2. LEARNING OBJECTIVES:
• Repair, steps involved in it.
• Granulation tissue
• Types of wound healing
• Complications
• Factors influencing
• Fracture healing
3. • REGENERATION is restoration to original tissue by
proliferation of parenchymal cells
Structure and function is retained
• REPAIR is healing of proliferation of connective tissue
resulting in fibrosis and scaring
Only structure is preserved.
4. REPAIR
The replacement of injured tissue by fibrous tissue.
Two processes are involved in repair:
1. Granulation tissue formation
2. Contraction of wounds
5.
6. STEPS INVOLVED IN REPAIR:
• Formation of blood clot
• Inflammation
• Granulation tissue formation
• Fibroblast proliferation and matrix accumulation
• Angiogenesis
• Wound contraction
• Remodelling
7.
8.
9. GRANULATION TISSUE
• Migration and proliferation of fibroblasts & deposition of loose
connective tissue, together with vessels and leukocytes
• New connective tissue with microscopic blood vessels that forms the
surface of the wound during healing process.
• Grows from the base of the wound and fill out the wound.
• Gross – pink, soft, granular, seen beneath scab of skin wound.
• Microscopically – fibroblast proliferation, capillaries, loose
extracellular matrix, inflammatory cells & macrophages.
10.
11.
12.
13.
14.
15. Classification of Wounds Closure
• Healing by Primary Intention:
– All Layers are closed. The incision that heals by first
intention does so in a minimum amount of time, with no
separation of the wound edges, and with minimal scar
formation.
• Healing by Secondary Intention:
– Deep layers are closed but superficial layers are left to
heal from the inside out. Healing by second is
appropriate in cases of infection, excessive trauma,
tissue loss, or imprecise approximation of tissue.
• Healing by Tertiary Intention:
– Also referred to as delayed primary closure.
17. PRIMARY INTENTION
• CHARACTERISTICS OF WOUND:
CLEAN AND UNINFECTED
SURGICALLY INCISED
WITHOUT MUCH LOSS OF CELLS AND TISSUE
EDGES OF WOUND APPROXIMATED BY SURGICAL SUTURES
• END RESULT
RAPID HEALING
NEAT SCAR
19. PRIMARY INTENTION
1. INITIAL HEMORRHAGE
SPACE B/W APPROXIMATED SURFACES IS FILLED WITH BLOOD
BLOOD CLOTS
WOUND IS SEALED
20. PRIMARY INTENTION
2. ACUTE INFLAMMATION RESPONSE
WITHIN 24 HRS
APPEARANCE OF POLYMORPHS
BY 3rd DAY – REPLACED BY MACROPHAGES
21. PRIMARY INTENTION
3. EPITHELIAL CHANGES
PROFILERATION OF BASAL CELLS OF EPIDERMIS
MIGRATING TOWARDS INCISIONAL SPACE
MIGRATED EPIDERMAL CELLS SEPARATE THE UNDERLYING
VIABLE DERMIS FROM OVERLYING NECROTIC DEBRIS AND CLOT BY
FORMING A SCAB.
NEW EPIDERMIS IS FORMED BY THE 5th DAY.
22. PRIMARY INTENTION
4 . ORGANISATION
BY 3RD DAY - INVASION OF FIBROBLASTS.
BY 5TH DAY - INVASION OF COLLAGEN FIBRILS
23. PRIMARY INTENTION
5 . SUTURE TRACKS
EACH SUTURE TRACK IS A SEPARATE WOUND.
AND UNDERGOES THE SAME PHENOMENA.
7TH DAY – SUTURE IS REMOVED.
25. SECONDARY INTENTION
• CHARACTERISTICS OF WOUND:
• LARGE TISSUE DEFECT
• EXTENSIVE LOSS OF CELLS AND TISSUES
• WOUND NOT APPROXIMATED BY SUTURES AND LEFT OPEN
• END RESULT:
LONGER TIME TAKEN FOR HEALING
LARGE SCAR
27. SECONDARY INTENTION
1. INITIAL HEMORRHAGE
SPACE B/W APPROXIMATED SURFACES IS FILLED WITH BLOOD
BLOOD CLOTS
WOUND IS SEALED
28. SECONDARY INTENTION
2. ACUTE INFLAMMATION RESPONSE
APPEARANCE OF POLYMORPHS INITIALLY
REPLACED BY MACROPHAGES WHICH CLEARS OFF THE DEBRIS
29. SECONDARY INTENTION
3. EPITHELIAL CHANGES
PROFILERATION OF BASAL CELLS OF EPIDERMIS
MIGRATING TOWARDS INCISIONAL SPACE
BUT GRANULATION TISSUE FROM BASE ALSO FILLS THE WOUND
SPACE.
