SlideShare a Scribd company logo
1 of 19
Download to read offline
KAPOSI SARCOMA
HABAKUK LARRY OMONDI
Introduction
• A multifocal systemic tumor of endothelial
cell origin.
• linked with human herpesvirus 8 infection
• Has Four clinical variants
• Responds to radiation and chemotherapy,
Clinical variants of KS
• classic KS
• endemic African KS
• immunosuppressive therapy–related KS
• HIV/AIDS-related KS
Classic KS
• Occurs in elderly males of eastern
European heritage.
• Predominantly arises on the legs but also
occurs in lymph nodes and abdominal
viscera.
• slow progression and has good prognosis
African-Endemic KS
• bimodal age distribution young adults, mean
age 35; and young children, mean age 3
years
• Males > females
• Has poor prognosis (young adults 5–8 years;
young children 2–3 years)
• Four clinical patterns
African-Endemic KS patterns
a) Nodular type: benign course and resembles classic
KS.
b) Florid or vegetating type: more aggressive. Nodular
extend deeply into the subcutis, muscle, and bone.
c) Infiltrative type: more aggressive has
mucocutaneous and visceral .
d) Lymphadenopathic type: children and young adults.
confined to lymph nodes and viscera, also involves
the skin and mucous membrane.
Iatrogenic Immunosuppression-
Associated KS
• Rare.
• Most commonly in solid-organ transplant
recipients
• chronic use of immunosuppressive drugs
• Resolves on cessation of
immunosuppression.
HIV/AIDS-Associated KS
• AIDS increases risk of KS ( 20,000 times that
those not infected with HIV)
• Common in homosexual men
• Rapid progression, extensive systemic
involvement
• KS of the bowel and/or lungs is responsible
for numerous deaths
Pathogenesis
• Initially polyclonal proliferation is due
angiogenic factors.
• Later becomes monoclonal.
• KS lesions produce growth factors.
• It is not know how HHV8 promotes the
process.
Clinical manifestation
• Mucocutaneous lesions are usually
asymptomatic
• lower extremities - edema and moderate
to severe pain
• Urethral or anal canal lesions-
obstruction
• Pulmonary KS - bronchospasm,
intractable coughing, shortness of breath,
progressive respiratory failure.
Skin lesions
ecchymotic-
like macule
patches
papules,
plaques
nodules tumours
The lesions are normally palpable even at the
patch stage.
Classic ks
Kaposi sarcoma
African KS
Oral kaposi sacroma
Investigations
• Skin biopsy- Vascular channels lined by
atypical endothelial cells.
- extravasated erythrocytes
with hemosiderin deposition
Imaging – abdominal ultrasound, cxr
Differential diagnosis
• Dermatofibroma
• melanocytic nevus
• ecchymosis
• granuloma annulare
• insect bite reactions
Management
• Radiotherapy
• Cryosurgery
• Photodynamic Therapy
• Excisional Surgery
• Intralesional Cytotoxic Chemotherapy
• Chemotherapy- single and combined
chemotherapy
If you’re not infected
you’re affected

More Related Content

What's hot

What's hot (20)

Hodgkin's lymphoma
Hodgkin's lymphomaHodgkin's lymphoma
Hodgkin's lymphoma
 
BURKITTS LYMPHOMA
 BURKITTS LYMPHOMA BURKITTS LYMPHOMA
BURKITTS LYMPHOMA
 
Squamous cell carcinoma skin
Squamous cell carcinoma skinSquamous cell carcinoma skin
Squamous cell carcinoma skin
 
Pleomorphic adenoma
Pleomorphic adenomaPleomorphic adenoma
Pleomorphic adenoma
 
Infectious mononucleosis
Infectious mononucleosisInfectious mononucleosis
Infectious mononucleosis
 
Multiple endocrine neoplasia (men) syndromes
Multiple endocrine neoplasia (men) syndromesMultiple endocrine neoplasia (men) syndromes
Multiple endocrine neoplasia (men) syndromes
 
Basal cell carcinoma (BCC)
Basal cell carcinoma (BCC)Basal cell carcinoma (BCC)
Basal cell carcinoma (BCC)
 
