StartUp Health Insights 2016 Midyear Report

© 2016 StartUp Health, LLC
A StartUp Health InsightsTM Report  
Published July 6, 2016 | Report data through June 30, 2016
Report is inclusive of seed, venture, corporate venture and private equity funding
Published: April 1, 2015
50+ MARKET FUNDING SPONSORED BY
StartUp Health Insights
Digital Health Funding Rankings
2016 Midyear Report
TM
TOP VENTURE FUNDING AND TOP MARKETS SPONSORED BY

Disclosure: Information, data and figures represent publicly available data through 6/30/16. © 2016 StartUp Health, LLC
Note: StartUp Health InsightsTM is inclusive of all seed, venture, corporate venture and private equity funding. • Source: StartUp Health Insights | www.startuphealth.com/insights
The digital health market broke historic records for midyear funding as investment reached $3.9B. Seed and Series A
financing rounds are substantially equal in number, demonstrating a still thriving early-stage innovation landscape. Most
funding dollars are being funneled to Series A rounds, creating opportunities for companies with validated solutions.
2
2016 Midyear and Q2 Summary
1
Rethinking Insurance: Oscar has continued to blaze an innovative trail through traditional health insurance as a new generation of
mobile-literate, “young invincibles” look for affordable, engaging and simple solutions for their insurance. Similar models, successful  
in their own ways, have followed suit as three of the top 10 deals year to date focused on tech-centered insurance.
2
Asia & the Middle East Make Their Mark: China, India and Israel have been adopting digital health solutions in significant ways over
the last several years, rolling out massive technologies for populations facing nuanced, yet substantially similar, health challenges
around the world.
3
Early-Stage Ecosystem: There was an almost even amount of Seed and Series A deals in the first half of 2016, making up almost  
65 percent of all funding rounds, though Series A deals garnered more capital. Companies receiving Seed financing are burdened  
with proving their model works on little capital, while opportunities for Series A financing remain abundant.
4
Publicly Traded Pioneers: As Evolent Health climbs back to its original IPO price, shareholders wonder what this means for other
publicly traded digital health companies and those considering public exits. While the real value of what these companies do may  
still be left for most to realize, the perceived value still remains lower than anticipated for many of these early innovators.
5
Global Innovation: More than 7,600 startups around the world are developing solutions in digital health, based on StartUp Health
Insights data. Innovation continues to thrive as borders between technologies, talent and nations disappear to spur real change in
medical systems at home and abroad.
DEALS & FUNDING INVESTORS 50+ MARKET

149
282
464
624
566
498
234
3
Digital Health Funding Snapshot Year Over Year (2016 YTD)
$2B
$4B
$6B
$8B
2010 2011 2012 2013 2014 2015 2016 YTD
Q1 Q2 Q3 Q4 $1.7B
2016 demonstrated the strongest ﬁrst half of a year, to date, with $3.9B total invested compared to the previous record
of $3.5B in the ﬁrst half of 2014. In alignment with past trends, funding continues to increase as deal count decreases.
Deal Count
$575M $755M
$1.1B $1.5B
$3.5B
$2.9B
$3.9B
Q1+Q2
$1.1B
$2B
$2.4B
$3B
$7B
$6B
$3.9B

Digital Health Funding Snapshot Month Over Month
4
$0
$250,000,000
$500,000,000
$750,000,000
$1,000,000,000
$1,250,000,000
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec
2013 2014 2015 2016 YTD
$1.25B
$1.00B
$0.75B
$0.50B
$0.25B
Comparing funding year over year, a clear pattern is evident in the deployment of capital forming with slower periods  
at the beginning of the year and during the summer, with May and September as major months for funding.

