Nano Particles can be engineered with distinctive compositions, sizes, shapes, and surface chemistries to enable noval techniques in a wide range of biological application
2. Content
Introduction
Definition
Classificaton Of Nanoparticles
Advantages Of Nanoparticles
Disadvantages Of Nanoparticles
Preparation of polymeric Nanoparticles
Targeted Nanoparticles
Equipments for Nanoparticles
Evaluation of nanoparticles
Conclusion
References
3. Introduction
Nanoparticles can be engineered with distinctive
compositions, sizes, shapes, and surface
chemistries to enable novel techniques in a wide
range of biological applications.
The unique properties of nanoparticles and their
behavior in biological milieu also enable exciting
and integrative approaches to studying
fundamental biological questions. T
4. Definition
“ Nanoparticles are sub-nanosized colloidal
structures composed of synthetic or semi-
synthetic polymers.”
Size range : 10–1000 nm
The drug is dissolved, entrapped, encapsulated
or attached to a nanoparticle matrix
.Based On Method Of Preparation:
Nanocapsules:- Nanocapsules are systems in
which the drug is confined to a cavity surrounded
by a unique polymer membrane.
Nanospheres:- Nanospheres are matrix systems
in which the drug is physically and uniformly
dispersed.
6. Advantages Of Nanoparticles
Nano particle can be administered by parenteral,
oral, nasal,occular routes.
By attaching specific ligands on to their
surfaces,nano particles can be used for directing
the drugs to specific target cells.
Improves stability and therapeutics index and
reduce toxic affects.
Both active & passive drug targetting can be
achieved by manipulating the particel size and
surface characteristics of nano particles
7. Disadvantages Of Nanoparticles
Small size & large surface area can lead to
particle aggregation .
Physical handling of nano particles is difficult in
liquid and dry forms.
Limited drug loading.
Toxic metabolites may form.
11. Evaluation of nanoparticles
1. Particle size
2. Density
3. Molecular weight
4. Structure and crystallinity
5. Specific surface area
6. Surface charge & electronic mobility
7. Surface hydrophobicity
8. Invitro release
9. Nanoparticle yield
10. Drug entrapment efficiency
12. Conclusion
Nanoparticles are one of the novel drug delivery
systems,which can be of potential use in
controlling and targeting drugdelivery as well as
in cosmetics textiles and paints. Judging bythe
current interest and previous successes,
nanoparticulatedrug delivery systems seems to
be a viable and promisingstrategy for the
biopharmaceutical industry.