
Amyl nitrate
(VaporoleĀ®)
0.3 ml
inhalation
30-60 sec 10 min
ISDN
(IsordilĀ®)
2.5 - 10 mg SL
5 - 30 mg po qid
2-5 min 2 - 4 hr
Nitroglycerin
(Nitro-bidĀ®) 2% ointment 15 min 4 - 8 hr
(NitrostatĀ®) 0.3 - 0.6 mg SL 1-3 min 10 - 45 min
(NitrogardĀ®) 1,2,3 mg XR tab 30 min 8 - 12 hr
(Transderm-
NitroĀ®)
2.5 - 15 mg/day
Transdermal
patch
30-60 min 24 hr
32. NG (contād)
ā¢ Dosing
ā 1 tablet (0.3 mg, 0.4 mg, or
0.6 mg strength) SL,
dissolved under the tongue
or in buccal pouch
immediately following
indication of anginal attack
ā During drug administration,
the patient should rest,
preferably in the sitting
position
ā Symptoms typically improve
within 5 minutes. If needed
for immediate relief of stable
angina symptoms, SL
nitroglycerin may be
repeated every 5 minutes as
needed, up to 3 doses
33. NG (contād)
ā¢ Adverse Effects
ā dizziness or fainting
ā flushing of the face or
neck
ā headache, this is
common after a dose,
but usually only lasts
for a short time
ā irregular heartbeat,
palpitations
ā nausea, vomiting
ā¢ Contraindication:
ā sildenafil (ViagraĀ®)
ā tadalafil (CialisĀ®)
ā vardenafil (LevitraĀ®)
ā¢ Lab monitoring not
necessary
35. What are Arrhythmias?
ā¢ Cardiac disorder of
ā Rate
ā Rhythm
ā Impulse generation
ā Conduction of electrical
impulses in the heart
ā¢ Causes
ā May develop from a
diseased heart
ā Consequence of chronic
drug therapy
ā¢ Symptoms
ā Mild palpitations ļ
cardiac arrest
ā¢ Treatment goal
ā Covert arrhythmia to a
normal rhythm
39. Class Participation Question #4:
True or False?
Although antiarrthymics are used for treating
arrhythmias, they can also PRODUCE
arrhythmias.
40. Class Participation Question #4:
True or False?
Although antiarrthymics are used for treating
arrhythmias, they can also PRODUCE
arrhythmias.
Answer: TRUE
41. The Catch 22 with Antiarrhythmics
ā¢ People with structural heart disease are at
INCREASED risk for arrhythmias!
ā¢ The problemā¦
ā Many antiarrhythmic drugs INCREASE sudden
death in these patients compared to placebo
42. Antiarrthymics: Class I
ā¢ Na channel blockers
ā¢ Common features
ā Local anesthetic activity
ā Interferes with movement of Na ions
ā Slow conduction velocity
ā Prolong refractory period
ā Decreases automaticity of the heart
43. Class IA
ā¢ Quinidine (Quinidine sulfateĀ®,
QuinagluteĀ®, QuinidexĀ®, CardioquinĀ®)
ā¢ Disopyramide (NorpaceĀ®)
ā¢ Procainimide (Procainimide HCIĀ®,
ProcanĀ®, ProcanabidĀ®, PronestylĀ®)
44. Class 1A ā Quinidine
ā¢ Derived from cinchona tree
ā¢ Depresses both the myocardium & conduction
system
ā¢ Overall effect: slows heart rate
ā¢ Pharmacokinetics
ā Well absorbed in GI tract after po administration
ā Metabolized to several active metabolites
ā Primarily excreted by urinary tract
ā Cardiac poison when large amounts are present in
blood
45. Class 1A ā Quinidine (contād)
ā¢ Adverse Effects
ā N/V, diarrhea, weakness, fatigue, cinchonism
ā¢ Drug Interactions
ā Hyperkalemia
ā Digitalis
ā propranolol
ā¢ Monitoring
ā CBC
ā ECG
ā serum quinidine concentrations (target range
2-6 Āµg/ml or higher)
ā¢ CI: AV block
47. Lidocaine ā Class IB
ā¢ MOA: blocks influx of Na fast channels
ā¢ What phase of the action potential does this affect?