$0
$250,000,000
$500,000,000
$750,000,000
$1,000,000,000
$1,250,000,000
2010 2011 2012 2013 2014 2015 2016 YTD
R² = 0.6016
$320M Series B
Digital Health Funding Snapshot Month Over Month
Though funding looks like it took a signiﬁcant dip in June of this year, this was largely due to the $500M Series A
investment in Ping An Good Doctor in May.
$150M Series C
$37.5M Venture
$37.9M Venture
$101M Series B
$394M Venture
$33M Series B
$31M Series A
$400M Series C
$230M Series B
$500M Series C
R2 = 0.5564
$1.25B
$1.00B
$0.75B
$0.50B
$0.25B
$400M Venture
$500M Series A
5

Company $ Invested Market / Subsector Notable Investor
1 $500M Patient Experience / Navigation Undisclosed
2 $400M Wellness / Insurance Khosla Ventures
3 $220M Big Data / Diagnostics GE Ventures
4 $175M Big Data / Personalized Health Roche
5 $160M Wellness / Insurance Spark Capital
6 $100M Personalized Health / Genomics Lightspeed Ventures
6 $100M Wellness / Behavioral Health Hinduja Group
8 $95M Wellness / Physical Fitness Summit Partners
9 $80M Wellness / Insurance Bessemer Venture Partners
10 $75M Medical Device / Diagnostics Orbimed
Chinese patient scheduling app, Ping An Good Doctor, leads 2016 with a half billion dollar deal. Companies rethinking the  
way we experience insurance are high in funding as Oscar, Clover and Bright Health scale their solutions.
The Top 10 Largest Deals of 2016 YTD
6

Company $ Invested Market / Subsector Notable Investor
1 $9.3M Personalized Health / Genomics Health Catalyst Capital Management
2 $9.2M Medical Device / Nutrition Foundry Group
3 $9.1M Medical Device / Mobile App Empire Capital Partner
4 $9.0M Medical Device / Wellness Andreessen Horowitz
4 $9.0M Wellness / Big Data TransLink Capital
6 $8.7M Personalized Health / Genomics Pilot Growth Equity
7 $8.5M Wellness / Nutrition Undisclosed
8 $8.2M Research / Patient Engagement Undisclosed
8 $8.2M Patient Experience / Telemedicine Partech Ventures
10 $8.0M Wellness / Nutrition SevenVentures Austria
The top deals under $10M show a diverse cross section of digital health innovation. While the most active markets are
evenly represented, there is an increase in genome-sequencing companies and medical device companies on this list.
The Top 10 Deals Under $10M of 2016 YTD
7

Market $ Invested # of Deals Notable Deals
1 Patient / Consumer Experience $958M 51
• Livongo
• DocPlanner
2 Wellness $854M 25
• Bloodbuy
• Healthline
3 Personalized Health / Quantified-Self $524M 19
• Guardant Health
• Prenetics
4 Big Data / Analytics $406M 19
• Lumiata
• Apixio
5 Workflow $328M 43
• Maxwell Health
• Captricity
6 Clinical Decision Support $234M 13
• ePatientFinder
• RubiconMD
7 Medical Device $227M 25
• MindMaze
• Halo Neuroscience
8 E-Commerce $172M 19
• Healthline
• Bloodbuy
9 Research $65M 17
• Elemental Machines
• Strata Oncology
10 Population Health $55M 18
• Virtual Health
• Lightbeam Health Solutions
The Top 10 Most Active Markets of 2016 YTD
8
Patient / consumer experience remains a dominant market in the ﬁrst half of the year, leading signiﬁcantly in both
funding amount and deal count.

The Top 10 Most Active US Metro Areas of 2016 YTD
Metro Area
1 SF Bay Area
2 New York City
3 San Diego
4 Boston
5 Chicago
6 Minneapolis
7 Los Angeles
8 Salt Lake City
9 Philadelphia
10 Phoenix
$286M
$753M
$131M
$70M
$967M
Boston
$122M Chicago
$54M
$67M
Phoenix
(3 Deals)
San Diego
(6 Deals)
SF Bay Area
(50 Deals)
Salt Lake City
(1 Deal)
Philadelphia
(6 Deals)
(8 Deals)
New York City
(26 Deals)
(10 Deals)
$107M
Minneapolis
(6 Deals)
$76M
Los Angeles
(6 Deals)
The San Francisco Bay Area and NYC Metro Area continue their dominance as hotbeds for digital health funding.  
New hubs continue to emerge and remain in the top 10 including Los Angeles, San Diego, Chicago and Minneapolis.
9

