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Needle-Free Drug Delivery: The Market for Alternatives to Needle-
Based Systems for Vaccine and Biologics

July 1, 2011




The line between drug delivery and drug substance will continue to become more
elusive in the near future as shown in the analysis, as researchers work to improve drug
properties through drug design and molecular modeling. Consequently, in the next
decade, drug delivery technologies will be a focal point of competition within the
pharmaceutical industry.

This Kalorama Information report, Needle-Free Drug Delivery: The Market for
Alternatives to Needle-Based Systems for Vaccine and Biologics takes a look at this
aspect of the pharmaceutical marketplace with figures and forecasts for pharmaceutical
companies and the companies that supply technology to them. The success of specific
drugs will be tied to innovative delivery techniques, which will enable the targeting that
will exploit the clinical properties of a new generation of drugs.

The needle-free drug delivery market is growing rapidly. The development of better
delivery systems in conjunction with the discovery of novel pharmacological compounds
will lead to significant improvements in drug delivery. This report looks at that trend and
reports current and forecasted revenues for the injectable drug delivery market,
segmented into two main categories:

               Needle-Free Products Market (Including Drug and Technology)
               Needle-Free Products Market (Technology Only)

This breakout makes the report relevant to business plans of either device technology
companies or pharmaceutical concerns. The report also includes information that will be
of assistance to business planners:

               Trends in the Vaccine Market
               Market Size and Forecast for Needle-Free Vaccine Technology
               Trends in Biopharmaceuticals
               Leading Pharmaceutical Product Sold With Needle-Free Technologies
               Products in Development
               Detailed Profiles of Key Companies in Needle-Free Technologies.
Current Market Size and Forecasts to 2013
      Needle-Free Cost Savings, Autojets, Health Care Reform, and Other Trends
      and Developments

Companies Profiled in the report include:

      Alkermes, Inc.
      ALZA Corp.
      Antares Pharma, Inc.
      Bioject Medical Technologies, Inc.
      CyDex, Inc.
      MGI Pharma, Inc
      Nektar Therapeutics
      Pacira Pharmaceuticals, Inc.
      pSivida
      SurModics, Inc
      Zogenix Corporation
      AP Pharma
      Baxter BioPharma Solutions
      QLT USA, Inc
      Ypsomed Holding AG

The research conducted by Kalorama included comprehensive research of secondary
sources such as company literature, databases, investment reports, and medical and
business journals. New technologies, market developments, and research and
development trends and expenditures were identified through patent and database
searches, as well as via interviews with key personnel. Person-to-person, email and
telephone interviews were the primary method of gathering information.


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Table of Contents

CHAPTER ONE: EXECUTIVE SUMMARY

       Market Drivers
             Demographics
             Pediatrics
       Market Size and Growth
             Total Needle-free Drug Delivery Market
             The Needle-free Drug Delivery Only Market
       Competitor and Market Analysis
       Biotech Markets

CHAPTER TWO: INTRODUCTION

       Scope and Methodology
       Drug Delivery Systems
       Phases of Drug Action
              Pharamcokinetics
       Needle-Free Drug Delivery
              Auto-injectors
              Pen Injectors
              Major Applications
              Self-Administration
              Vaccine Delivery
       Safety Concerns
       Local Reactions
       Needle-Free Products
       Review of Major Products on the Market
              Biojector 2000
Vitajet<
          Injex Drug Delivery System
          PowderMed
          Intraject
          Glide
          MediJector
          MiniJect
          Crossject
          PenJet
          Fentanyl ITS
          PLEASE

CHAPTER THREE: TRENDS AND DEVELOPMENTS

    Pen Injectors
           Auto-injectors
           Pen-Prep
           King
           KwikPen
           ImplanJect
           Bioject ID
    Novel Vaccine Delivery Development
           Edible Vaccines
           Mucosal Delivery
           Intranasal Delivery
           Vaccine Patches
           Vaccine Chips
    Delivery Systems Placement Trends
    Nanotechnology
    Drug Delivery Development
    MicroChip Technology
    DNA Vaccines
    Needle-Free Delivery Development
    Medical House/Dr. Reddy’s
    Flugen
    Inviragen
    Other
    Selected Products in Development

