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Xingdong Yang
1
Xingdong Yang
20110 Lorain Rd, Apt 301, Fairview Park, Ohio 44126
(216) 413-7198 yangx@ccf.org
EDUCATION
Ph.D. in Virology and Immunology Virginia-Maryland College of Veterinary
Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia (August
2010 – May 2015)
M.B.A Pamplin College of Business, Virginia Polytechnic Institute and State University,
Blacksburg, Virginia (Withdraw, August 2013-December 2013)
D.V.M Hunan Agricultural University, Changsha, China (August 2005 – May 2009)
RESEARCH EXPERIENCES
Postdoctoral Research Fellow (07/2015-present) Department of Cancer Biology, Lerner
Research Institute, Cleveland Clinic, 9500 Euclid Avenue Cleveland, Ohio 44195
Research projects:
1. Generation of IL9-producing NK cells (NK9) for the adoptive immunotherapy for
cancer.
2. Generation of stem cell like NK cells (NKsc) cells for the adoptive immunotherapy
for cancer
Graduate Research Assistant (08/2010 – 05/2015) Department of Biomedical Sciences and
Pathobiology, Virginia Maryland College of Veterinary Medicine, Virginia Tech, 1981 Kraft
Drive, Blacksburg, VA 24060
Dissertation: Study of Infection, Immunity, Vaccine and Therapeutics Using Neonatal
Gnotobiotic Pig Model for Human Enteric Viruses
The objective of my dissertation research project is to study infection, immunity, and evaluation
of vaccines and therapeutics for human enteric viruses using neonatal gnotobiotic pigs.
Research projects I completed:
1. Evaluation of dietary rice bran on the immunogenicity and protective efficacy of an
oral rotavirus vaccine and the therapeutic effects of rice bran for human rotavirus
infection and diarrhea using the gnotobiotic pig model.
Xingdong Yang
2
2. Development of a neonatal gnotobiotic pig model for human enterovirus 71 infection
and immune responses for evaluation of vaccines and antiviral drugs.
Undergraduate Research Assistant (05/2008 - 07/2010)
Projects I participated in:
1. Development of a rapid agglutination test for the highly pathogenic avian influenza H5N1
virus.
2. Development and application of ELISA for detection of antibodies against porcine circovirus
type 2.
3. Identification of the functions of cystatin A gene during salmonellosis in Ctenopharyngodon
idella.
4. Genomic sequencing and analysis of an 08HuN strain of porcine reproductive and
respiratory syndrome virus.
PEER-REVIEWED PUBLICATIONS
1. Yang X, Twitchell E, Li G, Wen K, Weiss M, Kocher J, Lei S, Ramesh A, Pelzer K, Ryan E
and Yuan L. High protective efficacy of rice bran against human rotavirus via enhancing
probiotic growth, gut barrier function, and innate immunity. Scientific Reports, Aug 2015.
Accepted.
2. Yang X and Yuan L. Neonatal gnotobiotic pig models for studying viral pathogenesis, immune
responses, and for vaccine evaluation. British Journal of Virology, 2014;1 (3): 87-91 (review).
3. Yang X, Wen K, Tin C, Li G, Wang H, Kocher J, Pelzer K, Ryan E, Yuan L. Dietary rice bran
protects against rotavirus diarrhea and promotes Th1 type immune responses to human
rotavirus vaccine in gnotobiotic pigs. Clin Vaccine Immunol. 2014;21(10): 1396-403.
PMID:2508055
4. Yang X, Li G, Wen K, Bui T, Liu F, Kocher J, Jortner BS, Vonck M, Pelzer K, Deng J, Zhu
R, Li Y, Qian Y, Yuan L. A neonatal gnotobiotic pig model of human enterovirus 71 infection
and associated immune responses. Emerg Microbes Infect. 2014;3(5): e35.
doi:10.1038/emi.2014.35
5. Yang X, Yu X. An introduction to epitope prediction methods and software. Rev Med Virol.
2009;19 (2):77-96. PMID: 19101924
6. Wen K, Yuan R, Weiss M, Kocher J, Yang X, Li G, Yuan L. Enhanced TLR3 and TLR9
responses by rotavirus plus Lactobacillus rhamnosus GG are associated with decreased
autophagic activity in porcine intestinal T cells. Under preparation.
7. Kocher J, Bui T, Wen K, Li G, Yang X, Lei S, Weiss M, Tan M, Xia M, Zhong W, Jiang X,
and Yuan L. Simvastatin reduces P particle vaccine efficacy against GII.4 human norovirus
diarrhea and suppresses intestinal T cell immune responses in gnotobiotic pigs. Clin Vaccine
Immunol. Submitted to Immunology.
8. Li G, Wen K, Yang X, Bui T, Liu F, Wang H, Kocher J, Pelzer K, and Yuan L. Divergent
impacts of Lactobacillus acidophilus dosage on intestinal and systemic dendritic cells in
gnotobiotic pigs. Submitted.
Xingdong Yang
3
9. Wen K, Liu F, Li G, Bai M, Kocher J, Yang X, Wang H, Clark-Deener S, Yuan L.
Lactobacillus Rhamnosus GG Dosage Affects the Adjuvanticity and Protection Against
Rotavirus Diarrhea in Gnotobiotic Pigs. J Pediatr Gastroenterol Nutr. 2015 Jan 5. [Epub
ahead of print] PMID: 25564808
10. Zhang H, Wang H, Shepherd M, Wen K, Li G, Yang X, Kocher J, Giri-Rachman E, Dickerman
A, Settlage R, Yuan L. Probiotics and virulent human rotavirus modulate the transplanted
human gut microbiota in gnotobiotic pigs. Gut Pathog. 2014;6:39. doi: 10.1186/s13099-014-
0039-8. PMID: 25349634.
11. Kocher J, Bui T, Giri-Rachman E, Wen K, Li G, Yang X, Liu F, Tan M, Xia M, Zhong W,
Jiang X, Yuan L. Intranasal P Particle Vaccine Provided Partial Cross-Variant Protection
against Human GII.4 Norovirus Diarrhea in Gnotobiotic Pigs. J Virol. 2014;88(17):9728-43.
doi: 10.1128/JVI.01249-14. PMID: 2492079.
12. Wen K, Tin C, Wang H, Yang X, Li G, Giri-Rachman E, Kocher J, Bui T, Clark-Deener S,
Yuan L. Probiotic Lactobacillus rhamnosus GG enhanced Th1 cellular immunity but did not
affect antibody responses in a human gut microbiota transplanted neonatal gnotobiotic pig
model. PLoS One. 2014;9(4):e94504. doi: 10.1371/journal.pone.0094504. PMID: 24722168.