Notable International Deals of 2016 YTD
China
Innovations continue to explode abroad as India pushes through its giant consumer-centric healthcare system, China
begins connecting millions of patients to doctors and Israel pushes groundbreaking software solutions.
Chengdu, China
$50M Series C
May 2016
Shanghai ,China
$500M Series A
May 2016
Beijing, China
$15M Series B 
March 2016
Gurgaon, India
$16M Series B
April 2016
Netherlands
$11M Series A 
March 2016
 
Toronto, Canada
$25M Series A
June 2016
London, UK
$25M Series A 
June 2016
Tel Aviv, Israel
$25M Series G
June 2016
Munich, Germany
$45M Series C 
March 2016
10

2010
2011
2012
2013
2014
2015
2016
0% 25% 50% 75% 100%
Seed Series A Series B Series C Series D Series E Series F+
Through the ﬁrst half of the year we have seen an equal amount of Seed and Series A deals. These early-stage deals
account for more than 65 percent of deal volume, speaking to investors’ continued interest in new innovations and
business models.
Deal Activity by Stage 2016 YTD
32% 33% 10%18% 4%
Deal Count
121
233
305
446
382
285
155 (YTD)
11

Despite a 1:1 distribution in the number of Seed and Series A rounds, actual funding is disproportionate, with a 1:5 ratio,
respectively. Series A financing totals $400M in the first half of the year, excluding Ping An Good Doctor, while Seed
financing is under $100M. Series B climbs to $600M, while the later rounds drop off in amount.
Funding Activity by Stage in 2016 YTD
34% 34% 9%17% 4%
$0M
$175M
$350M
$525M
$700M
Seed Series A* Series B Series C Series D Series E
Series A
12
*Ping An Good Doctor’s $500M Series A round not included in calculations

13
Deal Size Ranges & Medians by Stage for 2016 YTD
$0 $300M
While mid-stage deals displayed the greatest range of deal size at more than $200M, mid-stage and late-stage median
amounts were very close, with early-stage deal size median considerably lower.
$7.3M $15.0M $41.7M
$11M $100M
$2.5M $220M
$52K $25M
$14M
$3.9M
$15.5M
Late-stage (Series D+)
Mid-stage (Series B + Series C)
Early-stage (Seed + Series A*)
$3.9M
$17M
$21M
*Ping An Good Doctor’s $500M Series A round not included in calculations

Most Active Venture Investors of 2016 YTD
Firm 2016 YTD Deals 2015 Deals Stage
Early Mid Late
1 8 9
1 8 10
3 7 2
4 5 5
4 5 1
4 5 6
7 4 1
7 4 6
7 4 1
7 4 5
The ﬁrst six months of the year have been an active period for the 10 most active investors as all are on pace to surpass
their 2015 deal count, with half of the ﬁrms already meeting or exceeding the number.
14

Investor Volume of 2016 YTD
15
0
100
200
300
400
2016 YTD
21
57
368
1 Deal 2 Deals 3+ Deals
InvestorCount
# of Deals by Investor
2016 continues to demonstrate that the appetite for investment in the digital health sector is not waning. So far this year,
close to 450 investors have deployed capital in the sector, with 21 organizations investing in more than three deals.
DEALS & FUNDING 50+ MARKETINVESTORS
21

209
315
339
506
602 611
446
Number of Investors Year Over Year
Investors have been converging on the digital health industry, more than doubling the unique investor count since 2010.
2016 shows no sign of slowing down as the mid-year point tracked close to 450 discrete active investors in the space.
# of Unique Investors
$1.6B
$1.1B
0
100
200
300
400
500
2010 2011 2012 2013 2014 2015 2016 YTD
1 2 3 4 5 6+
InvestorCount
# of Deals by Investor
16

