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WELCOME
TO
JOURNAL CLUB PRESENTATION
Maj Jahangir Alam
Classified Specialist in Paediatrics
CMH Dhaka
REVIEW ON NEW CLINICAL PRACTICE GUIDELINE FOR
THE MANAGEMENT OF HIGH BLOOD PRESSURE IN
CHILDREN AND ADOLESCENTS
Authors : Joseph T. Flynn, Bonita E. Falkner
Oct 2017
Volume : 70
P : 683-86
Introduction
 Before 1977, there was no consistent
definition of hypertension in
childhood.
 Childhood hypertension had been
considered rare and, if detected, the
assumption was that it would be
secondary to an underlying disorder.
 In the mid-1970s, National Heart Lung and
Blood Institute (NHLBI) convened a task force
to examine available BP data on healthy
children.
 The recommendations of this task force on
detection, evaluation, and management of
hypertension in children and adolescents
were published in 1977 (1st report).
Introduction cont…
 Major updates were published in
1987(2nd), 1996(3rd), and
2004(4th).
 Interest in childhood hypertension
(HTN) has increased since the
2004 publication (forth report).
Introduction cont…
 Clinical Practice Guideline for Screening and
Management of High Blood Pressure in Children and
Adolescents are an update to the 2004 “Fourth
Report".
 It is known as "2017 AAP CPG“
Introduction cont….
Understand the changes in the new AAP childhood
hypertension guideline and how these changes will
affect the management of hypertension.
objectives
Definition of Hypertension in children & Adolescents
Categories For children aged 1-13 yr For children aged > 13 yr
Normal BP < 90th percentile <120/<80 mm Hg
Elevated BP > 90th percentile to < 95th
percentile 0r 120/80 mm Hg to
< 95th percentile (whichever is
lower)
120/<80 to 129/<80
mm Hg
Stage 1 HTN > 95th percentile to < 95th
percentile +12 mm Hg or
130/80 to 139/89 mm Hg (
Whichever is lower)
130/80 to 139/89 mm
Hg
Stage 2 HTN > 95th percentile + 12 mm Hg or
>140/90 mm Hg (whichever is
lower)
> 140/90 mm Hg
 BP >90th percentile is now termed
‘elevated BP’
 BP cut-points for Stage 1 and 2 HTN
simplified
 BP cut-points for adolescents ≥13
years of age are the same as in new
AHA/ACC adult HTN guideline
changes in CPG 2017 compared to forth report
 4th Report BP tables generated from BP values in
~70,000 healthy children where many of the children
had overweight or obesity
 New normative BP tables commissioned for this
clinical practice guideline, based only on BP readings
from ~50,000 normal-weight children
New normative blood pressure table
New blood pressure table
New blood pressure table
New blood pressure table
 Simplified BP table created
for use in initial screening
of BP values
 Based on 90th percentile
BP values for children at
5th height percentile
Simplified Blood Pressure Table
 NHBPEP guidelines recommended routine
measurement of BP in children and adolescents for
screening purposes at every healthcare encounter.
 The 2017 AAP CPG recommends that routine BP
screening be performed only at annual preventive
care visits unless any predisposing condition such as
obesity, diabetes mellitus, heart disease, or kidney
disease.
Routine BP Screening
 Confirmation of the diagnosis of
hypertension
suspected white-coat
hypertension;
 Evaluation for masked hypertension
with a history of repaired
coarctation of the aorta;
 Evaluation of BP pattern and risk for
hypertensive TOD in high-risk
conditions, such as CKD;
Ambulatory BP monitoring (ABPM)
 Evaluation for possible hypertension in
obstructive sleep apnea syndrome.
 Evaluation of BP in pediatric heart and
kidney transplant recipients;
 Assessment & monitoring of
treatment efficacy.
Ambulatory BP monitoring (ABPM)
 2004 Fourth Report recommended that
echocardiograms be obtained in all hypertensive
children and adolescents at the time of diagnosis of
hypertension.
 But 2017 CPG recommended that echocardiograms
be obtained to assess for cardiac TOD at the time
initiation of pharmacological treatment.
Echocardiography
 Additional time points for consideration of
echocardiography include
 monitoring of known TOD and
 when concentric LVH or reduced LV ejection
fraction is present on the initial
echocardiogram.
Echocardiography
Indications for antihypertensive medications is found
in the 2017 AAP CPG
I. Persistent hypertension despite lifestyle
modification, especially with an abnormal
echocardiogram; Symptomatic hypertension;
II. Stage 2 hypertension without a modifiable risk
factor; or
III. Any stage of hypertension in patients with
diabetes mellitus or CKD.
Antihypertensive medication
 The replacement of the term “prehypertension” with the
term “elevated blood pressure,”
 New normative pediatric blood pressure (BP) tables
 A simplified screening table for identifying BPs.
 A simplified BP classification in adolescents ≥13 years.
 Limited recommendation for screening BP.
 Expanded role for ambulatory BP monitoring.
 Revised recommendations for echocardiography.
Significant changes in these guidelines
 The 2017 AAP CPG is a comprehensive document that
addresses numerous aspects of the evaluation and
management of high BP in children and adolescents.
 It is the first pediatric hypertension guideline to be
developed from a strict evidence-based approach and
 First to be aligned as much as possible with a new
hypertension guideline for adults.
 However, further studies are required to confirm the
impact of new guidelines on the prevalence of
hypertension in children.
Conclusion
THANK YOU

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Understanding Key Changes in the 2017 AAP Childhood Hypertension Guideline