ā¢ Indication: ventricular arrhythmias
48. Dosage
ā¢ Vfib, Vtach
ā IM 300 mg. May be repeated after 60 to 90 min
ā IV bolus 50 to 100 mg at rate of 25 to
50 mg/min; may repeat, but do not exceed 200
to 300 mg/h
ā Continuous infusion 1 to 4 mg/min
ā¢ Lidocaine is prepared by mixing:
ā 2 Grams Lidocaine in 500 mL D5W
ā 1 Gram Lidocaine in 250 mL D5W
49. Lidocaine ā Class IB (contād)
ā¢ Common Adverse Effects
ā anxiety, nervousness
ā dizziness, drowsiness
ā feelings of coldness, heat, or numbness; or
pain at the site of the injection
ā N/V
ā¢ Monitoring
ā LFTs
ā Scr/BUN
ā serum lidocaine concentrations (target range
2-6 Āµg/ml): parenteral use
50. Lidocaine (contād)
ā¢ CI
ā Hypersensitivity to amide local anesthetics
ā Stokes-Adams syndrome
ā Wolff-Parkinson-White syndrome
ā severe degrees of sinoatrial, AV or intraventricular
block in absence of pacemaker
ā ophthalmic use
52. Flecainide ā Class IC
ā¢ MOA
ā Blocks fast Na channels depresses the upstroke of the
action potential, which is manifested as a decrease in the
maximal rate of phase 0 depolarization.
ā significantly slow His-Purkinje conduction and cause QRS
widening
ā shorten the action potential of Purkinje fibers without
affecting the surrounding myocardial tissue.
ā¢ Indications
ā Afib
ā Atrial flutter
ā Paroxysmal supraventricular tachycardias
ā Ventricular tachycardia prophylaxis
ā Wolff-Parkinson-White Syndrome
53. Flecainide ā Class IC
ā¢ Adverse Reactions
ā visual impairment, dizziness, asthenia, edema, abdominal
pain, constipation, headache, fatigue, and tremor, N/V,
arrhea, dyspepsia, anorexia, rash, diplopia, hypoesthesia,
paresthesia, paresis, ataxia, flushing, increased sweating,
vertigo, syncope, somnolence, tinnitus, anxiety, insomnia,
and depression.
ā¢ Avoid in
ā CHF
ā Acute MI
ā Hx of MI (LVEF < 30%)
ā¢ Monitoring
ā ECG
ā serum creatinine/BUN: baseline
55. Propranolol Warning
ā¢ 2 situations in which propranolol requires
extreme caution
ā AV block
ā CHF
ā Asthma or emphysema
56. Class III
ā¢ K+ channel blockers
ā¢ Drugs:
ā Prototype: Amiodarone (Cordarone)
ā Bretylium (Bretylol)
ā Sotalol (Betapace)
57. Amiodarone ā Class III
MOA
ā noncompetitively inhibits alpha- and beta-receptors,
ā possesses both vagolytic and calcium-channel
blocking properties
ā relaxes both smooth and cardiac muscle
ā¢ Indications
ā Vfib
ā Vtach
58. Vfib Amiodarone Dosage
ā¢ po
ā Initially, 800-1600 mg/day PO in single or divided doses
for a minimum of 1-3 weeks in a monitored setting until
an initial therapeutic response is achieved
ā followed by 600-800 mg/day PO in one or divided
doses for about one month.
ā Then reduce dosage again to the lowest effective
maintenance dose, usually 400 mg/day PO in one or
divided doses
ā¢ iv
ā initial IV rapid infusion of 150 mg over the first 10
minutes. Then begin a slow IV infusion of 1 mg/min for
the next 6 hours (total dose infused = 360 mg). Then,
the infusion rate is lowered to 0.5 mg/min for the next
18 hours (total dose infused = 540 mg). After the first
24 hours, a maintenance IV infusion of 0.5 mg/minute
(720 mg/day) is recommended.
59. Amiodarone ā Adverse Reactions
ā¢ Cardiovascular: exacerbation of the arrhythmias, CHF (3%) and bradycardia.
Cardiac arrhythmias, CHF, sinoatrial node dysfunction (1% to 3%); cardiac conduction
abnormalities, hypotension (less than 1%)
ā¢ CNS: 20% to 40% of patients and including malaise and fatigue, peripheral neuropathy, poor
coordination & gait, & tremor and involuntary movements; they are rarely a reason to stop
therapy and may respond to dose reductions or discontinuation; Abnormal gait/ataxia,
dizziness, lack of coordination, malaise and fatigue, paresthesias, tremor/abnormal involuntary
movements (4% to 9%); decreased libido, headache, insomnia, sleep disturbances (1% to 3%).
ā¢ Dermatologic: ~15% of patients, with photosensitivity being most common (approximately
10%). Sunscreen and protection from sun exposure may be helpful, and drug discontinuation is
not usually necessary. Prolonged exposure to amiodarone occasionally results in a blue-gray
pigmentation; Solar dermatitis/photosensitivity (4% to 9%); alopecia, blue skin discoloration,
rash, spontaneous ecchymosis (less than 1%).
