Non Malignant Lymphocyte disorders

1. NCS
University System
A Project of NCS Education System
Tanveer Tara
Senior Lecturer
Bachelor of Science in MLT
Masters of Science in Hematology

2. Non Malignant Lymphocyte
disorders.
Acquired and Conjenital
Acquired:Quntative in nature and self limited
reactive process to infection or inflamatory conditions.
Stimulated lymphocytes in infections and inflammatory
conditions are in various stages of activation.
Changes:
Morphological changes,
Lymphadenopathy
Splenomegaly…….

3. Acquired Quantitative disorders
• Lymphocytosis:
• Increased lymphocytes ALC 4x109/L
• Children 9x109/L
• Peripheral Cells 60% to 80%.
• Causes :
• Infectious mononucleosis
• EBV
• Toxoplasmosis
• Cmv
• Infectious LymphocytosisB
• Bordetella
• Lymphocytic Leukomoid Reactions.
• Plasmacytosis

4. INFECTIOUS MONONUCLEOSIS
• Lymphoproliferative cause by EBV.
• Effect young adults 14-24 yeear,
• Children before 4 years of age.
• Transmitted via Saliva ………
• EBV receptors on lympo Cd21.
• Lethargy ,headache ,fever ,chills ,sorethroat,
• :

5. Lab diagnosis
• Counts …high 12-25
• Lymphocytes >50/%
• Reactive lymphocytes
• Plasmacytoids cells also present.
• Paul Bunnel test.
• Increased ALT, AST, and lactic acid
dehydrogenase levels in blood
• Jaundice (occurs in about 5% of cases)

6. Infectiousmononucleosis

7. TOXOPLASMOSIS
• A disease caused by toxoplasmas, transmitted
chiefly through undercooked meat, or in soil
or cat feces. Symptoms generally pass
unremarked in adults, but infection can be
dangerous to unborn children.