  • 1. WELCOME TO JOURNAL CLUB PRESENTATION Maj Jahangir Alam Classified Specialist in Paediatrics CMH Dhaka
  • 2. REVIEW ON NEW CLINICAL PRACTICE GUIDELINE FOR THE MANAGEMENT OF HIGH BLOOD PRESSURE IN CHILDREN AND ADOLESCENTS Authors : Joseph T. Flynn, Bonita E. Falkner Oct 2017 Volume : 70 P : 683-86
  • 3. Introduction  Before 1977, there was no consistent definition of hypertension in childhood.  Childhood hypertension had been considered rare and, if detected, the assumption was that it would be secondary to an underlying disorder.
  • 4.  In the mid-1970s, National Heart Lung and Blood Institute (NHLBI) convened a task force to examine available BP data on healthy children.  The recommendations of this task force on detection, evaluation, and management of hypertension in children and adolescents were published in 1977 (1st report). Introduction cont…
  • 5.  Major updates were published in 1987(2nd), 1996(3rd), and 2004(4th).  Interest in childhood hypertension (HTN) has increased since the 2004 publication (forth report). Introduction cont…
  • 6.
  • 7.  Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents are an update to the 2004 “Fourth Report".  It is known as "2017 AAP CPG“ Introduction cont….
  • 8. Understand the changes in the new AAP childhood hypertension guideline and how these changes will affect the management of hypertension. objectives
  • 9. Definition of Hypertension in children & Adolescents Categories For children aged 1-13 yr For children aged > 13 yr Normal BP < 90th percentile <120/<80 mm Hg Elevated BP > 90th percentile to < 95th percentile 0r 120/80 mm Hg to < 95th percentile (whichever is lower) 120/<80 to 129/<80 mm Hg Stage 1 HTN > 95th percentile to < 95th percentile +12 mm Hg or 130/80 to 139/89 mm Hg ( Whichever is lower) 130/80 to 139/89 mm Hg Stage 2 HTN > 95th percentile + 12 mm Hg or >140/90 mm Hg (whichever is lower) > 140/90 mm Hg
  • 10.  BP >90th percentile is now termed ‘elevated BP’  BP cut-points for Stage 1 and 2 HTN simplified  BP cut-points for adolescents ≥13 years of age are the same as in new AHA/ACC adult HTN guideline changes in CPG 2017 compared to forth report
  • 11.  4th Report BP tables generated from BP values in ~70,000 healthy children where many of the children had overweight or obesity  New normative BP tables commissioned for this clinical practice guideline, based only on BP readings from ~50,000 normal-weight children New normative blood pressure table
  • 15.  Simplified BP table created for use in initial screening of BP values  Based on 90th percentile BP values for children at 5th height percentile Simplified Blood Pressure Table
  • 16.  NHBPEP guidelines recommended routine measurement of BP in children and adolescents for screening purposes at every healthcare encounter.  The 2017 AAP CPG recommends that routine BP screening be performed only at annual preventive care visits unless any predisposing condition such as obesity, diabetes mellitus, heart disease, or kidney disease. Routine BP Screening
  • 17.  Confirmation of the diagnosis of hypertension suspected white-coat hypertension;  Evaluation for masked hypertension with a history of repaired coarctation of the aorta;  Evaluation of BP pattern and risk for hypertensive TOD in high-risk conditions, such as CKD; Ambulatory BP monitoring (ABPM)
  • 18.  Evaluation for possible hypertension in obstructive sleep apnea syndrome.  Evaluation of BP in pediatric heart and kidney transplant recipients;  Assessment & monitoring of treatment efficacy. Ambulatory BP monitoring (ABPM)
  • 19.  2004 Fourth Report recommended that echocardiograms be obtained in all hypertensive children and adolescents at the time of diagnosis of hypertension.  But 2017 CPG recommended that echocardiograms be obtained to assess for cardiac TOD at the time initiation of pharmacological treatment. Echocardiography
  • 20.  Additional time points for consideration of echocardiography include  monitoring of known TOD and  when concentric LVH or reduced LV ejection fraction is present on the initial echocardiogram. Echocardiography
  • 21. Indications for antihypertensive medications is found in the 2017 AAP CPG I. Persistent hypertension despite lifestyle modification, especially with an abnormal echocardiogram; Symptomatic hypertension; II. Stage 2 hypertension without a modifiable risk factor; or III. Any stage of hypertension in patients with diabetes mellitus or CKD. Antihypertensive medication
  • 22.  The replacement of the term “prehypertension” with the term “elevated blood pressure,”  New normative pediatric blood pressure (BP) tables  A simplified screening table for identifying BPs.  A simplified BP classification in adolescents ≥13 years.  Limited recommendation for screening BP.  Expanded role for ambulatory BP monitoring.  Revised recommendations for echocardiography. Significant changes in these guidelines
  • 23.  The 2017 AAP CPG is a comprehensive document that addresses numerous aspects of the evaluation and management of high BP in children and adolescents.  It is the first pediatric hypertension guideline to be developed from a strict evidence-based approach and  First to be aligned as much as possible with a new hypertension guideline for adults.  However, further studies are required to confirm the impact of new guidelines on the prevalence of hypertension in children. Conclusion

Editor's Notes

  1. An important update in the 2017 AAP CPG is a change in the definition of hypertension in children and adolescents.
  2. In new BP table ht of the patient is clearly defined whereas in previous one height was reflected in centile chart. So in 4th report we need CDC growth chart for plotting height first.
  3. in previous chart after 95 th centile there was 99 th centile but in new chart it is 95th + 12 mm. so it is easy to classify stage 1 & stage 2 hypetension.
  4. Ambulatory BP monitoring (ABPM) is recommended in several places within the 2017 AAP CPG