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Cell junction & Junctional complexes
- 6. “Objectives Different types of cell junctions Functions of different types of cell junctions
- 7. Connection between the neighboring cells or contact between cell and extracellular matrix Cell junction
- 11. Basal domain Lateral domain Apical domain
- 12. Zonula occludens/ Tight junction Zonula adherens/ Adherent junction Macula adherens/ Desmosome Gap junction Hemidesmosome
- 13. Zonula occludens Zonula adherens Macula adherens Gap junction
- 14. Belt Something that occludes Something that adheres Spot Desmos- bond Soma- body Zonula occludens (tight junction) Zonula adherens Macula adherens (desmosome)
- 15. Zonula occludens
- 16. Also called tight junction Most apical of the junctions A continuous ribbon-like structure Forms a seal between adjacent cells Zonula occludens (contd.)
- 20. Seals adjacent cells to one another Controls passage of molecules between cells Separate apical and basolateral membrane domain Forms different blood barrier Zonula occludens (contd.)
- 21. Zonula occludens (contd.) Blood-brain barrier
- 22. Zonula occludens (contd.) Blood-thymic barrier Tight junction Reticulo-epithelial cell Enothelial cell
- 23. Zonula occludens (contd.) Blood-testis barrier
- 24. Zonula occludens (contd.) Blood-CSF barrier
- 25. Zonula adherens
- 26. Also called adherent junction Immediately below zonula occludens Also encircles epithelial cells Firmly anchor a cell to its neighbor cells Zonula adherens (contd.)
- 29. Provide point linking to the cytoskeleton of adjacent cells Strengthen and stabilizes nearby tight junction Zonula adherens (contd.)
- 30. Macula adherens
- 31. Also called desmosome In lateral domain of cell membrane Does encircles epithelial cells Macula adherens (contd.)
- 34. Provide point of strong intermediate filament coupling between adjacent cells Strengthen the tissue Macula adherens (contd.)
- 35. Macula adherens (contd.) Macula adherens in skin
- 36. Gap junction
- 37. A communicating junction In lateral domain of cell membrane Permit exchange of molecules and ions Gap junction (contd.)
- 40. Allows direct transport of small molecules and ions from one cell to another Gap junction (contd.)
- 41. Hemidesmosome
- 42. Anchoring junction In basal domain of cell membrane Resembles half desmosome Hemidesmosome (contd.)
- 45. Anchor cytoskeleton of cell to the basal lamina Hemidesmosome (contd.)
- 46. Points Zonula occludens Zonula adherens Macula adherens Hemidesmosome Gap junction Major transmembr-ane protein Occludin, claudin and junctional adhesion molecules E-cadherin, catenin complexes Desmoglein and desmocollin Integrins Connexin Cytoskeletal components Actin filaments Actin filaments Intermediat e filaments Intermediate filaments None Channel protein Absent Absent Absent Absent Present Communication Not possible Not possible Not possible Not possible Possible Function Acts as a barrier Adheres the adjacent cells Provides strong attachments between two cells Adheres the cell to the basal lamina Allows direct transmission of small molecules Summary