Bordetella class notes

Bordetella, Francisella & Brucella

General Overview of Bordetella, Francisella & Brucella ,[object Object],[object Object],[object Object],[object Object],[object Object]

Human Disease & Associated Pathogens Brucellosis melintensis Brucella Brucellosis abortus Brucellosis suis Brucellosis canis Tularemia tularensis Francisella Disease Species Genus Bronchopulmonary disease bronchiseptica Pertussis (milder form) parapertussis Pertussis pertussis Bordetella

Bordetella pertussis Basics ,[object Object],[object Object],[object Object],[object Object],[object Object],http://microvet.arizona.edu/Courses/MIC420/lecture_notes/bordetella_pertussis/ gram_pertussis.html

[object Object],[object Object],[object Object],[object Object],[object Object],Epidemiology of Bordetella pertussis Infection

Bordetella pertussis ,[object Object],[object Object],[object Object],[object Object]

Lipopolysaccharide ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Incidence & Severity of Pertussis Cases in USA

Age Distribution & Severity of Pertussis Cases

Changes in Age Distribution for Pertussis Cases Blue = 1988 Orange = 1998

Clinical Progression of Pertussis Most infectious, but generally not yet diagnosed Inflammation of respiratory mucosal memb. , or death

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Virulence Factors Associated with Bordetella pertussis

Virulence Factors Associated with Bordetella pertussis

Adhesions ,[object Object],[object Object],[object Object],http://www.rivm.nl/infectieziektenbulletin/bul1306/kinkhoest.jpg http://www.my-pharm.ac.jp/~yishibas/research/Pertussis1.jpg

Toxins ,[object Object],[object Object],[object Object],[object Object],[object Object],www.ibl.fr/u447/u447.htm

Pertussis Toxin ,[object Object],[object Object],gsbs.utmb.edu / microbook/ch031.htm www.med.sc.edu:85/ ghaffar/pertussis.jpg

Adenylate Cyclase Toxin ,[object Object],[object Object],[object Object],Babu et al., 2001

Laboratory Culture, Prevention & Treatment of Bordetella ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Differential Characteristics of Bordetella Species

Pertussis Laboratory Confirmation ,[object Object],[object Object],[object Object]

Bordetella pertussis Culture ,[object Object],[object Object],[object Object],[object Object]

PCR Testing ,[object Object],[object Object],[object Object],[object Object]

Critical Data for Pertussis Case Investigation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Francisella tularensis Infections

Francisella tularensis Infections (cont.)

Clinical Presentation of Tularemia NOTE: Also Gastrointestinal & Pneumonic forms of disease

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Epidemiology of F. tularensis Infection

Biochemical Variants (Biovar) of Francisella tularensis

[object Object],[object Object],[object Object],Virulence Factors of Fransicella tularensis

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Laboratory Culture, Prevention & Treatment of F. tularensis

Antibody Response to Francisella tularensis Infections

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Epidemiology of Brucellosis

Incidence of Brucellosis in USA

[object Object],[object Object],[object Object],Brucellosis in Animals

Human Brucellosis & Associated Species Severe

Brucellosis in Humans ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Brucellosis in Humans (cont.)

[object Object],[object Object],[object Object],[object Object],Clinical Presentation of Human Brucellosis

Bordetella class notes

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Bordetella class notes