CHAPTER FOUR MARKET SIZE AND GROWTH

    Competitive Landscape
    Market Size and Forecast
    Cost Considerations
    Drivers of the Needle-free Drug Delivery Market
    Biologics
Cancer
    Market
           Forecast
           Growth Expectation
    Drug Delivery Development
    MicroChip Technology
    DNA Vaccines
    Needle-Free Delivery Development
    Medical House/Dr. Reddy’s
    Flugen
    Inviragen
    Other
    Selected Products in Development
    Drug Delivery Technology Only Market
    Needle Free Vaccine Delivery Market
           Childhood Immunization in the United States
           Childhood Immunization Rates
           Challenges to the Vaccine Delivery System
           US Healthcare Reform
           Market for Pediatric Vaccines
           Market for Needle-Free Vaccine Delivery Systems

CHAPTER FIVE CONCLUSIONS

    Conclusion 1:
    Conclusion 2:
    Conclusion 3:
    Conclusion 4:
    Conclusion 5:

CHAPTER SiX COMPANY PROFILES

    ALZA Corp.
    DUROS
    ALZAMER
    Antares Pharma, Inc.
    Medi-Jector VISION
    Medi-Jector MJ8
    Vibex
    Aridis Pharmaceuticals, Inc
    Becton Dickinson and Company
    Accuspray
    Revenues
    Bioject Medical Technologies, Inc.
    Jupiter Jet
    Glide Pharma
ImplaJect
     Intercell AG
     MedImmune, Inc
     Mystic Pharmaceuticals, Inc
     Optinose, Inc
     Pharmajet, Inc
     PowderMed, Inc/Pfizer
     PowderMed
     Ypsomed Holding AG
     ServoPen
     Zogenix Corporation
     Zosano Pharma

APPENDIX: COMPANY DIRECTORY
                         LIST OF EXHIBITS
CHAPTER ONE: EXECUTIVE SUMMARY

     Figure 1-1: Worldwide Market for Needle-Free Delivery

CHAPTER TWO: INTRODUCTION

     Table 2-1: Sequence of Drug Action

CHAPTER THREE: TRENDS AND DEVELOPMENTS

     Table 3-1: Select Products in Development by Drug Delivery Companies

CHAPTER FOUR: MARKET SIZE AND GROWTH

     Table 4-1: Needle-Free Drug Delivery Technology Participants
     Figure 4-1: Cost per Million Injections by Injector Type
     Table 4-2: Worldwide Market for Needle-Free Drug Delivery Technology and
     Pharmaceuticals 2009-2016
     Figure 4-2: Needle-Free Drug Delivery Technology and Pharmaceuticals 2009-
     2016
     Figure 4-3: The Worldwide Market for Needle-Free Delivery Systems,
     Technology Only Revenues, 2009 to 2016
     Table 4-3: The Worldwide Market for Needle-Free Drug Delivery Systems by
     Pharmaceutical and Drug Delivery Component 2009-2016
     Figure 4-4: The Worldwide Market for Needle-Free Drug Delivery Systems
     Distribution of Revenue by Pharmaceutical and Drug Delivery Component 2011
     Table 4-4: Global Immunization Rates by Vaccine Type 2008
     Table 4-5: Immunization Profile of the United States: Population by Age Group,
     Number of Vaccine-Preventable Diseases Reported by Disease 2002-2008
     Figure 4-6: Pediatric Vaccine Market, 2005-2014
     Figure 4-7: Needle Free Vaccine Delivery Systems Market, 2009-2016
Available immediately for Online Download at

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Needle-Free Drug Delivery: The Market for Alternatives to Needle-Based Systems for Vaccine and Biologics