ā¢ Endocrine: Hyperthyroidism, hypothyroidism (1% to 3%).
ā¢ GI: GI complaints, most commonly anorexia, constipation, N/V (10% to 33%); anorexia,
constipation (4% to 9%); abdominal pain (1% to 3%)
ā¢ Hepatic: Abnormal liver function tests (4% to 9%); nonspecific hepatic disorders (1% to 3%)
ā¢ Ophthalmic: optic neuropathy and/or optic neuritis, in some cases progressing to corneal
degeneration, eye discomfort, lens opacities, macular degeneration, papilledema, permanent
blindness, photosensitivity, and scotoma, have been reported . Asymptomatic corneal
microdeposits are present in virtually all adult patients who have been on the drug for more than
6 months. Some patients develop eye symptoms of dry eyes, halos, and photophobia. Vision is
rarely affected and drug discontinuation is rarely needed. Visual disturbances (4% to 9%)
ā¢ Respiratory: Fibrosis, pulmonary inflammation (4% to 9%)
ā¢ Miscellaneous: Abnormal salivation, abnormal taste and smell, coagulation abnormalities,
edema, flushing (1% to 3%).
60. Amiodarone ā Class III (contād)
ā¢ Monitoring
ā CBC
ā chest x-ray
ā ECG
ā LFTs
ā ophthalmologic exam
ā PFTs: baseline
ā thyroid function tests (TFTs)
61. Class IV
ā¢ Ca channel blockers
ā¢ Drugs
ā Adenosine (Adenocard Ā®)
ā Diltiazim (CardizemĀ®, TiazacĀ®)
ā Verapamil (DoveraĀ®, IsoptinĀ®, CalanĀ®)
ā¢ Clinical Effects
ā widen the blood vessels
ā may decrease the heartās pumping strength
64. Epinephrine
ā¢ āfight or flight āhormone
ā¢ Aka āadrenalineā
ā¢ increases heart rate
and stroke volume
ā¢ dilates the pupils
ā¢ constricts arterioles in
the skin and
gastrointestinal tract
while dilating arterioles
in skeletal muscles
66. Epinephrine (contād)
ā¢ Indications
ā Vfib
ā Ventricular asystole
ā Cardiac arrest
ā Pulseless electrical
activity
ā¢ IV Dosage
ā IV: 1 mg (10 ml of a
1:10,000 solution) IV;
may repeat every 3-5
minutes
ā Each dose may be
given by peripheral
injection followed by a
20 ml flush of IV fluid.
67. Epinephrine
ā¢ Common Adverse Effects
ā anxiety or nervousness
ā dry mouth
ā drowsiness or dizziness
ā headache
ā increased sweating
ā nausea
ā weakness or tiredness
ā¢ Monitoring
ā ECG: in patients receiving IV therapy
ā PFTs
70. Vasoconstrictor
ā¢ any agent that produces vasoconstriction
and a rise in blood pressure (usually
understood as increased arterial pressure)
ā¢ Drugs
ā Prototype: Vasopressin
ā Epinephrine
ā Dobutamine
ā Dopamine
ā Norepinephrine
71. Vasopressin
ā¢ aka : āAVPā or āADHā
ā¢ MOA
ā ā the resorption of
water at the renal
collecting ducts
ā Vasoconstrictive
property: stimulates
the contraction of
vascular smooth
muscle in coronary,
splanchnic, GI,
pancreatic, skin, and
muscular vascular
beds
72. Vasopressin (contād)
ā¢ FDA indication: Diabetes Insipidus
ā¢ Non-FDA indications
ā Cardiac arrest
ā Cardiogenic shock
ā Cardiopulmonary resuscitation
ā Hypotension
ā Septic shock
ā And many moreā¦.
73. Vasopressin (contād)
ā¢ Dosage for cardiac arrest including
ventricular asystole and pulseless electrical
activity (PEA) during cardiopulmonary
resuscitation (CPR)
ā IV or intraosseous dosage:
ā¢ Adults: A single dose of 40 units IV (or intraosseous)
may be given one time to replace the first or second
dose of epinephrine during cardiac arrest
ā¢ Do not interrupt cardiopulmonary resuscitation to
administer drug therapy.
