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formulation pharmaceutics blistering pharmaceutical formulation coating defect coat defect coating defects tablets defects tablet defects orange peel effects roughness picking sticking tablet coating defects cracking colour variation dull film hazing filling bridging

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formulation pharmaceutics blistering pharmaceutical formulation coating defect coat defect coating defects tablets defects tablet defects orange peel effects roughness picking sticking tablet coating defects cracking colour variation dull film hazing filling bridging

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