7. SITE SUBSITE
Supraglottis Suprahyoid epiglottis
Infrahyoid epiglottis
Aryepiglottic folds
Arytenoids
Ventricular bands (false vocal
cords)
Glottis True vocal cords+ ant and post.
Commissure +rima glottidis(slit)
Subglottis Subglottic space upto lower
border of cricoid
8. 2.63% of all the body cancers in India
M:F = 10:1
40- 70 years
female incidence increasing
9.
10. Black tobacco > light tobacco - aromatic amines and
tobacco specific nitrosamines & Tar content.
Non filter cigarettes > filter cigarettes - tar content
Smoking hand-rolled cigarettes > commercially
manufactured cigarettes - 2.7* risk.
Chewing tobacco or inhaling snuff - 50% in risk.
Risk of developing ca larynx decreases with increasing
time since cessation of smoking, indicating tobacco as a
promoter and initiator in carcinogenesis.
SMOKING
11. Alcohol formaldehyde
( ) vit. A synthesis
mucosal de-epithelisation
mucosa exposed
Serum IgA levels in patients with
alcoholic liver disease
Associated malnutrition
15* RISK
12. OCCUPATIONAL EXPOSURE - asbestos, mustard gas, process of
isopropyl alcohol manufacturing, nickel refining, soot, tars, acid mists,
beryllium and bischloromethyl ether & the glass wool production.
GENETIC - Japanese and Russian
VIRUSES - HSV, HPV, EBV ( EBV- specific IgA
antibodies block IgG mediated tumor
destruction).
Previous RADIATION to head & neck
Low SOCIOECONOMIC STATUS - smoking habits
13. SUPRAGLOTTIC CANCER
site - epiglottis > false cords > aryepiglottic folds
Spread - vallecula, base of tongue & pyriform fossa.
Cancer of infrahyoid epiglottis & anterior ventricular band
extend into pre-epiglottic space and penetrate the thyroid cartilage.
14. Symptoms: Early -Throat pain
Dysphagia
Ipsilateral otalgia
LN mass in the neck.
Late - Weight loss
Respiratory obstruction
Halitosis (tumor necrosis)
Nodal mets - upper and middle jugular nodes.
Bilateral mets (epiglottis)
16. GLOTTIC CANCER
Most common site - Free edge and upper surface of the vocal cords in its
anterior and middle third
spread- anteriorly - anterior commissure &opposite cord
posteriorly - vocal process and arytenoids
upward – ventricle & false cord
downwards - subglottis
17. Symptoms : Early - Hoarseness Late – Stridor
Laryngeal obstruction
(increased size, edema/ cord fixation)
Nodal mets – practically absent, if early stage
23. Broadening of the larynx
Loss of crepitation
Tenderness of larynx
Weight loss
Chronic cough; Hemoptysis
Dysphagia
Odynophagia
Ipsilateral otalgia
Halitosis
Mass in the neck
HISTORY:
“patient in cancer age group having persistent or gradually increasing
hoarseness of voice for 3 weeks must have laryngeal examination to exclude
cancer”
Persistent hoarsenessDyspnea and stridor
24. Hoarseness of voice
Have you heard a patient with hoarseness of voice beforet.mp4 - YouTube - Copy.mp4
25. THANK YOU ALL MY
FRIENDS FOR BEING
PATIENT AND LISTENING
ME