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DESIGN OF COSMECEUTICAL
PRODUCT : SUN PROTECTION
Mr. Omkar Tipugade
M–Pharm, Sem II ( Pharmaceutics)
Shree Santkrupa College Of Pharmacy, Ghogaon.
AGENDA:
 Introduction to cosmeceutical
 Sun protection :
I. Introduction
II. Sun screen
III. Sunscreen classification
IV. Ideal sunscreen agent
V. Skin type & choice of sunscreen
VI. SPF value
INTRODUCTION TO COSMECEUTICAL
 Cosmeceutical is an ingredient with medicinal properties, which
manifests beneficial topical action and provide protection against
degenerative skin conditions.
 Are cosmetic product with biologically active ingredient purpoting to have
medical or drug like benefits.
 The FD & C act does not recognize any such category as “
cosmeceutical “ A product can be drug , a cosmetic or a combination of
both , but the term “ cosmeceutial “has no meaning under the law.
 Are product that have both cosmetic and therapeutics effect and are
intended to have beneficial effect on skin health and beauty.
 Cosmetical are available “ over the counter “ & are generally used as a
part of a regular skin care regime to help improve skin tone and texture ,
pigmentation and fine lines
SUN PROTECTION
I. Introduction
 Radiation of wavelength 2000-2500A° : penetrate the blood
veseels reaching the papillary layer.
 3200 -3900 A° : reach dermal
 2800-3200 A° : are both erythemogenic ( capble of producing
redness ) & pigmentogenic.
 More than 3900 A° : heating action.
 Intensity of erythema depend on absorption of ultra violet
radiation.
 Three type of skin tannings : 1. immediate tanning
2. delayed tanning
3. true tanning
 sun burns are the result of damage or destruction of cell in the prickle cell
layer of epidermis
 Histamine like substance released by the damaged or destructed cell
causes dilation of blood vessel & erythma . These substance also cause
swelling of the skin and stimulate basal cell to proliferate.
 Sun burn classified into four degree:
Degree 1: minimum erythema
degree 2 : vivid erythema
degree 3 : painful burn
degree 4 : blistering burn
II .Sun screen:
 Purpose of suntan preparation is to assist the skin in tanning without
painful effect & the purpose of anti-burn preparation is to minimize the
harmful effect of the sunburn.
 A number of organic compound have been screened for sunscreening
properties:
a. Azole
b. P-aminobenzoic acid & its derivatives.
c. Cinnamic acid derivatives
d. Coumarin derivatives
e. Quinine salt
f. Dibenzalactone & benzal actophenone
g. Hydrocarbon
h. Hydroquinone
i. Uric acid & violuric acid
j. anthraniltes
III. Sunscreen classification :
A) Physical
- Opaque formulation containing :
*titanium dioxide
*talc , kaolin
*zinc oxide
*ferric chloride
*icthyol , red petrolatum
- Mechanism : scatters of reflects UV radiation due to large
particles size .
B) Chemical
- formulation containing one or more :
*PABA ,PABA ester
* benzophenones
* cinnamates
* salicylates
* digalloyl trioleate
* anthranilates
- Mechanism : absorbs UV radiation
IV. Ideal sunscreen agent
 It should absorb erythonogenic radiation in the range of 290-320nm
without its break down.
 Its should allow full transmission of radiation in the range of 300-400nm
for tanning effect.
 Should be resistant to water & perspiration & should also be non-volatile.
 Should have suitable solubility characteristics.
 Odourless or should have only mild characteristics.
 Non-toxic, non -irritant and non-sensitizing.
 Should be capable of retaining its sunscreening property for several
hours.
 Should be stable under condition of use.
 Should not stain.
V.Skin type & choice of sunscreen:
 US FDA classification system for sunscreen product comprises of five
product category designation (PCD) to meet requirement of consumers
with different type of skin.
 Depending upon skin type & tanning history they are classified into six
group :
a. Always burns easily & never tan (i.e.sensitive)
b. always burns & tan minimally
c. burns moderately & tan gradually to a shade of light brown (i.e.normal)
d. burn minimally & always tans well (i.e.normal)
e. barely burn & tans profusely skin become dark brown (i.e.Insensitive)
f. never burn & skin become deeply pigmented.
VI .SPF value
 The SPF has been defined as ratio between the UV exposure required to
produce a minimally perceptible erythema on protected skin & the
exposure that will produce the erythema on unprotected skin
 The formal defination of SPF by the OTC Panel of the US FDA was
SPF value : MED (PS) / MED (US)
PS : minimum erythemal dose for protected skin after the application of
2mg/cm² of the final formulation of the sunscreen product .
US : minimum erythemal dose for unprotected skin i.e.skin to which no
sunscreen product has been applied .
the larger the SPF , the greater the sun protection
 For skin type mentioned above , sunscreening product with the following
SPF are recommended .
