1. Hypersensitivity Reactions A state of altered reactivity in which the body reacts with an exaggerated immune response to a foreign agent.

4. Hypersensitivity Reactions

6. Figure 10-1

11. Biologic effects of mediators

12. Biological effects of Eosinophil mediators Late stage of an allergic response includes the recruitment of eosinophils and Th2 cells contrast with a DTH (type IV) response which includes infiltration of macrophages and Th1 cells

15. Figure 10-12

21. TYPE II HYPERSENSITIVITY B. TYPE II CYTOTOXIC REACTIONS - IgG OR IgM MEDIATED, COMPLEMENT INVOLVED, REACTIONS MOST OFTEN EFFECT CELLULAR ELEMENTS IN INTIMATE CONTACT WITH CIRCULATING PLASMA EXAMPLES: HEMOLYTIC ANEMIA, TRANSFUSION REACTIONS

24. Human ABO Blood Types anti-A anti-B H O OOH none A, B, H AB ABH anti-A B, H B BBH or BOH anti-B A, H A AAH or AOH serum Abs ABO Ags on rbc rbc phenotype Genotype

36. Arthus Reaction

39. TYPE IV HYPERSENSITIVITY D. TYPE IV - CELL MEDIATED OR DELAYED HYPERSENSITIVITY T-CELL MEDIATED, SENSITIZED TO LOCALLY DEPOSITED ANTIGEN. REACTION MEDIATED BY RELEASE OF LYMPHOKINE AND/OR DIRECT CYTOTOXICITY EXAMPLES: CONTACT SENSITIVITY (POISON IVY)

42. Type IV hypersensitivity - Delayed-type hypersensitivity

43. Figure 10-34

44. Figure 10-35

47. TYPE IV DELAYED HYPERSENSITIVITY

51. (hives) Allergies 4 types of hypersensitivity reactions

52. Delayed-type hypersensitivity Immune complex disease