SQUAMOUS CELL CARCINOMA - ORAL CANCER PPT
SQUAMOUS CELL CARCINOMA - ORAL CANCER PPTSQUAMOUS CELL CARCINOMA - ORAL CANCER PPT
SQUAMOUS CELL CARCINOMA - ORAL CANCER PPT
 
Lipomas
LipomasLipomas
Lipomas
 
Systemic sclerosis..scleroderma
Systemic sclerosis..sclerodermaSystemic sclerosis..scleroderma
Systemic sclerosis..scleroderma
 
Hemangioma
HemangiomaHemangioma
Hemangioma
 
Lichen planus
Lichen planusLichen planus
Lichen planus
 
Papillary and follicular thyroid cancer
Papillary and follicular thyroid cancerPapillary and follicular thyroid cancer
Papillary and follicular thyroid cancer
 
Salivary gland tumors
Salivary gland tumorsSalivary gland tumors
Salivary gland tumors
 
Malignant Melanoma
 Malignant Melanoma Malignant Melanoma
Malignant Melanoma
 
NECROTISING FASCIITIS- The flesh eating infection
NECROTISING FASCIITIS- The flesh eating infectionNECROTISING FASCIITIS- The flesh eating infection
NECROTISING FASCIITIS- The flesh eating infection
 
Paget disease of the breast
Paget disease of the breastPaget disease of the breast
Paget disease of the breast
 
Multi nodular goitre (MNG)
Multi nodular goitre (MNG)Multi nodular goitre (MNG)
Multi nodular goitre (MNG)
 
Warts (Verruca) by Dr. Aryan
Warts (Verruca) by Dr. AryanWarts (Verruca) by Dr. Aryan
Warts (Verruca) by Dr. Aryan
 
Cerebral Malaria
Cerebral Malaria Cerebral Malaria
Cerebral Malaria
 

Similar to Kaposi sarcoma

Cervical lymphadenitis in the pediatric age group
Cervical lymphadenitis in the pediatric age groupCervical lymphadenitis in the pediatric age group
Cervical lymphadenitis in the pediatric age groupErasmus Hospital, ULB
 
Dermatology(kaposis sarcoma)
Dermatology(kaposis sarcoma)Dermatology(kaposis sarcoma)
Dermatology(kaposis sarcoma)Viju Rathod
 
Anal biopsy.pptx
Anal biopsy.pptxAnal biopsy.pptx
Anal biopsy.pptxOMJHA20
 
CANCER OF THE CERVIX.pptx
CANCER OF THE CERVIX.pptxCANCER OF THE CERVIX.pptx
CANCER OF THE CERVIX.pptxStevenOnyango5
 
Pathology of cervix
Pathology of cervixPathology of cervix
Pathology of cervixPrasad CSBR
 
Approach to lateral neck swelling in adults and children
Approach to lateral neck swelling in adults and childrenApproach to lateral neck swelling in adults and children
Approach to lateral neck swelling in adults and childrenDr Debmoy Ghatak
 
Clinical approach fever +lymphadenopathy
Clinical approach fever +lymphadenopathyClinical approach fever +lymphadenopathy
Clinical approach fever +lymphadenopathyWalaa Manaa
 
g218h_tumors-of-the-small-and-large-intestines (1).ppt
g218h_tumors-of-the-small-and-large-intestines (1).pptg218h_tumors-of-the-small-and-large-intestines (1).ppt
g218h_tumors-of-the-small-and-large-intestines (1).pptDrNirmalPrasadSah
 
Pathology of uterine cervix 2018 Sufia Husain
Pathology of uterine cervix 2018 Sufia HusainPathology of uterine cervix 2018 Sufia Husain
Pathology of uterine cervix 2018 Sufia HusainSufia Husain
 

Similar to Kaposi sarcoma (20)

Kaposi's Sarcmoa
Kaposi's SarcmoaKaposi's Sarcmoa
Kaposi's Sarcmoa
 
Kaposi sarcoma
Kaposi sarcomaKaposi sarcoma
Kaposi sarcoma
 
Vascular and Cardiac Tumors
Vascular  and Cardiac TumorsVascular  and Cardiac Tumors
Vascular and Cardiac Tumors
 
Cervix - 2nd year UG
Cervix - 2nd year UGCervix - 2nd year UG
Cervix - 2nd year UG
 