13. Liu F, Wen K, Li G, Yang X, Kocher J, Bui T, Jones D, Pelzer K, Clark-Deener S, Yuan L.
Dual Functions of Lactobacillus acidophilus NCFM as Protection Against Rotavirus Diarrhea.
J Pediatr Gastroenterol Nutr. 2014;58(2):171-8. doi: 10.1097/MPG.0000000000000197.
PMID: 24126832.
14. Liu F, Li G, Wen K, Wu S, Zhang Y, Bui T, Yang X, Kocher J, Sun J, Jortner B, Yuan L.
Lactobacillus rhamnosus GG on rotavirus-induced injury of ileal epithelium in gnotobiotic
pigs. J Pediatr Gastroenterol Nutr. 2013;57(6):750-8. doi: 10.1097/MPG.0b013e3182a356e1.
PMID: 24280990.
15. Wu S, Yuan L, Zhang Y, Liu F, Li G, Wen K, Kocher J, Yang X, Sun J. Probiotic Lactobacillus
rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the
gnotobiotic piglet intestine. Gut Pathog. 2013; 5(1):22. PMID: 23924832
16. Bui T, Kocher J, Li Y, Wen K, Li G, Liu F, Yang X, Leroith T, Tan M, Xia M, Zhong W,
Jiang X, Yuan L. Median infectious dose of human norovirus GII.4 in gnotobiotic pigs is
decreased by simvastatin treatment and increased by age. J Gen Virol. 2013; 94 (9);2005-16.
PMID:23804568
17. Ge M, Luo W, Jiang D, Li R, Zhao W, Chen G, Yang X, Yu X. Development and application
of a double-antigen sandwich enzyme-linked immunosorbent assay for detection of antibodies
to porcine circovirus 2. Clin Vaccine Immunol. 2012; 19(9):1480-6. PMID: 22815145
18. Wen K, Li G, Yang X, Bui T, Bai M, Liu F, Kocher J, Yuan L. CD4+ CD25- FoxP3+
regulatory cells are the predominant responding regulatory T cells after human rotavirus
infection or vaccination in gnotobiotic pigs. Immunology. 2012;137(2):160-71. PMID:
22716916
19. Wen K, Li G, Bui T, Liu F, Li Y, Kocher J, Lin L, Yang X, Yuan L. High dose and low dose
Lactobacillus acidophilus exerted differential immune modulating effects on T cell immune
responses induced by an oral human rotavirus vaccine in gnotobiotic pigs. Vaccine.
2012;30(6):1198-207. PMID: 22178726
TECHNICAL SKILLS
 Tissue RNA extraction, Polymerase chain reaction (PCR), RT-PCR and real-time PCR
Xingdong Yang
4
 Virological techniques (growth, purification, titration)
 Murine immune cell isolation, sorting, in vitro culture and differentiation for adoptive
immunotherapy
 Porcine primary cells isolation and culture (including neurons),
 Human and animal tissue culture
 ELISA
 SDS-PAGE
 Western blot
 Cell culture immunofluorescence (CCIF) assay
 Histopathology
 Immunohistochemistry
 ELISpot Assay
 Virus Neutralization Assay
 Intracellular staining and flow cytometry analysis (FlowJo)
 Mononuclear cell isolation from various pig tissues
 Bacteria culture and titration
 Animal model development
 Characterization of immune repsonses (T and B cells) to vaccination and virus infection
 Bioinformatics (epitope prediction and analysis software)
 Gene cloning
 Phage Display
 Basic statistics (SAS, GraphPad Prism)
PATENTS (Provisional)
1. MAPCS: a Cost Effective, Efficacious and Polyvalent Vaccine Platform for Infectious
Diseases and Cancer. VTIP 13-100
2. World Wide Lab (WWL), a website for sharing and trading innovative ideas, technologies and
inventions as well as linking the academia with industry around the world. VTIP 13-101
GRANT WRITING EXPERIENCE
1. World Wide Lab (WWL): a website for sharing and trading innovative ideas, technologies,
inventions and for linking the academia with industry around the world. CRCF Matching
Funds, Virginia CIT. Budget: $100,000. January 2013.
2. Development and commercialization of MAPCs technology as a cost-effective, efficacious and
polyvalent vaccine platform for infectious diseases and cancer. CRCF Matching Funds,
Virginia CIT. Budget: $100,000. January 2013.
3. Pathogenesis and immunity of human enterovirus 71 infection in gnotobiotic pigs. NIH R01
grant. Budget: $600,000. October 2012.
4. Predictive Modeling of Host-Human Enterovirus 71 Interactions. NIH U19 Grant. Budget:
5,000, 000. September 2012.
Xingdong Yang
5
5. Gather more preliminary data for submitting a NIH R01 grant (FOA # RFA-AI-12-021).
ICTAS grant. Budget: $10,000.00. May 2012
6. Development of a gnotobiotic pig model for study of enterovirus 71pathogenesis and
vaccines. Internal Research Competition Grant, VMRCVM, Budget: $25,000. May 2011
7. Preliminary Study on Developing a Pig Model of Human Enterovirus 71 Infection and
Disease. TSI animal model grant. Budget: $25,000. December 2010.
8. Grand Challenges Explorations in Global Health-Bill & Melinda Gates Foundation, round 3.
Budget $100,000. May 2009.
GRANTS RECEIVED
1. American Society for Virology Travel Grant Recipient, $500 Colorado State University-
Fort Collins, Pennsylvania, July 2014
2. American Society for Virology Travel Grant Recipient, $500 Penn State- State College,
Pennsylvania, July 2013
3. Study of human enterovirus 71 by transmission electron microscopy (TEM). Fralin Life
Science Funds, $2,770 Virginia Polytechnic Institute and State University, Blacksburg,
Virginia January 2013
PUBLISHED ABSTRACTS
1. Yuan L, Yang X, Eric Twitchell E, Wen K, Li G, Kocher J, Weiss M, Lei S, Ramesh A,
Ryan E. Dietary rice bran protects against viral gastroenteritis through preserving intestine
homeostasis and promoting growth of diarrhea-reducing probiotic bacteria in gnotobiotic
pigs. Vaccines for Enteric Diseases. The Royal College of Physicians of Edinburgh,
Edinburgh, UK. July 8-10 2015.
2. Kocher J, Bui T, Giri-Rachman E, Wen K, Li G, Yang X, Liu F, Tan M, Xia M, Zhong W,
Jiang X, Yuan L. P particle vaccine protects against cross-variant norovirus infection and
disease in a dose-dependent manner in gnotobiotic pigs. Abstract W2-03. 33rd Annual
Meeting of the American Society for Virology, Colorado State University, Fort Collins, CO.