REGENERATED EPIDERMIS BECOMES STRATIFIED AND
KERATINISED.
30. SECONDARY INTENTION
4. GRANULATION TISSUE
FORMED BY PROLIFERATION OF FIBROBLASTS AND
NEOVASCULARISAION.
NEW- RED, GRANULAR, FRAGILE
OLD- PALE, WHITE
NO REPLACEMENT OF HAIR FOLLICLES AND SWEAT GLANDS.
31. SECONDARY INTENTION
5. WOUND CONTRACTION
BY ACTION OF MYOFIBROBLASTS.
CONTRACTS TO 1/3RD TO 1/4TH OF ORIGINAL SIZE.
32. • PRESENCE OF INFECTION:
DUE TO BACTERIAL TOXINS
LEADS TO NECROSIS, SUPPURATION, THROMBOSIS
DELAYED HEALING
NEED FOR DEBRIDEMENT
36. S.NO FEATURES PRIMARY INTENTION SECONDARY INTENTION
1 CLEANLINESS CLEAN UNCLEAN
2 INFECTION MOSTLY UNINFECTED MAY BE INFECTED
3 MARGINS SUGICAL CLEAN MARGINS IRREGULAR
4 SUTURES USED NOT USED
5 HEALING SCANTY GRANULATION
TISSUE IN THE GAP
EXUBERANT GRANULATION
TISSUE IN THE GAP
6 OUTCOME NEAT LINEAR SCAR CONTRACTED IRREGULAR
WOUND
7 COMPLICATIONS EPIDERMAL INCLUSION CYST SUPPURATION
43. FRACTURE HEALING:
• Depends on
i. Nature of fracture – traumatic or pathological
ii. Type of fracture – complete or incomplete
iii. Simple (closed), comminuted (splintering of bone), compound
(communicating to skin surface)
44. STAGES OF FRACTURE HEALING
• PRIMARY UNION
• SECONDARY UNION
• PROCALLUS FORMATION
• OSSEOUS CALLUS FORMATION
• REMODELLING
45. PRIMARY UNION
• Ends of fracture are approximated
• By application of compression clamps
• Union takes place by the formation of Medullary callus without
periosteal callus formation
• Seen only in special conditions
46. SECONDARY UNION
• More common process
• Continuous
• It includes:
• PROCALLUS FORMATION
• OSSEOUS CALLUS FORMATION
• REMODELLING
47. PROCALLUS FORMATION
• It includes:
1) HAEMATOMA
2) LOCAL INFLAMMATORY RESPONSE
3) INGROWTH OF GRANULATION TISSUE
4) CALLUS COMPOSED OF WOVEN BONE AND CARTILAGE
48. HAEMATOMA
• Bleeding from torn vessels
• Fills the space
• Loss meshwork by blood and fibrin clot is formed
• This acts as framework for granulation tissue formation
49. LOCAL INFLAMMATORY RESPONSE
• Exudation of fibrin, polymorphs & macrophages.
• Macrophages clears the fibrin, red cells, exudate and debris and
necrosed bone
50. INGROWTH OF GRANULATION TISSUE
• Neovascularisation
• Proliferation of mesenchymal cells from periosteum and endosteum
• Results in soft tissue callus
51. CALLUS COMPOSED OF WOVEN BONE AND
CARTILAGE
• Cells of periosteum lays down collagen and osteoid matrix in
granulation tissue
• Osteoid matrix undergoes calcification – woven bone callus. This
covers the fracture end on both sides and bridges the gap.
52. OSSEOUS CALLUS FORMATION
• Procallus acts as scaffolding on which osseous callus is formed.
• Woven bone is cleared by incoming osteoclasts
• Calcified cartilage disintegrates.
• These are replaced by new blood vessels and osteoblasts which in
turn forms lamellar bone by developing Haversian system around the
blood vessels.
53. REMODELLING
• Osteoblastic laying and osteoclastic removal takes place
simultaneously.
• External callus is cleared away
• Compact bone is formed in place of callus
• Bonemarrow cavity develops
54.
55.
56. COMPLICATIONS:
• FIBROUS UNION: when immobilization is not done.
• NON-UNION: if soft tissue is interposed b/w fractured ends.
• DELAYED UNION: due to infection, inadequate blood supply, poor
nutrition, old age.