Cervical lymphadenitis in the pediatric age group
Cervical lymphadenitis in the pediatric age groupCervical lymphadenitis in the pediatric age group
Cervical lymphadenitis in the pediatric age group
 
Dermatology(kaposis sarcoma)
Dermatology(kaposis sarcoma)Dermatology(kaposis sarcoma)
Dermatology(kaposis sarcoma)
 
Male genital ii
Male genital iiMale genital ii
Male genital ii
 
Anal biopsy.pptx
Anal biopsy.pptxAnal biopsy.pptx
Anal biopsy.pptx
 
CANCER OF THE CERVIX.pptx
CANCER OF THE CERVIX.pptxCANCER OF THE CERVIX.pptx
CANCER OF THE CERVIX.pptx
 
Ch7 Neoplasia
Ch7 NeoplasiaCh7 Neoplasia
Ch7 Neoplasia
 
Cervix
CervixCervix
Cervix
 
Pathology of cervix
Pathology of cervixPathology of cervix
Pathology of cervix
 
Cervical cancer
Cervical cancerCervical cancer
Cervical cancer
 
Approach to lateral neck swelling in adults and children
Approach to lateral neck swelling in adults and childrenApproach to lateral neck swelling in adults and children
Approach to lateral neck swelling in adults and children
 
Bone and soft tissue pathology
Bone and soft tissue pathology  Bone and soft tissue pathology
Bone and soft tissue pathology
 
Clinical approach fever +lymphadenopathy
Clinical approach fever +lymphadenopathyClinical approach fever +lymphadenopathy
Clinical approach fever +lymphadenopathy
 
Amoebiasis PPT.pptx
Amoebiasis PPT.pptxAmoebiasis PPT.pptx
Amoebiasis PPT.pptx
 
g218h_tumors-of-the-small-and-large-intestines (1).ppt
g218h_tumors-of-the-small-and-large-intestines (1).pptg218h_tumors-of-the-small-and-large-intestines (1).ppt
g218h_tumors-of-the-small-and-large-intestines (1).ppt
 
Cervix cancer
Cervix cancerCervix cancer
Cervix cancer
 
Pathology of uterine cervix 2018 Sufia Husain
Pathology of uterine cervix 2018 Sufia HusainPathology of uterine cervix 2018 Sufia Husain
Pathology of uterine cervix 2018 Sufia Husain
 

More from Omondi Larry

POST parturm hemora.pptx
POST parturm hemora.pptxPOST parturm hemora.pptx
POST parturm hemora.pptxOmondi Larry
 
Child survival strategies 2019
Child survival strategies 2019Child survival strategies 2019
Child survival strategies 2019Omondi Larry
 
Upper urinary tract disorders
Upper urinary tract disordersUpper urinary tract disorders
Upper urinary tract disordersOmondi Larry
 
Lower urinary tract infection
Lower urinary tract infectionLower urinary tract infection
Lower urinary tract infectionOmondi Larry
 
Somatoform disorders
Somatoform disordersSomatoform disorders
Somatoform disordersOmondi Larry
 
Haemangioma of infancy
Haemangioma of infancyHaemangioma of infancy
Haemangioma of infancyOmondi Larry
 

More from Omondi Larry (10)

POST parturm hemora.pptx
POST parturm hemora.pptxPOST parturm hemora.pptx
POST parturm hemora.pptx
 
Child survival strategies 2019
Child survival strategies 2019Child survival strategies 2019
Child survival strategies 2019
 
Upper urinary tract disorders
Upper urinary tract disordersUpper urinary tract disorders
Upper urinary tract disorders
 
Lower urinary tract infection
Lower urinary tract infectionLower urinary tract infection
Lower urinary tract infection
 
Mood disorders
Mood disorders Mood disorders
Mood disorders
 
Somatoform disorders
Somatoform disordersSomatoform disorders
Somatoform disorders
 
Psoriasis
PsoriasisPsoriasis
Psoriasis
 
Haemangioma of infancy
Haemangioma of infancyHaemangioma of infancy
Haemangioma of infancy
 