June 21-25, 2014.
3. Li G, Wen K, Bui T, Weiss M, Kocher J, Yang X, Clark-Deener S, Ayares D, Yuan L.
Dendritic cell responses to human rotavirus vaccination and challenge in B cell-deficient
neonatal gnotobiotic pigs. Abstract P38-7. 33rd Annual Meeting of the American Society
for Virology, Fort Collins, CO. June 21-25, 2014.
4. Wen K, Bui T, Weiss M, Li G, Kocher J, Yang X, Clark-Deener S, Ayares D, Yuan L.
Identify the role of T cells in vaccine-induced protective immunity against rotavirus
infection and diarrhea using B cell deficient neonatal gnotobiotic pigs. Abstract W12-12.
33rd Annual Meeting of the American Society for Virology, Colorado State University, Fort
Collins, CO. June 21-25, 2014.
Xingdong Yang
6
5. Yang X, Li G, Wen K, Bui T, Liu F, Kocher J, Jortner B, Vonck M, Pelzer K, Deng J, Zhu
R, Li Y, Qian Y, Yuan L. Neonatal gnotobiotic pig model of human enterovirus 71 infection
and immune responses. Abstract W29-3. 33rd Annual Meeting of the American Society for
Virology, Colorado State University, Fort Collins, CO. June 21-25, 2014.
6. Kocher J, Bui T, Wen K, Li G, Liu F, Yang X, Tan M, Xia M, Jiang X, Yuan L.
Simvastatin increases susceptibility to human norovirus infection by down-regulating Th1
and up- regulating regulatory T cell responses. Abstract. 3rd Annual HNFE/ILSB Research
Symposium. Blacksburg, VA. May 1, 2014.
7. Kocher J, Bui T, Giri-Rachman E, Wen K, Li G, Yang X, Tan M, Xia M, Jiang X, Yuan L.
Intranasal P particle vaccine protects against human GII.4 norovirus infection and diarrhea
in gnotobiotic pigs. Abstract X-2. 5th International Conference on Caliciviruses, Beijing,
China. October 12-15, 2013.
8. Kocher J, Bui T, Wen K, Li G, Liu F, Yang X, Tan M, Xia M, Jiang X, Yuan L.
Simvastatin increases susceptibility to human norovirus infection by down-regulating Th1
and up- regulating regulatory T cell responses. Abstract P25-13. 32nd Annual Meeting of
the American Society for Virology, The Pennsylvania State University, University Park,
PA. July 20-24, 2013.
9. Yang X, Li G, Wen K, Wang H, Kocher J, Pelzer K, Ryan E, Yuan L. Dietary rice bran
supplementation protects against rotavirus diarrhea and enhances the protection rate of
human rotavirus vaccine in gnotobiotic pigs. Abstract P27-11. 32nd Annual Meeting of the
American Society for Virology, The Pennsylvania State University, University Park, PA.
July 20-24, 2013.
10. Wen K, Wang H, Li G, Yang X, Kocher J, Giri-Rachman E, Bui T, Yuan L. Evaluation of
Probiotic Adjuvant Lactobacillus Rhamnosus GG for Human Rotavirus Vaccine in a Novel
Neonatal Human Gut Microbiota Associated Gnotobiotic Pig Model. Abstract W2- 11. 32nd
Annual Meeting of the American Society for Virology, The Pennsylvania State University,
University Park, PA. July 20-24, 2013.
11. Kocher J, Bui T, Weiss M, Wen K, Li G, Liu F, Yang X, Giri-Rachman E, Yuan L. P
particle vaccine protects against HuNV gastroenteritis after induction of CD8 T cells and
reduced IL-10 production. Abstract. 2nd Annual HNFE/ILSB Annual Research Symposium,
Virginia Tech, Blacksburg, VA. May 1, 2013.
12. Yuan L, Wen K, Wang H, Li G, Yang X, Kocher J, Giri-Rachman E. Lactobacillus
rhamnosus GG enhances virus-specific effector T cell responses induced by human
Xingdong Yang
7
rotavirus vaccine in neonatal human gut microbiota associated gnotobiotic pigs. Abstract
182.12. Immunology 2013. AAI Annual Meeting. May 3-7, 2013. Honolulu, Hawaii.
13. Kocher J, Bui T, Weiss M, Wen K, Li G, Liu F, Yang X, Giri-Rachman E, Yuan L. P
particle vaccine protects against HuNV gastroenteritis after induction of CD8 T cells and
reduced IL-10 production. Abstract. 24th Annual Virginia-Maryland Regional College of
Veterinary Medicine Research Symposium, Virginia Tech, Blacksburg, VA. March 21,
2013.
14. Yang X, Li G, Wen K, Bui T, Liu F, Kocher J, Lin L, Jortner B.S., Vonck M, Pelzer K,
Deng J, Zhu R, Li Y, Qian Y, Yuan L. Development of a Novel Pig Model for Human
Enterovirus 71. Abstract. 24th Annual Virginia-Maryland Regional College of Veterinary
Medicine Research Symposium, Virginia Tech, Blacksburg, VA. March 21, 2013.
15. Yuan L, Liu F, Li G, Wen K, Wu S, Zhang Y, Bui T, Yang X, Kocher J, Sun J.
Lactobacillus rhamnosus GG protects human rotavirus-induced injuries in ileal epithelium
of gnotobiotic pigs. 11th International Symposium on double stranded RNA viruses.
November 27 - December 1, 2012. San Juan, Puerto Rico.
16. Yuan L, Wen K, Liu F, Li G, Bui T, Yang X, Kocher J. Probiotics as vaccine adjuvants:
dose effects of L. rhamnosus GG and L. acidophilus on modulation of protective immunity
against human rotavirus in gnotobiotic pigs. 4th ASM Conference on Beneficial Microbes,
October 22-26, 2012. San Antonio, TX.
17. Yuan L, Wen K, Liu F, Li G, Kocher J, Bai M, Yang X, Bui T. Lactobacillus rhamnosus
GG promotes IFN-γ producing T cell responses and suppresses regulatory T cell functions
in gnotobiotic pigs vaccinated with the attenuated human rotavirus vaccine. Abstract W21-
5. 31st Annual Meeting of the American Society for Virology, University of Wisconsin-
Madison, WI. July 21-25, 2012.
18. Liu F, Wen K, Li G, Kocher J, Bai M, Yang X, Bui T, Yuan L. Lactobacillus rhamnosus
GG (LGG) enhances virus-specific B cell and antibody responses induced by human
rotavirus vaccine and enhances protection rate against rotavirus diarrhea in Gnotobiotic
pigs. Abstract P37-10. 31st Annual Meeting of the American Society for Virology,
University of Wisconsin-Madison, WI. July 21-25, 2012.
