Predisposing factors for pre-eclampsia and eclampsia include fetal, maternal, and placental causes. Precipitating factors that can trigger the conditions include vasospasm, increased blood volume, platelet activation, and endothelial injury. This leads to hemodynamic changes, vasoconstriction, microangiopathic hemolytic anemia, and ultimately disseminated intravascular coagulation in severe cases, threatening both mother and fetus with organ damage, hypoxia, and other complications if left untreated.

1. PREDISPOSING FACTORS PRECIPITATING FACTORS
Causative Agents
Fetal Idiopathic Pre-eclampsia Coagulation
Presence/ defects In volume Vasospasm
Or Eclampsia
Decidual
cell
Platelet activation
Hemodynamic changes Vasoconstriction
Endothelium Production but Firbrin forms cross linked
injury shorter lifespan network in small blood & in
Hepatic sinusoids vessels
Hemolysis Thrombocytopenia Blocked hepatic blood flow
Microangiopathic Pain Elevated AST & Swelling
hemolytic anemia ALT
AL
Odd shaped RBC Oxygen supply
HELLP
Organ perfusion Syndrome
Mother Fetus
Disseminated Poor placental
intravascular coagulation perfusion
Paradoxical Bleeding Intrauterine growth retardation Hypoxia