74. Vasopressin (contād)
ā¢ Adverse Effects
ā Cardiovascular: Cardiac arrest; circumoral pallor;
arrhythmias; decreased cardiac output; angina;
myocardial ischemia; peripheral vasoconstriction; and
gangrene
ā CNS: Tremor; vertigo; āpoundingā in head
ā Dermatologic: Sweating; urticaria; cutaneous gangrene
ā GI: Abdominal cramps; nausea; vomiting; passage of gas
ā Hypersensitivity: Anaphylaxis (cardiac arrest and/or
shock) has been observed shortly after injection
ā Respiratory: Bronchial constriction.
ā¢ Monitoring
ā serum osmolality
ā serum Na
76. Diuretics
ā¢ āwater pillā
ā¢ Promotes formation
of urine by the
kidney ļ forced
diuresis
ā¢ Uses
ā HTN
ā Edema
ā Glaucoma
ā Anuria
77.
78. Diuretic Properties
Diuretic agent Site of Action & Misc.
Chlorothiazide PO/IV Distal Tubule
Calcium Reabsorption Increased
May transiently increase Lipids, BG and UA
Hypomagnesemia (may complicate K+ correction)
Severe Potassium Depletion ā Creation of Combos ???
Pregnancy categories: B and C
Hydrochlorothiazide
Indapamide
Metolazone (Mykrox)
Furosemide Ascending Limb of Henle
Ototoxocity (reversible and irreversible)
Hypokalemia (supplement with K+)
Pregnancy categories: B
Torsemide
Bumetanide
Ethacrynic acid
Amiloride Distal and Proximal tubule Impact
Hyperkalemia and serum creatinine elevations
Avoidance: BUN > 30 mg/dl or SCr > 1.5 mg/dl
Triamterene
Eplerenone Distal and Aldosterone receptor Impact
Same as amiloride and triamterene ā avoid K spare combosSpironolactone
79. Diuretics
ā¢ Prototype: Furosemide (LasixĀ®)
ā¢ MOA
ā inhibits the reabsorption of sodium and chloride in the
ascending limb of the loop of Henle
ā¢ Indications
ā Edema
ā HF
ā HTN
ā Nephrotic syndrome
ā Pulmonary edema
ā Renal impairment
80. Furosemide ā Edema Dosage
ā¢ po: Initially, 20-80 mg as a
single dose; may repeat
dose in 6-8 hr. Titrate
upward in 20-40 mg
increments. The usual
dosage is 40-120 mg/day.
Max dosage is 600 mg/day.
ā¢ IV or IM: Initially, 20-40 mg,
increasing by 20 mg every 2
hours prn to attain clinical
response. Administer IV
doses slowly. A max
infusion rate of 4 mg/min
has been recommended
when administering doses
>120 mg or for patients with
cardiac or renal failure
87. Heparin Recall in 2008
ā¢ In February 2008, the FDA issued a MedWatch in response to an
increase in the number of serious adverse events including allergic or
hypersensitivity-type reactions with the administration of higher bolus
doses of heparin. The reports have mainly involved the use of Baxter
multiple-dose vials; however, there have been reports of these reactions
occurring when the combination of multiple- and single-dose vials have been
used to administer a bolus dose. In February 2008, Baxter International
announced expanding their voluntary recall to include all lots and
doses of its Heparin Sodium UPS multi-dose, single-dose vials, and
HEP-LOCK heparin flush products. The company initially recalled nine
lots of heparin sodium injection multi-dose vials as a precautionary measure
due to a higher than usual number of reports of adverse patient reactions
involving the product. In March 2008, the FDA announced that the
contaminant found in samples of Baxter's heparin was oversulfated
chondroitin sulfate, a substance derived from animal cartilage. The FDA
also stated that it does not know whether this contaminant caused the
adverse events, only that a contaminant has been identified.
Investigations continue as to whether this contaminant was added to heparin
by accident or intentionally. Customers with questions regarding the Baxter
recall may contact the Center for One Baxter at 1-800-422-9837.
89. Warfarin ā Oral Anticoagulant
ā¢ MOA: Warfarin inhibits the synthesis of vitamin K-dependent
coagulation factors II, VII, IX, and X and anticoagulant
proteins C and S
90. Warfarin (contād)
ā¢ Indications
ā Stroke
ā DVT
ā Post MI
ā Afib
ā Cardiomyopathyā¦.and many more!
ā¢ Dosage
ā Initially, 2-5 mg PO or IV once daily, with dosage
adjustments made according to INR result
91. Warfarin Warnings
Bleeding Risk!
