2. Introduction
➢ The ‘Pharmacy and Therapeutic Committee’ (PTC) is a group of persons which
formulate policies regarding therapeutic use of drug.
➢ One of the methods or mode of ensuring the proper rationality in the use of
drugs is that the hospital organize and constitute,
“The Pharmacy and Therapeutic Committee”
Agra Public Pharmacy College, Agra 2
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3. Agra Public Pharmacy College, Agra 3
Advisory
Use of drugs in hospital
Educational
Professional staff training
programme
Drug safety and adverse
drug monitoring
Objective of the PTC
4. Agra Public Pharmacy College, Agra 4
Composition of Medical Staff in PTC
Chairman
Representative
of Nursing Staff
PHARMACIST
3- Physicians
7. Agra Public Pharmacy College, Agra 7
Functions of PTC:
1. This committee should meet regularly at least six times in the year and also as and when
necessary.
2. Advising medical, administrative, and pharmacy departments on drug related issues.
3. Developing drug policies and procedures.
4. Evaluating and selecting drugs for the formulary and providing for its periodic revision.
5. Managing adverse drug reactions.
6. Managing medication error.
8. Agra Public Pharmacy College, Agra 8
7. Criteria for inclusion of medicines on the formulary list (essential medicines list (EML))
8. Standard treatment guidelines and treatment algorithms, which should be the basis of
formulary selection
9. Generic substitution and therapeutic interchange
10. Information regarding new drugs which may have become commercially available.
11. Review of side effects, adverse drug reactions, toxic effects, drug interactions of drugs
12. Reports of various sub-committees.
9. PTC Role in Drug Safety:
➢ Drug safety is the moral, legal and professional obligation of pharmacist.
➢ There is a need to create safety awareness in all hospital departments.
➢ Following guidelines may sub serve the committee in ascertaining the adequate
safety factor of hospital pharmacy:
✓ The pharmacist should be aware of narcotic & psychotropic substances.
✓ The hospital must employ a qualified, at least, a registered pharmacist with at least B. Pharma
degree as ‘Chief Pharmacist’.
✓ Should not permit non-pharmacist personnel to dispense drugs and allied materials.
✓ Must provide adequate safe, work space, and storage facilities.
✓ Should have a drug formulary which periodically revised and kept up to date.
✓ The poisonous materials are separated from nonpoisonous materials in the pharmacy.
✓ Not permit non-pharmacist personnel.
Agra Public Pharmacy College, Agra 9
10. PTC Role in ADR’S:
➢ There is a proportionate increase in the drug reactions. In order to gain an
understanding of these problems and to formulate competent opinions,
prevention and treatment, the PTC must assume the responsibility for the
developing and instituting a procedure for the purpose of committee.
Agra Public Pharmacy College, Agra 10
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Monitoring on ADR-
▪Do not leave any item blank
▪Mark tick in the appropriate
box
▪Type or write in BLOCK
LETTERS
11. Agra Public Pharmacy College, Agra 11
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12. ➢ Every case of adverse drug reaction must be first reported by the attending
physician to the chairman of the PTC or clinical pharmacologist.
➢ The attending physician should complete the ‘Adverse Drug Reaction Report
form’ as illustrated above, on any patient having adverse reaction.
➢ The same is then ultimately recorded in the medical records.
➢ The PTC interacts with the various government bodies like- DTAB (Drugs
Technical Advisory Board), DCGI, AIIMS, PGI, Chandigarh for consultation.
➢ The medical record room will, upon the patients discharge, remove this report
from the medical record and forward it to the chairman, who in turn periodically
forward essential data to the central committee on Adverse Reactions formed by
the State Government or the drug control authorities of the state, Government
and the Drugs Controller or consultations with the bodies of experts such as
DTAB.
Agra Public Pharmacy College, Agra 12
13. Role of PTC in Emergency Drug List :
➢ Emergency drugs always ready for severe condition in hospital department
admitted patients.
➢ It is absolutely necessary for the PTC of a hospital to get prepared boxes
containing emergency drugs which should be always available readily for use at
the bed-side.
➢ List of such drugs and other supplies should be complied by the committee, and
it should find their place in emergency kits.
➢ The emergency boxes always contains different emergency drugs like- digoxin,
amphetamine, atropine, WOI, amylnitrite etc.
Agra Public Pharmacy College, Agra 13
14. Agra Public Pharmacy College, Agra 14
Tools in
Emergency
Box
Airway
equipment&
Ryles tube
Syringes of
various
range
Files for
breaking the
ampoule
15. Automatic Stop Order for Dangerous Drugs:
✓ All Drug Orders for narcotics, sedatives, hypnotic anticoagulants, and
antibiotics shall be automatically discontinued after 48 hours unless the order
indicates an exact number of doses to be administered, or the attending
physician, re-orders the medication.
✓ All orders for narcotics, sedative and hypnotics must be rewritten every 24
hours.
✓ In India, at present, this kind of system of issuing “ASODD” is not practiced
except for hospitals like Christian Medical Hospital Vellore or Jaslok Hospital,
Mumbai Escort group, Mayo Hospital etc.
Agra Public Pharmacy College, Agra 15
