This document contains revision questions about cell division, including mitosis and cytokinesis. It begins by defining key terms like mitosis, interphase, and the phases of the cell cycle. It then provides questions to test understanding of topics like DNA supercoiling during mitosis, the stages of mitosis, and calculating mitotic indices from micrographs. Later questions address the differences between animal and plant cytokinesis and the role of cyclins in cell cycle control. It concludes by defining cancer-related topics and analyzing a graph showing the correlation between cigarette smoking and lung cancer deaths.
1. Revision questions 1.6. Cell division
Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:miltiadis@stepsinbiology.com;
http://www.stepsinbiology.com
Understandings, Applications and Skills
Understandings:
• Mitosis is division of the nucleus into two genetically identical daughter
nuclei.
• Chromosomes condense by supercoiling during mitosis.
• Cytokinesis occurs after mitosis and is different in plant and animal cells.
• Interphase is a very active phase of the cell cycle with many processes
occurring in the nucleus and cytoplasm.
• Cyclins are involved in the control of the cell cycle.
• Mutagens, oncogenes and metastasis are involved in the development of
primary and secondary tumours.
Applications and skills:
• Application: The correlation between smoking and incidence of cancers.
• Skill: Identification of phases of mitosis in cells viewed with a microscope or
in a micrograph.
• Skill: Determination of a mitotic index from a micrograph.
2. Revision questions 1.6. Cell division
Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:miltiadis@stepsinbiology.com;
http://www.stepsinbiology.com
1. Define mitosis
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2. Outline the purpose of mitosis in eukaryotes.
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3. Distinguish between cell division in prokaryotes and mitosis in eukaryotes.
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4. Define: (a) interphase; (b) Growth phase 1 (G1); (c) Synthesis phase (S) and,
(d) Growth phase 2 (G2)
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Growth phase 1………………………………………………………………...
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Synthesis ………………………………………………………………..............
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Growth phase 2 ………………………………………………………………..
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3. Revision questions 1.6. Cell division
Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:miltiadis@stepsinbiology.com;
http://www.stepsinbiology.com
5. Outline the main events happening during interphase.
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6. Label and annotate the following structures
7. Outline how DNA supercoils into chromosomes and explain why this
supercoiling is essential during mitosis.
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A
B C D
4. Revision questions 1.6. Cell division
Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:miltiadis@stepsinbiology.com;
http://www.stepsinbiology.com
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8.Draw and label a pie chart to show the relative amount of time spent in each
phase of the cell cycle, including the stages of interphase and mitosis, as well
as cytokinesis.
9. Sketch and outline the stages of mitosis of an animal cell with a chromosome
number of four.
Stage / Sketch Outline
Prophase (early)
6. Revision questions 1.6. Cell division
Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:miltiadis@stepsinbiology.com;
http://www.stepsinbiology.com
10. In the micrograph given below we may see meristem cells in onion roots
undergoing mitosis. Indicate at least one cell in prophase, metaphase,
anaphase and telophase.
http://upload.wikimedia.org/wikipedia/commons/e/e3/Mitosis_%28261_13%29_Pressed%3B_root_meristem_of_
onion_%28cells_in_prophase,_metaphase,_anaphase,_telophase%29.jpg
7. Revision questions 1.6. Cell division
Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:miltiadis@stepsinbiology.com;
http://www.stepsinbiology.com
11. Calculate the mitotic index using the data given below
Interphase Prophase Metaphase Anaphase Telophase Total
Number
of cells
50 2 2 2 2
12. Calculate the mitotic index for the following micrograph.
http://www.mondadorieducation.it/media/contenuti/sfoglialibro/120900037338_cavagna_laboratoriobiologia/files/assets/s
eo/page11_images/0001.jpg
9. Revision questions 1.6. Cell division
Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:miltiadis@stepsinbiology.com;
http://www.stepsinbiology.com
16. The following diagrams outline the steps of cytokinesis in plant cells.
Annotate this diagrams in order to outline the process of cytokinesis in plant
cells.
17. Explain the role of cyclins in mitosis
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18. Define the following terms (a) benign tumour (b) malignant tumour (c)
cancer (d) carcinogen (d) mutagen (e) proto-oncogene and (f) Tumour-
suppressor genes.
10. Revision questions 1.6. Cell division
Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:miltiadis@stepsinbiology.com;
http://www.stepsinbiology.com
19. A study was carried out into the number of cigarettes smoked by men per
year and the number of deaths from lung cancer. The graph below shows the
results of this study.
EDEXCEL Biology AS Paper 1 January 2009
http://qualifications.pearson.com/en/support/support-topics/exams/past-papers.html
(a) Describe the changes in the number of deaths from lung cancer and
number of cigarette smoked between 1920 and 1975.
(b) Explain the meaning of the term correlation.
(c) Does correlation mean causality?
(c) Describe the evidence shown in this graph that suggests there is a
correlation between cigarette smoking and the number of deaths from lung
cancer.
(d) Give two additional pieces of information that would increase the validity
of any conclusions made from this study.