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Hematology Rivas2008 Lecture1

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Miami Dade
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Hematology - Oncology Introduction to Hematology Antonio Rivas PA-C January 2009
Objectives ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hematology : • From the Greek, haima-blood and logos discourse Hematology is the study of the blood and its main constituents: plasma and cells • Blood accounts for 7-8% of total body weight in an average 70kg adult • Total volume of blood is about 5-6L • The plasma is the fluid portion of the blood: 90% water and 10% proteins: Albumin,Globulins, and Fibrinogen • The formed elements are: the red blood cells, the white blood cells and the platelets.
Blood components
Hematology-Albumin ,[object Object],[object Object],[object Object]
Hematology - Globulins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hematology - Fibrinogen ,[object Object],[object Object]
Functions of the blood ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hematopoiesis: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hematopoiesis ,[object Object],[object Object],[object Object],[object Object]
Ontogeny: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pluripotent Stem cells ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Regulation of Hematopoiesis ,[object Object],[object Object],[object Object]
Cytokines and their activities. ,[object Object],[object Object],[object Object],[object Object]
Hematopoietic Differentiation Pathway
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Myeloid lineage-Erythrocytes ,[object Object],[object Object],[object Object],[object Object],[object Object]
Erythrocytes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Erythropoiesis ,[object Object],[object Object],[object Object]
Erythrocyte maturation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Erythrocyte maturation
Hemoglobin ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hemoglobin Molecule
Hemoglobin ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hemoglobin-Iron cycle ,[object Object],[object Object],[object Object],[object Object],[object Object]
Iron cycle ,[object Object],[object Object],[object Object],[object Object]
Erythrocyte destruction ,[object Object],[object Object],[object Object],[object Object]
Leukocytes - WBCs ,[object Object],[object Object],[object Object]
Granulocytes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Granulocytes origin and maturation ,[object Object],[object Object],[object Object]
Granulocytes maturation
Neutrophils ,[object Object],[object Object],[object Object],[object Object],[object Object]
Neutrophils ,[object Object],[object Object],[object Object],[object Object]
Neutrophils ,[object Object],[object Object]
Neutrophils ,[object Object],[object Object]
Neutrophils ,[object Object],[object Object],[object Object]
Neutropenia <1800/mm 3 or <1.8 × 10 9 /L ,[object Object],[object Object]
Eosinophils ,[object Object],[object Object],[object Object],[object Object],[object Object]
Eosinophils ,[object Object],[object Object]
Eosinophils ,[object Object],[object Object],[object Object],[object Object]
Eosinophilia (increased circulating eosinophils) > 5% or > 500 cells/mm 3 or > 0.5 × 10 9 /L ,[object Object],[object Object],[object Object],[object Object]
Basophils ,[object Object],[object Object],[object Object],[object Object],[object Object]
Monocytes/Macrophages ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Monocytes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Thrombocytes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Lymphocytes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Lymphocytes ,[object Object],[object Object],[object Object],[object Object]
B-Lymphocytes ,[object Object],[object Object],[object Object]
T-Lymphocytes ,[object Object],[object Object],[object Object],[object Object]
T-Lymphocytes ,[object Object],[object Object],[object Object],[object Object]
T- Helper / Suppressor ,[object Object],[object Object],[object Object],[object Object],[object Object]
Laboratory tests ,[object Object],[object Object],[object Object]
Complete Blood Count ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
WBC count ,[object Object],[object Object],[object Object],[object Object]
Leukocytosis ,[object Object],[object Object],[object Object],[object Object]
Leukocytosis ,[object Object],[object Object]
Other causes of leukocytosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Other causes of leukocytosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Leukocytosis and no evidence of clinical disease ,[object Object],[object Object],[object Object]
Steroid therapy modifies the leukocyte response ,[object Object],[object Object]
Leukopenia: WBC < 4000/mm 3 or < 4.0 × 10 3 /mm 3 or < 4.0 cells × 10 9 /L ,[object Object],[object Object],[object Object]
Leukopenia ,[object Object],[object Object],[object Object],[object Object]
Differential White Blood Cell Count (Diff; Differential Leukocyte Count) ,[object Object],[object Object]
Differential White Blood Cell Count (Diff; Differential Leukocyte Count) ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Differential White Blood Cell Count (Diff; Differential Leukocyte Count) ,[object Object],[object Object]
Differential White Blood Cell Count (Diff; Differential Leukocyte Count) ,[object Object],[object Object],[object Object]
Total RBC count ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Total RBC count ,[object Object],[object Object],[object Object]
Hemoglobin ,[object Object],[object Object],[object Object]
Hematocrit ,[object Object],[object Object],[object Object],[object Object]
Platelet count ,[object Object],[object Object],[object Object]
Red blood cell indices ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
RBCs indices ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
RBCs indices ,[object Object],[object Object],[object Object]
RBCS morphology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
RBCs morphology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
RBC morphology ,[object Object],[object Object],[object Object]
 
 
 
Poikilocytosis
Schistocyte
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Eosinophil
Small Lymphocyte
Basophil
Neutrophil
Monocyte
Target cells
Sickle cells
Macrocytes
Microcytes and Spherocytes
Plasma cells
Band Neutrophil
Nl small Lymphocyte
Hypersegmented Neutrophils
Atypical Monocytes
Monocytes
Tear drop cells
Giant Platetlets
Ovalocytes / Elliptocytes
Platetlets Nl

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