  • 1. Get more info on this report! Needle-Free Drug Delivery: The Market for Alternatives to Needle- Based Systems for Vaccine and Biologics July 1, 2011 The line between drug delivery and drug substance will continue to become more elusive in the near future as shown in the analysis, as researchers work to improve drug properties through drug design and molecular modeling. Consequently, in the next decade, drug delivery technologies will be a focal point of competition within the pharmaceutical industry. This Kalorama Information report, Needle-Free Drug Delivery: The Market for Alternatives to Needle-Based Systems for Vaccine and Biologics takes a look at this aspect of the pharmaceutical marketplace with figures and forecasts for pharmaceutical companies and the companies that supply technology to them. The success of specific drugs will be tied to innovative delivery techniques, which will enable the targeting that will exploit the clinical properties of a new generation of drugs. The needle-free drug delivery market is growing rapidly. The development of better delivery systems in conjunction with the discovery of novel pharmacological compounds will lead to significant improvements in drug delivery. This report looks at that trend and reports current and forecasted revenues for the injectable drug delivery market, segmented into two main categories: Needle-Free Products Market (Including Drug and Technology) Needle-Free Products Market (Technology Only) This breakout makes the report relevant to business plans of either device technology companies or pharmaceutical concerns. The report also includes information that will be of assistance to business planners: Trends in the Vaccine Market Market Size and Forecast for Needle-Free Vaccine Technology Trends in Biopharmaceuticals Leading Pharmaceutical Product Sold With Needle-Free Technologies Products in Development Detailed Profiles of Key Companies in Needle-Free Technologies.
  • 2. Current Market Size and Forecasts to 2013 Needle-Free Cost Savings, Autojets, Health Care Reform, and Other Trends and Developments Companies Profiled in the report include: Alkermes, Inc. ALZA Corp. Antares Pharma, Inc. Bioject Medical Technologies, Inc. CyDex, Inc. MGI Pharma, Inc Nektar Therapeutics Pacira Pharmaceuticals, Inc. pSivida SurModics, Inc Zogenix Corporation AP Pharma Baxter BioPharma Solutions QLT USA, Inc Ypsomed Holding AG The research conducted by Kalorama included comprehensive research of secondary sources such as company literature, databases, investment reports, and medical and business journals. New technologies, market developments, and research and development trends and expenditures were identified through patent and database searches, as well as via interviews with key personnel. Person-to-person, email and telephone interviews were the primary method of gathering information. More Biopharmaceuticals Reports by Kalorama Information What's Next in Biologics? (mAbs, rDNA, Interferons, and Other Biologics) 2011-2015 by Kalorama Information The future of the pharmaceutical market will be determined by biologics - drugs produced by natural organisms or recombinant techniques consisting of proteins and other ... World Pharmaceutical and Biopharmaceutical Market, 2010-2015 (Pipeline Analysis of the Top 50 Companies) by Kalorama Information What Will The Pharmaceutical Market Look Like in the Next Five Years? In this report, Kalorama has analyzed the late stage R&D pipeline of ... Drug Delivery Markets: Implantable / Injectable and Needle-Free Delivery Systems by Kalorama Information With pharmaceutical companies increasingly looking for ways to extend the revenue-
