1. Next Generation Sequencing Trends
(Clinical Applications, Systems Used, Accreditation Status,
Regulated Patient Sample Handling and Other Trends)
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4. Next Generation Sequencing Trends
(Clinical Applications, Systems Used, Accreditation Status, Regulated Patient
Sample Handling and Other Trends)
Next-generation sequencing is discussed frequently as a key to clinical diagnostics in the future. This
report looks at the status of NGS today, and seeks to provide insights on the “on-the-ground” status of
clinical sequencing. In the course of doing this, the report seeks to answer the following questions: What
is the status of clinical applications for Next Gen in laboratories currently? What vendors are winning?
What systems are seeing usage and for what applications? How are labs responding to business
pressures and regulatory challenges? What disease areas are seeing the most applications? What are
labs future purchasing plans and how are clinical applications driving these decisions?
This study, Next Generation Sequencing Trends focuses on an email and telephone consultation of 110
laboratories which was carried out from April to June of 2013, with the majority in the latter portion. The
survey effort targeted labs likely to be doing, or likely to be planning, applications of sequencing in either
diagnostic or clinical research settings. Due to the increasing importance of 2nd and 3rd-generation
systems in the market, the scope leans towards these types of sequencers. There are only 13
laboratories that have exclusively capillary systems, but these systems are still widely used. About 30% of
the systems in the respondents’ labs overall are capillary systems. The mix of labs reached in the surveys
provides both a range of industry segments as well as groups of labs with both types of systems.

5. Next Generation Sequencing Trends TOC Highlights
o Industrial Distribution of Respondents
o Numbers of 2nd and 3rd Generation Systems
o Distribution of Sequencer Models
o Number of Systems Owned Per Lab
o Growth in Sequencing, NGS vs Capillary Systems
o Verbatim Comments: Approaching Clinical Applications
o Disease/ Therapeutic Areas Where Sequencing Applied
o Changes or Improvements, NextGeneration Systems
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