Looking Back on Digital Health IPOs of 2015
Pop. Health
$101.3M
Pre-IPO VC Funding
$1,120M 
(Market Cap
6/29/16)
$195M on opening
(6/8/15)
1.06%
Wearables
$66M
Pre-IPO VC Funding
$2,660M
(Market Cap
6/29/16)
$732M on opening
(6/19/15)
(60.53%)
$108.9M
Pre-IPO VC Funding
Wellness
$661.4M 
(Market Cap
6/29/16)
$101M on opening
(6/22/15)
(4.87%)
$0
$15
$30
$45
$60 52-Week High & Low Share Price
Genomics
$154.1M
Pre-IPO VC Funding
$584.1M
(Market Cap
6/29/16)
$180M on opening
(7/7/15)
(46.36%) (51.24%)
Telemedicine
$157M on opening
(7/1/15)
$93M
Pre-IPO VC Funding
$680.8M
(Market Cap
6/29/16)
$102M on opening
(2/13/15)
$195.5M
Pre-IPO VC Funding
Genomics
(56.23%)
$232.7M
(Market Cap
6/29/16)
SharePrice($)
As digital health companies ﬁnd their identities in the public market, Evolent Health has risen to their initial offering
price. Other public companies still ﬂuctuate as the the market attempts to put a value on these new technologies.
17

As the overall digital health industry continues to expand, startups serving 50+ consumers - either directly or through
providers, payors and other healthcare stakeholders - are increasingly attracting investment.
Defining the 50+ Market in Digital Health
The 50+ relevant category includes companies, both B2C and
B2B2C, with products or services that also serve 50+
consumers. This excludes practice management solutions,
compliance software, lab support tools and other enterprise
systems that do not have a consumer touchpoint, as well as
companies specifically targeting other demographics like
children and young families.
The 50+ focused category includes B2C companies that
specifically target 50+ consumers and B2B2C companies that
provide products and services to payors, providers and others
that serve 50+ consumers.
Emergency Detection
and Response
Physical
Fitness
Diet and
Nutrition
Behavioral and
Emotional Health
Medical
Management
Aging With
Vitality
Social
Engagement
Vital Signs
Monitoring
Care
Navigation
18
This report spotlights two categories of startups: 50+ relevant
and 50+ focused companies. Companies in both categories
align with at least one of AARP’s nine areas of opportunity
featured in the graphic.

20%
40%
60%
80%
100%
53%
61%
57%
52% 51%
48%
62%
47%
50%
47% 45%
49%
45%
51%
Deals Funding
50+ Market Investments as % of Total Investments 2016 YTD
47%
45%
2010 2012 2013 20142011 2015
26%
2016 YTD
Investors in 2016 continue to focus approximately half of their funds and half of their deals on 50+ relevant companies.  
The opportunity to continue to support these types of solutions remains strong in the second half of the year.
19

Subsectors of Growth in the 50+ Sector
47%
45%
26%
Though the entire 50+ market continues to grow, the most active subsectors vary in terms of funding since 2010.
Personalized health has become an explosive winner while patient/ consumer experience maintains strong and steady
growth.
20
$0M
$100M
$200M
$300M
$400M
2010 2011 2012 2013 2014 2015 2016 YTD
Medical Device Patient/ Consumer Experience Personalized Health Wellness

1% 21% 41% 60% 80% 100%
Seed Series A Series B Series C Series D Series E+
50+ Market Investments by Round vs. Total Landscape
Industry
Investors relevant to the 50+ market are signiﬁcantly farther along in round type with less than 20 percent of deals being
early-stage (Seed or Series A). Series B deals make up the majority, at almost half of all funding in the 50+ market.
21
50+ Market
40%20%0%
13%
51%4%
4%
20% 14%
41% 18% 20% 4%
3% 8%

