Gout Presentation...

3. M.SARIM SHAFIQUE
BPD01093173
5TH C
UNIVERSITY OF LHR.

6. GOUT is a result of prolonged, untreated and
high uric acid level in the bloodstream. The
condition is also referred to as the 'Disease of
Kings' or the 'Rich Man's Disease’
Mostly observed in the men but also affects
women with menopause and other body parts
or joints as well.

7. It is accompanied by fever, intense joint pain and
inflammation of the tissues , in and around the
affected joint. Gout attacks the big toe, heel, ankle,
wrist, knee , fingers, elbow and/or the spine. There
have been cases where the condition has arisen out
of immobility caused to joints due to a previous
injury. Similarly , hyperuricemia patients also
develop tophi or uric acid crystal deposits in tissues
such as observed in the pinnae of the ear.

8. Different joints
that may be
involve in gout.
But at a time only
one joint is
involve in gout.

9. The most common joint involve
is METATARSOPHALANGIAL
JOINT OF BIG TOE.

11. Primary gout is due to the high level of
uric acid in blood that is hyperuricemia
which may be due to kidney problem and
/or intake of protien-rich food(purine rich
food) , alcohol and/or other herediatry
factors causes obesity , diabetes,
hypertension and heart diseases.

14. That arise from other medical conditions like
metabolic syndrome and blood cancer or leukemia.
Diuretics can also cause gout.

15. 1..In human,
sodium urate is the
end product of
purine metabolism.
2.Deposition of urate
crystals initiates an
inflammatory process.
3.Granulocytes
phagocytize urate
crystals , lysosomal
enzyme evoke an
inflammatory
response.
4.Production of
lactate in synovial
fluid.
5.Local decrease in
pH fosters further
deposition of urate
crystals.

17. Gout is suspected when a patient reports a
history of attacks of painful arthritis, particularly
at the base of the toes. Ankles and knees are the
next most commonly involved joints in gout.
Gout usually attacks one joint at a time .

18. .
The most reliable test for
gout is finding uric acid
crystals in a sample of the
joint by joint aspiration.
Microscopic analysis of
uric acid crystals ….
X-RAY image analysis…
BLOOD URIC ACID
LEVEL ..
Normally the blood uric acid
level is less than
6.8mg/dL.

19. And the other test which also help to diagnose gout is
BLOOD URIC ACID LEVEL ..
Normally the blood uric acid level is less than 6.8mg/dL . .

23. E.G .. Allopurinol
E.G .. Febuxostat
E.G .. Probenecid ,
Sulfinpyrazone

24. Inhibit leukocytes migration to joints .
Like Indomethacin, Mefenamic Acid