ā¢ Warfarin can cause major or fatal bleeding. Bleeding is more likely
to occur during the starting period and with a higher dose (resulting
in a higher international normalized ratio [INR]). Risk factors for
bleeding include high intensity of anticoagulation (INR of more than
4), 65 years of age and older, highly variable INRs, history of GI
bleeding, hypertension, cerebrovascular disease, serious heart
disease, anemia, malignancy, trauma, renal function impairment,
concomitant drugs, and long duration of warfarin therapy. Regular
monitoring of INR should be performed on all treated patients.
Those at high risk of bleeding may benefit from more frequent INR
monitoring, careful dose adjustment to desired INR, and a shorter
duration of therapy. Patients should be instructed about
prevention measures to minimize risk of bleeding and to report
immediately to health care provider signs and symptoms of
bleeding
ā¢ Pregnancy Category X
92. Warfarin (contād)
ā¢ SE
ā Hemorrhage: Signs of severe bleeding resulting in the loss of large
amounts of blood depend upon the location and extent of bleeding.
Symptoms include: chest, abdomen, joint, muscle, or other pain;
difficult breathing or swallowing; dizziness; headache; low blood
pressure; numbness and tingling; paralysis; shortness of breath;
unexplained shock; unexplained swelling; weakness
ā¢ Monitoring
ā INR
ā prothrombin time (PT)
ā stool guaiac
ā bleeding
ā DDIs
ā¢ NSAIDs
ā¢ 3 Gās
ā Garlic
ā Ginger
ā Ginsing
ā Vitamin K intake
96. Fibrinolytic Enzymes
ā¢ āclotbustersā
ā¢ MOA: stimulate the synthesis of
fibrinolysin which breaks the clot into
soluble products
ā¢ Drugs
ā Urokinase (AbbokinaseĀ®)
ā Anistreplase (EminaseĀ®)
ā Alteplase (ActivaseĀ®)
ā Reteplase (RetevaseĀ®)
ā Prototype: Streptokinase (StrepaseĀ®)
97. Streptokinase (contād)
ā¢ Indications
ā Acute MI
ā Acute ischemic stroke
ā Pulmonary embolism
ā Lysis of DVT
ā¢ Dose Administration
ā Parental infusion (usually IV)
ā Deep vein or arterial thrombosis
ā¢ IV: 250,000 IU over 30 min followed by 100,000 IU
per hour up to 72 hours
98. Streptokinase (contād)
ā¢ Adverse Effects
ā Hemorrhage
ā Concomitant use of heparin, oral
anticoagulants, NSAIDs is NOT
recommended because of the increased risk
of bleeding
ā Allergic reactions
103. Propranolol
ā¢ HTN Dosage
ā po: initially, 40 mg PO twice daily, then increase at
3-7 day intervals up to 160-480 mg/day, given in 2-
3 divided doses. Maximum dosage is 640 mg/day
ā¢ Main Effects
ā ā in rate, force of contraction, & conduction velocity
of the heart
ā Blocks carbohydrate & lipid metabolism
104. Propranolol (contād)
ā¢ Adverse Reactions
ā changes in blood sugar
ā cold hands or feet
ā difficulty breathing, wheezing
ā difficulty sleeping, nightmares
ā dizziness or fainting spells
ā hallucinations (seeing and hearing things that are not really there)
ā muscle cramps or weakness
ā skin rash, itching, dry peeling skin
ā slow heart rate (less than 50 beats per minute)
ā swelling of the legs and ankles
ā vomiting
ā dark coloration of skin
ā diarrhea
ā dry sore eyes
ā hair loss
ā nausea
ā sexual difficulties (impotence or decreased sexual urges)
ā weakness or tiredness
105. Propranolol (contād)
ā¢ Lab monitoring NOT
necessary
ā¢ Check vital signs
frequently with
parenteral drug
administration
ā¢ Observe patient for
signs of cardiac
depression &
hypotension
suppress fast rhythms of the heart (cardiac arrhythmias), such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation.
It is important to stress that these medications do NOT cure the underlying cause of an arrhythmia
Normal: depending on your age and physical conditioning 60-80 bpm
Tachcarydia: 150-250 bpm
Bradycardia: &lt; 60 bpm
Irregular heart beat due to extra beats or fibrillation
Antiarrhythmic drugs are grouped into 4 classes using the Vaughan Williams classification, introduced in 1970
Drugs are classfied based on its primary mechanism of its antiarrhythmic effect.
However, one of the limitations of the VW classifcations, is that many antiarrhtmic agenst have MULTIPLE MOAs
Arrythmias, hypertension, heart failure or myocardial infarctions
sodium, and magnesium levels. Low potassium and magnesium levels can lead to heart rhythm abnormalities, especially in patients already taking digoxin (Lanoxin). Please visit the digoxin (Lanoxin) site for further information.