The document discusses the future of 3D printing in pharmaceuticals and healthcare. It begins with a brief history of 3D printing, including its invention in 1984 and early applications in healthcare around 2000. It then provides details on the 3D printing process and some of the most common 3D printing technologies used in medical applications. The document outlines innovations like ZipDose, a 3D printed pill, and trends toward bioprinting of living tissues and organs. It forecasts growth in the 3D printing market, especially for medical uses. Challenges to adoption in India are noted as well as the transformative potential of 3D printing for medicine.

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PRESENTED BY:
Prashant Pandey
17PMM630
FUTURE OF 3D PRINTING IN
PHARMACEUTICAL & HEALTH CARE

2. The basics of the technology.
1

3. 3D Printing is a process of making a physical object from a three
dimensional digital model typically by layering down many thin layers
of a material in succession
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Processes
Additive
Manufacturing
(AM)
Rapid Prototyping
(RP),
Solid Free-form
fabrication (SFF)

4.  Charles Hull invented 3d printing which he called STEREOLITHOGRAPHY in
the early 1984.
 He obtained a patent in 1986.
 First research into applications in pharmaceutical & health care sector
appeared around 2000.
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5. 1984
• Charles Hull invented Stereolithography
1996
• Dr. Gabor Forgacs observed that cells stick together during
embryonic development
2000
• Urinary bladder augmentation using a synthetic scaffold seeded with
the patients' own cells
2003
• Thomas Boland's lab modified an inkjet printer to accommodate
and dispense cells in scaffolds
2009
• Organovo, creates the NovoGen MMX Bioprinter using Forgacs
technology
2010
• Organovo prints the first human blood vessel without the use of
scaffolds
2011
• Organavo develops 3D bioprinted disease models made from
human cells.
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6. A step by step process.
2

7. • There are about two dozen 3D printing processes, which use varying printer technologies, speeds, and
resolutions, and hundreds of materials.
• These technologies can build a 3D object in almost any shape imaginable as defined in a computer-
aided design (CAD) file.
• In a basic setup, the 3D printer first follows the instructions in the CAD file to build the foundation
for the object, moving the print head along the x–y plane.
• The printer then continues to follow the instructions, moving the print head along the z-axis to build
the object vertically layer by layer.
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9. The type of 3D printer chosen for an application often depends on the
materials to be used and how the layers in the finished product are
bonded.
The three most commonly used 3D printer technologies in medical
applications are:
• Selective Laser Sintering (SLS)
• Thermal Inkjet (TIJ) printing
• Fused Deposition Modeling (FDM).
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10. The latest innovations
3

11.  ZipDose is a 3D printer that creates pills by printing out thin layers of medicine in
powder form, with layers of a water based binder spread between each of the powder
layers.
 The result is a tablet that can dissolve with a sip of water in less than 5 seconds.
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Source- www.aprecia.com/Zipdose

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Source- www.aprecia.com/Zipdose

13.  A 3D printing process also allows layers of medications to be
packaged in better porous medium in precise dosages.
 The possibility to 3D print drugs on affordable devices could
eventually lead to cheaper medication.
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14. The latest Trend
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15. 3D BIOPRINTING
• The most latest technology in biofabrication of living structures using tissue
engineering is “Bioprinting”.
• Bioprinting is defined as the construction of tissue constructs using a set of
techniques that transfer biologically important materials onto a substrate with
computer-aided, specialized 3D printers.
Bioprinter
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17. Cells Hydrogel Bioprinter
Bioprinted
tissue or
organ
(Bioink)
(Biopaper)
COMPONENTS NEEDED FOR BIOPRINTING
Pre- processing
Processing
Post processing
3 Phases
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18. PRINTING PROCESS
Maturation
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19. Current Progress
Ear: 250 µm cells and collagen from rat tail make human ear in
15 min. Post-processing 3 months. To serve children with
hearing loss due to malformed outer ear.
Blood Vessels: Rigid but non-toxic sugar filaments form core.
Cells deposited around filaments. Subsequent blood flow
dissolves sugar.
Kidneys: Layer-by-layer building of scaffold and deposition of
kidney cells. Assembly to be transplanted into patient.
Degradation of scaffold to follow in-vivo.
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20. Skin grafts: laser scan wound to determine depth and area. One
inkjet ejects enzymes and second, cells. Layer is finally sealed by
human skin cells. Useful in war and disaster zones.
Bones: Print scaffold with ceramic or Titanium powder, incubation
of 1 day in culture of human stem cells. Repair of complex fractures
in accident survivors.
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Researchers at the National Library of
Medicine generate digital files from clinical
data, such as CT scans, that are used to make
custom 3D-printed surgical and medical
models.
A 3D model used for surgical
planning by neurosurgeons at the
Walter Reed National Military
Medical Center.