Xingdong Yang
8
19. Li G, Wen K, Liu F, Kocher J, Yang X, Bui T, Bai M, Yuan L. Lactobacillus rhamnosus
GG (LGG) enhances antigen presenting cell function in gnotobiotic pigs vaccinated and
challenged with Wa strain human rotaviruses. Abstract W21-9. 31st Annual Meeting of the
American Society for Virology, University of Wisconsin-Madison, WI. July 21-25, 2012.
20. Kocher J, Bui T, Wen K, Li G, Liu F, Yang X, Tan M, Xia M, Jiang X, Yuan L. Evaluation
of T cell and HBGA binding blocking antibody responses to P particle vaccination and
norovirus infection in gnotobiotic pig GII.4 challenge model. Abstract W50-5. 31st Annual
Meeting of the American Society for Virology, University of Wisconsin- Madison, WI. July
21-25, 2012.
21. Kocher J, Bui T, Lamar J, Wen K, Li G, Liu F, Yang X, Tan M, Xia M, Zhong W, Jiang X,
Yuan L. Evaluation of T cell and HBGA binding responses to P particle vaccination and
Norovirus infection in a gnotobiotic pig GII.4 challenge model. Abstract. 1st Annual
HNFE/ILSB Research Symposium, Virginia Tech, Blacksburg, VA. April 19, 2012.
22. Yuan L, Kocher, Bui T, Wen K, Li G, Liu F, Lin L, Yang X, Tan M, Xia M, Jiang X. P
Particle Mucosal Vaccine Induced Stronger Th1 and HBGA-Binding Blocking Antibody
Responses than Norovirus Infection in Gnotobiotic Pigs. BIT’s 4th World Congress of
Vaccine. Abstract # S-210. March 26-28, 2012. Beijing, China.
23. Yuan L, Wen K, Li G, Liu F, Lin L, Bui T, Kocher J, Yang X. Dose effect of probiotic
lactobacilli on innate and adaptive immune responses induced by an oral rotavirus vaccine.
Keystone Symposium: Malnutrition, Gut-Microbial Interactions and Mucosal Immunity to
Vaccines, New Delhi, India. November 7-11, 2011.
24. Kocher J, Bui T, Wen K, Li G, Liu F, Lin L, Yang X, Yuan L. Evaluation of Th1/Treg Cell
Responses to Norovirus Infection and the P particle Vaccine in the Gnotobiotic Pig Model.
Abstract 35. 23rd Annual Virginia-Maryland Regional College of Veterinary Medicine
Research Symposium, Virginia Tech, Blacksburg, VA. September 30, 2011.
25. Yang X, Wen K, Bui T, Li G, Kocher J, Lin L, Liu F, Jing J, Bai M, Qian Y, Jortner B,
Yuan L. Development of a Neonatal Gnotobiotic Pig Model for Human Enterovirus 71
Infection and Disease. Abstract 48. 23rd Annual Virginia-Maryland Regional College of
Veterinary Medicine Research Symposium, Virginia Tech, Blacksburg, VA. September 30,
2011.
26. Wen K, Li G, Bui T, Liu F, Li Y, Kocher J, Rao S, Lin L, Yang X, Yuan L. Low dose and
high dose lactobacilli exerted opposite immune modulating effects on T cell responses in
gnotobiotic pigs vaccinated with an attenuated human rotavirus vaccine. Abstract P34-8.
Xingdong Yang
9
30th Annual Meeting of the American Society for Virology, University of Minnesota,
Minneapolis, MN. July 16-20, 2011.
27. Li G, Wen K, Bui T, Liu F, Li Y, Kocher J, Rao S, Lin L, Yang X, Yuan L. Differential
immune modulating effects on dendritic cells by low and high dose lactobacilli in
gnotobiotic pigs vaccinated with an attenuated human rotavirus vaccine. Abstract P34-9.
30th Annual Meeting of the American Society for Virology, University of Minnesota,
Minneapolis, MN. July 16-20, 2011.
28. Yuan L, Wen K, Li G, Bui T, Liu F, Li Y, Kocher J, Rao S, Lin L, Yang X. Opposite
modulating effects on dendritic cell and T cell responses by low dose versus high dose
lactobacilli in gnotobiotic pigs. Abstract F83. The 15th International Congress of Mucosal
Immunology (ICMI 2011), Paris, France. July 6-9, 2011.
CONFERENCES
1. 33rd Annual Meeting of the American Society for Virology, Colorado State University, Fort
Collins, CO, June 2014 (presented “Neonatal Gnotobiotic Pig Model of Human Enterovirus 71
Infection and Immune Responses” in oral format)
2. 3rd Annual HNFE/ILSB Research Symposium, Virginia Tech, Blacksburg, VA, May 2014
(presented “Dietary Rice Bran Supplementation Protects against Rotavirus Diarrhea and Enhances
the Protection Rate of Human Rotavirus Vaccine in Gnotobiotic Pigs” in poster format)
3. 25th Annual Virginia-Maryland Regional College of Veterinary Medicine Research
Symposium, Virginia Tech, Blacksburg, VA, March 2014 (presented “Dietary Rice Bran
Supplementation Protects against Rotavirus Diarrhea and Enhances the Protection Rate of Human
Rotavirus Vaccine in Gnotobiotic Pigs” in poster format)
4. 32nd Annual Meeting of the American Society for Virology, The Pennsylvania State
University, State College, PA, July 2013 (presented “Dietary Rice Bran Supplementation
Protects against Rotavirus Diarrhea and Enhances the Protection Rate of Human Rotavirus Vaccine in
Gnotobiotic Pigs” in poster format)
5. 24th Annual Virginia-Maryland Regional College of Veterinary Medicine Research
Symposium, Virginia Tech, Blacksburg, VA, March 2013 (presented “Development of an
Neonatal Gnotobiotic Pig Model of Human Enterovirus 71 Infections” in poster format)
Xingdong Yang
10
6. 23rd Annual Virginia-Maryland Regional College of Veterinary Medicine Research
Symposium, Virginia Tech, Blacksburg, VA, September 2011 (attended)
POSITIONS
07/2015 - present Postdoctoral Research Fellow at Cleveland Clinic
08/2010 – 05/2015 Graduate Research Assistant at Virginia Tech
05/2008 - 07/2010 Research Assistant at Laboratory of Virology and Genetic Engineering,
Hunan Agricultural University
02/2008 - 04/2008 Intern at Hunan Province Animal Hospital
PROFESSIONAL SOCIETIES
American Society for Virology, Student Member, 2012-present
American Association for the Advancement of Science, Student Member, 2010 - present
OTHER SKILLS
 Great at independent and team work
 Interdisciplinary communication skills
 Personal, oral and written communication skills

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Jeff Xingdong Yang CV

  • 1. Xingdong Yang 1 Xingdong Yang 20110 Lorain Rd, Apt 301, Fairview Park, Ohio 44126 (216) 413-7198 yangx@ccf.org EDUCATION Ph.D. in Virology and Immunology Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia (August 2010 – May 2015) M.B.A Pamplin College of Business, Virginia Polytechnic Institute and State University, Blacksburg, Virginia (Withdraw, August 2013-December 2013) D.V.M Hunan Agricultural University, Changsha, China (August 2005 – May 2009) RESEARCH EXPERIENCES Postdoctoral Research Fellow (07/2015-present) Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue Cleveland, Ohio 44195 Research projects: 1. Generation of IL9-producing NK cells (NK9) for the adoptive immunotherapy for cancer. 2. Generation of stem cell like NK cells (NKsc) cells for the adoptive immunotherapy for cancer Graduate Research Assistant (08/2010 – 05/2015) Department of Biomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Virginia Tech, 1981 Kraft Drive, Blacksburg, VA 24060 Dissertation: Study of Infection, Immunity, Vaccine and Therapeutics Using Neonatal Gnotobiotic Pig Model for Human Enteric Viruses The objective of my dissertation research project is to study infection, immunity, and evaluation of vaccines and therapeutics for human enteric viruses using neonatal gnotobiotic pigs. Research projects I completed: 1. Evaluation of dietary rice bran on the immunogenicity and protective efficacy of an oral rotavirus vaccine and the therapeutic effects of rice bran for human rotavirus infection and diarrhea using the gnotobiotic pig model.