Skin type SPF
I 8 or more
II 6-7
III 4-5
IV 2-3
V 2
VI non-indicated
Thank you

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Design of cosmeceutical product : Sun protection

  • 1. DESIGN OF COSMECEUTICAL PRODUCT : SUN PROTECTION Mr. Omkar Tipugade M–Pharm, Sem II ( Pharmaceutics) Shree Santkrupa College Of Pharmacy, Ghogaon.
  • 2. AGENDA:  Introduction to cosmeceutical  Sun protection : I. Introduction II. Sun screen III. Sunscreen classification IV. Ideal sunscreen agent V. Skin type & choice of sunscreen VI. SPF value
  • 3. INTRODUCTION TO COSMECEUTICAL  Cosmeceutical is an ingredient with medicinal properties, which manifests beneficial topical action and provide protection against degenerative skin conditions.  Are cosmetic product with biologically active ingredient purpoting to have medical or drug like benefits.  The FD & C act does not recognize any such category as “ cosmeceutical “ A product can be drug , a cosmetic or a combination of both , but the term “ cosmeceutial “has no meaning under the law.  Are product that have both cosmetic and therapeutics effect and are intended to have beneficial effect on skin health and beauty.  Cosmetical are available “ over the counter “ & are generally used as a part of a regular skin care regime to help improve skin tone and texture , pigmentation and fine lines
  • 4. SUN PROTECTION I. Introduction  Radiation of wavelength 2000-2500A° : penetrate the blood veseels reaching the papillary layer.  3200 -3900 A° : reach dermal  2800-3200 A° : are both erythemogenic ( capble of producing redness ) & pigmentogenic.  More than 3900 A° : heating action.  Intensity of erythema depend on absorption of ultra violet radiation.  Three type of skin tannings : 1. immediate tanning 2. delayed tanning 3. true tanning
  • 5.  sun burns are the result of damage or destruction of cell in the prickle cell layer of epidermis  Histamine like substance released by the damaged or destructed cell causes dilation of blood vessel & erythma . These substance also cause swelling of the skin and stimulate basal cell to proliferate.  Sun burn classified into four degree: Degree 1: minimum erythema degree 2 : vivid erythema degree 3 : painful burn degree 4 : blistering burn
  • 6. II .Sun screen:  Purpose of suntan preparation is to assist the skin in tanning without painful effect & the purpose of anti-burn preparation is to minimize the harmful effect of the sunburn.  A number of organic compound have been screened for sunscreening properties: a. Azole b. P-aminobenzoic acid & its derivatives. c. Cinnamic acid derivatives d. Coumarin derivatives e. Quinine salt f. Dibenzalactone & benzal actophenone g. Hydrocarbon h. Hydroquinone i. Uric acid & violuric acid j. anthraniltes
  • 7. III. Sunscreen classification : A) Physical - Opaque formulation containing : *titanium dioxide *talc , kaolin *zinc oxide *ferric chloride *icthyol , red petrolatum - Mechanism : scatters of reflects UV radiation due to large particles size .
  • 8. B) Chemical - formulation containing one or more : *PABA ,PABA ester * benzophenones * cinnamates * salicylates * digalloyl trioleate * anthranilates - Mechanism : absorbs UV radiation
  • 9. IV. Ideal sunscreen agent  It should absorb erythonogenic radiation in the range of 290-320nm without its break down.  Its should allow full transmission of radiation in the range of 300-400nm for tanning effect.  Should be resistant to water & perspiration & should also be non-volatile.  Should have suitable solubility characteristics.  Odourless or should have only mild characteristics.  Non-toxic, non -irritant and non-sensitizing.  Should be capable of retaining its sunscreening property for several hours.  Should be stable under condition of use.  Should not stain.
  • 10. V.Skin type & choice of sunscreen:  US FDA classification system for sunscreen product comprises of five product category designation (PCD) to meet requirement of consumers with different type of skin.  Depending upon skin type & tanning history they are classified into six group : a. Always burns easily & never tan (i.e.sensitive) b. always burns & tan minimally c. burns moderately & tan gradually to a shade of light brown (i.e.normal) d. burn minimally & always tans well (i.e.normal) e. barely burn & tans profusely skin become dark brown (i.e.Insensitive) f. never burn & skin become deeply pigmented.
  • 11. VI .SPF value  The SPF has been defined as ratio between the UV exposure required to produce a minimally perceptible erythema on protected skin & the exposure that will produce the erythema on unprotected skin  The formal defination of SPF by the OTC Panel of the US FDA was SPF value : MED (PS) / MED (US) PS : minimum erythemal dose for protected skin after the application of 2mg/cm² of the final formulation of the sunscreen product . US : minimum erythemal dose for unprotected skin i.e.skin to which no sunscreen product has been applied . the larger the SPF , the greater the sun protection
  • 12.  For skin type mentioned above , sunscreening product with the following SPF are recommended . Skin type SPF I 8 or more II 6-7 III 4-5 IV 2-3 V 2 VI non-indicated