Dermatomyositis
DermatomyositisDermatomyositis
Dermatomyositis
 
Candidiasis
CandidiasisCandidiasis
Candidiasis
 

Recently uploaded

Generative AI in Health Care a scoping review and a persoanl experience.
Generative AI in Health Care a scoping review and a persoanl experience.Generative AI in Health Care a scoping review and a persoanl experience.
Generative AI in Health Care a scoping review and a persoanl experience.Vaikunthan Rajaratnam
 
How to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturallyHow to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturallyZurück zum Ursprung
 
High-Performance Thin-Layer Chromatography (HPTLC)
High-Performance Thin-Layer Chromatography (HPTLC)High-Performance Thin-Layer Chromatography (HPTLC)
High-Performance Thin-Layer Chromatography (HPTLC)kishan singh tomar
 
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptx
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptxBreast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptx
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptxNaveenkumar267201
 
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdf
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdfSGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdf
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdfHongBiThi1
 
SGK RỐI LOẠN TOAN KIỀM ĐHYHN RẤT HAY VÀ ĐẶC SẮC.pdf
SGK RỐI LOẠN TOAN KIỀM ĐHYHN RẤT HAY VÀ ĐẶC SẮC.pdfSGK RỐI LOẠN TOAN KIỀM ĐHYHN RẤT HAY VÀ ĐẶC SẮC.pdf
SGK RỐI LOẠN TOAN KIỀM ĐHYHN RẤT HAY VÀ ĐẶC SẮC.pdfHongBiThi1
 
SGK ĐIỆN GIẬT ĐHYHN RẤT LÀ HAY TUYỆT VỜI.pdf
SGK ĐIỆN GIẬT ĐHYHN        RẤT LÀ HAY TUYỆT VỜI.pdfSGK ĐIỆN GIẬT ĐHYHN        RẤT LÀ HAY TUYỆT VỜI.pdf
SGK ĐIỆN GIẬT ĐHYHN RẤT LÀ HAY TUYỆT VỜI.pdfHongBiThi1
 
Male Infertility Panel Discussion by Dr Sujoy Dasgupta
Male Infertility Panel Discussion by Dr Sujoy DasguptaMale Infertility Panel Discussion by Dr Sujoy Dasgupta
Male Infertility Panel Discussion by Dr Sujoy DasguptaSujoy Dasgupta
 
BENIGN BREAST DISEASE
BENIGN BREAST DISEASE BENIGN BREAST DISEASE
BENIGN BREAST DISEASE Mamatha Lakka
 
PAIN/CLASSIFICATION AND MANAGEMENT OF PAIN.pdf
PAIN/CLASSIFICATION AND MANAGEMENT OF PAIN.pdfPAIN/CLASSIFICATION AND MANAGEMENT OF PAIN.pdf
PAIN/CLASSIFICATION AND MANAGEMENT OF PAIN.pdfDolisha Warbi
 
pA2 value, Schild plot and pD2 values- applications in pharmacology
pA2 value, Schild plot and pD2 values- applications in pharmacologypA2 value, Schild plot and pD2 values- applications in pharmacology
pA2 value, Schild plot and pD2 values- applications in pharmacologyDeepakDaniel9
 
Pharmacokinetic Models by Dr. Ram D. Bawankar.ppt
Pharmacokinetic Models by Dr. Ram D.  Bawankar.pptPharmacokinetic Models by Dr. Ram D.  Bawankar.ppt
Pharmacokinetic Models by Dr. Ram D. Bawankar.pptRamDBawankar1
 
Mental health Team. Dr Senthil Thirusangu
Mental health Team. Dr Senthil ThirusanguMental health Team. Dr Senthil Thirusangu
Mental health Team. Dr Senthil Thirusangu Medical University
 
Adenomyosis or Fibroid- making right diagnosis
Adenomyosis or Fibroid- making right diagnosisAdenomyosis or Fibroid- making right diagnosis
Adenomyosis or Fibroid- making right diagnosisSujoy Dasgupta
 
Neurological history taking (2024) .
Neurological  history  taking  (2024)  .Neurological  history  taking  (2024)  .
Neurological history taking (2024) .Mohamed Rizk Khodair
 
Basic structure of hair and hair growth cycle.pptx
Basic structure of hair and hair growth cycle.pptxBasic structure of hair and hair growth cycle.pptx
Basic structure of hair and hair growth cycle.pptxkomalt2001
 