  • 2. Xingdong Yang 2 2. Development of a neonatal gnotobiotic pig model for human enterovirus 71 infection and immune responses for evaluation of vaccines and antiviral drugs. Undergraduate Research Assistant (05/2008 - 07/2010) Projects I participated in: 1. Development of a rapid agglutination test for the highly pathogenic avian influenza H5N1 virus. 2. Development and application of ELISA for detection of antibodies against porcine circovirus type 2. 3. Identification of the functions of cystatin A gene during salmonellosis in Ctenopharyngodon idella. 4. Genomic sequencing and analysis of an 08HuN strain of porcine reproductive and respiratory syndrome virus. PEER-REVIEWED PUBLICATIONS 1. Yang X, Twitchell E, Li G, Wen K, Weiss M, Kocher J, Lei S, Ramesh A, Pelzer K, Ryan E and Yuan L. High protective efficacy of rice bran against human rotavirus via enhancing probiotic growth, gut barrier function, and innate immunity. Scientific Reports, Aug 2015. Accepted. 2. Yang X and Yuan L. Neonatal gnotobiotic pig models for studying viral pathogenesis, immune responses, and for vaccine evaluation. British Journal of Virology, 2014;1 (3): 87-91 (review). 3. Yang X, Wen K, Tin C, Li G, Wang H, Kocher J, Pelzer K, Ryan E, Yuan L. Dietary rice bran protects against rotavirus diarrhea and promotes Th1 type immune responses to human rotavirus vaccine in gnotobiotic pigs. Clin Vaccine Immunol. 2014;21(10): 1396-403. PMID:2508055 4. Yang X, Li G, Wen K, Bui T, Liu F, Kocher J, Jortner BS, Vonck M, Pelzer K, Deng J, Zhu R, Li Y, Qian Y, Yuan L. A neonatal gnotobiotic pig model of human enterovirus 71 infection and associated immune responses. Emerg Microbes Infect. 2014;3(5): e35. doi:10.1038/emi.2014.35 5. Yang X, Yu X. An introduction to epitope prediction methods and software. Rev Med Virol. 2009;19 (2):77-96. PMID: 19101924 6. Wen K, Yuan R, Weiss M, Kocher J, Yang X, Li G, Yuan L. Enhanced TLR3 and TLR9 responses by rotavirus plus Lactobacillus rhamnosus GG are associated with decreased autophagic activity in porcine intestinal T cells. Under preparation. 7. Kocher J, Bui T, Wen K, Li G, Yang X, Lei S, Weiss M, Tan M, Xia M, Zhong W, Jiang X, and Yuan L. Simvastatin reduces P particle vaccine efficacy against GII.4 human norovirus diarrhea and suppresses intestinal T cell immune responses in gnotobiotic pigs. Clin Vaccine Immunol. Submitted to Immunology. 8. Li G, Wen K, Yang X, Bui T, Liu F, Wang H, Kocher J, Pelzer K, and Yuan L. Divergent impacts of Lactobacillus acidophilus dosage on intestinal and systemic dendritic cells in gnotobiotic pigs. Submitted.