Investors around the globe are funding companies that address the needs of 50+ consumers at all stages, with notable
involvement from corporate and strategic investors.
The Top 50+ Market Venture Investors of 2016 YTD
DEALS & FUNDING INVESTORS 50+ MARKET3+Deals2Deals
22

Sectors:
• We have a broad view of digital health and believe that the current trend is a cross-pollination of technology and data with all aspects of health and
healthcare. StartUp Health Insights
TM
tracks companies that enable health, wellness and the delivery of care through data / analytics, sensors, mobile,
internet-of-things, 3D printing and genomics and personalized medicine.
• Investments in subsectors are not mutually exclusive as deals are tagged with multiple subsectors.
• An extensive database quality assessment was conducted in 2015. A new system was implemented allowing StartUp Health to track innovation with
enhanced granularity. Additionally, gaps in funding data were researched and added into our database enabling us to identify fundings previously
unaccounted for in past reports.
Stage of funding:
• StartUp Health Insights
TM
records only publicly available data on cash for equity investments as the cash is actually received by the company. StartUp
Health Insights
TM
is inclusive of all accelerator, seed, venture, corporate venture and private equity funding.
• Early stage: The company has raised a Seed or Series A round
• Mid stage: The company has raised a Series B or Series C round
• Late stage: The company has raised a Series D or other growth equity round
• StartUp Health also tracks incubator rounds and other financings into privately-held entities (e.g. “unnamed” venture rounds, strategic investments, growth
equity and private equity).
• In tabulating deal activity by stage we exclude rounds not clearly associated with a specific stage.
Sources:
• Funding data is from StartUp Health Insights
TM
, the most comprehensive funding database for digital health, and managed by the StartUp Health team.
Information, data and figures represent only publicly available data, unless otherwise confirmed by the company receiving capital or a participating investor.
• Data for acquisitions slide is provided by a range of sources including StartUp Health Insights
TM
, CrunchBase, AngelList and news reports.
• StartUp Health works to ensure that the information contained in the StartUp Health Insights
TM
Report has been obtained from reliable sources. However,
StartUp Health cannot warrant the ultimate validity of the data obtained in this manner. All data is subject to verification with the venture capital firms and/
or the investee companies. Results are updated periodically. Therefore, all data is subject to change at any time. If you find an error please let us know so we
can correct it.
This report is provided for informational purposes and was prepared in good faith on the basis of public information available at the time of publication without
independent verification. StartUp Health does not guarantee or warrant the reliability or completeness of the data nor its usefulness in achieving any particular
purposes. StartUp Health shall not be liable for any loss, damage, cost or expense incurred by reason of any persons use or reliance on this report. This report is
a proprietary aggregation of publicly available data and shall not be forwarded or reproduced without the written consent of StartUp Health.
23
Our Methodologies

StartUp Health is a global health innovation community leading the movement to transform health by organizing and investing
in Healthcare Transformers. With a family of more than 300 Healthcare Transformers and 150 companies, StartUp Health
spans more than a dozen countries and 60 cities. StartUp Health’s lifetime platform for entrepreneurs includes the StartUp
Health Academy, StartUp Health Network, StartUp Health Studio and StartUp Health Ventures. StartUp Health was founded in
2011 by Steven Krein and Unity Stoakes and is chaired by former Time Warner CEO, Jerry Levin.
StartUp Health’s notable strategic partners and investors include AARP, AON, Aurora Health Care, California Health Care
Foundation, Steve Case, Cleveland Clinic, Conifer Health Solutions, Mark Cuban, Esther Dyson, Brad Feld, Genentech, GE
Ventures, Kaiser Permanente Ventures, Robert Wood Johnson Foundation and SeventySix Capital. Learn more at
startuphealth.com and follow @startuphealth.
24
About StartUp Health
StartUp Health InsightsTM Report Contributors: Troy Bannister, Polina Hanin, Jennifer Hankin, Nicole Kinsey, Tara Salamone

StartUp Health Companies

StartUp Health Insights 2016 Midyear Report

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