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Harvard team 3D prints blood vessel-lined
tissue that could one day be used to test
drugs
3D Printing Creates Low-Cost Prosthetic
Fingers

23. 3D Bone implant
Medical devices
Ear cartilage
Synthetic skin
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24. • Printing new Skin
• Printing cartilage &
bones
• Printing replacement
tissues
• Printing replacement
organs
• Specific organ
tissue replacement
for important organs
like heart and
kidney.
• Personalized
replacement for
3D printed joints
with custom fit.
• Life saving 3D
printed organ
replacement.
Research (today)
Technology Adoption
( after 5- 8 years)
Commercialization
(after 10- 15 years)
Bioprinting - Forecast
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25.  The Global 3D Bio printing Market was valued at approximately $570
million in 2015 and is expected to grow at a CAGR (Compound Annual
Growth rate) of around 25-27% during the forecast period that is from
2016 to 2022.
 Such high growth is majorly attributed to factors such as; growing
demand for tissues and organs for transplantation and the growing
technological advancements in 3D Bio printing technology.
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26.  Study shows that making Medical equipment is 1 of the 3 Major sector along
with Automobile and Aerospace.
 Bio printing(Medical/dental ) has the Fast growth rate of 50%/year increasing.
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Medical & Dental
16%
Pharmaceutical
12%
Aerospace &
Defence
15%Automotive
20%
Education &
Research
28%
Architecture
4%
Other
5%
3D Printing Market Share (2015)
Source- www.statia.com/worldwide-3d-printing

27.  Value chain of 3D printing includes various stakeholders,
namely:
◦ Research and Development
◦ 3D printer and material manufacturers
◦ Retailers
◦ Final consumers
 Various activities in Value chain analysis
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Primary
Activity Secondary
Activity
Source- www.ey.com/publication/vwLUAssets

28. Manufacturers
Suppliers
CustomersR&D
Primary Activities
 Research and development - responsible for changing the conventional
techniques of manufacturing and introducing new technology into the
market
 Manufacturers - construct components and accomplish higher precision
and advanced resolution while providing faster manufacturing process
 Consumers - automobile, defense, aerospace, industrial, healthcare,
education and research, arts, architecture and others.
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29. Support Activities :These activities indirectly influence the 3D
printing market size.
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Technology adoption
•High-end technologies used in development of new
techniques
Capital investment
•Influence the role of stakeholders, such as
manufacturers and consumers
Economies of scale
•Achieve the return on investment
Patent protection
•Help Inventors Turn Ideas Into Success

30.  According to a research conducted by 6Wresearch, India’s 3D printing market is
projected to grow at around 20 percent during 2014-19
 India 3D printer market is projected to cross $79 million by 2021
 Indian 3D printing platform think3D has announced it will be establishing a $6
million 3D printing facility in Andhra Pradesh, India (Andhra Pradesh MedTech Zone
-AMTZ)
 The $6 million facility is expected to enable India’s medical device market to
become more independent reducing total foreign import from 75% to 10%
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Source- www.amtz.in/think3d
-announce-6m-3d-print-facility-india

31. • High cost of
Manufacturing
• Lack Of
Awareness
• Still very
nascent
Industry
• Lack of
raw
Material
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32. • 3D printing has become a useful and potentially transformative
tool in a number of different fields, including medicine.
• As printer performance, resolution, and available materials have
increased, so have the applications.
• Researchers continue to improve existing medical applications
that use 3D printing technology and to explore new ones.
• The medical advances that have been made using 3D printing are
already significant and exciting, but some of the more
revolutionary applications, such as organ printing, will need time
to evolve.
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ANY QUESTIONS?