  • 3. Xingdong Yang 3 9. Wen K, Liu F, Li G, Bai M, Kocher J, Yang X, Wang H, Clark-Deener S, Yuan L. Lactobacillus Rhamnosus GG Dosage Affects the Adjuvanticity and Protection Against Rotavirus Diarrhea in Gnotobiotic Pigs. J Pediatr Gastroenterol Nutr. 2015 Jan 5. [Epub ahead of print] PMID: 25564808 10. Zhang H, Wang H, Shepherd M, Wen K, Li G, Yang X, Kocher J, Giri-Rachman E, Dickerman A, Settlage R, Yuan L. Probiotics and virulent human rotavirus modulate the transplanted human gut microbiota in gnotobiotic pigs. Gut Pathog. 2014;6:39. doi: 10.1186/s13099-014- 0039-8. PMID: 25349634. 11. Kocher J, Bui T, Giri-Rachman E, Wen K, Li G, Yang X, Liu F, Tan M, Xia M, Zhong W, Jiang X, Yuan L. Intranasal P Particle Vaccine Provided Partial Cross-Variant Protection against Human GII.4 Norovirus Diarrhea in Gnotobiotic Pigs. J Virol. 2014;88(17):9728-43. doi: 10.1128/JVI.01249-14. PMID: 2492079. 12. Wen K, Tin C, Wang H, Yang X, Li G, Giri-Rachman E, Kocher J, Bui T, Clark-Deener S, Yuan L. Probiotic Lactobacillus rhamnosus GG enhanced Th1 cellular immunity but did not affect antibody responses in a human gut microbiota transplanted neonatal gnotobiotic pig model. PLoS One. 2014;9(4):e94504. doi: 10.1371/journal.pone.0094504. PMID: 24722168. 13. Liu F, Wen K, Li G, Yang X, Kocher J, Bui T, Jones D, Pelzer K, Clark-Deener S, Yuan L. Dual Functions of Lactobacillus acidophilus NCFM as Protection Against Rotavirus Diarrhea. J Pediatr Gastroenterol Nutr. 2014;58(2):171-8. doi: 10.1097/MPG.0000000000000197. PMID: 24126832. 14. Liu F, Li G, Wen K, Wu S, Zhang Y, Bui T, Yang X, Kocher J, Sun J, Jortner B, Yuan L. Lactobacillus rhamnosus GG on rotavirus-induced injury of ileal epithelium in gnotobiotic pigs. J Pediatr Gastroenterol Nutr. 2013;57(6):750-8. doi: 10.1097/MPG.0b013e3182a356e1. PMID: 24280990. 15. Wu S, Yuan L, Zhang Y, Liu F, Li G, Wen K, Kocher J, Yang X, Sun J. Probiotic Lactobacillus rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the gnotobiotic piglet intestine. Gut Pathog. 2013; 5(1):22. PMID: 23924832 16. Bui T, Kocher J, Li Y, Wen K, Li G, Liu F, Yang X, Leroith T, Tan M, Xia M, Zhong W, Jiang X, Yuan L. Median infectious dose of human norovirus GII.4 in gnotobiotic pigs is decreased by simvastatin treatment and increased by age. J Gen Virol. 2013; 94 (9);2005-16. PMID:23804568 17. Ge M, Luo W, Jiang D, Li R, Zhao W, Chen G, Yang X, Yu X. Development and application of a double-antigen sandwich enzyme-linked immunosorbent assay for detection of antibodies to porcine circovirus 2. Clin Vaccine Immunol. 2012; 19(9):1480-6. PMID: 22815145 18. Wen K, Li G, Yang X, Bui T, Bai M, Liu F, Kocher J, Yuan L. CD4+ CD25- FoxP3+ regulatory cells are the predominant responding regulatory T cells after human rotavirus infection or vaccination in gnotobiotic pigs. Immunology. 2012;137(2):160-71. PMID: 22716916 19. Wen K, Li G, Bui T, Liu F, Li Y, Kocher J, Lin L, Yang X, Yuan L. High dose and low dose Lactobacillus acidophilus exerted differential immune modulating effects on T cell immune responses induced by an oral human rotavirus vaccine in gnotobiotic pigs. Vaccine. 2012;30(6):1198-207. PMID: 22178726 TECHNICAL SKILLS  Tissue RNA extraction, Polymerase chain reaction (PCR), RT-PCR and real-time PCR
  • 4. Xingdong Yang 4  Virological techniques (growth, purification, titration)  Murine immune cell isolation, sorting, in vitro culture and differentiation for adoptive immunotherapy  Porcine primary cells isolation and culture (including neurons),  Human and animal tissue culture  ELISA  SDS-PAGE  Western blot  Cell culture immunofluorescence (CCIF) assay  Histopathology  Immunohistochemistry  ELISpot Assay  Virus Neutralization Assay  Intracellular staining and flow cytometry analysis (FlowJo)  Mononuclear cell isolation from various pig tissues  Bacteria culture and titration  Animal model development  Characterization of immune repsonses (T and B cells) to vaccination and virus infection  Bioinformatics (epitope prediction and analysis software)  Gene cloning  Phage Display  Basic statistics (SAS, GraphPad Prism) PATENTS (Provisional) 1. MAPCS: a Cost Effective, Efficacious and Polyvalent Vaccine Platform for Infectious Diseases and Cancer. VTIP 13-100 2. World Wide Lab (WWL), a website for sharing and trading innovative ideas, technologies and inventions as well as linking the academia with industry around the world. VTIP 13-101 GRANT WRITING EXPERIENCE 1. World Wide Lab (WWL): a website for sharing and trading innovative ideas, technologies, inventions and for linking the academia with industry around the world. CRCF Matching Funds, Virginia CIT. Budget: $100,000. January 2013. 2. Development and commercialization of MAPCs technology as a cost-effective, efficacious and polyvalent vaccine platform for infectious diseases and cancer. CRCF Matching Funds, Virginia CIT. Budget: $100,000. January 2013. 3. Pathogenesis and immunity of human enterovirus 71 infection in gnotobiotic pigs. NIH R01 grant. Budget: $600,000. October 2012. 4. Predictive Modeling of Host-Human Enterovirus 71 Interactions. NIH U19 Grant. Budget: 5,000, 000. September 2012.
  • 5. Xingdong Yang 5 5. Gather more preliminary data for submitting a NIH R01 grant (FOA # RFA-AI-12-021). ICTAS grant. Budget: $10,000.00. May 2012 6. Development of a gnotobiotic pig model for study of enterovirus 71pathogenesis and vaccines. Internal Research Competition Grant, VMRCVM, Budget: $25,000. May 2011 7. Preliminary Study on Developing a Pig Model of Human Enterovirus 71 Infection and Disease. TSI animal model grant. Budget: $25,000. December 2010. 8. Grand Challenges Explorations in Global Health-Bill & Melinda Gates Foundation, round 3. Budget $100,000. May 2009. GRANTS RECEIVED 1. American Society for Virology Travel Grant Recipient, $500 Colorado State University- Fort Collins, Pennsylvania, July 2014 2. American Society for Virology Travel Grant Recipient, $500 Penn State- State College, Pennsylvania, July 2013 3. Study of human enterovirus 71 by transmission electron microscopy (TEM). Fralin Life Science Funds, $2,770 Virginia Polytechnic Institute and State University, Blacksburg, Virginia January 2013 PUBLISHED ABSTRACTS 1. Yuan L, Yang X, Eric Twitchell E, Wen K, Li G, Kocher J, Weiss M, Lei S, Ramesh A, Ryan E. Dietary rice bran protects against viral gastroenteritis through preserving intestine homeostasis and promoting growth of diarrhea-reducing probiotic bacteria in gnotobiotic pigs. Vaccines for Enteric Diseases. The Royal College of Physicians of Edinburgh, Edinburgh, UK. July 8-10 2015. 2. Kocher J, Bui T, Giri-Rachman E, Wen K, Li G, Yang X, Liu F, Tan M, Xia M, Zhong W, Jiang X, Yuan L. P particle vaccine protects against cross-variant norovirus infection and disease in a dose-dependent manner in gnotobiotic pigs. Abstract W2-03. 33rd Annual Meeting of the American Society for Virology, Colorado State University, Fort Collins, CO. June 21-25, 2014. 3. Li G, Wen K, Bui T, Weiss M, Kocher J, Yang X, Clark-Deener S, Ayares D, Yuan L. Dendritic cell responses to human rotavirus vaccination and challenge in B cell-deficient neonatal gnotobiotic pigs. Abstract P38-7. 33rd Annual Meeting of the American Society for Virology, Fort Collins, CO. June 21-25, 2014. 4. Wen K, Bui T, Weiss M, Li G, Kocher J, Yang X, Clark-Deener S, Ayares D, Yuan L. Identify the role of T cells in vaccine-induced protective immunity against rotavirus infection and diarrhea using B cell deficient neonatal gnotobiotic pigs. Abstract W12-12. 33rd Annual Meeting of the American Society for Virology, Colorado State University, Fort Collins, CO. June 21-25, 2014.