Red Blood Cells_anemia & polycythemia.pdf
Red Blood Cells_anemia & polycythemia.pdfRed Blood Cells_anemia & polycythemia.pdf
Red Blood Cells_anemia & polycythemia.pdfMedicoseAcademics
 
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdf
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdfCONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdf
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdfDolisha Warbi
 
"Radical excision of DIE in subferile women with deep infiltrating endometrio...
"Radical excision of DIE in subferile women with deep infiltrating endometrio..."Radical excision of DIE in subferile women with deep infiltrating endometrio...
"Radical excision of DIE in subferile women with deep infiltrating endometrio...Sujoy Dasgupta
 

Recently uploaded (20)

Generative AI in Health Care a scoping review and a persoanl experience.
Generative AI in Health Care a scoping review and a persoanl experience.Generative AI in Health Care a scoping review and a persoanl experience.
Generative AI in Health Care a scoping review and a persoanl experience.
 
How to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturallyHow to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturally
 
High-Performance Thin-Layer Chromatography (HPTLC)
High-Performance Thin-Layer Chromatography (HPTLC)High-Performance Thin-Layer Chromatography (HPTLC)
High-Performance Thin-Layer Chromatography (HPTLC)
 
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptx
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptxBreast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptx
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptx
 
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdf
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdfSGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdf
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdf
 
SGK RỐI LOẠN TOAN KIỀM ĐHYHN RẤT HAY VÀ ĐẶC SẮC.pdf
SGK RỐI LOẠN TOAN KIỀM ĐHYHN RẤT HAY VÀ ĐẶC SẮC.pdfSGK RỐI LOẠN TOAN KIỀM ĐHYHN RẤT HAY VÀ ĐẶC SẮC.pdf
SGK RỐI LOẠN TOAN KIỀM ĐHYHN RẤT HAY VÀ ĐẶC SẮC.pdf
 
SGK ĐIỆN GIẬT ĐHYHN RẤT LÀ HAY TUYỆT VỜI.pdf
SGK ĐIỆN GIẬT ĐHYHN        RẤT LÀ HAY TUYỆT VỜI.pdfSGK ĐIỆN GIẬT ĐHYHN        RẤT LÀ HAY TUYỆT VỜI.pdf
SGK ĐIỆN GIẬT ĐHYHN RẤT LÀ HAY TUYỆT VỜI.pdf
 
Male Infertility Panel Discussion by Dr Sujoy Dasgupta
Male Infertility Panel Discussion by Dr Sujoy DasguptaMale Infertility Panel Discussion by Dr Sujoy Dasgupta
Male Infertility Panel Discussion by Dr Sujoy Dasgupta
 
BENIGN BREAST DISEASE
BENIGN BREAST DISEASE BENIGN BREAST DISEASE
BENIGN BREAST DISEASE
 
PAIN/CLASSIFICATION AND MANAGEMENT OF PAIN.pdf
PAIN/CLASSIFICATION AND MANAGEMENT OF PAIN.pdfPAIN/CLASSIFICATION AND MANAGEMENT OF PAIN.pdf
PAIN/CLASSIFICATION AND MANAGEMENT OF PAIN.pdf
 
pA2 value, Schild plot and pD2 values- applications in pharmacology
pA2 value, Schild plot and pD2 values- applications in pharmacologypA2 value, Schild plot and pD2 values- applications in pharmacology
pA2 value, Schild plot and pD2 values- applications in pharmacology
 
Pharmacokinetic Models by Dr. Ram D. Bawankar.ppt
Pharmacokinetic Models by Dr. Ram D.  Bawankar.pptPharmacokinetic Models by Dr. Ram D.  Bawankar.ppt
Pharmacokinetic Models by Dr. Ram D. Bawankar.ppt
 
Mental health Team. Dr Senthil Thirusangu
Mental health Team. Dr Senthil ThirusanguMental health Team. Dr Senthil Thirusangu
Mental health Team. Dr Senthil Thirusangu
 
Biologic therapy ice breaking in rheumatology, Case based approach with appli...
Biologic therapy ice breaking in rheumatology, Case based approach with appli...Biologic therapy ice breaking in rheumatology, Case based approach with appli...
Biologic therapy ice breaking in rheumatology, Case based approach with appli...
 
