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Presented by:
Dan Mugan, Nathan Russell
Brian Sands, & Chad Corillo
Introduction
Advantages
 Performs millions of operations at same time
    Good for parallel computing
 Ability to use large amounts of working memory
    1 gram of DNA can hold 1 x 1014 MB of data
    Or 145 trillion CDs
       1 CD is 800 MB
Advantages
 Cheaper
 Lightweight
    1 lb of DNA has more computing power than all
     computers ever made
 Low power used to keep in original state
 Has ability to solve hardest problems in a matter of
  weeks
 Environmentally friendly
    Clean, readily available materials
Ethics
 Terrorism and Government Control
    Ability to release a virus to computers inside bodies
    If nanobots fail inside of body, it could destroy a persons
     organs that rely upon the bot
 Overpopulation
    With this technology people will live longer creating a
     higher demand on resources
Ethics
• Creation of superior race (cyborg)
   – Ability to use biocomputers to enhance certain abilities
     •   Intelligence
     •   Physical abilities
     •   Age
   – These people will outperform the have nots who cannot
     purchase the technology
   – Can be used like steroids but without the side effects
Ethics
 Computers taking over
    Biocomputers will eventually have the capability to solve
     problems on their own without human intervention
    This could mean a takeover by a Terminator type
     creation
 Would you put your life in the hands of a computer?
    Computers today are not trustworthy at all times
    Doctor malpractice
Disadvantages
• Molecular operations are not perfect
• DNA computing involves a relatively large amount of
  error
• As size of problem grows, probability of receiving
  incorrect answer eventually becomes greater than
  probability of receiving correct answer.
• Sometimes there are errors in the pairing of DNA
  strands
• Simple problems solved faster on electronic computers
Disadvantages
   Human assistance is required
   Time consuming lab procedures
   No universal method of data representation
   DNA has a half-life
     Solutions could dissolve away before end result is found
 Information can be untransmittable
    Current DNA algorithms compute successfully w/o
     passing any information from one processor to the next
     in a multiprocessor connection bus.
Medical Applications
 In 2004, a group in Israel claimed to have created a
 DNA automaton that can diagnose symptoms of
 cancer and administer a therapy
   In prostate cancer, and some others, diagnosis is based on
    molecular signatures
 It senses messenger RNA and can detect the
  abnormal mRNAs produced by genes involved in
  certain types of lung and prostate cancer.
 An anticancer drug is released if an abnormal mRNA
  is found
   It is also made of DNA
   Tumor related gene suppressed
Medical Applications
 DNA computers known as computational genes
  would be integrated into the genetic material
  already in the patients cells
 Computational genes are similar to ordinary gene
  DNA markers
   They will be programmed to react to a certain input with
    a certain output
   Replacement of coding for protein structure.
 Designed a computational DNA molecule that
  would answer 5 yes or no questions
 Questions used to establish the typical markers of
  whether or not prostate cancer was present
Medical Applications
 If 5 yes answers were received, then there would be a
  release of the drug.
 The researchers successfully applied this to a test system
  that recreates the typical molecular signatures of
  prostate cancer in vitro
   similar treatment on a test tube model of small cell lung
    cancer.

 This is what researchers hope is the beginning of the
  future for smart drugs
   Roam the body by fixing disease on the spot
   It would sense a change in the environment and respond      by
    releasing biological molecules
Medical Applications
 West Nile
   Could be used to distinguish between the various viral
    strains


 Diabetes
   Could monitor blood sugar levels and dispense insulin
    when needed.
Medical Applications
 May be several decades before such a system is
 operating inside the human body will become a reality

 Process of introducing genetic material into a person
 would need to be considered carefully.
   Bodies reaction may not be easily predicted
Computational Gene Challenges
 Delivery of the DNA into cells and incorporation into
 the patients' own DNA.

 Keeping them from being treated by the immune
 system as foreign invaders.
Artificial Intelligence
Conclusion

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Biological computers

  • 1. Presented by: Dan Mugan, Nathan Russell Brian Sands, & Chad Corillo
  • 2.
  • 4. Advantages  Performs millions of operations at same time  Good for parallel computing  Ability to use large amounts of working memory  1 gram of DNA can hold 1 x 1014 MB of data  Or 145 trillion CDs  1 CD is 800 MB
  • 5. Advantages  Cheaper  Lightweight  1 lb of DNA has more computing power than all computers ever made  Low power used to keep in original state  Has ability to solve hardest problems in a matter of weeks
  • 6.  Environmentally friendly  Clean, readily available materials
  • 7. Ethics  Terrorism and Government Control  Ability to release a virus to computers inside bodies  If nanobots fail inside of body, it could destroy a persons organs that rely upon the bot  Overpopulation  With this technology people will live longer creating a higher demand on resources
  • 8. Ethics • Creation of superior race (cyborg) – Ability to use biocomputers to enhance certain abilities • Intelligence • Physical abilities • Age – These people will outperform the have nots who cannot purchase the technology – Can be used like steroids but without the side effects
  • 9. Ethics  Computers taking over  Biocomputers will eventually have the capability to solve problems on their own without human intervention  This could mean a takeover by a Terminator type creation  Would you put your life in the hands of a computer?  Computers today are not trustworthy at all times  Doctor malpractice
  • 10. Disadvantages • Molecular operations are not perfect • DNA computing involves a relatively large amount of error • As size of problem grows, probability of receiving incorrect answer eventually becomes greater than probability of receiving correct answer. • Sometimes there are errors in the pairing of DNA strands • Simple problems solved faster on electronic computers
  • 11. Disadvantages  Human assistance is required  Time consuming lab procedures  No universal method of data representation  DNA has a half-life  Solutions could dissolve away before end result is found  Information can be untransmittable  Current DNA algorithms compute successfully w/o passing any information from one processor to the next in a multiprocessor connection bus.
  • 12. Medical Applications  In 2004, a group in Israel claimed to have created a DNA automaton that can diagnose symptoms of cancer and administer a therapy  In prostate cancer, and some others, diagnosis is based on molecular signatures  It senses messenger RNA and can detect the abnormal mRNAs produced by genes involved in certain types of lung and prostate cancer.  An anticancer drug is released if an abnormal mRNA is found  It is also made of DNA  Tumor related gene suppressed
  • 13. Medical Applications  DNA computers known as computational genes would be integrated into the genetic material already in the patients cells  Computational genes are similar to ordinary gene DNA markers  They will be programmed to react to a certain input with a certain output  Replacement of coding for protein structure.  Designed a computational DNA molecule that would answer 5 yes or no questions  Questions used to establish the typical markers of whether or not prostate cancer was present
  • 14. Medical Applications  If 5 yes answers were received, then there would be a release of the drug.  The researchers successfully applied this to a test system that recreates the typical molecular signatures of prostate cancer in vitro  similar treatment on a test tube model of small cell lung cancer.  This is what researchers hope is the beginning of the future for smart drugs  Roam the body by fixing disease on the spot  It would sense a change in the environment and respond by releasing biological molecules
  • 15. Medical Applications  West Nile  Could be used to distinguish between the various viral strains  Diabetes  Could monitor blood sugar levels and dispense insulin when needed.
  • 16. Medical Applications  May be several decades before such a system is operating inside the human body will become a reality  Process of introducing genetic material into a person would need to be considered carefully.  Bodies reaction may not be easily predicted
  • 17. Computational Gene Challenges  Delivery of the DNA into cells and incorporation into the patients' own DNA.  Keeping them from being treated by the immune system as foreign invaders.