  • 6. Xingdong Yang 6 5. Yang X, Li G, Wen K, Bui T, Liu F, Kocher J, Jortner B, Vonck M, Pelzer K, Deng J, Zhu R, Li Y, Qian Y, Yuan L. Neonatal gnotobiotic pig model of human enterovirus 71 infection and immune responses. Abstract W29-3. 33rd Annual Meeting of the American Society for Virology, Colorado State University, Fort Collins, CO. June 21-25, 2014. 6. Kocher J, Bui T, Wen K, Li G, Liu F, Yang X, Tan M, Xia M, Jiang X, Yuan L. Simvastatin increases susceptibility to human norovirus infection by down-regulating Th1 and up- regulating regulatory T cell responses. Abstract. 3rd Annual HNFE/ILSB Research Symposium. Blacksburg, VA. May 1, 2014. 7. Kocher J, Bui T, Giri-Rachman E, Wen K, Li G, Yang X, Tan M, Xia M, Jiang X, Yuan L. Intranasal P particle vaccine protects against human GII.4 norovirus infection and diarrhea in gnotobiotic pigs. Abstract X-2. 5th International Conference on Caliciviruses, Beijing, China. October 12-15, 2013. 8. Kocher J, Bui T, Wen K, Li G, Liu F, Yang X, Tan M, Xia M, Jiang X, Yuan L. Simvastatin increases susceptibility to human norovirus infection by down-regulating Th1 and up- regulating regulatory T cell responses. Abstract P25-13. 32nd Annual Meeting of the American Society for Virology, The Pennsylvania State University, University Park, PA. July 20-24, 2013. 9. Yang X, Li G, Wen K, Wang H, Kocher J, Pelzer K, Ryan E, Yuan L. Dietary rice bran supplementation protects against rotavirus diarrhea and enhances the protection rate of human rotavirus vaccine in gnotobiotic pigs. Abstract P27-11. 32nd Annual Meeting of the American Society for Virology, The Pennsylvania State University, University Park, PA. July 20-24, 2013. 10. Wen K, Wang H, Li G, Yang X, Kocher J, Giri-Rachman E, Bui T, Yuan L. Evaluation of Probiotic Adjuvant Lactobacillus Rhamnosus GG for Human Rotavirus Vaccine in a Novel Neonatal Human Gut Microbiota Associated Gnotobiotic Pig Model. Abstract W2- 11. 32nd Annual Meeting of the American Society for Virology, The Pennsylvania State University, University Park, PA. July 20-24, 2013. 11. Kocher J, Bui T, Weiss M, Wen K, Li G, Liu F, Yang X, Giri-Rachman E, Yuan L. P particle vaccine protects against HuNV gastroenteritis after induction of CD8 T cells and reduced IL-10 production. Abstract. 2nd Annual HNFE/ILSB Annual Research Symposium, Virginia Tech, Blacksburg, VA. May 1, 2013. 12. Yuan L, Wen K, Wang H, Li G, Yang X, Kocher J, Giri-Rachman E. Lactobacillus rhamnosus GG enhances virus-specific effector T cell responses induced by human
  • 7. Xingdong Yang 7 rotavirus vaccine in neonatal human gut microbiota associated gnotobiotic pigs. Abstract 182.12. Immunology 2013. AAI Annual Meeting. May 3-7, 2013. Honolulu, Hawaii. 13. Kocher J, Bui T, Weiss M, Wen K, Li G, Liu F, Yang X, Giri-Rachman E, Yuan L. P particle vaccine protects against HuNV gastroenteritis after induction of CD8 T cells and reduced IL-10 production. Abstract. 24th Annual Virginia-Maryland Regional College of Veterinary Medicine Research Symposium, Virginia Tech, Blacksburg, VA. March 21, 2013. 14. Yang X, Li G, Wen K, Bui T, Liu F, Kocher J, Lin L, Jortner B.S., Vonck M, Pelzer K, Deng J, Zhu R, Li Y, Qian Y, Yuan L. Development of a Novel Pig Model for Human Enterovirus 71. Abstract. 24th Annual Virginia-Maryland Regional College of Veterinary Medicine Research Symposium, Virginia Tech, Blacksburg, VA. March 21, 2013. 15. Yuan L, Liu F, Li G, Wen K, Wu S, Zhang Y, Bui T, Yang X, Kocher J, Sun J. Lactobacillus rhamnosus GG protects human rotavirus-induced injuries in ileal epithelium of gnotobiotic pigs. 11th International Symposium on double stranded RNA viruses. November 27 - December 1, 2012. San Juan, Puerto Rico. 16. Yuan L, Wen K, Liu F, Li G, Bui T, Yang X, Kocher J. Probiotics as vaccine adjuvants: dose effects of L. rhamnosus GG and L. acidophilus on modulation of protective immunity against human rotavirus in gnotobiotic pigs. 4th ASM Conference on Beneficial Microbes, October 22-26, 2012. San Antonio, TX. 17. Yuan L, Wen K, Liu F, Li G, Kocher J, Bai M, Yang X, Bui T. Lactobacillus rhamnosus GG promotes IFN-γ producing T cell responses and suppresses regulatory T cell functions in gnotobiotic pigs vaccinated with the attenuated human rotavirus vaccine. Abstract W21- 5. 31st Annual Meeting of the American Society for Virology, University of Wisconsin- Madison, WI. July 21-25, 2012. 18. Liu F, Wen K, Li G, Kocher J, Bai M, Yang X, Bui T, Yuan L. Lactobacillus rhamnosus GG (LGG) enhances virus-specific B cell and antibody responses induced by human rotavirus vaccine and enhances protection rate against rotavirus diarrhea in Gnotobiotic pigs. Abstract P37-10. 31st Annual Meeting of the American Society for Virology, University of Wisconsin-Madison, WI. July 21-25, 2012.
