Let's start with the famous quote of Aldous Huxley : "The charm of history and its enigmatic lesson consist in the fact that, from age to age, nothing changes and yet everything is completely different."

1. History and evolution in Clinical researc
Let's start with the famous quote of Aldous Huxley : "The charm of history and its
enigmatic lesson consist in the fact that, from age to age, nothing changes and yet
everything is completely different."
Clinical Research has evolved a long way since its inception, whether documented or
not. It traverses a long and amazing journey. The recorded history of clinical trials
dates back to the biblical descriptions of 500 BC. The journey encompasses from
dietary therapy - legumes and lemons - to drugs.
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3. Pre Lind era:
605-562 BC
The Old Testament depicts that King Nebuchadnezzar II ordered the children of royal
blood to eat only meat and wine for three years. Daniel requested that he and three
other children would be allowed to eat only bread and water. Noticeably Daniel and the
three children were healthier and more lively than those who were given the wine and
meat diet.
1537
Ambroise Pare,a Renaissance surgeon, unintentionally carried out a clinical trial when
ceased to continue the standard treatment of boiling oil for open wounds. He
experimented by making a mixing of egg yolk, turpentine and oil of rose and applied
to the wounds. Surprisingly noticed that the wounds treated with this mixture healed
well compared to those which became swollen and infected with the standard
treatment.
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4. Lind and trial of scurvy:
Lind and trial of scurvy:
1747
James Lind is markedly considered the originator of the modern clinical research trial
because he
was the first to introduce the use of a control group. He conducted the trial on a group of
sailors suffering from scurvy. He prescribed same diet to all but fed one additional
item such as cider and vinegar to one group and fed the other group with lemon juice.
The group who took the lemon juice supplement recovered from scurvy in just six
days.
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6. A Common Technical Document (CTD) was developed. The CTD acts as a standard
casebook used in Europe, Japan and the U.S. for proposing data gathered in clinical
trials to respective governing authorities.
Clinical Research review by CRB Solutions is sufficient to make you consider and take
up a career in this field.
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7. THANK YOU !!!