Adenomyosis or Fibroid- making right diagnosis
Adenomyosis or Fibroid- making right diagnosisAdenomyosis or Fibroid- making right diagnosis
Adenomyosis or Fibroid- making right diagnosis
 
Neurological history taking (2024) .
Neurological  history  taking  (2024)  .Neurological  history  taking  (2024)  .
Neurological history taking (2024) .
 
Basic structure of hair and hair growth cycle.pptx
Basic structure of hair and hair growth cycle.pptxBasic structure of hair and hair growth cycle.pptx
Basic structure of hair and hair growth cycle.pptx
 
Red Blood Cells_anemia & polycythemia.pdf
Red Blood Cells_anemia & polycythemia.pdfRed Blood Cells_anemia & polycythemia.pdf
Red Blood Cells_anemia & polycythemia.pdf
 
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdf
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdfCONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdf
CONNECTIVE TISSUE (ANATOMY AND PHYSIOLOGY).pdf
 
"Radical excision of DIE in subferile women with deep infiltrating endometrio...
"Radical excision of DIE in subferile women with deep infiltrating endometrio..."Radical excision of DIE in subferile women with deep infiltrating endometrio...
"Radical excision of DIE in subferile women with deep infiltrating endometrio...
 

Kaposi sarcoma

  • 2. Introduction • A multifocal systemic tumor of endothelial cell origin. • linked with human herpesvirus 8 infection • Has Four clinical variants • Responds to radiation and chemotherapy,
  • 3. Clinical variants of KS • classic KS • endemic African KS • immunosuppressive therapy–related KS • HIV/AIDS-related KS
  • 4. Classic KS • Occurs in elderly males of eastern European heritage. • Predominantly arises on the legs but also occurs in lymph nodes and abdominal viscera. • slow progression and has good prognosis
  • 5. African-Endemic KS • bimodal age distribution young adults, mean age 35; and young children, mean age 3 years • Males > females • Has poor prognosis (young adults 5–8 years; young children 2–3 years) • Four clinical patterns
  • 6. African-Endemic KS patterns a) Nodular type: benign course and resembles classic KS. b) Florid or vegetating type: more aggressive. Nodular extend deeply into the subcutis, muscle, and bone. c) Infiltrative type: more aggressive has mucocutaneous and visceral . d) Lymphadenopathic type: children and young adults. confined to lymph nodes and viscera, also involves the skin and mucous membrane.
  • 7. Iatrogenic Immunosuppression- Associated KS • Rare. • Most commonly in solid-organ transplant recipients • chronic use of immunosuppressive drugs • Resolves on cessation of immunosuppression.
  • 8. HIV/AIDS-Associated KS • AIDS increases risk of KS ( 20,000 times that those not infected with HIV) • Common in homosexual men • Rapid progression, extensive systemic involvement • KS of the bowel and/or lungs is responsible for numerous deaths
  • 9. Pathogenesis • Initially polyclonal proliferation is due angiogenic factors. • Later becomes monoclonal. • KS lesions produce growth factors. • It is not know how HHV8 promotes the process.
  • 10. Clinical manifestation • Mucocutaneous lesions are usually asymptomatic • lower extremities - edema and moderate to severe pain • Urethral or anal canal lesions- obstruction • Pulmonary KS - bronchospasm, intractable coughing, shortness of breath, progressive respiratory failure.
  • 11. Skin lesions ecchymotic- like macule patches papules, plaques nodules tumours The lesions are normally palpable even at the patch stage.
  • 16. Investigations • Skin biopsy- Vascular channels lined by atypical endothelial cells. - extravasated erythrocytes with hemosiderin deposition Imaging – abdominal ultrasound, cxr
  • 17. Differential diagnosis • Dermatofibroma • melanocytic nevus • ecchymosis • granuloma annulare • insect bite reactions
  • 18. Management • Radiotherapy • Cryosurgery • Photodynamic Therapy • Excisional Surgery • Intralesional Cytotoxic Chemotherapy • Chemotherapy- single and combined chemotherapy
  • 19. If you’re not infected you’re affected