  • 8. Xingdong Yang 8 19. Li G, Wen K, Liu F, Kocher J, Yang X, Bui T, Bai M, Yuan L. Lactobacillus rhamnosus GG (LGG) enhances antigen presenting cell function in gnotobiotic pigs vaccinated and challenged with Wa strain human rotaviruses. Abstract W21-9. 31st Annual Meeting of the American Society for Virology, University of Wisconsin-Madison, WI. July 21-25, 2012. 20. Kocher J, Bui T, Wen K, Li G, Liu F, Yang X, Tan M, Xia M, Jiang X, Yuan L. Evaluation of T cell and HBGA binding blocking antibody responses to P particle vaccination and norovirus infection in gnotobiotic pig GII.4 challenge model. Abstract W50-5. 31st Annual Meeting of the American Society for Virology, University of Wisconsin- Madison, WI. July 21-25, 2012. 21. Kocher J, Bui T, Lamar J, Wen K, Li G, Liu F, Yang X, Tan M, Xia M, Zhong W, Jiang X, Yuan L. Evaluation of T cell and HBGA binding responses to P particle vaccination and Norovirus infection in a gnotobiotic pig GII.4 challenge model. Abstract. 1st Annual HNFE/ILSB Research Symposium, Virginia Tech, Blacksburg, VA. April 19, 2012. 22. Yuan L, Kocher, Bui T, Wen K, Li G, Liu F, Lin L, Yang X, Tan M, Xia M, Jiang X. P Particle Mucosal Vaccine Induced Stronger Th1 and HBGA-Binding Blocking Antibody Responses than Norovirus Infection in Gnotobiotic Pigs. BIT’s 4th World Congress of Vaccine. Abstract # S-210. March 26-28, 2012. Beijing, China. 23. Yuan L, Wen K, Li G, Liu F, Lin L, Bui T, Kocher J, Yang X. Dose effect of probiotic lactobacilli on innate and adaptive immune responses induced by an oral rotavirus vaccine. Keystone Symposium: Malnutrition, Gut-Microbial Interactions and Mucosal Immunity to Vaccines, New Delhi, India. November 7-11, 2011. 24. Kocher J, Bui T, Wen K, Li G, Liu F, Lin L, Yang X, Yuan L. Evaluation of Th1/Treg Cell Responses to Norovirus Infection and the P particle Vaccine in the Gnotobiotic Pig Model. Abstract 35. 23rd Annual Virginia-Maryland Regional College of Veterinary Medicine Research Symposium, Virginia Tech, Blacksburg, VA. September 30, 2011. 25. Yang X, Wen K, Bui T, Li G, Kocher J, Lin L, Liu F, Jing J, Bai M, Qian Y, Jortner B, Yuan L. Development of a Neonatal Gnotobiotic Pig Model for Human Enterovirus 71 Infection and Disease. Abstract 48. 23rd Annual Virginia-Maryland Regional College of Veterinary Medicine Research Symposium, Virginia Tech, Blacksburg, VA. September 30, 2011. 26. Wen K, Li G, Bui T, Liu F, Li Y, Kocher J, Rao S, Lin L, Yang X, Yuan L. Low dose and high dose lactobacilli exerted opposite immune modulating effects on T cell responses in gnotobiotic pigs vaccinated with an attenuated human rotavirus vaccine. Abstract P34-8.
  • 9. Xingdong Yang 9 30th Annual Meeting of the American Society for Virology, University of Minnesota, Minneapolis, MN. July 16-20, 2011. 27. Li G, Wen K, Bui T, Liu F, Li Y, Kocher J, Rao S, Lin L, Yang X, Yuan L. Differential immune modulating effects on dendritic cells by low and high dose lactobacilli in gnotobiotic pigs vaccinated with an attenuated human rotavirus vaccine. Abstract P34-9. 30th Annual Meeting of the American Society for Virology, University of Minnesota, Minneapolis, MN. July 16-20, 2011. 28. Yuan L, Wen K, Li G, Bui T, Liu F, Li Y, Kocher J, Rao S, Lin L, Yang X. Opposite modulating effects on dendritic cell and T cell responses by low dose versus high dose lactobacilli in gnotobiotic pigs. Abstract F83. The 15th International Congress of Mucosal Immunology (ICMI 2011), Paris, France. July 6-9, 2011. CONFERENCES 1. 33rd Annual Meeting of the American Society for Virology, Colorado State University, Fort Collins, CO, June 2014 (presented “Neonatal Gnotobiotic Pig Model of Human Enterovirus 71 Infection and Immune Responses” in oral format) 2. 3rd Annual HNFE/ILSB Research Symposium, Virginia Tech, Blacksburg, VA, May 2014 (presented “Dietary Rice Bran Supplementation Protects against Rotavirus Diarrhea and Enhances the Protection Rate of Human Rotavirus Vaccine in Gnotobiotic Pigs” in poster format) 3. 25th Annual Virginia-Maryland Regional College of Veterinary Medicine Research Symposium, Virginia Tech, Blacksburg, VA, March 2014 (presented “Dietary Rice Bran Supplementation Protects against Rotavirus Diarrhea and Enhances the Protection Rate of Human Rotavirus Vaccine in Gnotobiotic Pigs” in poster format) 4. 32nd Annual Meeting of the American Society for Virology, The Pennsylvania State University, State College, PA, July 2013 (presented “Dietary Rice Bran Supplementation Protects against Rotavirus Diarrhea and Enhances the Protection Rate of Human Rotavirus Vaccine in Gnotobiotic Pigs” in poster format) 5. 24th Annual Virginia-Maryland Regional College of Veterinary Medicine Research Symposium, Virginia Tech, Blacksburg, VA, March 2013 (presented “Development of an Neonatal Gnotobiotic Pig Model of Human Enterovirus 71 Infections” in poster format)
  • 10. Xingdong Yang 10 6. 23rd Annual Virginia-Maryland Regional College of Veterinary Medicine Research Symposium, Virginia Tech, Blacksburg, VA, September 2011 (attended) POSITIONS 07/2015 - present Postdoctoral Research Fellow at Cleveland Clinic 08/2010 – 05/2015 Graduate Research Assistant at Virginia Tech 05/2008 - 07/2010 Research Assistant at Laboratory of Virology and Genetic Engineering, Hunan Agricultural University 02/2008 - 04/2008 Intern at Hunan Province Animal Hospital PROFESSIONAL SOCIETIES American Society for Virology, Student Member, 2012-present American Association for the Advancement of Science, Student Member, 2010 - present OTHER SKILLS  Great at independent and team work  Interdisciplinary communication skills  Personal, oral and written communication skills