  • 3. earning lifetime of their biggest products, drug delivery has become an important focus of the ... The World Market for Biosimilars and the Potential for US Follow-on Biologics by Kalorama Information Biosimilars, or generic biologic drugs, are marketed around the world but still restricted in the U.S. This may soon change, and Kalorama Information has ... The World Market for Cancer Therapeutics and Biotherapeutics, 3rd. Edition by Kalorama Information Worldwide cancer affects more than 10 million people each year. This number is expected to increase by 2.4% by 2020 to 14 million each ... Table of Contents CHAPTER ONE: EXECUTIVE SUMMARY Market Drivers Demographics Pediatrics Market Size and Growth Total Needle-free Drug Delivery Market The Needle-free Drug Delivery Only Market Competitor and Market Analysis Biotech Markets CHAPTER TWO: INTRODUCTION Scope and Methodology Drug Delivery Systems Phases of Drug Action Pharamcokinetics Needle-Free Drug Delivery Auto-injectors Pen Injectors Major Applications Self-Administration Vaccine Delivery Safety Concerns Local Reactions Needle-Free Products Review of Major Products on the Market Biojector 2000
  • 4. Vitajet< Injex Drug Delivery System PowderMed Intraject Glide MediJector MiniJect Crossject PenJet Fentanyl ITS PLEASE CHAPTER THREE: TRENDS AND DEVELOPMENTS Pen Injectors Auto-injectors Pen-Prep King KwikPen ImplanJect Bioject ID Novel Vaccine Delivery Development Edible Vaccines Mucosal Delivery Intranasal Delivery Vaccine Patches Vaccine Chips Delivery Systems Placement Trends Nanotechnology Drug Delivery Development MicroChip Technology DNA Vaccines Needle-Free Delivery Development Medical House/Dr. Reddy’s Flugen Inviragen Other Selected Products in Development CHAPTER FOUR MARKET SIZE AND GROWTH Competitive Landscape Market Size and Forecast Cost Considerations Drivers of the Needle-free Drug Delivery Market Biologics
  • 5. Cancer Market Forecast Growth Expectation Drug Delivery Development MicroChip Technology DNA Vaccines Needle-Free Delivery Development Medical House/Dr. Reddy’s Flugen Inviragen Other Selected Products in Development Drug Delivery Technology Only Market Needle Free Vaccine Delivery Market Childhood Immunization in the United States Childhood Immunization Rates Challenges to the Vaccine Delivery System US Healthcare Reform Market for Pediatric Vaccines Market for Needle-Free Vaccine Delivery Systems CHAPTER FIVE CONCLUSIONS Conclusion 1: Conclusion 2: Conclusion 3: Conclusion 4: Conclusion 5: CHAPTER SiX COMPANY PROFILES ALZA Corp. DUROS ALZAMER Antares Pharma, Inc. Medi-Jector VISION Medi-Jector MJ8 Vibex Aridis Pharmaceuticals, Inc Becton Dickinson and Company Accuspray Revenues Bioject Medical Technologies, Inc. Jupiter Jet Glide Pharma
  • 6. ImplaJect Intercell AG MedImmune, Inc Mystic Pharmaceuticals, Inc Optinose, Inc Pharmajet, Inc PowderMed, Inc/Pfizer PowderMed Ypsomed Holding AG ServoPen Zogenix Corporation Zosano Pharma APPENDIX: COMPANY DIRECTORY LIST OF EXHIBITS CHAPTER ONE: EXECUTIVE SUMMARY Figure 1-1: Worldwide Market for Needle-Free Delivery CHAPTER TWO: INTRODUCTION Table 2-1: Sequence of Drug Action CHAPTER THREE: TRENDS AND DEVELOPMENTS Table 3-1: Select Products in Development by Drug Delivery Companies CHAPTER FOUR: MARKET SIZE AND GROWTH Table 4-1: Needle-Free Drug Delivery Technology Participants Figure 4-1: Cost per Million Injections by Injector Type Table 4-2: Worldwide Market for Needle-Free Drug Delivery Technology and Pharmaceuticals 2009-2016 Figure 4-2: Needle-Free Drug Delivery Technology and Pharmaceuticals 2009- 2016 Figure 4-3: The Worldwide Market for Needle-Free Delivery Systems, Technology Only Revenues, 2009 to 2016 Table 4-3: The Worldwide Market for Needle-Free Drug Delivery Systems by Pharmaceutical and Drug Delivery Component 2009-2016 Figure 4-4: The Worldwide Market for Needle-Free Drug Delivery Systems Distribution of Revenue by Pharmaceutical and Drug Delivery Component 2011 Table 4-4: Global Immunization Rates by Vaccine Type 2008 Table 4-5: Immunization Profile of the United States: Population by Age Group, Number of Vaccine-Preventable Diseases Reported by Disease 2002-2008 Figure 4-6: Pediatric Vaccine Market, 2005-2014 Figure 4-7: Needle Free Vaccine Delivery Systems Market, 2009-2016
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